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Linguodidactic potential of Microsoft Teams applications for teaching English vocabulary
2021
SHS Web of Conferences
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The paper analyzes the existing research and case studies of using Microsoft 365 Teams (MS Teams) for educational purposes while teaching English as a Foreign Language (EFL) during distance learning in the midst of the Covid-19 pandemic and provides an introduction to the innovative use of MS Teams. The given article reveals some aspects of implementing Microsoft Teams applications (MS Teams apps) with a strong linguodidactic potential (Collaboard, WordClouds, Mindomo, Kahoot, Flipgrid,
doi:10.1051/shsconf/202112701017
fatcat:uqdtqm7w4raq7ifaniesuvfjtq
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... myQuiz, Fortune Cookie) in university students' vocabulary teaching. The authors underline the methodological value of the abovementioned MS Teams apps and give some examples of the linguodidactic use of MS Teams apps in their own EFL teaching practice. Data were collected following the methods of theoretical analysis, the educational experiment was conducted following the empirical methods. The study provides an algorithm for a new way of teaching vocabulary to EFL students during distance learning and indicates which MS Teams apps can be used in terms of the stage of teaching vocabulary, exercise type, and activity type. As a result, the most optimal combination of using MS Teams apps to teach vocabulary during distance learning has been revealed: Collaboard, Mindomo (preparation) + Quizlet, WordClouds (presentation) + myQuiz, Kahoot (practice) + Flipgrid, Fortune Cookie (production).
RepeatFiller newly identifies megabases of aligning repetitive sequences and improves annotations of conserved non-exonic elements
[article]
2019
bioRxiv
pre-print
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Transposons and other repetitive sequences make up a large part of complex genomes. Repetitive sequences can be co-opted into a variety of functions and thus provide a source for evolutionary novelty. However, comprehensively detecting ancestral repeats that align between species is difficult since considering all repeat-overlapping seeds in alignment methods that rely on the seed-and-extend heuristic results in prohibitively high runtimes. Here, we show that ignoring repeat-overlapping
doi:10.1101/696922
fatcat:wdq65vi2bvdu3jejsa4z7yykza
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... t seeds when aligning entire genomes misses numerous alignments between repetitive elements. We present a tool - RepeatFiller - that improves genome alignments by incorporating previously-undetected local alignments between repetitive sequences. By applying RepeatFiller to genome alignments between human and 20 other representative mammals, we uncover between 22 and 84 megabases of previously-undetected alignments that mostly overlap transposable elements. We further show that the increased alignment coverage improves the annotation of conserved non-exonic elements, both by discovering numerous novel transposon-derived elements that evolve under constraint and by removing thousands of elements that are not under constraint in placental mammals. In conclusion, RepeatFiller contributes to comprehensively aligning repetitive genomic regions, which facilitates studying transposon co-option and genome evolution.
RepeatFiller newly identifies megabases of aligning repetitive sequences and improves annotations of conserved non-exonic elements
2019
GigaScience
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Background Transposons and other repetitive sequences make up a large part of complex genomes. Repetitive sequences can be co-opted into a variety of functions and thus provide a source for evolutionary novelty. However, comprehensively detecting ancestral repeats that align between species is difficult because considering all repeat-overlapping seeds in alignment methods that rely on the seed-and-extend heuristic results in prohibitively high runtimes. Results Here, we show that ignoring
doi:10.1093/gigascience/giz132
pmid:31742600
pmcid:PMC6862929
fatcat:ysipx7hop5h3vkbyykx72tsg3e
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... -overlapping alignment seeds when aligning entire genomes misses numerous alignments between repetitive elements. We present a tool, RepeatFiller, that improves genome alignments by incorporating previously undetected local alignments between repetitive sequences. By applying RepeatFiller to genome alignments between human and 20 other representative mammals, we uncover between 22 and 84 Mb of previously undetected alignments that mostly overlap transposable elements. We further show that the increased alignment coverage improves the annotation of conserved non-exonic elements, both by discovering numerous novel transposon-derived elements that evolve under constraint and by removing thousands of elements that are not under constraint in placental mammals. Conclusions RepeatFiller contributes to comprehensively aligning repetitive genomic regions, which facilitates studying transposon co-option and genome evolution. Source code: https://github.com/hillerlab/GenomeAlignmentTools
A new and updated resource for codon usage tables
2017
BMC Bioinformatics
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Due to the degeneracy of the genetic code, most amino acids can be encoded by multiple synonymous codons. Synonymous codons naturally occur with different frequencies in different organisms. The choice of codons may affect protein expression, structure, and function. Recombinant gene technologies commonly take advantage of the former effect by implementing a technique termed codon optimization, in which codons are replaced with synonymous ones in order to increase protein expression. This
doi:10.1186/s12859-017-1793-7
pmid:28865429
pmcid:PMC5581930
fatcat:wlveqvoqr5byhfloqqxzorqyx4
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... que relies on the accurate knowledge of codon usage frequencies. Accurately quantifying codon usage bias for different organisms is useful not only for codon optimization, but also for evolutionary and translation studies: phylogenetic relations of organisms, and host-pathogen co-evolution relationships, may be explored through their codon usage similarities. Furthermore, codon usage has been shown to affect protein structure and function through interfering with translation kinetics, and cotranslational protein folding. Results: Despite the obvious need for accurate codon usage tables, currently available resources are either limited in scope, encompassing only organisms from specific domains of life, or greatly outdated. Taking advantage of the exponential growth of GenBank and the creation of NCBI's RefSeq database, we have developed a new database, the High-performance Integrated Virtual Environment-Codon Usage Tables (HIVE-CUTs), to present and analyse codon usage tables for every organism with publicly available sequencing data. Compared to existing databases, this new database is more comprehensive, addresses concerns that limited the accuracy of earlier databases, and provides several new functionalities, such as the ability to view and compare codon usage between individual organisms and across taxonomical clades, through graphical representation or through commonly used indices. In addition, it is being routinely updated to keep up with the continuous flow of new data in GenBank and RefSeq. Conclusion: Given the impact of codon usage bias on recombinant gene technologies, this database will facilitate effective development and review of recombinant drug products and will be instrumental in a wide area of biological research. The database is available at hive.biochemistry.gwu.edu/review/codon.
The Criminological Description and Prevention of School Shootings and Cyberbullying in Russia and Abroad
2021
Всероссийский криминологический журнал
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The authors analyze modern manifestations of violence in educational establishments, such as school shootings and cyberbullying. Cyberbullying and, to a greater degree, school shootings remain practically unresearched by Russian legal scholars, while foreign authors stress the necessity of their research with the purpose of identifying the determinants of deviant behavior and optimizing its prevention. The authors used the materials of criminal cases to study the criminological characteristics
doi:10.17150/2500-4255.2021.15(5).578-591
fatcat:kxmwz4ksybac3ftw6csn3n6qxa
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... f cyberbullying and school shootings, and identified their close interconnection. They analyzed and specified the conceptual framework, offered a classification of school shootings, and described their main types. It is stated that mass murders in educational establishments are an independent criminal phenomenon not connected with the concept of a terrorist attack, involvement of young people into extremist activities or driving an adolescent to a suicide. A general criminological description of school shootings is presented: the authors show its dynamics in Russia and abroad and single out its key determinants. The criminological features of the personality of the criminal are described using the following indices: gender, age, education, specifics of upbringing, moral and psychological traits, specifics of goals and ambitions, etc. It is stated that in the overwhelming majority of cases attacks in educational establishments were carried out by males of 14–18 years old. Most perpetrators had skills in the use of firearms. The authors examined foreign publications on the topic and conducted a comparative analysis of the spread of school shootings and cyberbullying in Russia, the USA and the EU countries from the standpoint of situational approach. It was determined that the overwhelming number of cases of school shootings registered in the world history happened in the USA, while in the EU the cases were evidently sporadic. In Russia in the last seven years there has been a trend for annual mass murders in educational institutions. Using the analysis of foreign experience and the results of a large-scale interviewing of schoolchildren and teachers in different regions of Russia, the authors suggest measures of preventing school shootings and cyberbullying while taking into account specific national features.
Balancing control and flexibility in joint risk management: Lessons learned from two construction projects
2013
International Journal of Project Management
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Please cite this article as: Osipova, E., Eriksson, P.E., Balancing control and flexibility in joint risk management: Lessons learned from two construction projects, International Journal of Project Management ...
Osipova and Eriksson, 2011a; Tang et al., 2007) and not achieving its main objectiveto bring more certainty to a project by minimizing threats and maximizing opportunities. ...
Despite the fact that JRM is arguably an effective tool, the use of JRM still seems to be rare (Doloi, 2009; Osipova and Eriksson, 2011b; Rahman and Kumaraswamy, 2004) . ...
doi:10.1016/j.ijproman.2012.09.007
fatcat:2mzf2drfafhvdfxvdtreeewuwy
Expression of Cytochrome c3 from Desulfovibrio vulgaris in Plant Leaves Enhances Uranium Uptake and Tolerance of Tobacco
2021
International Journal of Molecular Sciences
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Cytochrome c3 (uranyl reductase) from Desulfovibrio vulgaris can reduce uranium in bacterial cells and in cell-free systems. This gene was introduced in tobacco under control of the RbcS promoter, and the resulting transgenic plants accumulated uranium when grown on a uranyl ion containing medium. The uptaken uranium was detected by EM in chloroplasts. In the presence of uranyl ions in sublethal concentration, the transgenic plants grew phenotypically normal while the control plants'
doi:10.3390/ijms222312622
pmid:34884428
pmcid:PMC8657950
fatcat:fx25v75t3bdjho2t57pjbmfrbq
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... was impaired. The data on uranium oxidation state in the transgenic plants and the possible uses of uranium hyperaccumulation by plants for environmental cleanup are discussed.
Genetic Diversity in Invasive Populations of Lupinus polyphyllus Lindl. and Heracleum sosnowskyi Manden
2021
Biology
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In our study, two aggressive-invasive species, Lupinus polyphyllus Lindl. and Heracleum sosnowskyi Manden. from Russia and Ukraine, were investigated. The success in naturalization of both species is associated with human activities, since they have been used in agriculture and floriculture and both have qualities such as environmental tolerance, high fertility and phenotypic plasticity. The purpose of this study was to determine the level of genetic diversity of both species. For Heracleum
doi:10.3390/biology10111094
pmid:34827091
pmcid:PMC8614902
fatcat:gxftccbhzbairj6uxokbt2impm
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... owskyi Manden., genetic diversity was compared in invasive and native populations. For Lupinus polyphyllus Lindl., the genetic diversity was compared in variety, feral and invasive populations. A genetic diversity was formulated using RAPD, ISSR and REMAP. For Heracleum sosnowskyi Manden., the average genetic diversity within the invasive population was similar (0.432), but slightly less (0.502) than within the native Caucasian population. This may suggest the successful naturalization of invaders and almost complete reconstruction of their genetic diversity. For Lupinus polyphyllus Lindl., the genetic diversity for the invasive population was the highest, with an average of 0.294, while for variety, it was the lowest, with an average of 0.194. The feral population had an intermediate place with an average of 0.248, which could suggest an increase of diversity in the process of naturalization.
Student radio stations in the Siberian Federal District: editorial and program policies
Студенческие радиостанции Сибирского федерального округа: редакционная и программная политика
2017
Vestnik Tomskogo gosudarstvennogo universiteta Filologiya
Студенческие радиостанции Сибирского федерального округа: редакционная и программная политика
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E -m a il: v ik to ria _ b e le n k o @ m a il.r u Ekaterina S. Osipova, tio n s . ...
doi:10.17223/19986645/47/14
fatcat:odswhar27bawpb75su2jchhkee
Improvement in billets quality from billet caster by roller suspension of secondary cooling zone stiffening
2018
MATEC Web of Conferences
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Presently, continuous casting machines are widely used in metallurgical industry for production of high quality billets. And the maximum economic and resource-saving effect is achieved by the use of continuously casting small-section billets. Proceeding to the continuous casting has tightened the requirements for product quality and the main objective has become to determine the factors influencing the billet quality. It is necessary to design competently a zone of secondary cooling, for
doi:10.1051/matecconf/201822402048
fatcat:u5ckmkevxnhjjgkwzanweoo2km
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... ment of quality of production. Having changed her design and as a result the loadings operating on a zone of secondary cooling will decrease and the rigidity of a design will increase. Billet casters with basic radius of 9 m were put in operation at OAO "MMK" in 2004. The new casters were designed for production of 100x100, 124x124, 120x150 и 152x170 mm billets. However, in the course of commissioning of three new rolling mills supplied by Danieli, the specialists of MMK have developed a technology for production of 150x150 mm billets. Open stream casting is used for casting of billets of all sizes, shrouded casting is used for production of 150x150 and 152x170 mm billets. The quality of the billet is determined by internal defects (centre porosity, centerline segregation, crack segregation streamer, bright fringe, edge point contamination, blow hole) and external defects (shell, rhomboidity, scratch, protuberance, concavity, teeming arrest). Investigation of the available data from sheets with information on distribution of intrashop rejects provided by production control department of OAO "MMK" has shown that the main type of billet defects is non conformance of section geometry. Different defects of manufactured grades of steel (St2sp, St3sp; SV-08A; 60СА) were analysed. Such geometry defect as "rhomboidity" has turned to have the highest percentage of occurrence in comparison with other defects (50%; 56%; 28,6%; 45,6%). Geometry defects are caused by non-compliance of the following process parameters: 1) casting speed (stripping speed) and related water consumption in the secondary cooling zone; 2) casting temperature (temperature of hot metal in a ladle); 3) method of casting (open stream, shrouded); 4) design of the secondary cooling zone.
Residue Network Involved in the Allosteric Regulation of Cystathionine β-Synthase Domain-Containing Pyrophosphatase by Adenine Nucleotides
2019
ACS Omega
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Inorganic pyrophosphatase containing regulatory cystathionine β-synthase (CBS) domains (CBS-PPase) is inhibited by adenosine monophosphate (AMP) and adenosine diphosphate and activated by adenosine triphosphate (ATP) and diadenosine polyphosphates; mononucleotide binding to CBS domains and substrate binding to catalytic domains are characterized by positive cooperativity. This behavior implies three pathways for regulatory signal transduction - between regulatory and active sites, between two
doi:10.1021/acsomega.9b01879
pmid:31572856
pmcid:PMC6761619
fatcat:dqiirfy5ena6latdoc4smwl6ya
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... tive sites, and between two regulatory sites. Bioinformatics analysis pinpointed six charged or polar amino acid residues of Desulfitobacterium hafniense CBS-PPase as potentially important for enzyme regulation. Twelve mutant enzyme forms were produced, and their kinetics of pyrophosphate hydrolysis was measured in wide concentration ranges of the substrate and various adenine nucleotides. The parameters derived from this analysis included catalytic activity, Michaelis constants for two active sites, AMP-, ATP-, and diadenosine tetraphosphate-binding constants for two regulatory sites, and the degree of activation/inhibition for each nucleotide. Replacements of arginine 295 and asparagine 312 by alanine converted ATP from an activator to an inhibitor and markedly affected practically all the above parameters, indicating involvement of these residues in all the three regulatory signaling pathways. Replacements of asparagine 312 and arginine 334 abolished or reversed kinetic cooperativity in the absence of nucleotides but conferred it in the presence of diadenosine tetraphosphate, without effects on nucleotide-binding parameters. Modeling and molecular dynamics simulations revealed destabilization of the subunit interface as a result of asparagine 312 and arginine 334 replacements by alanine, explaining abolishment of kinetic cooperativity. These findings identify residues 295, 312, and 334 as crucial for CBS-PPase regulation via CBS domains.
Photostimulation of Extravasation of Beta-Amyloid through the Model of Blood-Brain Barrier
2020
Electronics
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Alzheimer's disease (AD) is an incurable pathology associated with progressive decline in memory and cognition. Phototherapy might be a new promising and alternative strategy for the effective treatment of AD, and has been actively discussed over two decades. However, the mechanisms of therapeutic photostimulation (PS) effects on subjects with AD remain poorly understood. The goal of this study was to determine the mechanisms of therapeutic PS effects in beta-amyloid (Aβ)-injected mice. The
doi:10.3390/electronics9061056
fatcat:znxin2kwn5cg5f37bxexrucasq
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... ological severity score and the new object recognition tests demonstrate that PS 9 J/cm2 attenuates the memory and neurological deficit in mice with AD. The immunohistochemical assay revealed a decrease in the level of Aβ in the brain and an increase of Aβ in the deep cervical lymph nodes obtained from mice with AD after PS. Using the in vitro model of the blood-brain barrier (BBB), we show a PS-mediated decrease in transendothelial resistance and in the expression of tight junction proteins as well an increase in the BBB permeability to Aβ. These findings suggest that a PS-mediated BBB opening and the activation of the lymphatic clearance of Aβ from the brain might be a crucial mechanism underlying therapeutic effects of PS in mice with AD. These pioneering data open new strategies in the development of non-pharmacological methods for therapy of AD and contribute to a better understanding of the PS effects on the central nervous system.
Bifunctional activation of amine-boranes by the W/Pd bimetallic analogs of "frustrated Lewis pairs"
2021
Chemical Science
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The reaction between basic [(PCP)Pd(H)] (PCP=2,6-(CH2P(t-C4H9)2)2C6H4) and acidic [LWH(CO)3] (L = Cp (1a), Tp (1b); Cp = η5-cyclopentadienyl, Tp = κ3-hydridotris(pyrazolyl)borate) leads to the formation of bimolecular complexes [LW(CO)2(µ-CO)∙∙∙Pd(PCP)] (4a,...
doi:10.1039/d0sc06114j
pmid:34163642
pmcid:PMC8179527
fatcat:d6wturphqvcuhgm537tqlux2iq
Characteristics of Lipid Peroxidation Processes and Antioxidant Status in Teenagers-Boys of Different Ethnic Groups with Exogenous Constitutional Obesity and Non-Alcoholic Fatty Liver Disease
2018
International Journal of Biomedicine
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The aim of this research was to study changes in the LPO-AOD processes in Mongoloid and Caucasian teenagers with exogenous constitutional obesity (ECO), including those complicated by non-alcoholic fatty liver disease (NAFLD). Materials and Methods: A total of 18 Mongoloid teenage boys and 17 Caucasian teenage boys with NAFLD (Clinical group 1 and Clinical group 2, respectively) on the background of ECO of the first degree were examined. For comparison, data of 37 apparently healthy Mongoloid
doi:10.21103/article8(4)_oa7
fatcat:4msq3yplsrfclk326esiccrz4u
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... enage boys (Control group 1) and 23 Caucasian teenage boys (Control group 2) was used. The plasma level of antioxidant parameters (total antioxidant activity [TTA], SOD activity, α-tocopherol and retinol) and primary/ secondary products of LPO (conjugated dienes [CD], ketodienes and conjugated trienes [KD-CT], and thiobarbituric acid reactive substances [TBARS]) were determined using spectrophotometric and fluorometric methods. Results: Evaluation of the activity of LPO reactions in Clinical group 1 indicated an increase in the content of compounds with DB relative to Control group 1. A similar trend was found in the concentration of CD and KD-CT. In Clinical group 2, we found a statistically significant increase only in the values of KD-CT. In the parameters of the AOD system, multidirectional changes of patients parameters compared with the control group were observed in Clinical group 1: the increased values of TAA, SOD activity, and reduced levels of α-tocopherol, retinol, and GSSG. In Clinical group 2, lower values of α-tocopherol, GSSG, and SOD activity were observed relative to Control group 2. Differences between the two ethnic groups were present in the control groups-the reduced level of TAA, GSH and the increased level of GSSG in the group of Mongoloids; just as in clinical groups with NAFLD, a high level of SOD activity was observed in Mongoloids compared to Caucasians. Conclusion: The changes revealed in the redox state in Mongoloid and Caucasian teenagers with ECO and NAFLD indicate high activity of LPO processes and severe deficiency of antioxidant vitamins in patients of both ethnic groups. The obtained results allow us to recommend administration of antioxidant drugs in addition to courses of metabolic therapy in comprehensive treatment of patients with ECO and NAFLD. (International Journal of Biomedicine. 2018;8(4):306-310.)
Сlinical and genetic characteristics of skeletal cyliopathies – short-rib thoracic dysplasia
2022
Ortopediâ, Travmatologiâ i Vosstanovitelʹnaâ Hirurgiâ Detskogo Vozrasta
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BACKGROUND: Ciliopathies include the large group of hereditary diseases caused by mutations in the genes encoding primary cilia components. The largest type of skeletal ciliopathies is short-rib thoracic dysplasia. AIM: This study describes the clinical and genetic characteristics of Russian patients with STRD with or without polydactyly caused by mutations in the genes DYNC2H1, DYNC2I2, IFT80, and IFT140. MATERIALS AND METHODS: A comprehensive examination of 10 unrelated children aged from 9
doi:10.17816/ptors91116
fatcat:gxo6z2j3hragvov5wjuygjkzai
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... ys to 9 years, with phenotypic signs of short-rib thoracic dysplasia with or without polydactyly, was conducted. The diagnosis was confirmed using genealogical analysis, clinical examination, neurological examination, radiography, and targeted sequencing of a panel consisting of 166 genes responsible for the development of inherited skeletal pathology. RESULTS: As a result of the molecular genetic analysis, four short-rib thoracic dysplasia genetic variants were identified. Seven patients were diagnosed with short-rib thoracic dysplasia type 3, and three unique patients were diagnosed with types 11, 2, and 9 due to mutations in the DYNC2H1 and DYNC2I2, IFT80, and IFT140 genes, respectively. From the 14 detected variants, six were identified for the first time. As in the previously described patient samples, in the analyzed sample, more than half of the cases were due to a mutation in the DYNC2H1 gene, which is responsible for the SRTD type 3. The differences in the severity of clinical manifestations and the disease course in patients with mutations in certain regions of the gene, which have a different effect on its protein product function, have been shown. CONCLUSIONS: The results of this molecular genetic study broaden the spectrum of mutations in the DYNC2H1, DYNC212, and IFT140 genes causing short-rib thoracic dysplasia and confirm the usefulness of the whole-exome sequencing as the most informative method for identifying mutations of the genetically heterogeneous short-rib thoracic dysplasia group.
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