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Elena Castroviejo, Louise McNally e Galit Sassoon (Eds.). The Semantics of Gradability, Vagueness, and Scale Structure. Experimental Perspectives

Inês Cantante
2021 Linguística : Revista de Estudos Linguísticos da Universidade do Porto  
Cantante, Inês -Elena Castroviejo, Louise McNally e Galit Sassoon (Eds.)... Revista de Estudos Linguísticos da Universidade doPorto -Vol. 16 -2021 -105 -110  ... 
doi:10.21747/16466195/ling16r1 fatcat:uwhbhnfelnfoboumuuniup7eiu

Amazing DPs

Elena Castroviejo, Magdalena Schwager
2015 Semantics and Linguistic Theory  
However, in some other configurations, a restrictive interpretation is awkward (see also Castroviejo (to appear)); here, the non-restrictive interpretation paraphrased in (36b) is much more natural. (36  ... 
doi:10.3765/salt.v0i0.2475 fatcat:47cscvd445dgzfvtnaap55znvi

Amazing DPs

Elena Castroviejo, Magdalena Schwager
2008 Semantics and Linguistic Theory  
However, in some other configurations, a restrictive interpretation is awkward (see also Castroviejo (to appear)); here, the non-restrictive interpretation paraphrased in (36b) is much more natural. (36  ... 
doi:10.3765/salt.v18i0.2475 fatcat:ialpolklabfe5oqwuimf2tzs64

Deconstructing Exclamations

Elena Castroviejo Miró
2008 Catalan Journal of Linguistics  
2008 Elena Castroviejo Miró CatJL 7, 2008 Elena Castroviejo Miró  ...  CatJL 7, 2008 Elena Castroviejo Miró CatJL 7, 2008 Elena Castroviejo Miró CatJL 7, 2008 Elena Castroviejo Miró CatJL 7, 2008 Elena Castroviejo Miró .  ... 
doi:10.5565/rev/catjl.132 fatcat:rx3u2fbzlzcyfgc7w74xnq5ura

Gradation in modified AdjPs

Elena Castroviejo-Miro
2015 Semantics and Linguistic Theory  
Castroviejo (2011) provides a few suggestions. (41) It's amazing that Bill is so tall.  ...  Finally, Castroviejo (2008) claims that Extremely adverbs in these particular configurations behave like expressives in composing with the gradable adjective in a different domain of meaning.  ... 
doi:10.3765/salt.v0i0.2638 fatcat:mgygmi6hl5hzjaxaovfdwg2hnu

'So' as a weak degree expression

Elena Castroviejo-Miro
2011 Semantics and Linguistic Theory  
This paper aims to answer three questions about the degree expression 'so' in English: (i) what semantics does it contribute? (I.e., in what ways is 'so' different from 'enough'?) (ii) how can we explain its restricted distribution? And (iii) how does the that-clause compose with 'so'? I point out that equating 'enough' and 'so' (as has been done in the literature) is problematic, and I propose that a new approach that establishes an analogy between"so" and weak pronouns can yield satisfactory
more » ... nswers to questions (i)--(iii). In a nutshell, I argue that there are two 'so's: a strong (deictic) one and a weak (anaphoric) one. I concentrate on weak 'so' and show that its limited distribution has to do with the informational properties of weak items more generally. I further claim that its accompanying that-clause is not a complement of 'so', but rather an adjoined sentence that provides a bona fide focus to the sentence.
doi:10.3765/salt.v21i0.2624 fatcat:v65yj2ywezchvjybdnzofni7hm

Generic and action-dependent abilities in Spanish 'Be capable'

Elena Castroviejo, Isabel Oltra-Massuet
2018 Glossa  
Glossa general linguistics a journal of Castroviejo, Elena and Isabel Oltra-Massuet. 2018 . Generic and action-dependent abilities in Spanish 'Be capable'.  ...  A third problematic issue concerns the empirical coverage of Castroviejo & Oltra-Massuet (2015b; 2016) .  ... 
doi:10.5334/gjgl.495 fatcat:i7v4uhfz3beirle2veeq2wxiky

Approaching Results in Catalan and Spanish Deadjectival Verbs

Isabel Oltra-Massuet, Elena Castroviejo
2013 Catalan Journal of Linguistics  
CatJL 12, 2013 Isabel Oltra-Massuet; Elena Castroviejo  ...  Castroviejo .  ... 
doi:10.5565/rev/catjl.17 fatcat:ysetttozdnh5bagtlgkfcx4lqi

Ocular Exploration in the Diagnosis and Follow-Up of the Alzheimer's Dementia [chapter]

Elena Salobrar-Garcia, Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Universidad Complutense de Madrid, Madrid, Spain, Rosa de Hoz, Ana I. Ramírez, Juan J. Salazar, Pilar Rojas, Inés López-Cuenca, Jose Fernández-Albarral, José M. Ramírez, Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Universidad Complutense de Madrid, Madrid, Spain, Facultad de Óptica y Optometría, Universidad Complutense de Madrid, Madrid, Spain, Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Universidad Complutense de Madrid, Madrid, Spain (+9 others)
2019 Alzheimer's Disease  
The retina is part of the central nervous system (CNS), and therefore, in Alzheimer' s disease (AD), retinal and optic nerve degeneration could take place. This degeneration leads to neurofunctional changes that can be detected early and followed up throughout the evolution of the disease. As opposed to other CNS structures, the eye is easily accessible for in vivo observation. Retinal organization allows for the identification of its different neurons, and in consequence, detection of minimal
more » ... hanges taking place during neurodegeneration is possible. Functional vision studies performed on AD patients in recent years have shown how visual acuity, contrast sensitivity, color vision, and visual integration vary with the progression of neurodegeneration. The development of optical coherence tomography in ophthalmology has meant a breakthrough in retinal exploratory techniques, allowing the obtention of high-resolution images using light. This technique enables retinal analysis in the earliest stages of AD, being considered as a biomarker of neuronal
doi:10.15586/alzheimersdisease.2019.ch10 fatcat:6mpgs3tzwrenxo6rofz5st3tfu

Generics as default? Comparing the acquisition of universals and generics in Spanish

Elena Castroviejo, Dimitra Lazaridou-Chatzigoga, Marta Ponciano, Agustí­n Vicente
2021 Experiments in Linguistic Meaning  
Castroviejo, Dimitra Lazaridou-Chatzigoga, Marta Ponciano and Agustín Vicente: Generics as default?  ...  Castroviejo, Dimitra Lazaridou-Chatzigoga, Marta Ponciano and Agustín Vicente: Generics as default?  ... 
doi:10.3765/elm.1.4857 fatcat:e4a2vnx3pnhclb63kfcqnqbwn4

Cross-Linguistic Experimental Evidence Distinguishing the Role of Context in Disputes over Taste and Possibility [chapter]

E. Allyn Smith, Elena Castroviejo, Laia Mayol
2015 Lecture Notes in Computer Science  
doi:10.1007/978-3-319-25591-0_33 fatcat:ksmguegz6fhkxm53le5m6cnyii

β-RA targets mitochondrial metabolism and adipogenesis, leading to therapeutic benefits against CoQ deficiency and age-related overweight [article]

Agustín Hidalgo-Gutiérrez, Eliana Barriocanal-Casado, María Elena Díaz-Casado, Pilar González-García, Riccardo Zenezini Chiozzi, Darío Acuña-Castroviejo, Luis Carlos López
2021 bioRxiv   pre-print
Hum Mol Genet 22: 1233-48 Garcia-Corzo L, Luna-Sanchez M, Doerrier C, Ortiz F, Escames G, Acuna-Castroviejo D, Lopez LC (2014) Ubiquinol-10 ameliorates mitochondrial encephalopathy associated with CoQ  ...  Nat Rev Mol Cell Biol 19: 121-135 Hidalgo-Gutierrez A, Barriocanal-Casado E, Bakkali M, Diaz-Casado ME, Sanchez-Maldonado L, Romero M, Sayed RK, Prehn C, Escames G, Duarte J, Acuna-Castroviejo D, Lopez  ... 
doi:10.1101/2021.04.13.438670 fatcat:v5kvwyixvjckliefysys53afgq

Effect of 5-Azacitidine Treatment on Redox Status and Inflammatory Condition in MDS Patients

Paola Montes, Ana Guerra-Librero, Paloma García, María Elena Cornejo-Calvo, María del Señor López, Tomás de Haro, Laura Martínez-Ruiz, Germaine Escames, Darío Acuña-Castroviejo
2022 Antioxidants  
This study focused on the impact of the treatment with the hypomethylating agent 5-azacitidine on the redox status and inflammation in 24 MDS patients. Clinical and genetic features of MDS patients were recorded, and peripheral blood samples were used to determine the activity of the endogenous antioxidant defense system (superoxide dismutase, SOD; catalase, CAT; glutathion peroxidase, GPx; and reductase, GRd, activities), markers of oxidative damage (lipid peroxidation, LPO, and advanced
more » ... ion protein products, AOPP). Moreover, pro-inflammatory cytokines and plasma nitrite plus nitrate levels as markers of inflammation, as well as CoQ10 plasma levels, were also measured. Globally, MDS patients showed less redox status in terms of a reduction in the GSSG/GSH ratio and in the LPO levels, as well as increased CAT activity compared with healthy subjects, with no changes in SOD, GPx, and GRd activities, or AOPP levels. When analyzing the evolution from early to advanced stages of the disease, we found that the GPx activity, GSSG/GSH ratio, LPO, and AOPP increased, with a reduction in CAT. GPx changes were related to the presence of risk factors such as high-risk IPSS-R or mutational score. Moreover, there was an increase in IL-2, IL-6, IL-8, and TNF-α plasma levels, with a further increase of IL-2 and IL-10 from early to advanced stages of the disease. However, we did not observe any association between inflammation and oxidative stress. Finally, 5-azacitidine treatment generated oxidative stress in MDS patients, without affecting inflammation levels, suggesting that oxidative status and inflammation are two independent processes.
doi:10.3390/antiox11010139 pmid:35052643 pmcid:PMC8773071 fatcat:jvh76tqcp5be7dfewz3ghlik4a

Modification of Nitric Oxide Synthase Activity and Neuronal Response in Rat Striatum by Melatonin and Kynurenine Derivatives

Josefa León, Francisco Vives, Elena Crespo, Encarnación Camacho, Antonio Espinosa, MigueL. A. Gallo, Germaine Escames, Darío Acuña-Castroviejo
2008 Journal of neuroendocrinology  
Tryptophan is mainly metabolized in the brain through methoxyindole and kynurenine pathways. The methoxyindole pathway produces (among other compounds) melatonin, which displays inhibitory effects on human and animal central nervous systems, including a significant attenuation of excitatory, glutamate-mediated responses. The kynurenine pathway produces kynurenines that interact with brain glutamate-mediated responses. Nitric oxide (NO) increases glutamate release, and melatonin and kynurenines
more » ... ay act via modification of NO synthesis. In the present study, the effects of melatonin and four synthetic kynurenines were studied on the activity of rat striatal nitric oxide synthase (NOS) and on the response of rat striatal neurons to sensorimotor cortex (SMCx) stimulation, a glutamate-mediated response. Melatonin inhibited both NOS activity and the striatal glutamate response, and these effects were dose-related. Compound A (2-acetamide-4-(3-methoxyphenyl)-4-oxobutyric acid) did not inhibit NOS activity but inhibited the striatal response similarly to melatonin. Compound B (2-acetamide-4-(2-amino-5-methoxyphenyl)-4-oxobutyric acid) was more potent than melatonin in inhibiting both NOS activity and the striatal response. Compound C (2-butyramide-4-(3-methoxyphenyl)-4-oxobutyric acid) did not change NOS activity, but increased the striatal response. Compound D (2-butyramide-4-(2-amino-5-methoxyphenyl)-4-oxobutyric acid) showed potent inhibitory effects on both NOS activity and striatal glutamate-mediated response. A structure-related effect of the kynurenine derivatives was observed, and those with an amino group in position 2 of the benzenic ring had more potent effects than melatonin itself in inhibiting striatal NOS activity and the response of striatal neurons to SMCx.
doi:10.1046/j.1365-2826.1998.00203.x pmid:9630400 fatcat:igxatlw25nhibfcehsv3kmexum

β-RA Targets Mitochondrial Metabolism and Adipogenesis, Leading to Therapeutic Benefits against CoQ Deficiency and Age-Related Overweight

Agustín Hidalgo-Gutiérrez, Eliana Barriocanal-Casado, María Elena Díaz-Casado, Pilar González-García, Riccardo Zenezini Chiozzi, Darío Acuña-Castroviejo, Luis Carlos López
2021 Biomedicines  
Primary mitochondrial diseases are caused by mutations in mitochondrial or nuclear genes, leading to the abnormal function of specific mitochondrial pathways. Mitochondrial dysfunction is also a secondary event in more common pathophysiological conditions, such as obesity and metabolic syndrome. In both cases, the improvement and management of mitochondrial homeostasis remain challenging. Here, we show that beta-resorcylic acid (β-RA), which is a natural phenolic compound, competed in vivo with
more » ... 4-hydroxybenzoic acid, which is the natural precursor of coenzyme Q biosynthesis. This led to a decrease in demethoxyubiquinone, which is an intermediate metabolite of CoQ biosynthesis that is abnormally accumulated in Coq9R239X mice. As a consequence, β-RA rescued the phenotype of Coq9R239X mice, which is a model of primary mitochondrial encephalopathy. Moreover, we observed that long-term treatment with β-RA also reduced the size and content of the white adipose tissue (WAT) that is normally accumulated during aging in wild-type mice, leading to the prevention of hepatic steatosis and an increase in survival at the elderly stage of life. The reduction in WAT content was due to a decrease in adipogenesis, an adaptation of the mitochondrial proteome in the kidneys, and stimulation of glycolysis and acetyl-CoA metabolism. Therefore, our results demonstrate that β-RA acted through different cellular mechanisms, with effects on mitochondrial metabolism; as such, it may be used for the treatment of primary coenzyme Q deficiency, overweight, and hepatic steatosis.
doi:10.3390/biomedicines9101457 pmid:34680574 fatcat:h2lfhx7hkjec3imn37i7pkk5dm
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