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Effects of changing from non-accelerated to accelerated MRI for follow-up in brain atrophy measurement

Kelvin K. Leung, Ian M. Malone, Sebastien Ourselin, Jeffrey L. Gunter, Matt A. Bernstein, Paul M. Thompson, Clifford R. Jack, Michael W. Weiner, Nick C. Fox
2015 NeuroImage  
Moving from non-accelerated baseline scans to accelerated scans for follow-up may have surprisingly little effect on computed atrophy rates depending on the exact sequence details and the scanner manufacturer  ...  We investigated the impact on brain atrophy as measured by k-means normalized boundary shift integral (KN-BSI) and deformation-based morphometry when changing from non-accelerated to accelerated MRI acquisitions  ...  The authors would like to thank the image analysts and the research associates in the Dementia Research Centre for their help in the study, and the ADNI study subjects and investigators for their participation  ... 
doi:10.1016/j.neuroimage.2014.11.049 pmid:25481794 pmcid:PMC4300278 fatcat:cdwfey2norbsfaofja3yn3gdga

A Comparison of Accelerated and Non-accelerated MRI Scans for Brain Volume and Boundary Shift Integral Measures of Volume Change: Evidence from the ADNI Dataset

Emily N. Manning, Kelvin K. Leung, Jennifer M. Nicholas, Ian B. Malone, M. Jorge Cardoso, Jonathan M. Schott, Nick C. Fox, Josephine Barnes
2017 Neuroinformatics  
The aim of this study was to assess whether the use of accelerated MRI scans in place of non-accelerated scans influenced brain volume and atrophy rate measures in controls and subjects with mild cognitive  ...  Finally, we estimated sample size requirements for a hypothetical clinical trial when using atrophy rates from accelerated scans and non-accelerated scans.  ...  , and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.  ... 
doi:10.1007/s12021-017-9326-0 pmid:28316055 pmcid:PMC5443885 fatcat:r275iy4z3jfwzoxggklvtnqckq

Accelerated Brain Atrophy on Serial Computed Tomography

Abdullah Bin Zahid, Artem Mikheev, Neha Srivatsa, James Babb, Uzma Samadani, Henry Rusinek
2016 Journal of computer assisted tomography  
This translates to an increase in atrophy rate from 0.5% to 1.4% in AD versus to 1.1% in non-AD group after 10 years.  ...  In terms of brain volume normalized to ICS, the acceleration in atrophy rate for non-AD patients was 0.0578%/yr 2 (95%C.I. 0.0389%/yr 2 to 0.0767%/yr 2 ) again, 1.5× faster, i.e. 0.0919%/yr 2 (95% C.I.  ...  Steven and Alexandra Cohen Veterans Center for Post-Traumatic Stress and Traumatic Brain Injury  ... 
doi:10.1097/rct.0000000000000435 pmid:27224227 pmcid:PMC5025331 fatcat:zsik6cmacnh6pbcrkogku6hdfq

Does MRI scan acceleration affect power to track brain change?

Christopher R.K. Ching, Xue Hua, Derrek P. Hibar, Chadwick P. Ward, Jeffrey L. Gunter, Matt A. Bernstein, Clifford R. Jack, Michael W. Weiner, Paul M. Thompson
2015 Neurobiology of Aging  
No such whole brain difference was detected for the 12-month scan interval (n=156). Effect sizes for structural brain changes were not detectably different in accelerated versus  ...  Using tensor-based morphometry (TBM), no significant difference was detected in numerical summaries of atrophy rates from accelerated and nonaccelerated scans in subgroups of patients with Alzheimer's  ...  Acknowledgments Algorithm development and image analysis for this study was funded, in part, by grants to PT from the NIBIB (R01 EB008281, R01 EB008432) and by the NIA, NIBIB, NIMH, the National Library  ... 
doi:10.1016/j.neurobiolaging.2014.05.039 pmid:25444601 pmcid:PMC4374606 fatcat:espouns3xfgtlkcc3ssq6662ta

Diabetes mellitus and progression of vascular brain lesions and brain atrophy in patients with symptomatic atherosclerotic disease. The SMART-MR study

Minke Kooistra, Mirjam I. Geerlings, Willem P.T.M. Mali, Koen L. Vincken, Yolanda van der Graaf, Geert Jan Biessels
2013 Journal of the Neurological Sciences  
Methods: In 663 patients (58 ± 10 years) from the SMART-MR study (n = 89 with DM), 1.5 T MRI and neuropsychological examination were performed at baseline and after 3.9 ± 0.4 years follow-up.  ...  We assessed whether DM increased the rate of progression of brain atrophy, vascular brain lesions, and cognitive decline in patients with symptomatic atherosclerotic disease.  ...  The effect of group reflects the mean difference between patients with DM and patients without DM; the effect of time reflects the mean change in measures of brain volume (% ICV) or mean change in z-score  ... 
doi:10.1016/j.jns.2013.06.019 pmid:23835088 fatcat:y6ift6pjffdwfbtkkah7vgj75i

Changes in brain anatomy during the course of posttraumatic stress disorder

Valerie A. Cardenas, Kristin Samuelson, Maryann Lenoci, Colin Studholme, Thomas C. Neylan, Charles R. Marmar, Norbert Schuff, Michael W. Weiner
2011 Psychiatry Research : Neuroimaging  
Longitudinal changes in brain volume were measured using deformation morphometry. For the group as a whole PTSD+ patients did not show significant ongoing brain atrophy compared to PTSD-.  ...  The goal of this study was to determine whether PTSD was associated with an increase in timerelated decline in macrostructural brain volume and whether these changes were associated with accelerated cognitive  ...  Acknowledgments We are grateful to the staff at the Center for Imaging of Neurodegenerative Diseases at the San Francisco VA Hospital for MRI scanning, and to Linda Chao, Susanne Mueller, Brigitte Apfel  ... 
doi:10.1016/j.pscychresns.2011.01.013 pmid:21683556 pmcid:PMC3175765 fatcat:ksptpyvmivbqtjnj64lnqvv34a

Presymptomatic atrophy in autosomal dominant Alzheimer's disease: A serial magnetic resonance imaging study

Kirsi M. Kinnunen, David M. Cash, Teresa Poole, Chris Frost, Tammie L.S. Benzinger, R. Laila Ahsan, Kelvin K. Leung, M. Jorge Cardoso, Marc Modat, Ian B. Malone, John C. Morris, Randall J. Bateman (+23 others)
2018 Alzheimer's & Dementia  
Identifying at what point atrophy rates first change in Alzheimer's disease is important for informing design of presymptomatic trials.  ...  The authors had full access to the data used in the study and made the final decision to submit for publication. Data collection and sharing for this project was supported  ...  Acknowledgements The study sponsors had no role in any aspects of designing or executing this study.  ... 
doi:10.1016/j.jalz.2017.06.2268 pmid:28738187 pmcid:PMC5751893 fatcat:g5dmub7zgvdijbho7jn5qb5pdm

Longitudinal Assessment of Global and Regional Rate of Grey Matter Atrophy in 1,172 Healthy Older Adults: Modulation by Sex and Age

Fabrice Crivello, Nathalie Tzourio-Mazoyer, Christophe Tzourio, Bernard Mazoyer, Emmanuel Andreas Stamatakis
2014 PLoS ONE  
To characterize the neuroanatomical changes in healthy older adults is important to differentiate pathological from normal brain structural aging.  ...  This pattern was replicated at the regional level, with the exception of the hippocampi, which showed a rate of GM atrophy that accelerated with age (2.8%/year per year of age) similarly for men and women  ...  Acknowledgments The authors thank Blandine Grassiot and Nicolas Delcroix for their technical assistance with data processing. Author Contributions  ... 
doi:10.1371/journal.pone.0114478 pmid:25469789 pmcid:PMC4255026 fatcat:lk6aa4dbdjh3ja6lr2xhadg2vq

Atrophy rates accelerate in amnestic mild cognitive impairment

C. R. Jack, S. D. Weigand, M. M. Shiung, S. A. Przybelski, P. C. O'Brien, J. L. Gunter, D. S. Knopman, B. F. Boeve, G. E. Smith, R. C. Petersen
2007 Neurology  
However, this approach suffers from cohort effects and other biases. Serial measurements acquired in the same individuals are needed to assess atrophy rates.  ...  Results-In aMCI-P the change in pre to post index rate (i.e. acceleration) of ventricular expansion was 1.7 cm 3 /yr, and acceleration in brain shrinkage was 5.3 cm 3 /yr.  ...  clinical follow up after the series of MRI studies.  ... 
doi:10.1212/01.wnl.0000281688.77598.35 pmid:18032747 pmcid:PMC2734477 fatcat:l6ptgfnl5ne43ekvtgey6odadu

Deep learning based quantification of the accelerated brain aging rate in glioma patients after radiotherapy [article]

Selena I. Huisman, Arthur T.J. van der Boog, Fia Cialdella, Joost J.C. Verhoeff, Szabolcs David
2021 medRxiv   pre-print
Utilizing a pre-trained deep learning model, brain age is estimated for all patients' pre-radiotherapy planning and follow-up MRI scans to get a quantification of the changes occurring in the brain over  ...  The experienced tissue atrophy is similar to the effects of normal aging in healthy individuals.  ...  This indicates that the changes in aging, on average, are accelerated. Fig. 7 . For each graph, the predicted change in aging (y axis) is shown over the time during follow-up in months (x axis).  ... 
doi:10.1101/2021.12.22.21267899 fatcat:v5krrqsggjhqlc47vqucdzxupu

Time to Amyloid Positivity and Preclinical Changes in Brain Metabolism, Atrophy, and Cognition: Evidence for Emerging Amyloid Pathology in Alzheimer's Disease

Philip S. Insel, Rik Ossenkoppele, Devon Gessert, William Jagust, Susan Landau, Oskar Hansson, Michael W. Weiner, Niklas Mattsson
2017 Frontiers in Neuroscience  
Methods: In 89 cognitively healthy elders with up to 10 years of follow-up, we estimated the points at which rates of fluorodeoxyglucose (FDG) PET, MRI, and cognitive and functional decline begin to accelerate  ...  Aβ pathology is associated with longitudinal changes of brain metabolism, atrophy, and cognition, in cognitively healthy elders.  ...  The fact that most atrophy measures were not significantly accelerating before manifest Aβ+ was in line with previous results of atrophy only after brain hypometabolism and subtle cognitive changes appeared  ... 
doi:10.3389/fnins.2017.00281 pmid:28567001 pmcid:PMC5434146 fatcat:woi7f67gv5baxmmx73zmswf4ly

Atrophied brain lesion volume, a magnetic resonance imaging biomarker for monitoring neurodegenerative changes in multiple sclerosis

Robert Zivadinov, Niels Bergsland, Michael G. Dwyer
2018 Quantitative Imaging in Medicine and Surgery  
Furthermore, atrophied T2-LV accumulation in that study was accelerated from years 5 to 10 of the follow-up, whereas accumulation of total T2-LV de-accelerated in the same time period, which suggests that  ...  However, most non-conventional MRI measures show steady linear changes over time and are not particularly dependent on changes in disease stage.  ... 
doi:10.21037/qims.2018.11.01 pmid:30598875 pmcid:PMC6288055 fatcat:bdkymd3ru5ge7l7hlvnawqawje

Longitudinal changes in brain volumes and cerebrovascular lesions on MRI in patients with manifest arterial disease: The SMART-MR study

Pieternella H. van der Veen, Majon Muller, Koen L. Vincken, Theo D. Witkamp, Willem P.T.M. Mali, Yolanda van der Graaf, Mirjam I. Geerlings
2014 Journal of the Neurological Sciences  
Within the SMART-MR study, using brain MRI data from baseline and after on average 3.9 years of follow-up, intracranial volume (ICV), total brain, cortical gray matter, ventricular, white matter lesion  ...  In patients with manifest arterial disease, brain atrophy tended to accelerate with older age and men had more progression of brain atrophy and cerebrovascular lesions than women.  ...  Bars represent the mean (standard error) adjusted change in brain volume after on average 3.9 years of follow-up. Adjusted for baseline measurement of brain structure and follow-up period.  ... 
doi:10.1016/j.jns.2013.11.029 pmid:24314719 fatcat:kikr7dyvrbas5jcgum2miz46eq

Magnetic resonance imaging in Alzheimer's Disease Neuroimaging Initiative 2

Clifford R. Jack, Josephine Barnes, Matt A. Bernstein, Bret J. Borowski, James Brewer, Shona Clegg, Anders M. Dale, Owen Carmichael, Christopher Ching, Charles DeCarli, Rahul S. Desikan, Christine Fennema-Notestine (+31 others)
2015 Alzheimer's & Dementia  
The primary objective of the magnetic resonance imaging (MRI) core of ADNI has been to improve methods for clinical trials in Alzheimer's disease (AD) and related disorders.  ...  Methods: We review the contributions of the MRI core from present and past cycles of ADNI (ADNI-1, -Grand Opportunity and -2). We also review plans for the future-ADNI-3.  ...  Scan acceleration may influence some brain measures, but had minimal effects on TBM-derived atrophy measures, and effect sizes for structural brain changes were not detectably different in accelerated  ... 
doi:10.1016/j.jalz.2015.05.002 pmid:26194310 pmcid:PMC4523217 fatcat:xf473xlapvgbvekh4oxvkyk5wy

Longitudinal assessment of global and regional atrophy rates in Alzheimer's disease and dementia with Lewy bodies

Elijah Mak, Li Su, Guy B. Williams, Rosie Watson, Michael Firbank, Andrew M. Blamire, John T. O'Brien
2015 NeuroImage: Clinical  
& objective: Percent whole brain volume change (PBVC) measured from serial MRI scans is widely accepted as a sensitive marker of disease progression in Alzheimer3s disease (AD).  ...  Conclusions: AD showed a faster rate of global brain atrophy compared to DLB, which had similar rates of atrophy to HC.  ...  For the purpose of the present study, we included only subjects with MRI assessments from both baseline and 1-year follow-up.  ... 
doi:10.1016/j.nicl.2015.01.017 pmid:25685712 pmcid:PMC4325088 fatcat:vvtrswaon5hgzn44urbinenfvm
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