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Impaired splanchnic and peripheral glucose uptake in liver cirrhosis

Eiichi Imano, Tsutomu Kanda, Yoshihisa Nakatani, Masaaki Motomura, Katsumi Arai, Munehide Matsuhisa, Yoshimitsu Yamasaki, Masatsugu Hori
1999 Journal of Hepatology  
Background/Aim: Patients with liver cirrhosis are insulin-resistant and frequently glucose-intolerant. Although peripheral glucose uptake has been shown to be impaired in liver cirrhosis, little is known about the significance of splanchnic (hepatic) glucose uptake after oral glucose load. Methods/Results: We performed an oral glucose tolerance test and euglycemic hyperinsulinemic clamp with oral glucose load for eight patients with liver cirrhosis and eight patients with chronic active
more » ... s. The patients with liver cirrhosis had higher plasma glucose levels 2 h after glucose load than those with chronic active hepatitis (228∫22 mg/dl vs 102∫9 mg/dl, p∞0.01). Using the euglycemic hyperinsulinemic clamp with oral glucose load, we simultaneously measured peripheral and splanchnic glucose uptake. Peripheral glucose up-. 469 take in liver cirrhosis was 6.1∫0.7 mg ¡ kg ª1 ¡ min ª1 , which was lower than that in healthy volunteers (10.5∫0.9 mg ¡ kg ª1 ¡ min ª1 , p∞0.05) and in chronic active hepatitis (8.4∫0.3 mg ¡ kg ª1 ¡ min ª1 , p∞0.05). Furthermore, splanchnic glucose uptake in liver cirrhosis was much lower (20.1∫3.4%) than in healthy volunteers (36.0∫4.0%, p∞0.05) and in chronic active hepatitis (37.2∫3.1%, p∞0.05). Conclusion: These results suggest that glucose intolerance in patients with liver cirrhosis is caused by a defect of the glucose uptake of both splanchnic and peripheral tissues.
doi:10.1016/s0168-8278(99)80039-7 pmid:10488706 fatcat:6iumuvgmavd5zdayk7t5vvp274

QT Dispersion is Increased in Diabetic Patients with Foot Ulcer

Eiichi Imano, Rieko Yoshioka, Yoshihisa Nakatani, Katsumi Arai, Masaaki Motomura, Tsutomu Kanda, Yoshimitsu Yamasaki, Masatsugu Hori
2000 Journal of atherosclerosis and thrombosis  
doi:10.5551/jat1994.6.13 pmid:10870676 fatcat:lsoeckwecnetzprd3z424uswfe

Biochemical and Ultrastructural Evaluations of the Effect of Ischemic Preconditioning on Ischemic Myocardial Injury

Eiichi Geshi, Haruhiko Ishioka, Akihiko Nomizo, Masaki Nakatani, Takashi Katagiri
1998 Japanese Circulation Journal - English Edition  
3] [4] [5] [6] [7] Clinically, if this effect occurs in patients with unstable angina prior to an attack of myocardial infarction, it can be expected to reduce the infarct size and improve the prognosis. It has been reported that during percutaneous transluminal coronary angioplasty, the first balloon inflation reduces the ST segment changes, myocardial lactate production, and coronary vein flow induced by the subsequent balloon inflation. 8 A recent trial has shown the possibility that angina
more » ... efore myocardial infarction may confer an IP benefit on the human heart. 9 ] [3] [4] [5] [6] [7] [8] [9] [10] Since the recent reports of Downey's group 2, 4, 6 the activation of adenosine A1 receptor has been considered one of the most likely mechanisms of this
doi:10.1253/jcj.62.915 pmid:9890206 fatcat:hbrg252ftbep3bdq2nsbvss6yq

Oxytocin attenuates feelings of hostility depending on emotional context and individuals' characteristics

Tetsu Hirosawa, Mitsuru Kikuchi, Haruhiro Higashida, Eiichi Okumura, Sanae Ueno, Kiyomi Shitamichi, Yuko Yoshimura, Toshio Munesue, Tsunehisa Tsubokawa, Yasuhiro Haruta, Hideo Nakatani, Takanori Hashimoto (+1 others)
2012 Scientific Reports  
Authors Eiichi Okumura, Sanae Ueno and Kiyomi Shitamichi undertook the statistical analysis, and author Tetsu Hirosawa wrote the first draft of the manuscript.  ...  Author Haruhiro Higashida, Yuko Yoshimura, Toshio Munesue, Tsunehisa Tsubokawa, Yasuhiro Haruta, Hideo Nakatani, Takanori Hashimoto and Yoshio Minabe managed the literature searches and analyses.  ... 
doi:10.1038/srep00384 pmid:22540030 pmcid:PMC3337658 fatcat:3aqhz756cvc7ffrj5q4eikresi

Surface Chemical Studies of the Polished Surface of Heavy Crown Glasses

1958 Journal of the Ceramic Association Japan  
doi:10.2109/jcersj1950.66.754_233 fatcat:plplsbqivfdwhcpoudcm3b3zlu

Possible Modulation of Process Extension by N-Methyl-D-aspartate Receptor Expressed in Osteocytic MLO-Y4 Cells

Hiroyuki Fujita, Eiichi Hinoi, Eri Nakatani, Tomomi Yamamoto, Takeshi Takarada, Yukio Yoneda
2012 Journal of Pharmacological Sciences  
In contrast to osteoblasts, little attention has been paid to expression profiles of different glutamatergic signaling machineries in osteocytes, which are the most abundant cells with a possible role as a mechanical sensor in bone. Here, we show that N-methyl-D-aspartate receptor (NMDAR) is expressed by osteocytic cells in five-weeks-old mouse tibiae in vivo as well as by osteocytic MLO-Y4 cells in vitro. Sustained exposure to the NMDAR antagonist dizocilpine significantly increased the number
more » ... of cells with processes in cultured MLO-Y4 cells. These results suggest that NMDAR would be expressed by osteocytes with an unidentified role in the process extension.
doi:10.1254/jphs.12068sc pmid:22641131 fatcat:dyeuton5onfrbmjjawrbazzrv4

A Case of Double Gallbladder with Adenocarcinoma Arising from the Left Hepatic Duct: A Case Report and Review of the Literature

Masahiro Kawanishi, Yukio Kuwada, Yutaka Mitsuoka, Shogo Sasao, Teruo Mouri, Eiichi Takesaki, Tadateru Takahashi, Kazuhiro Toyota, Tamaki Nakatani
2010 Gastroenterology Research and Practice  
Double gallbladder is a rare congenital biliary anomaly, but an accessory gallbladder arising from the left hepatic duct is a more remarkably rare congenital anomaly. We report a case of double gallbladder with adenocarcinoma and gallstones, which was preoperatively diagnosed by endoscopic retrograde cholangiopancreatography (ERCP) and then confirmed by open laparotomy. A review of the literature is presented.
doi:10.1155/2010/721946 pmid:20811488 pmcid:PMC2926673 fatcat:e4tdktldqjc4fpknicj5nsqiza

78. Relation between the ash contents and the gasification rate of coal char with steam

Yasushi SEKINE, Hiroyuki NAKATANI, Misa CHIBA, Eiichi KIKUCHI, Masahiko MATSUKATA
2002 Proceedings of Conference on Coal Science  
化 に お ける 灰 分 とガ ス 化 速 度 の 相 関 ( 早 大理 工 ) O 関根 泰 ・ 中谷 浩 之 ・ 千 葉美 沙 ・ 菊 地 英 一 ・ 松 方 正 彦 Re 藍 ation betWeen the ash eontents and the gasification rate of coal char with steam OYasushi SEKINE , Hiroyuki NAKATANI  ...  , Misa CHIBA , Eiichi KIKUCHI , Masahiko MArSUKATA ( Department ofApplied Chemistry , Waseda University ) SYNOPSIS : We conducted steam gasification of various coal char under atomospheric prcssure on  ... 
doi:10.20550/jiesekitanronbun.39.0_173 fatcat:fukbhqivonc7lmdmdlan5iyrem

IgG4-Related Disease Complicated by Brain Parenchymal Lesions Successfully Treated with Corticosteroid Therapy: A Case Report

Jumpei Temmoku, Shuzo Sato, Haruki Matsumoto, Yuya Fujita, Erina Suzuki, Makiko Yashiro-Furuya, Naoki Matsuoka, Tomoyuki Asano, Eiichi Ito, Setsu Nakatani-Enomoto, Hiroko Kobayashi, Hiroshi Watanabe (+2 others)
2020 Tohoku journal of experimental medicine  
Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) is distinguished by the infiltration of IgG4-positive plasma cells in a variety of tissues and organs including the pancreas, salivary glands, retroperitoneal lesions, kidney, and lymph nodes with elevated serum IgG4 levels. Even so, central nervous system (CNS) lesions such as brain parenchymal lesions associated with IgG4-RD are scarce. So far, only six cases of IgG4-RD in relation with brain parenchymal lesions have been described, with its
more » ... haracteristics still being not clear. Here we have detailed a case of IgG4-RD with brain parenchymal lesions and reviewed previously-reported cases of IgG4-RD with brain parenchymal lesions. A 62-year-old Japanese male suffering from lung silicosis was admitted to our hospital for abdominal discomfort and altered consciousness. He has shown no major neurologic abnormalities except for drowsiness, urinary retention, and fecal incontinence. Brain magnetic resonance imaging has shown scattered hyperintense signals in the brain parenchyma. The serum IgG4 levels were elevated and systemic lymph nodes were enlarged. Biopsy from inguinal lymph nodes has shown massive infiltration of IgG4-positive plasma cells: the ratio of IgG4-positive/IgG-positive plasma cells was nearly 100%. Based on clinical courses, images, laboratory data, and pathological findings, a diagnosis of IgG4-RD that was complicated by brain parenchymal lesions and sacral nerve disturbance was confirmed. The patient was then given methylprednisolone pulse therapy (1g for 3 days) succeeding oral prednisolone (1 mg per body weight). The clinical and radiological improvements together with steroid therapy proposed IgG4-RD to be the cause of the lesions.
doi:10.1620/tjem.251.161 pmid:32641642 fatcat:r5qn2yuou5gobgq34hckaeyjmm

A case of severe acute myocarditis with persistent defect in 123I-MIBG myocardial scintigraphy
症例 123I-MIBG心筋シンチグラフィにて遷延する欠損を認めた激症型心筋炎の1例

Tomoya Yamashita, Yasunori Ichikawa, Eiji Takai, Tatsuya Kuniyoshi, Makoto Nakatani, Takaaki Motoyama, Eiichi Tajiri, Yutaka Furuta, Tatsuhiko Motooka
1996 Shinzo  
doi:10.11281/shinzo1969.28.10_827 fatcat:i7lzew55qbay7amrzt4awbwvxy

3P356 New data deposition website "ADIT-NMR" of BMRB as a biological macro molecular NMR database(Others,Poster Presentations)
3P356 生体高分子NMRデータベース : BMRBの新しいデータ登録ウェブサイト「ADIT-NMR」(その他,ポスター発表,第45回日本生物物理学会年会)

Eiichi Nakatani, Yoko Harano, Hideo Akutsu, Haruki Nakamura, Toshimichi Fujiwara
2007 Seibutsu Butsuri  
doi:10.2142/biophys.47.s292_1 fatcat:rwjx425mxvd27d2mywujzmfh5q

Semaphorin 4D inhibits neutrophil activation and is involved in the pathogenesis of neutrophil-mediated autoimmune vasculitis

Masayuki Nishide, Satoshi Nojima, Daisuke Ito, Hyota Takamatsu, Shohei Koyama, Sujin Kang, Tetsuya Kimura, Keiko Morimoto, Takashi Hosokawa, Yoshitomo Hayama, Yuhei Kinehara, Yasuhiro Kato (+9 others)
2017 Annals of the Rheumatic Diseases  
Objectives Inappropriate activation of neutrophils plays a pathological role in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). The aim of this study was to investigate the functions of semaphorin 4D (SEMA4D) in regulation of neutrophil activation, and its involvement in AAV pathogenesis. Methods Serum levels of soluble SEMA4D were evaluated by ELISA. Blood cell-surface expression of membrane SEMA4D was evaluated by flow cytometry. To determine the functional
more » ... between neutrophil membrane SEMA4D and endothelial plexin B2, wildtype and SEMA4D −/− mice neutrophils were cultured with an endothelial cell line (MS1) stained with SYTOX green, and subjected to neutrophil extracellular trap (NET) formation assays. The efficacy of treating human neutrophils with recombinant plexin B2 was assessed by measuring the kinetic oxidative burst and NET formation assays. Results Serum levels of soluble SEMA4D were elevated in patients with AAV and correlated with disease activity scores. Cell-surface expression of SEMA4D was downregulated in neutrophils from patients with AAV, a consequence of proteolytic cleavage of membrane SEMA4D. Soluble SEMA4D exerted pro-inflammatory effects on endothelial cells. Membranous SEMA4D on neutrophils bound to plexin B2 on endothelial cells, and this interaction decreased NET formation. Recombinant plexin B2 suppressed neutrophil Rac1 activation through SEMA4D's intracellular domain, and inhibited pathogeninduced or ANCA-induced oxidative burst and NET formation. Conclusions Neutrophil surface SEMA4D functions as a negative regulator of neutrophil activation. Proteolytic cleavage of SEMA4D as observed in patients with AAV may amplify neutrophil-mediated inflammatory responses. SEMA4D is a promising biomarker and potential therapeutic target for AAV.
doi:10.1136/annrheumdis-2016-210706 pmid:28416516 pmcid:PMC5738596 fatcat:7mv73g5fkza4bpn73uvamd6l5y

Clinical Significance of Serum Leptin Levels and its Relationship with Glycemic Control and Insulin Resistance in Non-Insulin-Dependent Diabetes Mellitus Patients
糖尿病患者における血清レプチン濃度の臨床的意義 longitudinal studyによる検討

Tsutomu Nishida, Eiichi Imano, Yoshihisa Nakatani, Masaaki Motomura, Katsumi Arai, Tsutomu Kanda
1999 Journal of the Japan Diabetes Society  
Patients with NIDDM (35 males and 21 females, mean age 57.2•}12.2 years, BMI 24.9•}4.5 kg/
doi:10.11213/tonyobyo1958.42.503 fatcat:iv435wolrffpfn6w636b6nfxmu

7-3.石灰石からの塩化物の揮発挙動(Session 4.7.8 燃焼・環境対策技術・エネルギー評価/経済)
7-3. Volatilization behavior of chlorinated compounds from limestone

2000 Proceedings of the Annual Conference of The Japan Institute of Energy  
doi:10.20550/jietaikaiyoushi.9.0_281 fatcat:odrkdyvu5fb6rotohaco3inyzy

An automated system designed for large scale NMR data deposition and annotation: application to over 600 assigned chemical shift data entries to the BioMagResBank from the Riken Structural Genomics/Proteomics Initiative internal database

Naohiro Kobayashi, Yoko Harano, Naoya Tochio, Eiichi Nakatani, Takanori Kigawa, Shigeyuki Yokoyama, Steve Mading, Eldon L. Ulrich, John L. Markley, Hideo Akutsu, Toshimichi Fujiwara
2012 Journal of Biomolecular NMR  
Biomolecular NMR chemical shift data are key information for the functional analysis of biomolecules and the development of new techniques for NMR studies utilizing chemical shift statistical information. Structural genomics projects are major contributors to the accumulation of protein chemical shift information. The management of the large quantities of NMR data generated by each project in a local database and the transfer of the data to the public databases are still formidable tasks
more » ... of the complicated nature of NMR data. Here we report an automated and efficient system developed for the deposition and annotation of a large number of data sets including 1 H, 13 C and 15 N resonance assignments used for the structure determination of proteins. We have demonstrated the feasibility of our system by applying it to over 600 entries from the internal database generated by the RIKEN Structural Genomics/Proteomics Initiative (RSGI) to the public database, BioMagResBank (BMRB). We have assessed the quality of the deposited chemical shifts by comparing them with those predicted from the PDB coordinate entry for the corresponding protein. The same comparison for other matched BMRB/PDB entries deposited from 2001-2011 has been carried out and the results suggest that the RSGI entries greatly improved the quality of the BMRB database. Since the entries include chemical shifts acquired under strikingly similar experimental conditions, these NMR data can be expected to be a promising resource to improve current technologies as well as to develop new NMR methods for protein studies.
doi:10.1007/s10858-012-9641-6 pmid:22689068 pmcid:PMC4308039 fatcat:a3kf7viodnck3jdtieliaoqmgm
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