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Electrical Characterization of 3D Au Microelectrodes for Use in Retinal Prostheses

Sangmin Lee, Jae Ahn, Jong-Mo Seo, Hum Chung, Dong-Il Cho
2015 Sensors  
In this paper, the electrical characteristics of 2D and 3D Au microelectrodes were investigated.  ...  Interface impedances were measured and similar dynamic ranges were obtained for both 2D and 3D Au microelectrodes.  ...  Conflicts of Interest The authors declare no conflict of interest.  ... 
doi:10.3390/s150614345 pmid:26091397 pmcid:PMC4507638 fatcat:o4224rmc7rhqpgzjjjneyhxnoa

Near-Infrared Tandem Organic Photodiodes for Future Application in Artificial Retinal Implants

Giulio Simone, Dario Di Carlo Rasi, Xander de Vries, Gaël H. L. Heintges, Stefan C. J. Meskers, René A. J. Janssen, Gerwin H. Gelinck
2018 Advanced Materials  
Acknowledgements The authors thank Dario Simone for his contribution to this work.  ...  This demonstrates the viability of high-resolution retinal prostheses based on flexible OPD arrays.  ...  Therefore, our approach aims at combining the benefits of organic flexible implants and stimulating microelectrodes, paving the way toward future development of high-resolution retinal prostheses based  ... 
doi:10.1002/adma.201804678 pmid:30318658 fatcat:rsepy6p76zguzatz4voumvpq24

Design and Implementation Challenges of Microelectrode Arrays: A Review

Bahareh Ghane-Motlagh, Mohamad Sawan
2013 Materials Sciences and Applications  
microstimulation capabilities, while maintaining low-impedance pathways for charge injection, high-charge transfer, and high-spatial resolution in recent years.  ...  The emerging field of neuroprosthetics is focused on design and implementation of neural prostheses to restore some of the lost neural functions.  ...  Acknowledgements We gratefully acknowledge the financial support from the Natural Sciences and Engineering Research Council of Canada (NSERC) and the Canada Research Chair in smart medical devices, and  ... 
doi:10.4236/msa.2013.48059 fatcat:35d5joxgzbebtousgfrspmwdde

Bioinspired Artificial Eyes: Optic Components, Digital Cameras, and Visual Prostheses

Gil Ju Lee, Changsoon Choi, Dae-Hyeong Kim, Young Min Song
2017 Advanced Functional Materials  
The advantages of natural vision systems include high visual acuity, wide field of view, wavelength-free imaging, improved aberration correction and depth of field, and high motion sensitivity.  ...  The diverse vision systems found in nature can provide interesting design inspiration for imaging devices, ranging from optical subcomponents to digital cameras and visual prostheses, with more desirable  ...  This research was supported by the Creative Materials Discovery Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (NRF-2017M3D1A1039288).  ... 
doi:10.1002/adfm.201705202 fatcat:3gs4wnrmpfaa5ho4e6ay7shlbi

Recent trends in microelectrode array technology for in vitro neural interface platform

Raeyoung Kim, Sunghoon Joo, Hyunjun Jung, Nari Hong, Yoonkey Nam
2014 Biomedical Engineering Letters  
Microelectrode array (MEA) technology is a widely used platform for the study of in vitro neural networks as it can either record or stimulate neurons by accessing multiple sites of neural circuits simultaneously  ...  The MEA technology has been applied to neural network analysis, drug screening and neural prostheses studies. In this paper, the MEA technology is reviewed and the future prospect is discussed.  ...  ACKNOWLEDGEMENTS This work was supported by the National Research Foundation of Korea grants (NRF-2012R1A2A1A01007327).  ... 
doi:10.1007/s13534-014-0130-6 fatcat:pheeijriazcyze7iumdlbpgqpy

Holographic optogenetic stimulation of patterned neuronal activity for vision restoration

Inna Reutsky-Gefen, Lior Golan, Nairouz Farah, Adi Schejter, Limor Tsur, Inbar Brosh, Shy Shoham
2013 Nature Communications  
Recently, light-sensitive proteins that photosensitize quiescent neurons have generated unprecedented opportunities for optogenetic neuronal control, inspiring early development of optical retinal prostheses  ...  In blind retinas, we demonstrate reliable holographically patterned optogenetic stimulation of retinal ganglion cells with millisecond temporal precision and cellular resolution.  ...  -G. and N.F. were supported by fellowships from the Israeli Ministry of Science and Technology. We thank E. Zemel and I. Perlman for their assistance.  ... 
doi:10.1038/ncomms2500 pmid:23443537 fatcat:po4zxqlrvrgw3hqhfrqndqr7u4

High Fidelity Bidirectional Neural Interfacing with Carbon Fiber Microelectrodes Coated with Boron‐Doped Carbon Nanowalls: An Acute Study

Maryam A. Hejazi, Wei Tong, Alastair Stacey, Shi H. Sun, Molis Yunzab, Ali Almasi, Young Jun Jung, Hamish Meffin, Kate Fox, Khatereh Edalati, Athavan Nadarajah, Steven Prawer (+2 others)
2020 Advanced Functional Materials  
Microfiber electrodes with neuron-scale cross sections have the potential to improve the spatial resolution for both stimulation and recording, while minimizing the chronic inflammation response after  ...  When used for neural interfacing, the coated microelectrodes successfully elicited localized stimulation responses in explanted retina, and were also able to detect signals from single neurons, in vivo  ...  The authors acknowledge use of the Advanced Microscopy Facility at Bio21 (The University of Melbourne) for SEM imaging and the National Vision Research Institute for use of electrophysiology equipment.  ... 
doi:10.1002/adfm.202006101 fatcat:r37u2fj4xjcrjig5et55n2vn6a

Novel Graphene Electrode for Retinal Implants: An in vivo Biocompatibility Study

Diep Nguyen, Manon Valet, Julie Dégardin, Leyna Boucherit, Xavi Illa, Jose de la Cruz, Elena Del Corro, Jessica Bousquet, Jose A Garrido, Clément Hébert, Serge Picaud
2021 Frontiers in Neuroscience  
Having a high conductivity and large electrochemical window, graphene is a candidate material for electrical stimulation with retinal prosthesis.  ...  Implants were monitored by optical coherence tomography (OCT) and eye fundus which indicated a high stability in vivo up to 3 months before histology studies were done.  ...  For retinal prostheses, as for most brain machine interfaces, conductive electrode materials with a high double layer capacitance are expected to offer improved spatial resolution (Joucla and Yvert, 2009  ... 
doi:10.3389/fnins.2021.615256 pmid:33746697 pmcid:PMC7969870 fatcat:fclt3c2c6rexflx4sd7oiuymka

Recent Progress in Wireless Sensors for Wearable Electronics

Young-Geun Park, Sangil Lee, Jang-Ung Park
2019 Sensors  
prostheses.  ...  Also, state-of-the-art research related to the application of wearable sensor systems with wireless functionality is discussed, including electronic skin, smart contact lenses, neural interfaces, and retinal  ...  Acknowledgments: The authors own many thanks to the anonymous reviewers for their instructive comments. Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/s19204353 pmid:31600870 pmcid:PMC6848938 fatcat:ogirk7mofndnzn4elqdqflgzfe

Subretinal electronic chips allow blind patients to read letters and combine them to words

E. Zrenner, K. U. Bartz-Schmidt, H. Benav, D. Besch, A. Bruckmann, V.-P. Gabel, F. Gekeler, U. Greppmaier, A. Harscher, S. Kibbel, J. Koch, A. Kusnyerik (+7 others)
2010 Proceedings of the Royal Society of London. Biological Sciences  
The chip generates a corresponding pattern of 38 Â 40 pixels, each releasing light-intensity-dependent electric stimulation pulses.  ...  A light-sensitive, externally powered microchip was surgically implanted subretinally near the macular region of volunteers blind from hereditary retinal dystrophy.  ...  This procedure determined voltage thresholds for perception, accustomed the patients to electrically evoked visual impressions and tested retinal excitability and spatial resolution.  ... 
doi:10.1098/rspb.2010.1747 pmid:21047851 pmcid:PMC3081743 fatcat:haol6ru6jffwtbzzgfpvc5an6q

Advances in Nano Neuroscience: From Nanomaterials to Nanotools

Niccolò Paolo Pampaloni, Michele Giugliano, Denis Scaini, Laura Ballerini, Rossana Rauti
2019 Frontiers in Neuroscience  
We then describe nanotools such as nanowires and nano-modified MEA for high-performance electrophysiological recording and stimulation of neuronal electrical activity.  ...  For instance, a renewed interest in the development of prostheses or neural interfaces was driven by the availability of novel nanomaterials that enabled the fabrication of implantable bioelectronics interfaces  ...  both for high-resolution imaging and as probes to label specific molecules or biological tissues (Jaiswal et al., 2004) .  ... 
doi:10.3389/fnins.2018.00953 pmid:30697140 pmcid:PMC6341218 fatcat:j6ul6bslbzg63lqk26zvshdqzu

New Era of Electroceuticals: Clinically Driven Smart Implantable Electronic Devices Moving towards Precision Therapy

RaviPrakash Magisetty, Sung-Min Park
2022 Micromachines  
In the name of electroceuticals, bioelectronic devices have transformed and become essential for dealing with all physiological responses.  ...  and qualified smart electroceutical implant for targeted clinical use.  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/mi13020161 pmid:35208286 pmcid:PMC8876842 fatcat:2ctpuebpyvdkpmkvkeapxbhlje

Multiscale engineering of functional organic polymer interfaces for neuronal stimulation and recording

Yingjie Wu, Qihan Zhang, He Wang, Mingfeng Wang
2020 Materials Chemistry Frontiers  
Specifically, the applications of new polymeric materials and technologies for neuron science and engineering...  ...  Development of new materials and technologies for neural interfacing, stimulation and recording has attracted increasing attention.  ...  materials and structures for clinical applications in guided nerve repair. 2.3.2 2D films of electrically conducting polymers for neural stimulation.  ... 
doi:10.1039/d0qm00279h fatcat:ticv6lpmirbc7lbcv263o3kpsq

Demonstration of artificial visual percepts generated through thalamic microstimulation

J. S. Pezaris, R. C. Reid
2007 Proceedings of the National Academy of Sciences of the United States of America  
Electrical stimulation of the visual system might serve as the foundation for a prosthetic device for the blind.  ...  Gaze locations for electrical targets were well predicted by measured visual response maps of cells at the electrode tips. With two electrodes, two distinct targets could be independently created.  ...  For repeatability, we examined the size of endpoint clusters through the mean of major and minor axes of fitted 2D Gaussians.  ... 
doi:10.1073/pnas.0608563104 pmid:17452646 pmcid:PMC1863473 fatcat:3qgjipepijeodlc7wbqd3smdhq

A Review of Organic and Inorganic Biomaterials for Neural Interfaces

Pouria Fattahi, Guang Yang, Gloria Kim, Mohammad Reza Abidian
2014 Advanced Materials  
Finally, technical and scientific challenges are discussed regarding biocompatibility, mechanical mismatch, and electrical properties faced by these nanomaterials for the development of long-lasting functional  ...  Recent advances in nanotechnology have generated wide interest in applying nanomaterials for neural prostheses.  ...  Acknowledgments This work was supported by the Material Research Institute and start-up funds at Pennsylvania State University.  ... 
doi:10.1002/adma.201304496 pmid:24677434 pmcid:PMC4373558 fatcat:4oln5mhjmbdj3h3pdl7v27zfmi
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