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MicroRNAs in opioid addiction: elucidating evolution

Emily J. Wood, Leonard Lipovich
2012 Frontiers in Genetics  
doi:10.3389/fgene.2012.00241 pmid:23233859 pmcid:PMC3516178 fatcat:co4rfsnyv5at3dkmzdxtk6x36e

Indoor particulate matter in rural, wood stove heated homes

Erin O. Semmens, Curtis W. Noonan, Ryan W. Allen, Emily C. Weiler, Tony J. Ward
2015 Environmental Research  
Ambient particulate matter (PM) exposures have adverse impacts on public health, but research evaluating indoor PM concentrations in rural homes in the United States using wood as fuel for heating is limited  ...  Our findings demonstrate relatively high mean PM concentrations in these wood burning homes and suggest potential targets for interventions for improving indoor air quality and health in rural settings  ...  heavy), source of wood, and approximate age of wood.  ... 
doi:10.1016/j.envres.2015.02.005 pmid:25701812 pmcid:PMC4385435 fatcat:txp4tr4gufbzpnyvufsu47y6ny

Genetic Parameters of White Striping and Meat Quality Traits Indicative of Pale, Soft, Exudative Meat in Turkeys (Meleagris gallopavo)

Ryley J. Vanderhout, Emily M. Leishman, Emhimad A. Abdalla, Shai Barbut, Benjamin J. Wood, Benjamin J. Wood, Benjamin J. Wood, Christine F. Baes, Christine F. Baes
2022 Frontiers in Genetics  
Due to the increasing prevalence of growth-related myopathies and abnormalities in turkey meat, the ability to include meat quality traits in poultry breeding strategies is an issue of key importance. In the present study, genetic parameters for meat quality traits and their correlations with body weight and meat yield were estimated using a population of purebred male turkeys. Information on live body, breast, thigh, and drum weights, breast meat yield, feed conversion ratio, breast lightness
more » ... L*), redness (a*), and yellowness (b*), ultimate pH, and white striping (WS) severity score were collected on 11,986 toms from three purebred genetic lines. Heritability and genetic and partial phenotypic correlations were estimated for each trait using an animal model with genetic line, hatch week-year, and age at slaughter included as fixed effects. Heritability of ultimate pH was estimated to be 0.34 ± 0.05 and a range of 0.20 ± 0.02 to 0.23 ± 0.02 for breast meat colour (L*, a*, and b*). White striping was also estimated to be moderately heritable at 0.15 ± 0.02. Unfavorable genetic correlations were observed between body weight and meat quality traits as well as white striping, indicating that selection for increased body weight and meat yield may decrease pH and increase the incidence of pale meat with more severe white striping. The results of this analysis provide insight into the effect of current selection strategies on meat quality and emphasize the need to include meat quality traits into future selection indexes for turkeys.
doi:10.3389/fgene.2022.842584 pmid:35309137 pmcid:PMC8927805 doaj:422b14c09d3049aca58daaf55e83e435 fatcat:uvxyri7vtfd7tfe5ex3gocxgva

Climate fails to predict wood decomposition at regional scales

Mark A. Bradford, Robert J. Warren II, Petr Baldrian, Thomas W. Crowther, Daniel S. Maynard, Emily E. Oldfield, William R. Wieder, Stephen A. Wood, Joshua R. King
2014 Nature Climate Change  
Disaggregated data instead reveal that local-scale factors explain 73% of the variation in wood decomposition, and climate only 28%.  ...  We test whether climate controls on the decomposition rate of dead wood-a carbon stock estimated to represent 73 ± 6 Pg carbon globally 8 -are sensitive to the spatial scale from which they are inferred  ...  Neupane and J. Snajdr for laboratory assistance, and P. Raymond  ... 
doi:10.1038/nclimate2251 fatcat:ug7mjd4nt5csvjhi2j3msr53ve

Measuring Attributes of Rigor in Information Analysis [chapter]

Daniel J. Zelik, Emily S. Patterson, David D. Woods
2018 Macrocognition Metrics and Scenarios  
., 2005; Woods, 2005) . ACKNOWLEDGMENTS This research was supported by the Department of Defense (BAA-001-04).  ...  Thus, rigor represents a mechanism for revealing the observability of an analysis process (Woods, Patterson, & Roth, 2002) .  ...  Study Description The design of the study was based on the Elicitation by Critique (EBC) methodology (Miller, Patterson, & Woods, 2006) .  ... 
doi:10.1201/9781315593173-7 fatcat:3aq42n4p7bghtd2eevpdpp7sse

Evidence-Based Valuation in Oncology:

John J. Doyle, Emily Hawryluk, Jeffrey Niemira, Brian Wood
2018 Therapeutic Innovation and Regulatory Science  
Value demonstration in health care remains a challenge. This paper examines traditional approaches to pricing and the evolution of value-based pricing (VBP), and proposes a new framework for evidence-based valuation (EBV). The main objective of EBV is to estimate the value-based pricing range for the new medicine, identify key product attributes that drive value as perceived by various stakeholders, and then elucidate the requisite evidence to support those value claims. Methods: EBV centers on
more » ... a structured framework for estimating a drug's price based on its perceived value to various stakeholders. The EBV framework consists of identifying key value attributes that drive adoption of a drug in a given therapeutic area; gaining insights into stakeholder value considerations and evidence requirements; and quantifying stakeholders' perceptions of specific value attributes within pricing premiums. Results: An example demonstrates the application of the EBV framework in a simplified manner for 3 drugs indicated for renal cell carcinoma, 3 drugs for prostate cancer, and 1 drug for melanoma. HTAs, published trial results, and publications archived in PubMed between 2005 and 2013 were analyzed to identify key value attributes. The following 5 attributes were considered: overall survival (OS), progression-free survival (PFS), population size, trial comparator, and adverse events. Conclusions: The method described offers a means to appraise pharmaceuticals in an environment increasingly focused on evidence-based medicine and value-based health care. Keywords evidence-based value framework, value demonstration in health care, pricing in oncology
doi:10.1177/2168479018786701 pmid:30037308 fatcat:ydgdfdehfbcjzmswicblaqze3a

Matrix-free hydrodynamic study on the size distribution and conformation of three technical lignins from wood and non-wood

Qushmua E. Alzahrani, Gary G. Adams, Richard B. Gillis, Tabot M.D. Besong, M. Samil Kök, Emily Fong, Richard A. Harding, Jan E.G. van Dam, Richard J.A. Gosselink, Arthur J. Rowe, Stephen E. Harding
2016 Holzforschung  
SEDFIT-MSTAR reveals a near-linear plot of ln J(r) vs. r 2 for kraft L [where J(r) is the local concentration (expressed in fringe units) at radial positions r]; however, evidence of upward curvature is  ...  Lignin ν for ν s = 0.6 ml g -1 ν for ν s = 1.0 ml g -1 ν for ν s = Figure 1 : 1 Sedimentation velocity of wood lignins.  ... 
doi:10.1515/hf-2014-0318 fatcat:a33inewac5cltnvysedy6jxvwe

Mechanical Regulation of Microvascular Angiogenesis [article]

Marissa A Ruehle, Emily A Eastburn, Steven A LaBelle, Laxminarayanan Krishnan, Jeffrey A. Weiss, Joel D Boerckel, Levi B Wood, Robert E Guldberg, Nick J Willett
2020 bioRxiv   pre-print
Neovascularization is a critical early step toward successful tissue regeneration during wound healing. While vasculature has long been recognized as highly mechanosensitive (to fluid shear, pulsatile luminal pressure, etc.), the effects of extracellular matrix strains on angiogenesis are poorly understood. Previously, we found that dynamic matrix compression in vivo potently regulated neovascular growth during tissue regeneration; however, whether matrix deformations directly regulate
more » ... sis remained unknown. Here, we tested the effects of load initiation time, strain magnitude, and mode of compressive deformation (uniform compression vs. compressive indentation that also introduced shear stress) on neovascularization and key angiogenic and mechanotransduction signaling pathways by microvascular fragments in vitro. We hypothesized that neovascularization would be enhanced by delayed, moderate compression and inhibited by early, high magnitude compression and by compressive indentation. Consistent with our hypothesis, early, high magnitude loading inhibited vessel growth, while delayed loading enhanced vessel growth. Compressive indentation led to longer, more branched networks than uniform compression; particularly at high strain magnitude. Gene expression was differentially regulated by time of load initiation; genes associated with active angiogenic sprouts were downregulated by early loading but upregulated by delayed loading. Canonical gene targets of the YAP/TAZ mechanotransduction pathway were increased by loading and abrogated by pharmacological YAP inhibition. Together, these data demonstrate that neovascularization is directly responsive to dynamic matrix strain and is particularly sensitive to the timing of load initiation. This work further identifies putative mechanoregulatory angiogenic mechanisms and implicates a critical role for dynamic mechanical cues in vascularized tissue regeneration.
doi:10.1101/2020.01.14.906354 fatcat:htj2travbrcoxoztpxgb7754um

Randomized Trial of Interventions to Improve Childhood Asthma in Homes with Wood-burning Stoves

Curtis W. Noonan, Erin O. Semmens, Paul Smith, Solomon W. Harrar, Luke Montrose, Emily Weiler, Marcy McNamara, Tony J. Ward
2017 Environmental Health Perspectives  
METHODS: A three-arm placebo-controlled randomized trial was conducted in homes with wood-burning stoves among children with asthma.  ...  particular Pediatric Asthma Quality of Life Questionnaire (PAQLQ) scores, relative to placebo, among children living with asthma in homes with wood-burning stoves.  ...  Acknowledgments The authors thank J. Balmes and K. Smith for their advice on study design. The authors also thank 3M Company for advice and materials in the design of the placebo filter.  ... 
doi:10.1289/ehp849 pmid:28935614 pmcid:PMC5915210 fatcat:a7qepgam7fcd3amjiyhazvh2um

Promoting Cardiovascular Health and Reducing Disparities Among American Indians and Alaska Natives

Emily J. Jones, J. Cedric Woods, Laura L. Hayman
2013 Journal of Cardiovascular Nursing  
J. Cedric Woods, PhD Director, Institute for New England Native American Studies, University of Massachusetts, Boston.  ... 
doi:10.1097/jcn.0b013e31826341cd pmid:22914257 fatcat:kgz6v36ywvcuda44czttcwi5xm

Lithiation and Delithiation of Lead Sulfide (PbS)

Sean M. Wood, Emily J. Powell, Adam Heller, C. Buddie Mullins
2015 Journal of the Electrochemical Society  
The lithiation and delithiation of PbS was studied. Below 1.0 V vs. Li/Li + , lithiation produced a series of Li-Pb alloys and Li 2 S. The Li-Pb alloys were reversibly lithiated and delithiated, but at a 1 C rate their capacity faded through 100 cycles. Above 1.5 V vs. Li/Li + , Li 2 S is electrooxidized to Li + and soluble polysulfides, and the sulfide is irreversibly depleted. ) unless CC License in place (see abstract). ecsdl.org/site/terms_use address. Redistribution subject to ECS terms of
more » ... use (see 207.241.231.81 Downloaded on 2018-07-19 to IP Journal of The Electrochemical Society, 162 (7) A1182-A1185 (2015) A1185 of separator membranes and Solvay Fluor for their contribution of fluoroethylene carbonate. ) unless CC License in place (see abstract). ecsdl.org/site/terms_use address. Redistribution subject to ECS terms of use (see 207.241.231.81 Downloaded on 2018-07-19 to IP
doi:10.1149/2.0241507jes fatcat:35pfuvarergbhah35ejrdqlm2a

Housing and Management of Turkey Flocks in Canada

Nienke van Staaveren, Emily M. Leishman, Sarah M. Adams, Benjamin J. Wood, Alexandra Harlander-Matauschek, Christine F. Baes
2020 Animals  
., straw, wood shavings) provided (100%).  ...  Only a few farmers attempted to specify the type of wood shavings they used, with most references being made to kiln-dried wood, soft wood, pine and spruce.  ...  When details on the type of wood shaving used were requested, most farmers were unable to provide this information.  ... 
doi:10.3390/ani10071159 pmid:32650501 fatcat:7oaunpu46fbh5gl22vhxe47jse

Stochastic processes dominate the within and between host evolution of influenza virus [article]

John T. McCrone, Robert J. Woods, Emily T. Martin, Ryan E. Malosh, Arnold S. Monto, Adam S. Lauring
2017 bioRxiv   pre-print
The global evolutionary dynamics of influenza virus ultimately derive from processes that take place within and between infected individuals. Here we define the dynamics of influenza A virus populations in human hosts through next generation sequencing of 249 specimens from 200 individuals collected over 6290 person-seasons of observation. Because these viruses were collected over 5 seasons from individuals in a prospective community-based cohort, they are broadly representative of natural
more » ... infections with seasonal viruses. We used viral sequence data from 35 serially sampled individuals to estimate a within host effective population size of 30-70 and an in vivo mutation rate of 4x10-5 per nucleotide per cellular infectious cycle. These estimates are consistent across several models and robust to the models's underlying assumptions. We also identified 43 epidemiologically linked and genetically validated transmission pairs. Maximum likelihood optimization of multiple transmission models estimates an effective transmission bottleneck of 1-2 distinct genomes. Our data suggest that positive selection of novel viral variants is inefficient at the level of the individual host and that genetic drift and other stochastic processes dominate the within and between host evolution of influenza A viruses.
doi:10.1101/176362 fatcat:scm3h3l3gfbqtfb6vl2khm5lii

Inherent physiological artifacts in EEG during tDCS

Nigel Gebodh, Zeinab Esmaeilpour, Devin Adair, Kenneth Chelette, Jacek Dmochowski, Adam J. Woods, Emily S. Kappenman, Lucas C. Parra, Marom Bikson
2019 NeuroImage  
The cardiac artifact, sometimes referred to as a ballistocardiographic artifact (Rubin and Daube, 2016 Artifacts and the EEG Britton, J; Schmitt, 2017) , was observed consistently during stimulation  ... 
doi:10.1016/j.neuroimage.2018.10.025 pmid:30321643 pmcid:PMC6289749 fatcat:z6fqmtfgszc2jgoz3wwlvwsoay

Homologous alignment cloning: a rapid, flexible and highly efficient general molecular cloning method

Lendl Tan, Emily J. Strong, Kyra Woods, Nicholas P. West
2018 PeerJ  
myriad of potential outcomes, including the ability to express a gene of interest in diverse backgrounds to characterise phenotypic consequences of specific genes (Nasmyth, 1978; Struhl & Davis, 1977; Wood  ...  Emily J. Strong performed the experiments. Kyra Woods performed the experiments. Nicholas P.  ... 
doi:10.7717/peerj.5146 pmid:30038856 pmcid:PMC6054264 fatcat:s6lih4hd2vai7a5r3cif5eprda
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