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Res. 16: 165 EIICHI OICEZAKI, SHOJI KOIKE and EIICHI MAKINOCentral Research Laboratory, Hokuriku Seiyaku Co., Ltd., Fukui A new antibacterial drug, NY-198, was studied for mutagenicity using in vitro ...doi:10.11250/chemotherapy1953.36.supplement2-base_422 fatcat:joqwr3kedbex3m32cl3xyg6eqq
Atrophic variant of dermatofibrosarcoma protuberans (DFSP) is a distinct form of DFSP. Case presentation: Here, we report the case of a 19-year-old woman with a small congenital atrophic plaque on the right precordium. The lesion remained atrophic for more than 10 years. Several years earlier, a portion of the plaque became tuberous and enlarged. Physical examination revealed a 25 × 30 mm erythematous atrophic plaque surrounded by three hard, smooth, and orange-colored nodules of varying sizesdoi:10.1186/s13000-016-0474-6 pmid:26932148 pmcid:PMC4774026 fatcat:dzmswnqcr5adnoedto76ghqkqa
more »... n the right precordium, along with visible subcutaneous adipose tissue and cutaneous veins. Biopsy of the nodule and atrophic plaque revealed dense proliferation of spindle-shaped tumor cells from the dermis to the subcutaneous adipose tissue, and positive immunostaining for CD34 and vimentin in addition to negative staining for factor XIIIa and α-smooth muscle actin. Reverse transcription polymerase chain reaction (RT-PCR) of the tumor tissue revealed the presence of a COL1A1-PDGFB fusion gene. Thus, congenital atrophic dermatofibrosarcoma protuberans was diagnosed. No metastasis to the lungs or regional lymph nodes was found on magnetic resonance imaging. Wide local excision and split-thickness skin grafting was performed and neither recurrence nor metastasis has been observed for 5 years and 8 months since the surgery. Conclusion: This case indicates that a congenital atrophic lesion could represent a quiescent phase of DFSP. Awareness of this rare condition can aid with early diagnosis and thereby improve the prognosis of DFSP.
neoplasm, formerly called "blastic NK cell lymphoma", is an aggressive lymphoma which often begins with cutaneous nodules in the elderly. The tumor cells have a CD4+, CD56+, CD3-phenotype, and recent studies suggest they derive from a plasmacytoid dendritic cell. A 72-year-old man was referred to us because of an eight-month history of a nodule on his right cheek. The biopsy specimen showed the infiltration of immature lymphoid cells in the entire dermis with a phonotype of CD4+, CD56+, CD123+doi:10.5227/skincancer.21.125 fatcat:7654pbtbcbe45h2zpsfdp5yw5y
more »... nd CD3-phenotype. Epstein-Barr virus infection was denied. We diagnosed the patient as having CD4+/CD56+ hematodermic neoplasm, and treated him with CHOP therapy. Skin lesions were once cleared up, but similar lesions soon recurred. Although, we added irradiation for the lesions present, new lesions occurred on the unirradiated region. Then, we treated him with whole-body irradiation, which cleared all of the skin lesions, but he died 2 months after discharge, probably due to the progressive internal lymphoma. [Skin Cancer (Japan) 2006; 21: 125-131]
JAAD Case Reports
Technol. 2010, 101, 8493−8501. (9) Makino, A.; Kizaka-Kondoh, S.; Yamahara, R.; Hara, I.; Kanzaki, T.; Ozeki, E.; Hiraoka, M.; Kimura, S. ... Biol. 2013, 40, 387−394. (11) Hara, E.; Makino, A.; Kurihara, K.; Ueda, M.; Hara, I.; Kawabe, T.; Yamamoto, F.; Ozeki, E.; Togashi, K.; Kimura, S. ...doi:10.1021/ml500112u pmid:25147606 pmcid:PMC4137364 fatcat:jwwzh554tfcytauywjrb7vmmm4
We applied photoreflectance (PR) spectroscopy for contactless determination of the electric field strength at buried interfaces in metal–insulator–semiconductor (MIS) structures. The PR is an all-optical version of an electromodulated reflectance spectroscopy. The tradeoff of this adoption is that this requires an additional feedback system to eliminate background problems induced by scattered pump light and/or photoluminescence. A microcomputer-based feedback system has been developed for thisdoi:10.3390/solids2020008 fatcat:5z2afvfdpvfqljs2h6dtpgirx4
more »... elimination. Despite the very tiny signal intensity, we successfully attained a sufficiently good signal–noise ratio to determine the electric field strength in oxide-based MIS interfaces that exhibits a large, unwanted photoluminescence signal. The field strength was evaluated to be ca. 0.25 kV/cm.
., 2002; Makino et al.,2003) . 2003) . し か し,移 動 者 の捜 索 に お い て はGPSの 測 位 精 度 は 重 要 で は な い の で あ ろ うか.そ うで あ るな らば,GPSの 測 位 精 度 の他 に ど の よ うな 要 因が 移 動 者 を捜 索 す る 作 業 に影 響 を与 え るの で あ ろ うか. ...doi:10.5638/thagis.12.57 fatcat:a46pwkos7begrjg6feqbj4j7py
Cells cope with temperature elevations, which cause protein misfolding, by expressing heat shock proteins (HSPs). This adaptive response is called the heat shock response (HSR), and it is regulated mainly by heat shock transcription factor (HSF). Among the four HSF family members in vertebrates, HSF1 is a master regulator of HSP expression during proteotoxic stress including heat shock in mammals, whereas HSF3 is required for the HSR in birds. To examine whether only one of the HSF familydoi:10.1371/journal.pone.0180776 pmid:28686674 pmcid:PMC5501597 fatcat:u65ln27ncfeprbau5j2zijfisu
more »... s possesses the potential to induce the HSR in vertebrate animals, we isolated cDNA clones encoding lizard and frog HSF genes. The reconstructed phylogenetic tree of vertebrate HSFs demonstrated that HSF3 in one species is unrelated with that in other species. We found that the DNA-binding activity of both HSF1 and HSF3 in lizard and frog cells was induced in response to heat shock. Unexpectedly, overexpression of lizard and frog HSF3 as well as HSF1 induced HSP70 expression in mouse cells during heat shock, indicating that the two factors have the potential to induce the HSR. Furthermore, knockdown of either HSF3 or HSF1 markedly reduced HSP70 induction in lizard cells and resistance to heat shock. These results demonstrated that HSF1 and HSF3 cooperatively regulate the HSR at least in lizards, and suggest complex mechanisms of the HSR in lizards as well as frogs. conserved transcription factor heat shock factor (HSF), which binds to the heat shock response element (HSE) in eukaryotes    . In contrast to the single HSF gene in yeast, worm, and fruit fly, four HSF genes (HSF1, HSF2, HSF3, and HSF4) have been isolated in vertebrates, including chicken, mouse, and human [9, 10]. Among vertebrate HSFs, HSF1 is a master regulator of HSP expression during proteotoxic stresses, including heat shock, in mammals. HSF1 mostly remains as an inert monomer in unstressed conditions. In response to heat shock, it is converted to an active trimer that binds to HSEs in HSP promoters, and robustly induces the transcription of these genes [11, 12] . The induction of HSPs is associated with increased proteostasis capacity and resistance to cell death. Mammalian HSF2, HSF3, and HSF4 are also involved in the maintenence of proteostasis capacity by regulating the expression of non-HSP genes such as αB-and γ-crystallins and PDZK3     . However, they are dispensable for the induction of HSP expression during proteotoxic stresses [14, 17, 18] , although they modify it to some extent [19, 20] . Of particular note, chicken HSF1 is dispensable for stress-induced HSP expression, indicating that it is functionally different from mammalian HSF1. Instead, chicken HSF3 (cHSF3) is required for the induction of HSP expression [21-23]. cHSF3 remains as an inert dimer in unstressed conditions, and forms an active trimer in response to heat shock  . Thus, cHSF3 has unique properties and plays a pivotal role in the regulation of the chicken HSR. However, the potential to induce HSP expression had been lost in mouse HSF3, and the human HSF3 gene is a pseudogene  . Thus, the indispensable role of HSF3 has so far been considered to be specific in birds. Recently, whole genomic sequences of a variety of animal species have been determined and released to the public. It was revealed that all four HSF genes exist in vertebrate species, including in reptiles and amphibians  . To uncover roles of HSFs in the HSR in vertebrates, we isolated complementary DNAs of lizard and frog HSF family members and examined their potential to induce HSP expression during heat shock. Unexpectedly, we found that both HSF1 and HSF3 have the potential to induce HSP expression in lizards and frogs. Materials and methods Cell cultures and treatments Immortalized wild-type (stock #10) or HSF1-/-(stock #4) mouse embryonic fibroblasts (MEFs) , human HEK293 cells, and chicken DF-1 fibroblast (ATCC CRL-12203)  cell lines were maintained at 37˚C in 5% CO 2 in Dulbecco's modified Eagle's medium (DMEM; Gibco/Life Technologies) supplemented with 10% fetal bovine serum (FBS) (Sigma Life Science). Lizard gekko lung-1 (GL-1) epithelial cells isolated from Gekko gecko (ATCC CCL-111)  were maintained at 30˚C in 5% CO 2 in Ham's F-12K medium (Gibco/Life Technologies) supplemented with 15% FBS. Western clawed frog epithelial-like Speedy cells derived from Xenopus tropicalis (or Silurana tropicalis) tadpole hindlimbs  were provided by Dr. Nicolas Pollet (Institute of Systems and Synthetic Biology, Genopole, CNRS, France), and maintained at 28˚C in Leibovitz's L-15 Medium (Sigma Life Science)/double distilled water (2:1) supplemented with 10% FBS. To induce heat shock in the cultured cells, the culture dishes were sealed with parafilm and submerged in a water bath at indicated heat shock temperature. Care and treatment of lizards and frogs Adult female brown anole lizards, Anolis sagrei, were collected in Havana city, Cuba during 2009 to 2011 (for RNA isolation), and transported alive to Tohoku University, Japan as described previously  . Briefly, we collected A. sagrei in Havana City, which was not a Characterization of heat shock factors in lizards PLOS ONE | https://doi.
An internal hernia may be either congenital or acquired. The reported incidence of such hernias is 1-2%. In rare cases, internal hernias are the cause of small bowel obstruction, with a reported incidence of 0.2-0.9%. Transmesocolic hernia of the ascending colon is especially rare. We report a case of transmesocolic hernia of the ascending colon with intestinal obstruction diagnosed preoperatively. A 91-year-old Japanese female was admitted to our hospital with abdominal distention and vomitingdoi:10.1159/000339691 pmid:22740809 pmcid:PMC3383250 fatcat:7rualyuocbg7zgwd7fwoa6duym
more »... of 3 days duration. She had no past history of any abdominal surgery. Abdominal examination revealed distention and tenderness in the right iliac fossa. Abdominal computed tomography revealed ileus in the sac at the left side of the ascending colon and dilatation of the oral side of the intestine. We diagnosed a transmesocolic hernia of the ascending colon with intestinal obstruction and performed emergency surgery. At the time of operation, there was internal herniation of ileal loops through a defect in the ascending mesocolon, without any strangulation of the small bowel. The contents were reduced and the tear in the ascending mesocolon was closed. The postoperative course was uneventful and the patient was discharged 14 days after surgery. In conclusion, preoperative diagnosis of bowel obstruction caused by a congenital mesocolic hernia remains difficult despite the techniques currently available, so it is important to consider the possibility of a transmesocolic hernia when diagnosing a patient with ileus with no past history of abdominal surgery.
[Purpose] This study aimed to examine the impact of changing the drop vertical jump stance time on kinematic and kinetic parameters by ordering to high jump or quick jump for consistent stance time and a more accurate assessment of anterior cruciate ligament injury risk. [Participants and Methods] The participants were 20 healthy female students. The drop vertical jump was started by instructing the participants to stand on a 30-cm platform with both legs stationary. The task was performeddoi:10.1589/jpts.31.670 pmid:31528007 pmcid:PMC6698476 fatcat:4oheatmqufhddpttff3bldrijm
more »... the participants were instructed to perform high jump or quick jump. [Results] Stance time was significantly shorter with quick jump than with high jump. Quick jump showed significantly higher knee abduction angles at initial contact and peak vertical ground reaction force, and lower hip flexion, knee flexion, and ankle dorsiflexion angles at the lowest point of the center of mass. Quick jump showed a significantly higher peak vertical ground reaction force. The knee abduction moment at initial contact was not significantly different between the 2 conditions. [Conclusion] Quick jump was better than high jump for making stance time consistent, and the differences in kinematic and kinetic characteristics by oral instructions should be considered when using drop vertical jump.
Primary malignant melanoma of the esophagus (PMME) has been reported to be a rare and highly malignant disease, and to date a standard treatment strategy has not been established due to limited evidence. The aim of the present study was to investigate the clinicopathological characteristics of this extremely rare disease. A total of 6 out of 2,093 patients with PMME treated in our institution between 1995 and 2016 were retrospectively analyzed and their clinicopathological parameters includingdoi:10.3892/ol.2019.10519 pmid:31423256 pmcid:PMC6614672 fatcat:grnayhu6z5bkvdccjsuufdlmny
more »... reatment course and long-term survival were investigated. The major clinicopathological characteristics of patients were that they were >70 years of age, male sex, dysphagia at first diagnosis, and macroscopic black protruding tumors located in the lower third of the thoracic esophagus. Four of the five patients receiving pretherapeutic endoscopic biopsy were correctly diagnosed with PMME, and two patients received preoperative treatment with ineffective histopathological responses. There were two unresectable cases, one was treated with an immune-checkpoint inhibitor and the other received palliative care. Three of the four patients receiving curative surgery developed hematogenous recurrence within two years of surgery and only one patient with pT1aN0M0 achieved long-term survival. The median overall survival of all six patients was 19.6 (6.4-40.5) months. Patients with stage I disease exhibited significantly more favorable prognoses than those with stage II-IV (P=0.025) and surgically-treated patients had significantly better prognoses than those who did not receive surgery (P=0.018). In conclusion, PMME was associated with highly malignant features and tended to develop hematogenous metastases even after radical resection. Early diagnosis appears to be important to cure this refractory disease.
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