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Dual echo vessel-encoded ASL for simultaneous BOLD and CBF reactivity assessment in patients with ischemic cerebrovascular disease
2014
Magnetic Resonance in Medicine
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Purpose-Blood oxygenation level-dependent (BOLD)-weighted and vessel-encoded arterial spin labeling (VE-ASL) MRI provide complementary information and can be used in sequence to gauge hemodynamic contributions ...
However, BOLD signal changes did not differ significantly between labeling scenarios (P>0.003) or across territories (P>0.002), indicating BOLD signal changes in response to carbogen offer low sensitivity ...
Recent evidence suggests that reduction of BOLD SNR as a result of background suppression application during dual echo ASL does not significantly decrease the sensitivity of the BOLD contrast as measured ...
doi:10.1002/mrm.25268
pmid:24757044
pmcid:PMC4435663
fatcat:yodya2yz3rafjpojcorireks3y
Measurement of cerebral perfusion with arterial spin labeling: Part 1. Methods
2007
Journal of the International Neuropsychological Society
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Arterial spin labeling (ASL) is a magnetic resonance imaging (MRI) method that provides a highly repeatable quantitative measure of cerebral blood flow (CBF). ...
ASL measures of perfusion can aid in the interpretation of the BOLD signal change and, when combined with BOLD, can measure the change in oxygen utilization accompanying changes in behavioral state. ...
such as gadolinium, and arterial spin labeling MRI. ...
doi:10.1017/s1355617707070646
pmid:17445301
fatcat:jjd57u2lpfagll7befcvxvjdci
Dual-Echo Arterial Spin Labeling for Brain Perfusion Quantification and Functional Analysis
2019
Concepts in magnetic resonance. Part A, Bridging education and research
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Arterial Spin Labeling (ASL) is a noninvasive MRI-based method to measure cerebral blood flow (CBF). ...
We analyzed the influence of TE on CBF values and brain connectivity provided by CBF and concurrent BOLD (cc-BOLD) time series. ...
Regarding acquisition and analysis, Ghariq and colleagues investigated some specific aspects of the signal and suggested the use of background suppression to reduce BOLD contamination and to increase CBF ...
doi:10.1155/2019/5040465
fatcat:nnr424rs5bcqhiml37mvo5mg7u
Resolving intrinsic ambiguities of the fMRI signal in the human brain
[article]
2019
bioRxiv
pre-print
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However, the BOLD signal is physiologically complex, depending on the baseline state of the brain and the balance of changes in blood flow and oxygen metabolism in response to a change in neural activity ...
The MRI methods used required only an additional 12 minutes of scanning, can be implemented on any MRI system, and painted a more complete picture of the physiological effects of caffeine. ...
Effects of
background suppression on the sensitivity of dual-echo arterial spin labeling
MRI for BOLD and CBF signal changes. ...
doi:10.1101/833681
fatcat:bwwivzkyojfivktld2ox7vzp2e
Calibrated bold fMRI with an optimized ASL-BOLD dual-acquisition sequence
2016
NeuroImage
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The concatenation of these two imaging sequences allowed separate optimization of the acquisition for CBF and BOLD data. ...
Further, the potential of the dualacquisition sequence for M-mapping on the basis of a hypercapnia gas breathing challenge and for quantification of CMRO 2 changes in response to a motor activation task ...
Acknowledgments The authors are indebted to Dr. Benedikt Poser for providing the code of the dual-echo EPI sequence. ...
doi:10.1016/j.neuroimage.2016.08.007
pmid:27502047
pmcid:PMC5159288
fatcat:g2wafxhanzg5thzbzv74lmvyha
Applications of arterial spin labeled MRI in the brain
2012
Journal of Magnetic Resonance Imaging
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It has been almost two decades since the use of arterial spin labeling (ASL) for noninvasive perfusion imaging was first reported. ...
As a result, basic science and clinical applications of ASL MRI have begun to proliferate. Although ASL MRI can be carried out in any organ, most studies to date have focused on the brain. ...
greatly facilitate the use of background suppression pulses to reduce the static brain signal and increase sensitivity (35) (36) (37) . ...
doi:10.1002/jmri.23581
pmid:22246782
pmcid:PMC3326188
fatcat:jjjie2xdrjaupl3zcv4nxt2jlu
Noninvasive measurement of the cerebral blood flow response in human lateral geniculate nucleus with arterial spin labeling fMRI
2008
Human Brain Mapping
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Arterial spin labeling (ASL) is an MRI method that can provide direct measures of functional cerebral blood flow (CBF) changes. ...
However, due in part to the low intrinsic signal-to-noise ratio of the ASL method, measures of functional CBF changes in the LGN are challenging and have not previously been reported. ...
Arterial spin labeling (ASL) is a noninvasive MRI method that can provide quantitative measures of CBF, which is a well-defined physiological quantity Williams et al., 1992] . ...
doi:10.1002/hbm.20459
pmid:17712783
pmcid:PMC2848166
fatcat:oxg3ezlcsbadljlr2l7m3iix2q
Measurement of cerebral perfusion using MRI
2010
Imaging in Medicine
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In DSC-MRI, the conversion from signal changes to contrast agent concentration, the arterial input function measurement and the deconvolution method are the most important elements. ...
MRI provides the opportunity of combining perfusion imaging with high-quality anatomical imaging and is therefore, for most brain diseases, the modality of choice. ...
Acquisition is based on pseudo-continuous arterial spin labeling at 3 Tesla with 1650 ms label duration, 1525 ms delay, background suppression and a multislice single-shot echo-planar imaging readout module.future ...
doi:10.2217/iim.09.30
fatcat:du4trprf5zcsxbsqy365tyu2di
Comparison of 3 T and 7 T ASL techniques for concurrent functional perfusion and BOLD studies
2017
NeuroImage
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A B S T R A C T Arterial spin labeling (ASL) is the primary non-invasive MRI approach to measure baseline cerebral blood flow (CBF) in healthy subjects and patients. ...
To this aim, we investigated a wide range of parameters that can influence CBF and BOLD signal sensitivities: spatial resolution, labeling scheme, parallel imaging and echo time. ...
Laurentius Huber for the implementation and validation of the tr-FOCI RF pulse and Sriranga Kashyap for help with the stimulus setup. The authors are indebted to Professor Dr. ...
doi:10.1016/j.neuroimage.2017.05.038
pmid:28528845
fatcat:ewfgglck4zgurfnm3vekmivuzu
Characterizing Resting-State Brain Function Using Arterial Spin Labeling
2015
Brain Connectivity
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Arterial spin labeling (ASL) is an increasingly established magnetic resonance imaging (MRI) technique that is finding broader applications in studying the healthy and diseased brain. ...
surrogate of the metabolic activity within corresponding networks; and (3) the study of resting-state dynamic CBF-BOLD coupling and cerebral metabolism: the use of dynamic CBF information obtained using ...
Acknowledgments The authors acknowledge the following sources of funding: Canadian Institutes of Health Research (App. 286286, J.J.C.), Natural Sciences and Engineering Research Council of Canada (App. ...
doi:10.1089/brain.2015.0344
pmid:26106930
pmcid:PMC4652156
fatcat:bcp4otgrcnabfn3iqkf72mlriq
Noise Reduction in Arterial Spin Labeling Based Functional Connectivity Using Nuisance Variables
2016
Frontiers in Neuroscience
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of healthy adults using state of the art 3D background-suppressed (BS) GRASE pseudo-continuous ASL (pCASL) and dual-echo 2D-EPI pCASL sequences. ...
Furthermore, 3D BS GRASE pCASL shows much higher temporal SNR compared to dual-echo 2D-EPI pCASL and similar effects of noise reduction as those observed for BOLD. ...
of healthy adults using state of the art 3D background-suppressed (BS) GRASE pseudo-continuous ASL (pCASL) and dual-echo 2D-EPI pCASL sequences. ...
doi:10.3389/fnins.2016.00371
pmid:27601973
pmcid:PMC4993769
fatcat:lkvd2zvd7rbjpivozmzujsuau4
Cerebral oxygen extraction fraction MRI: techniques and applications
[article]
2022
arXiv
pre-print
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These MRI OEF techniques are based on T2 of blood, phase of blood signal, susceptibility of blood-containing voxel, effect of deoxyhemoglobin on signal behavior in extravascular tissue, and calibration ...
of BOLD signal using gas-inhalation. ...
CBF can be measured globally by using phase-contrast MRI to quantify blood flow in the feeding arteries 29 or regionally by using arterial spin labeling (ASL) MRI. 30 It is worth noting that non-invasive ...
arXiv:2202.01350v1
fatcat:hefhe7f5hbabzjtm4pmudscdpy
Arterial Spin Labeling (ASL) fMRI: Advantages, Theoretical Constrains and Experimental Challenges in Neurosciences
2012
International Journal of Biomedical Imaging
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Arterial spin labeling (ASL) is a noninvasive fMRI technique that uses arterial water as an endogenous tracer to measure CBF. ...
While underscoring the main advantages of ASL versus other techniques such as BOLD, we also expound on inherent challenges and confounds in ASL perfusion imaging. ...
Acknowledgments The authors are greatly indebted to Scott Small, M.D., for insightful discussions regarding the application of fMRI in disease. ...
doi:10.1155/2012/818456
pmid:22966219
pmcid:PMC3432878
fatcat:mm5qzhspjnacfi6kt6ldtnzk7e
Laminar perfusion imaging with zoomed arterial spin labeling at 7 Tesla
[article]
2021
bioRxiv
pre-print
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Laminar fMRI based on BOLD and CBV contrast at ultrahigh magnetic fields has been applied for studying the dynamics of mesoscopic brain networks. ...
Here we introduce a novel 3D zoomed pseudo-continuous arterial spin labeling technique at 7T that offers the unique capability for quantitative measurements of laminar cerebral blood flow (CBF) both at ...
Acknowledgments This work was supported by the National Institute of Health (NIH) grant UH3-NS100614, S10-OD025312, R01-NS114382 and R01-EB028297. ...
doi:10.1101/2021.04.13.439689
fatcat:muhly3iiqjcjvdzk4xla36ivly
A Primer on Functional Magnetic Resonance Imaging
2007
Neuropsychology Review
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The physiological complexity of the BOLD signal is emphasized. In the third section, arterial spin labeling (ASL) measures of cerebral blood flow are presented. ...
Arterial spin labeling inverts or saturates the magnetization of flowing spins to measure the rate of delivery of blood to capillaries. ...
With the use of background suppression methods and spin-echo readouts, ASL functional measures have been shown to be less prone than BOLD to false activations during overt speech paradigms, reflecting ...
doi:10.1007/s11065-007-9028-8
pmid:17468956
fatcat:v4c7dkp3xvantedcmh62kmq55m
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