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MTHFR promotes heterochromatin maintenance

Bingtao Zhu, Zhikai Xiahou, Heyu Zhao, Bin Peng, Hongchang Zhao, Xingzhi Xu
2014 Biochemical and Biophysical Research Communications - BBRC  
to methionine.  ...  Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in the folate cycle, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation  ...  This work was supported by the National Natural Science  ... 
doi:10.1016/j.bbrc.2014.04.082 pmid:24769206 fatcat:u2xpebz72rah3gs3ic36mhn53i

Genome-Wide Association Study of Diabetogenic Adipose Morphology in the GENetics of Adipocyte Lipolysis (GENiAL) Cohort

Veroniqa Lundbäck, Agné Kulyté, Peter Arner, Rona J. Strawbridge, Ingrid Dahlman
2020 Cells  
We performed a genome-wide association study (GWAS) in the unique GENetics of Adipocyte Lipolysis (GENiAL) cohort comprising 948 participants who have undergone abdominal subcutaneous adipose biopsy with  ...  We set out to identify genetic loci associated with adipose morphology and functionally evaluate candidate genes for impact on adipocyte development.  ...  Tag genome-wide association study (GWAS) SNPs associated with type 2 diabetes and with adipose morphology in the current study.  ... 
doi:10.3390/cells9051085 pmid:32349335 pmcid:PMC7291295 fatcat:lmitb7cltff5hb4orgkmwmrddi

Advances in genetics and molecular breeding of three legume crops of semi-arid tropics using next-generation sequencing and high-throughput genotyping technologies

Rajeev K Varshney, Himabindu Kudapa, Manish Roorkiwal, Mahendar Thudi, Manish K Pandey, Rachit K Saxena, Siva K Chamarthi, Murali Mohan S, Nalini Mallikarjuna, Hari Upadhyaya, Pooran M Gaur, L Krishnamurthy (+3 others)
2012 Journal of Biosciences  
Molecular markers are the most powerful genomic tools to increase the efficiency and precision of breeding practices for crop improvement.  ...  These trait-associated robust markers along with other genomic resources including genetic maps and genomic resources will certainly accelerate crop improvement programmes in the SAT legumes.  ...  To overcome the constraints related to production in SAT legumes using genomics-assisted breeding, identification/ discovery of marker trait association between the trait of interest and a genetic marker  ... 
doi:10.1007/s12038-012-9228-0 pmid:23107917 fatcat:ef5z4ral4relfcbbmmpfjeyw5u

Identification of genes associated with productivity traits and salinity tolerance from activation tagged lines of rice [article]

Vamsee Raja Kota, Madhansekhar Kalva, Dashavanthareddy Vudem, Ramachandrareddy Attipalli, Venkateswararao Khareedu
2021 bioRxiv   pre-print
World-wide crop productivity is hugely impacted by diverse eco-environmental conditions.  ...  Furthermore, AT lines disclosed enhanced plant water content, photosynthetic efficiency, stomatal conductance, water use efficiency and maximum quantum yield when compared to WT plants, leading to improved  ...  These results indicate that AT lines showed higher A Sat values by 25% to 50 % under 3 5 4 .  ... 
doi:10.1101/2021.01.22.427785 fatcat:7cl736tglzcahiyiopnuskfe6e

Rex (Encoded by DVU_0916) in Desulfovibrio vulgaris Hildenborough Is a Repressor of Sulfate Adenylyl Transferase and Is Regulated by NADH

G. A. Christensen, G. M. Zane, A. E. Kazakov, X. Li, D. A. Rodionov, P. S. Novichkov, I. Dubchak, A. P. Arkin, J. D. Wall, W. W. Metcalf
2014 Journal of Bacteriology  
Although the enzymes for dissimilatory sulfate reduction by microbes have been studied, the mechanisms for transcriptional regulation of the encoding genes remain unknown.  ...  Therefore, the DVU_0916 protein has been predicted to be a transcriptional repressor of genes encoding proteins that function in the process of sulfate reduction inD. vulgarisHildenborough.  ...  From an examination of genome sequences, Rex has been predicted to be present in a wide range of microbes, including Gram-negative and Grampositive aerobes and anaerobes.  ... 
doi:10.1128/jb.02083-14 pmid:25313388 pmcid:PMC4288696 fatcat:kfdh3byjufhn7je2xipzpgmnfi

Photosynthetic parameters of switchgrass (Panicum virgatum) under low radiation: Influence of stable overexpression of Miscanthus×giganteus PPDK on responses to light and CO2 under warm and cool growing conditions

Mathew Halter, Jackson Mitchell, David G.J. Mann, Balasubramaniam Muthukumar, C. Neal Stewart, Erik T. Nilsen
2015 New Negatives in Plant Science  
Abbreviations: A/C i curve, photosynthetic response to intercellular CO 2 concentration; A/Q curve, photosynthetic response to incident light curve; A sat , light saturated photosynthetic rate; AQE, apparent  ...  Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).  ...  The authors would like to thank John Goodwin for technical assistance.  ... 
doi:10.1016/j.neps.2015.08.001 fatcat:sl5slynkyngphmfd4j3eplwvs4

Whole genome sequencing of experimental hybrids supports meiosis-like sexual recombination in Leishmania

Ehud Inbar, Jahangheer Shaik, Stefano A. Iantorno, Audrey Romano, Chukwunonso O. Nzelu, Katherine Owens, Mandy J. Sanders, Deborah Dobson, James A. Cotton, Michael E. Grigg, Stephen M. Beverley, David Sacks (+1 others)
2019 PLoS Genetics  
wide patterns of recombination, demonstrating that classical crossing over occurs at meiosis, and allowed us to construct the first physical and genetic maps in Leishmania.  ...  The hybrids were equivalent to F1 progeny, heterozygous throughout most of the genome for the markers that were homozygous and different between the parents.  ...  The extra genome was contributed by LiL/HYG to three of the hybrids, and by LmFV1/SAT to one.  ... 
doi:10.1371/journal.pgen.1008042 pmid:31091230 pmcid:PMC6519804 fatcat:25k3raitnnfrneapif5jkb5p3m

Genome-Wide Association Study ofArabidopsis thalianaIdentifies Determinants of Natural Variation in Seed Oil Composition

Sandra E. Branham, Sara J. Wright, Aaron Reba, C. Randal Linder
2015 Journal of Heredity  
The renewable source of highly reduced carbon provided by plant triacylglycerols (TAGs) fills an ever increasing demand for food, biodiesel, and industrial chemicals.  ...  Here, we characterized the seed oil composition of 391 world-wide, wild accessions of Arabidopsis thaliana, and performed a genome-wide association study (GWAS) of the 9 major fatty acids in the seed oil  ...  Acknowledgments Thank you to T. Juenger for providing accession seed. We are grateful for analysis advice from G. Morrison, J. Lasky and T. Nakov.  ... 
doi:10.1093/jhered/esv100 pmid:26704140 pmcid:PMC4885229 fatcat:4o5brijitja6vhwnuwlkit7pvm

Validity of a new automated software program for visceral adipose tissue estimation

E W Demerath, K J Ritter, W A Couch, N L Rogers, G M Moreno, A Choh, M Lee, K Remsberg, S A Czerwinski, W C Chumlea, R M Siervogel, B Towne
2006 International Journal of Obesity  
Objective: Our aim was to compare estimates of VAT (visceral adipose tissue) and SAT (subcutaneous adipose tissue) using the new Hippo Fatt software against those from a widely used, validated, computer-assisted  ...  Average VAT was 9.4% lower and average SAT was 3.7% higher using Hippo Fatt compared to slice-O-matic; the overestimation of SAT tended to be greater among individuals with greater adiposity.  ...  Acknowledgements This work was supported by Grants HD12252 and DK064870 from the National Institutes of Health, Bethesda, MA, USA.  ... 
doi:10.1038/sj.ijo.0803409 pmid:16770332 pmcid:PMC1783906 fatcat:tytynfj4erhfrg4fgniq6ubynm

From sulfur to homoglutathione: thiol metabolism in soybean

Hankuil Yi, Geoffrey E. Ravilious, Ashley Galant, Hari B. Krishnan, Joseph M. Jez
2010 Amino Acids  
Here, we review the details of thiol metabolism in soybean, its potential biotechnology value, what is known about the pathways from sulfur uptake to glutathione synthesis in soybean, how the soybean genome  ...  from the soybean genome may guide the next steps in exploring this biochemical system.  ...  C-terminal phosphorylation of SAT affects CRC formation and whether this post-translation modification is more widely used to modulate feedback inhibition by cysteine.  ... 
doi:10.1007/s00726-010-0572-9 pmid:20364282 fatcat:bbcvxuhda5g63ld5dssumg2vsy

Affinity Purification of O-Acetylserine(thiol)lyase from Chlorella sorokiniana by Recombinant Proteins from Arabidopsis thaliana

Giovanna Salbitani, Markus Wirtz, Rüdiger Hell, Simona Carfagna
2014 Metabolites  
In order to enable the identification of OASTL proteins from non-model organisms such as C. sorokiniana, the recombinant his-tagged SAT5 protein from Arabidopsis thaliana was immobilized by metal chelate  ...  The successful application of SAT/OASTL interaction for purification confirms for the first time the existence of the cysteine synthase complexes in microalgae.  ...  Acknowledgments Giovanna Salbitani was supported by a fellowship (FORGIARE) funded by Polo delle Scienze e delle Tecnologie, University "Federico II" of Naples and by Compagnia San Paolo di Torino.  ... 
doi:10.3390/metabo4030629 pmid:25093930 pmcid:PMC4192684 fatcat:q427raee3ffrhavpght357zxuu

The Tag Genome

Jesse Vig, Shilad Sen, John Riedl
2012 ACM transactions on interactive intelligent systems (TiiS)  
We describe an application of the tag genome called Movie Tuner which enables users to navigate from one item to nearby items along dimensions represented by tags.  ...  This article introduces the tag genome, a data structure that extends the traditional tagging model to provide enhanced forms of user interaction.  ...  Like Symeonidis et al. [2008] , we apply dimensionality reduction techniques to overcome the sparsity in tagging systems.  ... 
doi:10.1145/2362394.2362395 fatcat:hnlpdmuofzfn7ak2znus4awuga

Niche partitioning in the Rimicaris exoculata holobiont: the case of the first symbiotic Zetaproteobacteria

Marie-Anne Cambon-Bonavita, Johanne Aubé, Valérie Cueff-Gauchard, Julie Reveillaud
2021 Microbiome  
Results Our data enabled us to reconstruct 49 metagenome-assembled genomes (MAGs) from the TAG and Rainbow vent fields, including 16 with more than 90% completion and less than 5% contamination based on  ...  Here, we generated shotgun metagenomes from Rimicaris exoculata cephalothoracic epibiotic communities to reconstruct and investigate symbiotic genomes.  ...  We are really grateful to two anonymous reviewers for their constructive comments, which helped us to improve the manuscript.  ... 
doi:10.1186/s40168-021-01045-6 pmid:33845886 pmcid:PMC8042907 fatcat:mkkfjnxlefas3cjvi2nd2vad3i

Insect phylogenomics: results, problems and the impact of matrix composition

H. O. Letsch, K. Meusemann, B. Wipfler, K. Schutte, R. Beutel, B. Misof
2012 Proceedings of the Royal Society of London. Biological Sciences  
.), and Paraneoptera (thrips, lice, bugs in the wide sense).  ...  As recent EST datasets are characterized by a heterogeneous distribution of available genes across taxa, we use different rationales to optimize the data matrix composition.  ...  B.M. and K.M. were supported by the DFG grant MI 649/6.  ... 
doi:10.1098/rspb.2012.0744 pmid:22628473 pmcid:PMC3385742 fatcat:pjibn2lembdchnwvybcmzoswqa

A Comprehensive Analysis of Common and Rare Variants to Identify Adiposity Loci in Hispanic Americans: The IRAS Family Study (IRASFS)

Chuan Gao, Nan Wang, Xiuqing Guo, Julie T. Ziegler, Kent D. Taylor, Anny H. Xiang, Yang Hai, Steven J. Kridel, Jerry L. Nadler, Fouad Kandeel, Leslie J. Raffel, Yii-Der I. Chen (+10 others)
2015 PLoS ONE  
Five SNPs from two novel loci attained genome-wide significance (P<5.00x10 -8 ) in IRASFS.  ...  In conclusion, a genome-wide and exome chip association study was conducted that identified two novel loci (IDH1 and ZGRF1) associated with adiposity.  ...  The authors would like to acknowledge the members of the GUARDIAN Consortium.  ... 
doi:10.1371/journal.pone.0134649 pmid:26599207 pmcid:PMC4658008 fatcat:ntprrulvkja7lcfih62542ahim
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