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Effects of resting state condition on reliability, trait specificity, and network connectivity of brain function measured with arterial spin labeled perfusion MRI

Zhengjun Li, Marta Vidorreta, Natalie Katchmar, David C. Alsop, Daniel H. Wolf, John A. Detre
2018 NeuroImage  
These biomarkers include time-averaged regional brain function as manifested by regional cerebral blood flow (CBF) measured using arterial spin labeled (ASL) perfusion MRI and correlated temporal fluctuations  ...  on reliability and reproducibility as well as trait specificity of regional brain function.  ...  DCA is an inventor of pseudocontinuous ASL and receives a share of postmarket royalties from his institution's licenses to GE Healthcare, Philips Healthcare, Siemens Healthineers, Hitachi Medical, and  ... 
doi:10.1016/j.neuroimage.2018.02.028 pmid:29454933 pmcid:PMC5957091 fatcat:3t2qtqjfurddrgdcotyvz2jvzy

Quantifying the Link between Anatomical Connectivity, Gray Matter Volume and Regional Cerebral Blood Flow: An Integrative MRI Study

Bálint Várkuti, Mustafa Cavusoglu, Alexander Kullik, Björn Schiffler, Ralf Veit, Özge Yilmaz, Wolfgang Rosenstiel, Christoph Braun, Kamil Uludag, Niels Birbaumer, Ranganatha Sitaram, Olaf Sporns
2011 PLoS ONE  
But regions of the brain can be characterised further with respect to their gray matter volume or resting state perfusion.  ...  Methodology/Principal Findings: We quantified the covariation of these traits by conducting an integrative MRI study on 23 subjects, utilising a combination of Diffusion Tensor Imaging, Arterial Spin Labeling  ...  We would also especially like to thank the developers of the DTI and Fibertools Software Package from the Department of Radiology, Medical Physics, University Hospital Freiburg Dr. Björn Kreher, Dr.  ... 
doi:10.1371/journal.pone.0014801 pmid:21525993 pmcid:PMC3078126 fatcat:n2voftly7zdhffy5ernbisivbm

Common and dissociable regional cerebral blood flow differences associate with dimensions of psychopathology across categorical diagnoses

A N Kaczkurkin, T M Moore, M E Calkins, R Ciric, J A Detre, M A Elliott, E B Foa, A Garcia de la Garza, D R Roalf, A Rosen, K Ruparel, R T Shinohara (+5 others)
2017 Molecular Psychiatry  
CBF during a resting state was quantified on a voxelwise basis using arterial spin labeled perfusion MRI at 3T.  ...  Resting-state regional cerebral blood flow (CBF) can be measured noninvasively with MRI and abnormalities in regional CBF are present in many neuropsychiatric disorders.  ...  Supported by RC2 grants from the National Institute of Mental Health MH089983 and MH089924 and P50MH096891.  ... 
doi:10.1038/mp.2017.174 pmid:28924181 pmcid:PMC5858960 fatcat:ezq4rbbfung5ph52gzzibk7r7e

Arterial spin labeling provides a reliable neurobiological marker of autism spectrum disorder

Benjamin E. Yerys, John D. Herrington, Gregory K. Bartley, Hua-Shan Liu, John A. Detre, Robert T. Schultz
2018 Journal of Neurodevelopmental Disorders  
Arterial spin labeled perfusion MRI allows noninvasive quantification of regional CBF as part of a multimodal MRI protocol. This method is almost entirely absent from ASD research to date.  ...  We also sought to examine the reproducibility of CBF measures, and their relationship to individual differences in facial recognition and ASD symptoms.  ...  We thank Meghan McDermott Puglia for supporting culling of video data percentages, Jennifer Bertollo for the assistance in creating figures and in general preparation of the manuscript, and Mitchell Walker  ... 
doi:10.1186/s11689-018-9250-0 pmid:30541425 pmcid:PMC6292037 fatcat:dhfhg7vtsvbqpeh6ijty2ewaaa

Using arterial spin labeling to examine mood states in youth

Nina Mikita, Mitul A. Mehta, Fernando O. Zelaya, Argyris Stringaris
2015 Brain and Behavior  
Arterial spin labeling (ASL) imaging is particularly well-suited to study sustained cerebral states in young people, due to its robustness to low-frequency drift, excellent interscan reliability, and noninvasiveness  ...  The effects of happy mood on rCBF patterns were generally stronger than the effects of sad mood.  ...  Arterial spin labeling appears especially well-suited to studying the neural signatures of different mood states and their specific features, such as duration and intensity.  ... 
doi:10.1002/brb3.339 pmid:26085964 pmcid:PMC4467773 fatcat:jzjhnvozqvgq5jauux6dutdq7i

Dopaminergic modulation of regional cerebral blood flow: an arterial spin labelling study of genetic and pharmacological manipulation of COMT activity

M Martens, FA Kennedy McConnell, N Filippini, CE Mackay, PJ Harrison, EM Tunbridge
2021 NeuroImage  
We then assessed regional cerebral blood flow at rest using pulsed arterial spin labelling. Perfusion was affected by both genotype and drug.  ...  However, its effects on cerebral perfusion have been relatively unexplored.  ...  Whole-brain perfusion imaging was performed using Siemens' pulsed arterial spin labelling (ASL) product PICORE-Q2TIPS pulsed arterial spin labelling (ASL) product sequence, with a 2D gradient spin echo  ... 
doi:10.1016/j.neuroimage.2021.117999 pmid:33789133 fatcat:lfgljwvrfbgovjcurrfdws36xi

Central Mechanisms of Pain Revealed Through Functional and Structural MRI

Karen D. Davis, Massieh Moayedi
2012 Journal of Neuroimmune Pharmacology  
Two types of functional MRI discussed in this review provide insight into pain mechanisms: stimulusevoked fMRI and task-free ("resting state") fMRI.  ...  Perfusion MR (e.g., arterial spin labeling) can also provide task-free information pertaining to ongoing brain activity that may reflect spontaneous (ongoing) chronic pain.  ...  connectivity with functional MRI); 4) Neuronal activity as reflected by regional cerebral blood flow (arterial spin labeling perfusion MRI); 5) Gray matter volume and cortical thickness (structural MRI  ... 
doi:10.1007/s11481-012-9386-8 pmid:22825710 fatcat:mo4zs7ipdrevbghrdjwuorot2q

Perfusion MRI Indexes Variability in the Functional Brain Effects of Theta-Burst Transcranial Magnetic Stimulation

Caterina Gratton, Taraz G. Lee, Emi M. Nomura, Mark D'Esposito, Yu-Feng Zang
2014 PLoS ONE  
CBF changes were measured both before and after TMS on each day from a series of interleaved resting state and perfusion scans.  ...  Twenty-seven participants each completed four combined TMS-fMRI sessions during which both resting state Blood Oxygen Level Dependent (BOLD) and perfusion Arterial Spin Labeling (ASL) scans were recorded  ...  Acknowledgments We thank JJ Wang and Ze Wang for their ASL sequences and processing scripts and Ben Inglis, Liz Castle, and Sonia's Bishop lab for help with implementing them.  ... 
doi:10.1371/journal.pone.0101430 pmid:24992641 pmcid:PMC4081571 fatcat:pbku4scz2bc5fooh7biwsxpuda

Coupling Between Resting Cerebral Perfusion and EEG

R. L. O'Gorman, S.-S. Poil, D. Brandeis, P. Klaver, S. Bollmann, C. Ghisleni, R. Lüchinger, E. Martin, A. Shankaranarayanan, D. C. Alsop, L. Michels
2012 Brain Topography  
Here we compare whole-brain arterial spin labelling perfusion MRI and EEG in a group of healthy adults (n = 16, ten females, median age: 27 years, range 21-48) during an eyes closed rest condition.  ...  In addition, central alpha frequency positively correlated with perfusion in a network of brain regions associated with the modulation of attention and preparedness for external input, and central theta  ...  electroencephalography (EEG), magnetoencephalography (MEG), and arterial spin labelling (ASL) perfusion MRI.  ... 
doi:10.1007/s10548-012-0265-7 pmid:23160910 fatcat:klxvabqnqfecdgjt2epsgah2vi

Advances in neuroimaging of traumatic brain injury and posttraumatic stress disorder

Robert W. Van Boven, Greg S. Harrington, David B. Hackney, Andreas Ebel, Grant Gauger, J. Douglas Bremner, Mark D'Esposito, John A. Detre, E. Mark Haacke, Clifford R. Jr Jack, William J. Jagust, Denis Le Bihan (+4 others)
2009 Journal of rehabilitation research and development  
For TBI, we focus on findings and advances in neuroimaging that hold promise for better detection, characterization, and monitoring of objective brain changes in symptomatic patients with combat-related  ...  Advances in brain imaging offer important biomarkers of structural, functional, and metabolic information concerning the brain.  ...  Evaluate brain networks related to cognitive states. Evaluate brain "resting state" or "default" networks. PW-MRI Direct measure of blood flow, allows quantification of blood perfusion.  ... 
doi:10.1682/jrrd.2008.12.0161 pmid:20104401 pmcid:PMC3233771 fatcat:3u7sew7nezbbjpyczxe3f3mura

Correlation Between Levels of Delusional Beliefs and Perfusion of the Hippocampus and an Associated Network in a Non–Help-Seeking Population

Rick P.F. Wolthusen, Garth Coombs, Emily A. Boeke, Stefan Ehrlich, Stephanie N. DeCross, Shahin Nasr, Daphne J. Holt
2018 Biological Psychiatry: Cognitive Neuroscience and Neuroimaging  
METHODS-To investigate this question, structural and pulsed arterial spin labeling scans were collected in 77 adult participants with no psychiatric history.  ...  A self-report measure of delusional ideation was collected on the day of scanning.  ...  Acknowledgments This work was supported by National Institute of Mental Health Grant Nos. RO1 MH095904 and K23 MH076054 (to DJH).  ... 
doi:10.1016/j.bpsc.2017.06.007 pmid:29529413 pmcid:PMC5854214 fatcat:cxurjuyhvjg7pbi2tuejg7avj4

Advances in Diagnostics for Neurodegenerative Disorders [chapter]

Arun L. W. Bokde, James F. M. Meaney, Niall P. Sheehy, Richard B. Reilly, Sharon Abrahams, Colin P. Doherty
2011 Neurodegenerative Disorders  
Beginning with neuropsychological analysis, this review ranges though structural (anatomic), dynamic, and functional brain imaging using MRI and radio-nucleotide scanning to complex neurophysiological  ...  The future of multi-modality imaging and its contribution to, not only to diagnosis, but to classification, prognosis, and treatment outcome in neurodegeneration is considered.  ...  methods such as arterial spin labeling.  ... 
doi:10.1007/978-1-84996-011-3_2 fatcat:uiny5spraje4vnkz6akr6weq5i

Recent Advances in Translational Magnetic Resonance Imaging in Animal Models of Stress and Depression

Allison L. McIntosh, Shane Gormley, Leonardo Tozzi, Thomas Frodl, Andrew Harkin
2017 Frontiers in Cellular Neuroscience  
Regional changes in brain structure, functional connectivity, and metabolite concentrations have been reported in depressed patients, giving insight into the networks and brain regions involved, however  ...  Magnetic resonance imaging (MRI) is a valuable translational tool that can be used to investigate alterations in brain structure and function in both patients and animal models of disease.  ...  ACKNOWLEDGMENTS The authors would like to acknowledge support from the Marie Curie Brain Imaging Return to Health (r'Birth) consortium.  ... 
doi:10.3389/fncel.2017.00150 pmid:28596724 pmcid:PMC5442179 fatcat:odsdrxv7i5d6bnrve566th6rgy

Resting-State Functional Connectivity Changes in Aging apoE4 and apoE-KO Mice

V. Zerbi, M. Wiesmann, T. L. Emmerzaal, D. Jansen, M. Van Beek, M. P. C. Mutsaers, C. F. Beckmann, A. Heerschap, A. J. Kiliaan
2014 Journal of Neuroscience  
Recently, brain functional connectivity (FC) in apoE-ε4 carriers has been investigated by means of resting-state fMRI, showing a marked differentiation in several functional networks at different ages  ...  To test this hypothesis, we integrated several different MRI techniques with immunohistochemistry and investigated FC changes in relation with perfusion, diffusion, and synaptic density in apoE4 and apoE-knock-out  ...  To study brain perfusion under resting conditions, a flow-sensitive alternating inversion recovery arterial spin labeling (FAIR ASL) technique was used (Kim, 1995; Zerbi et al., 2014) .  ... 
doi:10.1523/jneurosci.0684-14.2014 pmid:25319693 pmcid:PMC6705289 fatcat:txx6kxeg7bbm3bo24ralfnyk7i

Caffeine Caused a Widespread Increase of Resting Brain Entropy

Da Chang, Donghui Song, Jian Zhang, Yuanqi Shang, Qiu Ge, Ze Wang
2018 Scientific Reports  
cortex, and motor network, consistent with the beneficial effects of caffeine (such as vigilance and attention) on these areas.  ...  Entropy is an important trait of brain function and high entropy indicates high information processing capacity.  ...  This study was supported by Natural Science Foundation of Zhejiang Province Grant LZ15H180001, the Youth 1000 Talent Program of China, National Natural Science Foundation of China (No. 61671198).  ... 
doi:10.1038/s41598-018-21008-6 pmid:29426918 pmcid:PMC5807546 fatcat:coouzgzwgbcchd237ngebxzlvy
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