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Lecture Notes in Computer Science
Realistic medical procedure simulators improve the learning curve of the clinicians if they can reproduce real conditions and use. This paper describes the improvement of a transrectal ultrasound guided prostate biopsy simulator by adding the simulation of real-time prostate movements and deformations. A discrete bio-mechanical model is used to modify a 3D texture of an ultrasound image volume in order to quickly simulate the actual displacements and deformations. This paper describes thisdoi:10.1007/978-3-319-12057-7_14 fatcat:twjixje5pnedbkteuvcuihbija
more »... and presents how the mesh deformation is used to induce the UltraSound volume deformation. The validation of the method is based on both a quantitative and a qualitative assessment. Experimental images acquired on a phantom are compared using mutual information metrics to the resulting generated images. This comparison shows that the proposed method offers realistic deformed 3D ultrasound images at interactive time. The method was successfully integrated to improve the transrectal ultrasound simulator.
VertigO -la revue électronique en sciences de l'environnement, Volume 16 numéro 3 | décembre 2016 INDEX AUTEURS EMMANUELLE ATHIMON MOHAMED MAANAN THIERRY SAUZEAU JEAN-LUC SARRAZIN Les ... , 2015 ; Sarrazin, 2014 ; Garnier, 2010b) . ...doi:10.4000/vertigo.17927 fatcat:x2qf6e2v2zeshpcfkucesorcjm
Aims: The challenge regarding COVID-19 is to prevent complications and fatal evolution. Azithromycin (AZM) and hydroxychloroquine (HCQ) have proven their antiviral effect in vitro. We aimed to assess the efficacy and safety of AZM alone or combined to HCQ, prescribed, at an early stage, in patients with Covid-19, in a primary care setting. Study Design: Retrospective observational study. Place and Duration of Study: Patients have been followed by private practitioners in France, between Marchdoi:10.9734/ajmah/2020/v18i730224 fatcat:sm5zeyf5znevljwe3zdln6ezw4
more »... d April 2020. Methodology: Eighty-eight patients received either no or a symptomatic treatment (NST) (n=34) or AZM alone (n=34) or AZM+HCQ (n=20). The efficacy end point was the time to clinical recovery and the safety end point was the occurrence of cardiovascular events. To improve the evidence level, a case-control analysis was performed on a sample of 57 patients (19/group) matched for age, sex and BMI. Results: The mean (SD) times to achieve clinical recovery were respectively 25.8 days (11.1), 12.9 days (13.4) and 9.2 days (9.3), showing a statistically significant difference between NST and AZM alone (p<0.0001) or AZM+HCQ (p<0.0001). The statistical difference between NST and AZM was confirmed (p=0.0149) as well as the difference with AZM+HCQ (p=0.0002). No cardiac toxicity was recorded in any patient. No statistical difference was shown between AZM and AZM+HCQ groups, although the dual therapy tended to be more effective in patients over 50 years, based on an analysis using the cox model. Conclusion: AZM and AZM+HCQ favourably impacted the course of the disease. We need trials, ideally prospective/double blind, to show if a statistical difference can be evidenced with a broader group, and clarify the indications of each treatment depending on initial clinical presentation.
| | | Organic Pollution and Genotoxicity of Sediments of the Palun Marshes (Berre Lagoon, France) Carole Di Giorgio, Wei Liu, Luc Sarrazin, Emmanuel Wafo Université de la Méditerra Xavier Moreau, Laetitia ...doi:10.2134/jeq2009.0178 pmid:20176829 fatcat:cfd4mq5ynvfdhbgl645eoxtfhe
3D UltraSound (US) probes are used in clinical applications for their ease of use and ability to obtain intraoperative volumes. In surgical navigation applications a calibration step is needed to localize the probe in a general coordinate system. This paper presents a new hand-eye calibration method using directly the kinematic model of a robot and US volume registration data that does not require any 3D localizers. First results show a targeting error of 2.34 mm on an experimental setup usingdoi:10.1109/embc.2015.7318251 pmid:26736191 dblp:conf/embc/SarrazinPBT15 fatcat:t7tdzw3ndzgabdw64ogeqicovq
more »... anual segmentation of five beads in ten US volumes. the problem AX = XB with a minimum number of three measures with different rotations and translations.
Background--We examined a large community-based sample of patients with atrial fibrillation (AF) and valvular heart disease (VHD) (excluding prosthetic valves) with a goal to compare outcomes among patients with AF, with and without VHD, taking warfarin, dabigatran, and rivaroxaban. Methods and Results--We identified Medicare beneficiaries enrolled in Medicare Part D benefit plan from 2011 to 2013 with newly diagnosed AF (18 137 patients with VHD [dabigatran, 1979; rivaroxaban, 2027; warfarin,doi:10.1161/jaha.118.008773 pmid:29622591 pmcid:PMC6015407 fatcat:utgikzswkvdndc7j3f4xzbv7py
more »... 4 131] and 85 596 patients without VHD [dabigatran, 13 522; rivaroxaban, 14 257; warfarin, 57 817]). Primary outcomes of all-cause mortality, ischemic strokes, major bleeding, and myocardial infarction were compared across the 3 anticoagulants using 3-way propensity-matched samples. After propensity matching, a total of 5871 patients with VHD and 40 221 patients without VHD and AF were studied. Both dabigatran and rivaroxaban were associated with significantly lower risk of death in patients with VHD with AF (dabigatran versus warfarin: hazard ratio, 0.71; 95% confidence interval, 0.52-0.98; P=0.038; rivaroxaban versus warfarin: hazard ratio, 0.68; 95% confidence interval, 0.49-0.95; P=0.022). Nongastrointestinal bleeding was significantly reduced with dabigatran and rivaroxaban versus warfarin in those with VHD (dabigatran versus warfarin: hazard ratio, 0.17; 95% confidence interval, 0.06-0.49; P=0.001; rivaroxaban versus warfarin: hazard ratio, 0.37; 95% confidence interval, 0.17-0.84; P=0.017). Ischemic stroke and gastrointestinal bleeding rates did not differ between rivaroxaban, dabigatran, and warfarin in patients with VHD. The effects of the 3 anticoagulants on outcomes were comparable in patients with and without VHD and with AF. Conclusions--In this cohort of Medicare beneficiaries with VHD (excluding patients with prosthetic valves) and new-onset AF between 2011 and 2013, novel oral non-vitamin K anticoagulants were safe and effective options for prevention of systemic thromboembolism.
, Fabio Marti, Nicolas Heck, Cécile Galléa, Mohamed Doulazmi, Sergi Roig Puiggros, Juan Antonio Moreno-Bravo, Marie Vidailhet, Alain Trembleau, Philippe Faure, Alain Chédotal, Emmanuel Roze, and Isabelle ... Volume 34 Supplemental Information Loss of floor plate Netrin-1 impairs midline crossing of corticospinal axons and leads to mirror movements Oriane Pourchet, Marie-Pierre Morel, Quentin Welniarz, Nadège Sarrazin ...doi:10.1101/2020.02.20.958595 fatcat:2nexstscjjfatgxapelp3v4oge
Kinase-targeted agents demonstrate antitumor activity in advanced metastatic clear cell renal cell carcinoma (ccRCC), which remains largely incurable. Integration of genomic approaches through small-molecules and genetically based high-throughput screening holds the promise of improved discovery of candidate targets for cancer therapy. The 786-O cell line represents a model for most ccRCC that have a loss of functional pVHL (von Hippel-Lindau). A multiplexed assay was used to study the cellulardoi:10.3390/cancers13030576 pmid:33540838 fatcat:4jbarotg6ne2ve6fjvne2oasfu
more »... fitness of a panel of engineered ccRCC isogenic 786-O VHL− cell lines in response to a collection of targeted cancer therapeutics including kinase inhibitors, allowing the interrogation of over 2880 drug–gene pairs. Among diverse patterns of drug sensitivities, investigation of the mechanistic effect of one selected drug combination on tumor spheroids and ex vivo renal tumor slice cultures showed that VHL-defective ccRCC cells were more vulnerable to the combined inhibition of the CK2 and ATM kinases than wild-type VHL cells. Importantly, we found that HIF-2α acts as a key mediator that potentiates the response to combined CK2/ATM inhibition by triggering ROS-dependent apoptosis. Importantly, our findings reveal a selective killing of VHL-deficient renal carcinoma cells and provide a rationale for a mechanism-based use of combined CK2/ATM inhibitors for improved patient care in metastatic VHL-ccRCC.
Computer Assisted Medical Intervention (CAMI hereafter) is a complex multi-disciplinary field. CAMI research requires the collaboration of experts in several fields as diverse as medicine, computer science, mathematics, instrumentation, signal processing, mechanics, modeling, automatics, optics, etc.doi:10.1109/embc.2013.6610654 pmid:24110841 pmcid:PMC3891168 dblp:conf/embc/PromayonFBDFHLP13 fatcat:22gs44iz6fdilk3ydpbfghvqsa
National Union Catalog
Emmanuel A Dieudonné Mario —, comte de. Ménorial de Sainte-Hélene. Francesco, d. 1838. Mémoires, ou Les derniers momens de Napoléon. | ee Library of Congress DC149.894 Sarrazin, Jean, 1770-1850? ... Printed by L. 0. rate, Title from Leland Stan- CATALOG OF PRINTED CARDS Sarrazin, Gregor Ignatz, 1857-1915. Wigamur. Eine li Gregor Sarrazin. Strassburg, K. J. ...
Acteurs et réseaux du savoir 210 Emmanuel Minel Urfé, Honoré d'. L'Astrée. Deuxième partie. ... Édition critique établie sous la direction de Delphine Denis, par Jean-Marc Chatelain, Delphine Denis, Camille Esmein-Sarrazin, Laurence Giavarini, Frank Greiner, Françoise Lavocat et Stéphane Macé 216 ...doi:10.1515/kl-2016-frontmatter3-4 fatcat:vcndprky4vgk5dbdgkqfdn3lke
Acta Apostolicae Sedis
Sarrazin L., 410. Sarto Ioannes Baptista, 430. Sarto Ioseph Melchior (Pius Pp. X), 428, 718. Sartoris Dominicus, ‘50. Sassi Franciscus, 528. Sassoli de’ Bianchi Iosephus (marchio), 530. ... Sanz Casasnovas Emmanuel, 687. Sanz de Samper Richardus, 507, 511. Sarazzani Philippus (comes), 529. Sardi Vincentius, archiep. tit. Caesarien- sis in Palaestina, 511, 683. Sarna Ladislaus, 370. ...
The Journal of Applied Ecology
Olofsson Esben Olsen Ola Olsson David Onstad Gerard Oostermeijer Steve Ormerod Loki Osborn Mark Osborn Juliet Osborne Graham Osier Orjan Ostman Norman Owen-Smith Robin Pakeman Steve Palmer Maurizio Paoletti Emmanuel ... Mathieu Rouget Stephen Roxburgh David Roy Jeffrey Royle Sandrine Ruette Michael Runge Kalle Ruokolainen Jeremy Russell-Smith Hakan Rydin Hugh Safford Kaj Sand-Jensen Nate Sanders Fiona Sanderson Francois Sarrazin ...
Revue Des Deux Mondes
L’Etna d'autrefois s'appelle aujourd’hui Mongibello, c'est un souvenir de la domination sarrazine. ... Le premier travail de la municipalité avait été de changer le nom des rues, et sur de larges pancartes, en grosses lettres tracées à la main, on pouvait lire : rue Garibaldi, rue Victor-Emmanuel, place ...
Daneault Serge, « Cancer, souffrance et services de santé », Maison Michel-Sarrazin, Cahiers francophones de soins palliatifs, 01/2013, 13, 1, p. 9-16. ... Mpinga Emmanuel, Verloo Henk, Bondolfi Alberto, Pellissier François, Rapin Charles-Henri, Chastonay Ph., « Attitude des infirmières et des aidessoignantes face aux conflits en soins palliatifs », Soins ...doi:10.3917/jalmalv.126.0117 fatcat:gvljlsopsfci5k4gmk3abkkt7y
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