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Morant and C. ...doi:10.1109/roman.2011.6005284 dblp:conf/ro-man/ChernovaDMB11 fatcat:apwknmndi5fnxfs2piu2wh5aru
Glioblastoma cancer-stem like cells (GSCs) display marked resistance to ionizing radiation (IR), a standard of care for glioblastoma patients. Mechanisms underpinning radio-resistance of GSCs remain largely unknown. Chromatin state and the accessibility of DNA lesions to DNA repair machineries are crucial for the maintenance of genomic stability. Understanding the functional impact of chromatin remodeling on DNA repair in GSCs may lay the foundation for advancing the efficacy ofdoi:10.1038/s41467-020-18549-8 pmid:32948765 pmcid:PMC7501306 fatcat:siy3e7lpgbdqffgwxyp7mpbr5a
more »... g therapies. Here, we present the results of a high-content siRNA microscopy screen, revealing the transcriptional elongation factor SPT6 to be critical for the genomic stability and self-renewal of GSCs. Mechanistically, SPT6 transcriptionally up-regulates BRCA1 and thereby drives an error-free DNA repair in GSCs. SPT6 loss impairs the self-renewal, genomic stability and tumor initiating capacity of GSCs. Collectively, our results provide mechanistic insights into how SPT6 regulates DNA repair and identify SPT6 as a putative therapeutic target in glioblastoma.
Physical Review B
A novel method for the direct correlation at the nanoscale of structural and optical properties of single GaAs nanowires is reported. Nanowires consisting of 100% wurtzite and nanowires presenting zinc-blende/wurtzite polytypism are investigated by photoluminescence spectroscopy and transmission electron microscopy. The photoluminescence of wurtzite GaAs is consistent with a band gap of 1.5 eV. In the polytypic nanowires, it is shown that the regions that are predominantly composed of eitherdoi:10.1103/physrevb.83.045303 fatcat:j3ve5zmezbcqrlxxkrbgv7ewle
more »... c-blende or wurtzite phase show photoluminescence emission close to the bulk GaAs band gap, while regions composed of a nonperiodic superlattice of wurtzite and zinc-blende phases exhibit a redshift of the photoluminescence spectra as low as 1.455 eV. The dimensions of the quantum heterostructures are correlated with the light emission, allowing us to determine the band alignment between these two crystalline phases. Our first-principles electronic structure calculations within density functional theory, employing a hybrid-exchange functional, predict band offsets and effective masses in good agreement with experimental results.
Due to cardiovascular safety concerns, the European Medicines Agency (EMA) recommended new contraindications and changes to product information for diclofenac across Europe in 2013. This study aims to measure its impact among targeted populations. Quarterly interrupted time series regression (ITS) analyses of diclofenac initiation among cohorts with contraindications (congestive cardiac failure CHF, ischaemic heart disease IHD, peripheral arterial disease PAD, cerebrovascular disease CVD) anddoi:10.1111/bcp.14478 pmid:32668021 fatcat:cogkm2bpx5e4xae4yk77dshs4y
more »... utions (hypertension, hyperlipidaemia, diabetes) from Denmark, The Netherlands, England and Scotland RESULTS: The regulatory action was associated with significant immediate absolute reductions in diclofenac initiation in: all countries for IHD (Denmark -0.08%, 95%CI -0.13,-0.03; England -0.09%, 95%CI -0.13 to -0.06%; The Netherlands -1.84%, 95%CI -2.51 to -1.17%; Scotland -0.34%, 95%CI -0.38 to -0.30%), PAD and hyperlipidaemia; The Netherlands, England and Scotland for hypertension and diabetes; and England and Scotland for CHF and CVD. Post-intervention there was a significant negative trend in diclofenac initiation in: The Netherlands for IHD (-0.12%, 95%CI -0.19 to -0.04), PAD (-0.13%, 95%CI -0.22 to-0.05), hypertension, hyperlipidaemia and diabetes; and in Scotland for CHF (-0.01%, 95%CI -0.02 to -0.007%), IHD (-0.017, 95%CI -0.02,-0.01%), PAD and hypertension. In England, diclofenac initiation rates fell less steeply. In Denmark changes were more strongly associated with the earlier EMA 2012 regulatory action. Although significant reductions in diclofenac initiation occurred, patients with contraindications continued to be prescribed diclofenac the extent of which varied by country and target condition. Understanding reasons for such variation may help to guide the design or dissemination of future safety warnings.
How to cite this article: Morales DR, Morant SV, MacDonald TM, et al. ...doi:10.1002/pds.4955 pmid:31899936 pmcid:PMC7079064 fatcat:6dz3lablrzajnjlleyqdg2xwni
Hydroxyzine is indicated for the management of anxiety, skin and sleep disorders. In 2015, the European Medicines Agency (EMA) concluded that hydroxyzine was pro-arrhythmogenic and changes to the product information were implemented in Europe. This study aimed to evaluate their impact in Denmark, Scotland, England and the Netherlands. Quarterly time series analyses measuring hydroxyzine initiation, discontinuation, and switching to other antihistamines, benzodiazepines and antidepressants indoi:10.1002/pds.5191 pmid:33386650 fatcat:uwnm53lwv5cafl3fxr625tapsy
more »... mark, England, Scotland and the Netherlands from 2009-2018. Data were analysed using interrupted time series regression. Hydroxyzine initiation in quarter one 2010 in Denmark, Scotland, England and the Netherlands per 100,000 was: 23.5, 91.5, 35.9 and 34.4 respectively. Regulatory action was associated with a significant: immediate fall in hydroxyzine initiation per 100,000 in England (-12.05, 95%CI -18.47 to -5.63) and Scotland (-19.01, 95%CI -26.99 to -11.02); change to a negative trend in hydroxyzine initiation per 100,000/quarter in England (-1.72, 95%CI -2.69 to -0.75) and Scotland (-2.38, 95%CI -3.32 to -1.44). Regulatory action was associated with a significant: immediate rise in hydroxyzine discontinuation per 100,000 in England (3850, 95%CI 440 to 7240). No consistent changes were observed in the Netherlands or Denmark. Regulatory action was associated with no switching to other antihistamines, benzodiazepines or antidepressants following hydroxyzine discontinuation in any country. The 2015 EMA regulatory action was associated with heterogeneous impact with reductions in hydroxyzine initiation varying by country. There was limited impact on discontinuation with no strong evidence suggesting unintended consequences of major switching to other antihistamines, benzodiazepines or antidepressants.
We propose a new set of browser security indicators, based on user research and an understanding of the design challenges faced by browsers. To motivate the need for new security indicators, we critique existing browser security indicators and survey 1,329 people about Google Chrome's indicators. We then evaluate forty icons and seven complementary strings by surveying thousands of respondents about their perceptions of the candidates. Ultimately, we select and propose three indicators. Ourfatcat:ikptdhddmrc25cicniq5aehcxi
more »... osed indicators have been adopted by Google Chrome, and we hope to motivate others to update their security indicators as well.
., 315 Daniel, 46 Dorothy, 56 Ebenezer, 133 Elizabeth, 56 George H., 97, 98 Hannah, 56 Moor, Moor,'t More, Sarah, 12, 14 Susanna, 292-204 Theodosius, 12 Thomas, 161 Moors, Martha, 25 Moot, Keziah, 26 Morant ... Cezar, 245 Elisabeth Quay, 245 Frank, 210 Gene, 24 Jack, 210 Julia Ann, 252 Marcus, 252 Mary, 252 Nathaniel, 252 Thomas, 141 Morys, John, 299 Moseley, i Henry, 162 Mosely, } Samuel, Nathan, 245 Rebecca ...
Ce plan d'eau est identifiable sur le plan Morant de 1548 et pourrait avoir Archéologie de la France -Informations , Alsace Strasbourg -Les DiaconessesADLFI. ... Archéologie de la France -Informations , Alsace appartenu à l'hospice des Pauvres-passants et Pauvres-Pélerins implanté, a priori, dans l'actuelle rue Ste-Elisabeth. ...doi:10.4000/adlfi.8173 fatcat:2dwudlmtkffslaotgrt5ug42qu
Jaquea de hem, ende Janneken d’huysvronwe van Abraham Willemson. ...enijer Muesevoet, filius Thomas ende syner huysvrouwe Elisabeth, geboren den 13 Martij in S‘Jooris a Coslaney,* ende war gedoopt den ... I find from Morant that Nicolas Freeman of Dedham acquired the Manor of Great Horkeslej’ in 1712, and was succeeded there by three nephews in turn—Nicolas, llobert, and John—the manor being entailed on ...
Voir Elisabeth Hsu, « La médecine chinoise traditionnelle en république populaire de Chine : d'une 'tradition inventée' à une 'modernité alternative' », dans Anne Cheng, éd., La pensée en Chine aujourd'hui ... », Evelyn Soulié de Morant dans Emilie Gomart, George Soulié de Morant (1878-1955) and the promotion of acupuncture in France, M.Phil. moins vrai que le succès de George Soulié de Morant comme acupuncteur ...doi:10.4000/dht.656 fatcat:7u4plafyfjacroy3qfkr6vzu4u
Shorry were absolned in or Oourts, and Elisabeth Cunninghu (now a poore widdowe and charged wth three SmaU children) was absolued a little before that; m Longe since they were prsented to Norweh Court ... Holman’s MSS. were sold, it is said, some to Morant, others to Baw- hnson, others to Mr. Booth. Some of the MSS. are now in the Ash- bumham Collections, others were left by Bawlinson to the Bodleian. ...
Mora Martinez, Gaspar Morante, Antonio Morante Blanco, Rodrigo Morawetz, Klaus Mordukhovich, Boris S. ............. Moreau, Pierre-Etienne Morel, Bertrand Moreno, J. P. Moret, Bernard M. ... Naeve-Steinweg, Elisabeth As “ESR err Nagasawa, Takeyuki Nagatou, K. naa Nagel, Christian ..... Nagel, Rainer ....... Nahlus, Nazih Naidénoy, S. V. meas Nair, M. Thamban Nair, N. ...
The Gentleman's Magazine
Morant Gale, esq., of Upham, Hants. At Clifton, Richard G. ... Dalton Scoones, Incumbent of Langley, Bucks., to Elisabeth, second dau. of the late John Haggard, LL.D., of Doctors’ Commons. ...
., 1611 Morant, Ricardo B., 5745 Miyatake, Tadashi, 4664 Mordvinov, E. ... G., 6208 Murray, Elisabeth A., 6180 Murray, Michael r 1673, 1676 Murray, omg * 5580 Murray, Ray, 48 Murray, Robin _ 4576, 6955 4 Murthy, R. C. Murthy, R. ...
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