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Enhanced Regional Homogeneity and Functional Connectivity in Subjects With White Matter Hyperintensities and Cognitive Impairment

Qing Ye, Xin Chen, Ruomeng Qin, Lili Huang, Dan Yang, Renyuan Liu, Bing Zhang, Feng Bai, Yun Xu
2019 Frontiers in Neuroscience  
Higher local coherence of activities in the SPG/SOG and higher connectivity of the SPG/SOG with parietal and frontal regions are related to CI in WMH subjects.  ...  No significant differences in WMH volume, the number of WMH lesions and brain volume were shown between the 2 WMH groups.  ...  Finally, gray matter volume, white matter volume, cerebrospinal fluid volume and whole brain volume were obtained in each subject.  ... 
doi:10.3389/fnins.2019.00695 pmid:31333409 pmcid:PMC6617843 fatcat:fvzav4kejjax3f5fyd5x53posu

An exploratory study into the influence of laterality and location of hippocampal sclerosis on seizure prognosis and global cortical thinning

Alireza Mansouri, Jurgen Germann, Alexandre Boutet, Gavin J. B. Elias, Brij Karmur, Clemens Neudorfer, Aaron Loh, Mary Pat McAndrews, George M. Ibrahim, Andres M. Lozano, Taufik A. Valiante
2021 Scientific Reports  
The slope of cortical volume loss over time, however, was greater in subjects with right seizure focus.  ...  Finally, the right hippocampus was found to have greater brain-wide connectivity, compared to the left side, based on normative connectomic data.  ...  The white matter and pial surfaces were extracted and registered to the MNI152 surface template.  ... 
doi:10.1038/s41598-021-84281-y pmid:33633325 pmcid:PMC7907189 fatcat:dazl6dtvabh3xmmkpxuw2h5w2y

Specific EEG Changes Associated with Atrophy of Hippocampus in Subjects with Mild Cognitive Impairment and Alzheimer's Disease

D. V. Moretti, A. Prestia, C. Fracassi, G. Binetti, O. Zanetti, G. B. Frisoni
2012 International Journal of Alzheimer's Disease  
Seventy-nine subjects with MCI and 11 patients with AD underwent EEG recording and MRI scan. The MCI group was subdivided in three subgroups according to growing hippocampal atrophy.  ...  We evaluated the association between hippocampal atrophy and increase of the EEG markers alpha3/alpha2 relative power ratio in mild cognitive impairment (MCI) and Alzheimer's disease patients.  ...  Hippocampal and white matter hyperintensities (WMHs) volumes were obtained for each subject.  ... 
doi:10.1155/2012/253153 pmid:22506130 pmcid:PMC3296269 fatcat:rnw4yqwxhnfwdaxem4i6if3oim

Review of Cerebral Microangiopathy and Alzheimer's Disease: Relation between White Matter Hyperintensities and Microbleeds

C. Hommet, K. Mondon, T. Constans, E. Beaufils, T. Desmidt, V. Camus, J.P. Cottier
2011 Dementia and Geriatric Cognitive Disorders  
The aim of this review was to provide a perspective of brain MRI in the detection of microangiopathy, including both white matter hyperintensities (WMHs) and microbleeds (MBs), and their clinical consequences  ...  The first types of small-vessel disease to be described were white matter hyperintensities (WMHs).  ...  Disclosure Statement The authors have no sponsorship or funding arrangements to disclose relating to the present paper.  ... 
doi:10.1159/000335568 pmid:22301385 fatcat:acwfwwhh2fdtfbvyx7ckla7oei

Evidence of a Relation Between Hippocampal Volume, White Matter Hyperintensities, and Cognition in Subjective Cognitive Decline and Mild Cognitive Impairment

2019 The journals of gerontology. Series B, Psychological sciences and social sciences  
Group comparisons were done using cognitive data, and then correlated with hippocampal volumes and white matter hyperintensities (WMHs).  ...  Scores on episodic memory tests correlated with hippocampal volumes in both MCI and SCD, whereas performance on executive tests correlated with WMH in all of our groups.  ...  CH = cognitively healthy; MCI = mild cognitive impairment; SCD = subjective cognitive decline; WMH = white matter hyperintensities.  ... 
doi:10.1093/geronb/gbz120 pmid:31758692 pmcid:PMC7424270 fatcat:nipaceeq25avhfl3fzojgtvioy

White Matter Hyperintensity Burden Is Associated With Hippocampal Subfield Volume in Stroke

Mark R. Etherton, Panagiotis Fotiadis, Anne-Katrin Giese, Juan E. Iglesias, Ona Wu, Natalia S. Rost
2020 Frontiers in Neurology  
Forty patients with acute ischemic stroke and moderate/severe white matter hyperintensity burden were included in this analysis. Median WMH volume was 9.0 cm3.  ...  White matter hyperintensities of presumed vascular origin (WMH) are a prevalent form of cerebral small-vessel disease and an important risk factor for post-stroke cognitive dysfunction.  ...  Forty patients with acute ischemic stroke and moderate/severe white matter hyperintensity burden were included in this analysis. Median WMH volume was 9.0 cm 3 .  ... 
doi:10.3389/fneur.2020.588883 pmid:33193055 pmcid:PMC7649326 fatcat:wh2bopihjzgrthzwrggungi7lq

"Small World" architecture in brain connectivity and hippocampal volume in Alzheimer's disease: a study via graph theory from EEG data

Fabrizio Vecchio, Francesca Miraglia, Francesca Piludu, Giuseppe Granata, Roberto Romanello, Massimo Caulo, Valeria Onofrj, Placido Bramanti, Cesare Colosimo, Paolo Maria Rossini
2016 Brain Imaging and Behavior  
The aim of the present study was to evaluate a possible correlation between BSmall World^characteristics of the brain connectivity architecture-as extracted from EEG recordings-and hippocampal volume in  ...  Brain imaging plays an important role in the study of Alzheimer's disease (AD), where atrophy has been found to occur in the hippocampal formation during the very early disease stages and to progress in  ...  The surface of the white matter voxels was refined to obtain better accuracy in the gray/white boundary and was then subsequently deformed outward to find the pial surface, according to Fischl and Dale  ... 
doi:10.1007/s11682-016-9528-3 pmid:26960946 fatcat:4lo4yuzayjhdhh4gkl7ql4ylki

Subclinical Cognitive and Neuropsychiatric Correlates and Hippocampal Volume Features of Brain White Matter Hyperintensity in Healthy People

Gianfranco Spalletta, Mariangela Iorio, Daniela Vecchio, Federica Piras, Valentina Ciullo, Nerisa Banaj, Stefano L. Sensi, Walter Gianni, Francesca Assogna, Carlo Caltagirone, Fabrizio Piras
2020 Journal of Personalized Medicine  
White matter hyperintensities (WMH) are associated with brain aging and behavioral symptoms as a possible consequence of disrupted white matter pathways.  ...  In this study, we investigated, in a cohort of asymptomatic subjects aged 50 to 80, the relationship between WMH, hippocampal atrophy, and subtle, preclinical cognitive and neuropsychiatric phenomenology  ...  matter hyperintensities volume (in mm 3 ) and distribution in the WMH+ group.  ... 
doi:10.3390/jpm10040172 pmid:33076372 fatcat:xruyq2pynbhsnm5kbn4jz3j2wi

Nodal Global Efficiency in Front-Parietal Lobe Mediated Periventricular White Matter Hyperintensity (PWMH)-Related Cognitive Impairment

Haifeng Chen, Lili Huang, Dan Yang, Qing Ye, Mengdi Guo, Ruomeng Qin, Caimei Luo, Mengchun Li, Lei Ye, Bing Zhang, Yun Xu
2019 Frontiers in Aging Neuroscience  
White matter hyperintensity (WMH) is widely observed in the elderly population and serves as a key indicator of cognitive impairment (CI). However, the underlying mechanism remains to be elucidated.  ...  normal cognition and 38 healthy controls (HCs), and we found that WMH-CIND subjects displayed decreased global efficiency at the levels of the whole brain, specific subnetworks [fronto-parietal network  ...  White matter hyperintensity subjects with cognitive impairment without dementia (CIND), WMH subjects with normal cognition and healthy subjects were recruited for the present study.  ... 
doi:10.3389/fnagi.2019.00347 pmid:31920627 pmcid:PMC6914700 fatcat:diq6ifpjrbb2hoy56s2rqemwei

Hippocampal and cortical atrophy predict dementia in subcortical ischemic vascular disease

G. Fein, V. Di Sclafani, J. Tanabe, V. Cardenas, M. W. Weiner, W. J. Jagust, B. R. Reed, D. Norman, N. Schuff, L. Kusdra, T. Greenfield, H. Chui
2000 Neurology  
of brain atrophy (i.e., hippocampal, cortical gray matter, and CSF volumes).  ...  The authors examined the relationship between the severity of cognitive impairment and 1) volume, number, and location of lacunes; 2) volume of white matter signal hyperintensities (WMSH); and 3) measures  ...  With the few exceptions noted below, lacunes were defined as lesions 3 to 15 mm in length, hyperintense rela- tive to CSF on the PD image, and located in the subcortical gray and white matter.  ... 
doi:10.1212/wnl.55.11.1626 pmid:11113215 pmcid:PMC2733356 fatcat:dcmrtgmjh5dnndf4n7ujpwc45i

Detrimental effects of hypercortisolism on brain structure and related risk factors

Yaxi Chen, Junhuai Zhang, Huiwen Tan, Jiaqi Li, Yerong Yu
2020 Scientific Reports  
Compared with the NFA subjects, the patients with CD had more cortical (P < 0.01) and subcortical atrophy (P < 0.01) and a higher prevalence of white matter hyperintensity (WMH) (P < 0.01).  ...  In conclusions, brain atrophy and WMH were more likely to appear in CD patients and were possibly partially reversible following correction of hypercortisolism.  ...  Acknowledgements We would like to thank all the participants for their contribution to this study.  ... 
doi:10.1038/s41598-020-68166-0 pmid:32728036 fatcat:jxgut5kosrdbjiqywsv6np7t5u

Suicidal brains: A review of functional and structural brain studies in association with suicidal behaviour

C. van Heeringen, S. Bijttebier, K. Godfrin
2011 Neuroscience and Biobehavioral Reviews  
Further study is needed to elaborate these findings and to investigate to what extent changes in the structure and function of suicidal brains are amenable to psychological and/or biological interventions  ...  This systematic review of comparative imaging studies of suicidal brains shows that changes in the structure and functions of the brain in association with suicidal behaviour are mainly found in the orbitofrontal  ...  Conflicts of interest The authors have neither financial interest in, nor financial support for writing this review.  ... 
doi:10.1016/j.neubiorev.2010.08.007 pmid:20826179 fatcat:2rplnlfcxvg6rc7hhh34rvtsfy

Lesion-Function Analysis from Multimodal Imaging and Normative Brain Atlases for Prediction of Cognitive Deficits in Glioma Patients

Martin Kocher, Christiane Jockwitz, Philipp Lohmann, Gabriele Stoffels, Christian Filss, Felix M. Mottaghy, Maximilian I. Ruge, Carolin Weiss Lucas, Roland Goldbrunner, Nadim J. Shah, Gereon R. Fink, Norbert Galldiks (+2 others)
2021 Cancers  
functional cortical network atlas and to the JHU atlas of white matter (WM) tracts, and their influence on cognitive test scores relative to a cohort of matched healthy subjects was assessed.  ...  Cognitive deficits are common in glioma patients following multimodality therapy, but the relative impact of different types and locations of treatment-related brain damage and recurrent tumors on cognition  ...  According to current brain function theories, performance in higher cognitive domains depends on the specialized function of cortical regions and their interaction in multiple networks [16] .  ... 
doi:10.3390/cancers13102373 pmid:34069074 fatcat:b7b66s2rdzdivbwltitzhw2i4m

Mapping vulnerability to bipolar disorder: a systematic review and meta-analysis of neuroimaging studies

Paolo Fusar-Poli, Oliver Howes, Andreas Bechdolf, Stefan Borgwardt
2012 Journal of Psychiatry & Neuroscience  
We then performed a region of interest (ROI) analysis and a whole-brain meta-analysis combined with a formal effect-sizes meta-analysis in a subset of studies.  ...  The HR group showed increased grey matter volume compared with patients with established bipolar disorder.  ...  Fusar-Poli designed the study, acquired the data and wrote the article. All authors analyzed the data, reviewed the article and approved its publication.  ... 
doi:10.1503/jpn.110061 pmid:22297067 pmcid:PMC3341409 fatcat:6mmy2ixbu5hphhzxfndj6l4q3y

Quantitative Magnetic Resonance Imaging Differences Between Alzheimer Disease With and Without Subcortical Lacunes

Yuan-Yu Hsu, Norbert Schuff, Diane L. Amend, An-Tao Du, David Norman, Helena C. Chui, William J. Jagust, Michael W. Weiner
2002 Alzheimer Disease and Associated Disorders  
The aim of this study was to determine the effects of subcortical lacunar infarcts on brain structure in patients with AD.  ...  (WM), white matter signal hyperintensities (WMSH), lacunes, and hippocampus.  ...  white matter signal hyperintensities (WMSH); lacunar infarcts (Marder et al., 1995) and microinfarcts (Goulding et al., 1999) are also detected on MRI.  ... 
doi:10.1097/00002093-200204000-00002 pmid:12040300 pmcid:PMC1820852 fatcat:zieazb6fgzaxjcjdhj2ovsfpoi
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