A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2022; you can also visit the original URL.
The file type is application/pdf.
Filters
Elena Castroviejo, Louise McNally e Galit Sassoon (Eds.). The Semantics of Gradability, Vagueness, and Scale Structure. Experimental Perspectives
2021
Linguística : Revista de Estudos Linguísticos da Universidade do Porto
Preserved Fulltext
Cantante, Inês -Elena Castroviejo, Louise McNally e Galit Sassoon (Eds.)... Revista de Estudos Linguísticos da Universidade doPorto -Vol. 16 -2021 -105 -110 ...
doi:10.21747/16466195/ling16r1
fatcat:uwhbhnfelnfoboumuuniup7eiu
Amazing DPs
2015
Semantics and Linguistic Theory
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2010; you can also visit the original URL.
The file type is application/pdf.
However, in some other configurations, a restrictive interpretation is awkward (see also Castroviejo (to appear)); here, the non-restrictive interpretation paraphrased in (36b) is much more natural. (36 ...
doi:10.3765/salt.v0i0.2475
fatcat:47cscvd445dgzfvtnaap55znvi
Amazing DPs
2008
Semantics and Linguistic Theory
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2010; you can also visit the original URL.
The file type is application/pdf.
However, in some other configurations, a restrictive interpretation is awkward (see also Castroviejo (to appear)); here, the non-restrictive interpretation paraphrased in (36b) is much more natural. (36 ...
doi:10.3765/salt.v18i0.2475
fatcat:ialpolklabfe5oqwuimf2tzs64
Deconstructing Exclamations
2008
Catalan Journal of Linguistics
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2018; you can also visit the original URL.
The file type is application/pdf.
2008 Elena Castroviejo Miró
CatJL 7, 2008 Elena Castroviejo Miró ...
CatJL 7, 2008 Elena Castroviejo Miró
CatJL 7, 2008 Elena Castroviejo Miró
CatJL 7, 2008 Elena Castroviejo Miró
CatJL 7, 2008 Elena Castroviejo Miró
. ...
doi:10.5565/rev/catjl.132
fatcat:rx3u2fbzlzcyfgc7w74xnq5ura
Gradation in modified AdjPs
2015
Semantics and Linguistic Theory
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2018; you can also visit the original URL.
The file type is application/pdf.
Castroviejo (2011) provides a few suggestions. (41) It's amazing that Bill is so tall. ...
Finally, Castroviejo (2008) claims that Extremely adverbs in these particular configurations behave like expressives in composing with the gradable adjective in a different domain of meaning. ...
doi:10.3765/salt.v0i0.2638
fatcat:mgygmi6hl5hzjaxaovfdwg2hnu
'So' as a weak degree expression
2011
Semantics and Linguistic Theory
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2018; you can also visit the original URL.
The file type is application/pdf.
This paper aims to answer three questions about the degree expression 'so' in English: (i) what semantics does it contribute? (I.e., in what ways is 'so' different from 'enough'?) (ii) how can we explain its restricted distribution? And (iii) how does the that-clause compose with 'so'? I point out that equating 'enough' and 'so' (as has been done in the literature) is problematic, and I propose that a new approach that establishes an analogy between"so" and weak pronouns can yield satisfactory
doi:10.3765/salt.v21i0.2624
fatcat:v65yj2ywezchvjybdnzofni7hm
more »
... nswers to questions (i)--(iii). In a nutshell, I argue that there are two 'so's: a strong (deictic) one and a weak (anaphoric) one. I concentrate on weak 'so' and show that its limited distribution has to do with the informational properties of weak items more generally. I further claim that its accompanying that-clause is not a complement of 'so', but rather an adjoined sentence that provides a bona fide focus to the sentence.
Generic and action-dependent abilities in Spanish 'Be capable'
2018
Glossa
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
Glossa general linguistics a journal of Castroviejo, Elena and Isabel Oltra-Massuet. 2018 . Generic and action-dependent abilities in Spanish 'Be capable'. ...
A third problematic issue concerns the empirical coverage of Castroviejo & Oltra-Massuet (2015b; 2016) . ...
doi:10.5334/gjgl.495
fatcat:i7v4uhfz3beirle2veeq2wxiky
Approaching Results in Catalan and Spanish Deadjectival Verbs
2013
Catalan Journal of Linguistics
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2021; you can also visit the original URL.
The file type is application/pdf.
CatJL 12, 2013 Isabel Oltra-Massuet; Elena Castroviejo ...
Castroviejo
. ...
doi:10.5565/rev/catjl.17
fatcat:ysetttozdnh5bagtlgkfcx4lqi
Ocular Exploration in the Diagnosis and Follow-Up of the Alzheimer's Dementia
[chapter]
2019
Alzheimer's Disease
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
The retina is part of the central nervous system (CNS), and therefore, in Alzheimer' s disease (AD), retinal and optic nerve degeneration could take place. This degeneration leads to neurofunctional changes that can be detected early and followed up throughout the evolution of the disease. As opposed to other CNS structures, the eye is easily accessible for in vivo observation. Retinal organization allows for the identification of its different neurons, and in consequence, detection of minimal
doi:10.15586/alzheimersdisease.2019.ch10
fatcat:6mpgs3tzwrenxo6rofz5st3tfu
more »
... hanges taking place during neurodegeneration is possible. Functional vision studies performed on AD patients in recent years have shown how visual acuity, contrast sensitivity, color vision, and visual integration vary with the progression of neurodegeneration. The development of optical coherence tomography in ophthalmology has meant a breakthrough in retinal exploratory techniques, allowing the obtention of high-resolution images using light. This technique enables retinal analysis in the earliest stages of AD, being considered as a biomarker of neuronal
Generics as default? Comparing the acquisition of universals and generics in Spanish
2021
Experiments in Linguistic Meaning
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2021; you can also visit the original URL.
The file type is application/pdf.
Castroviejo, Dimitra Lazaridou-Chatzigoga, Marta Ponciano and Agustín Vicente: Generics as default? ...
Castroviejo, Dimitra Lazaridou-Chatzigoga, Marta Ponciano and Agustín Vicente: Generics as default? ...
doi:10.3765/elm.1.4857
fatcat:e4a2vnx3pnhclb63kfcqnqbwn4
Cross-Linguistic Experimental Evidence Distinguishing the Role of Context in Disputes over Taste and Possibility
[chapter]
2015
Lecture Notes in Computer Science
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2018; you can also visit the original URL.
The file type is application/pdf.
β-RA targets mitochondrial metabolism and adipogenesis, leading to therapeutic benefits against CoQ deficiency and age-related overweight
[article]
2021
bioRxiv
pre-print
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2021; you can also visit the original URL.
The file type is application/pdf.
Hum Mol Genet 22: 1233-48 Garcia-Corzo L, Luna-Sanchez M, Doerrier C, Ortiz F, Escames G, Acuna-Castroviejo D, Lopez LC (2014) Ubiquinol-10 ameliorates mitochondrial encephalopathy associated with CoQ ...
Nat Rev Mol Cell Biol 19: 121-135 Hidalgo-Gutierrez A, Barriocanal-Casado E, Bakkali M, Diaz-Casado ME, Sanchez-Maldonado L, Romero M, Sayed RK, Prehn C, Escames G, Duarte J, Acuna-Castroviejo D, Lopez ...
doi:10.1101/2021.04.13.438670
fatcat:v5kvwyixvjckliefysys53afgq
Effect of 5-Azacitidine Treatment on Redox Status and Inflammatory Condition in MDS Patients
2022
Antioxidants
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2022; you can also visit the original URL.
The file type is application/pdf.
This study focused on the impact of the treatment with the hypomethylating agent 5-azacitidine on the redox status and inflammation in 24 MDS patients. Clinical and genetic features of MDS patients were recorded, and peripheral blood samples were used to determine the activity of the endogenous antioxidant defense system (superoxide dismutase, SOD; catalase, CAT; glutathion peroxidase, GPx; and reductase, GRd, activities), markers of oxidative damage (lipid peroxidation, LPO, and advanced
doi:10.3390/antiox11010139
pmid:35052643
pmcid:PMC8773071
fatcat:jvh76tqcp5be7dfewz3ghlik4a
more »
... ion protein products, AOPP). Moreover, pro-inflammatory cytokines and plasma nitrite plus nitrate levels as markers of inflammation, as well as CoQ10 plasma levels, were also measured. Globally, MDS patients showed less redox status in terms of a reduction in the GSSG/GSH ratio and in the LPO levels, as well as increased CAT activity compared with healthy subjects, with no changes in SOD, GPx, and GRd activities, or AOPP levels. When analyzing the evolution from early to advanced stages of the disease, we found that the GPx activity, GSSG/GSH ratio, LPO, and AOPP increased, with a reduction in CAT. GPx changes were related to the presence of risk factors such as high-risk IPSS-R or mutational score. Moreover, there was an increase in IL-2, IL-6, IL-8, and TNF-α plasma levels, with a further increase of IL-2 and IL-10 from early to advanced stages of the disease. However, we did not observe any association between inflammation and oxidative stress. Finally, 5-azacitidine treatment generated oxidative stress in MDS patients, without affecting inflammation levels, suggesting that oxidative status and inflammation are two independent processes.
Modification of Nitric Oxide Synthase Activity and Neuronal Response in Rat Striatum by Melatonin and Kynurenine Derivatives
2008
Journal of neuroendocrinology
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL.
The file type is application/pdf.
Tryptophan is mainly metabolized in the brain through methoxyindole and kynurenine pathways. The methoxyindole pathway produces (among other compounds) melatonin, which displays inhibitory effects on human and animal central nervous systems, including a significant attenuation of excitatory, glutamate-mediated responses. The kynurenine pathway produces kynurenines that interact with brain glutamate-mediated responses. Nitric oxide (NO) increases glutamate release, and melatonin and kynurenines
doi:10.1046/j.1365-2826.1998.00203.x
pmid:9630400
fatcat:igxatlw25nhibfcehsv3kmexum
more »
... ay act via modification of NO synthesis. In the present study, the effects of melatonin and four synthetic kynurenines were studied on the activity of rat striatal nitric oxide synthase (NOS) and on the response of rat striatal neurons to sensorimotor cortex (SMCx) stimulation, a glutamate-mediated response. Melatonin inhibited both NOS activity and the striatal glutamate response, and these effects were dose-related. Compound A (2-acetamide-4-(3-methoxyphenyl)-4-oxobutyric acid) did not inhibit NOS activity but inhibited the striatal response similarly to melatonin. Compound B (2-acetamide-4-(2-amino-5-methoxyphenyl)-4-oxobutyric acid) was more potent than melatonin in inhibiting both NOS activity and the striatal response. Compound C (2-butyramide-4-(3-methoxyphenyl)-4-oxobutyric acid) did not change NOS activity, but increased the striatal response. Compound D (2-butyramide-4-(2-amino-5-methoxyphenyl)-4-oxobutyric acid) showed potent inhibitory effects on both NOS activity and striatal glutamate-mediated response. A structure-related effect of the kynurenine derivatives was observed, and those with an amino group in position 2 of the benzenic ring had more potent effects than melatonin itself in inhibiting striatal NOS activity and the response of striatal neurons to SMCx.
β-RA Targets Mitochondrial Metabolism and Adipogenesis, Leading to Therapeutic Benefits against CoQ Deficiency and Age-Related Overweight
2021
Biomedicines
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2021; you can also visit the original URL.
The file type is application/pdf.
Primary mitochondrial diseases are caused by mutations in mitochondrial or nuclear genes, leading to the abnormal function of specific mitochondrial pathways. Mitochondrial dysfunction is also a secondary event in more common pathophysiological conditions, such as obesity and metabolic syndrome. In both cases, the improvement and management of mitochondrial homeostasis remain challenging. Here, we show that beta-resorcylic acid (β-RA), which is a natural phenolic compound, competed in vivo with
doi:10.3390/biomedicines9101457
pmid:34680574
fatcat:h2lfhx7hkjec3imn37i7pkk5dm
more »
... 4-hydroxybenzoic acid, which is the natural precursor of coenzyme Q biosynthesis. This led to a decrease in demethoxyubiquinone, which is an intermediate metabolite of CoQ biosynthesis that is abnormally accumulated in Coq9R239X mice. As a consequence, β-RA rescued the phenotype of Coq9R239X mice, which is a model of primary mitochondrial encephalopathy. Moreover, we observed that long-term treatment with β-RA also reduced the size and content of the white adipose tissue (WAT) that is normally accumulated during aging in wild-type mice, leading to the prevention of hepatic steatosis and an increase in survival at the elderly stage of life. The reduction in WAT content was due to a decrease in adipogenesis, an adaptation of the mitochondrial proteome in the kidneys, and stimulation of glycolysis and acetyl-CoA metabolism. Therefore, our results demonstrate that β-RA acted through different cellular mechanisms, with effects on mitochondrial metabolism; as such, it may be used for the treatment of primary coenzyme Q deficiency, overweight, and hepatic steatosis.
« Previous
Showing results 1 — 15 out of 189 results