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Effects of Single-Nucleotide Polymorphisms in Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2): A Comprehensive Study

Zoya Khalid, Omar Almaghrabi, Emil Alexov
2020 Computational and Mathematical Methods in Medicine  
Calmodulin-dependent protein kinase kinase 2 (CAMKK2) is a protein kinase that belongs to the serine/threonine kinase family.  ...  This is the first detailed study that predicts the deleterious nsSNPs in CAMKK2 and contributes positively in providing a better understanding of disease mechanisms.  ...  Single-nucleotide polymorphisms (SNPs) are the most common type of genetic variation, and identifying those SNPs which have a phenotypic effect is a major challenge for medical researchers.  ... 
doi:10.1155/2020/7419512 pmid:33082841 pmcid:PMC7559224 fatcat:x7eoqpucx5fiznkzcuhpmrtgay

Post-print: Polymorphisms in CAMKK2 may predict sensory neuropathy in African HIV patients. DOI: 10.1007/s13365-015-0421-4

Hayley Goullee, Antonia Wadley, Catherine Cherry, Richard Allcock, Micheal Black, Peter Kamerman, Patricia Price
2017 Figshare  
Here, we assess the impact of single-nucleotide polymorphisms (SNPs) in a cluster of three genes that affect inflammation and neuronal repair: P2X7R, P2X4R and CAMKK2.  ...  Post-print copy of: Goullee H, Wadley AL, Cherry CL, Allcock RJN, Black M, Kamerman PR, Price P. Polymorphisms in CAMKK2 may predict sensory neuropathy in African HIV patients.  ...  Acknowledgements We thank the staff and the patients of the Virology Clinic in the Charlotte Maxeke Johannesburg Academic Hospital, and Florence Mtsweni for acting as the interpreter for the study.  ... 
doi:10.6084/m9.figshare.5374681.v1 fatcat:ssgkxse7w5dqlatxv7awevzttu

Current insights into the implications of m6A RNA methylation and autophagy interaction in human diseases

Xuechai Chen, Jianan Wang, Muhammad Tahir, Fangfang Zhang, Yuanyuan Ran, Zongjian Liu, Juan Wang
2021 Cell & Bioscience  
In this review, we summarize the latest studies describing the impact of m6A modification in autophagy regulation and discuss the role of m6A modification-autophagy axis in different human diseases, including  ...  Thus, both m6A modification and autophagy could play a crucial role in the onset and progression of various human diseases.  ...  This study showed that reduction in METTL14 levels provided stability to the mRNA of calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2).  ... 
doi:10.1186/s13578-021-00661-x fatcat:utxttanfmrgxzou7wcrxnfidma

Integrative molecular characterization of Chinese prostate cancer specimens

Qiang Wei, Wen-Hua Huang, Shi-Dong Lv, Hong-Yi Wang, Xin-Pei Yu, Qi-Liang Zhai, Yao-Bin Wu
2019 Asian Journal of Andrology  
Lysine (K)-specific methyltransferase 2D (KMT2D), zinc finger homeobox 3 (ZFHX3), A-kinase anchoring protein 9 (AKAP9), and GLI family zinc finger 1 (GLI1) were frequently mutated in our cohort.  ...  Despite extensive studies of its phenotypic and genetic properties in Western populations, its molecular basis is not clear in Chinese patients.  ...  In particular, positive correlations were identified between KMT2D and AR (r = 0.31, P = 0.046), the AR downstream target calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) (r = 0.45, P = 0.046  ... 
doi:10.4103/aja.aja_36_19 pmid:31134918 pmcid:PMC7155802 fatcat:en44fijrtfecloccjejv567dti

Calcipressin 1, Csp1, CALP1 [chapter]

2018 Encyclopedia of Signaling Molecules  
Acknowledgments I apologize to the colleagues working on the LAMMER protein kinases whose excellent work could not be completely described or cited due to severe limitations on space and the number of  ...  Work in the laboratory of LR is supported by the University of Paris Sud and the CNRS.  ...  A type 2 diabetes (T2D) associated single nucleotide polymorphism (SNP) has been found in the C3G gene in a Finnish population.  ... 
doi:10.1007/978-3-319-67199-4_100487 fatcat:6h522cm42bfs7hazekfqeme4d4

Review: Precision medicine and driver mutations: Computational methods, functional assays and conformational principles for interpreting cancer drivers

Ruth Nussinov, Hyunbum Jang, Chung-Jung Tsai, Feixiong Cheng, Anna R R Panchenko
2019 PLoS Computational Biology  
However, statistics of mutations do not identify a change in protein conformation; therefore, it may not define sufficiently accurate actionable mutations, neglecting those that are rare.  ...  Among the many thematic overviews of precision oncology, this review innovates by further comprehensively including precision pharmacology, and within this framework, articulating its protein structural  ...  AGC, kinase group AGC; C-spine, catalytic spine; CaM, Calmodulin; CAMKK2, Calcium/Calmodulin dependent protein kinase kinase 2; cAMP, cyclic AMP; PDB, protein data bank; PKA Cα, protein kinase catalytic  ... 
doi:10.1371/journal.pcbi.1006658 fatcat:ii47m4bybraz7edark3m6axcby

The Present and Future of Prostate Cancer Urine Biomarkers

Marina Rigau, Mireia Olivan, Marta Garcia, Tamara Sequeiros, Melania Montes, Eva Colás, Marta Llauradó, Jacques Planas, Inés de Torres, Juan Morote, Colin Cooper, Jaume Reventós (+2 others)
2013 International Journal of Molecular Sciences  
Moreover, a great improvement in high-throughput "omic" techniques has presented considerable opportunities for the identification of new biomarkers.  ...  Current screening techniques lack specificity, and a decisive diagnosis of PCa is based on prostate biopsy.  ...  SLC45A3-BRAF fusion gene, mutations and gain in prostate cancer Diagnostic and therapeutic target Tissue RNA and DNA [35-37] CAMKK2 Calcium/calmodulin- dependent protein kinase kinase 2.  ... 
doi:10.3390/ijms140612620 pmid:23774836 pmcid:PMC3709804 fatcat:chcouboeb5fyngc6fpva6qz3du

A comprehensive analysis of gene expression profiles in distal parts of the mouse renal tubule

Sylvain Pradervand, Annie Zuber Mercier, Gabriel Centeno, Olivier Bonny, Dmitri Firsov
2010 Pflügers Archiv: European Journal of Physiology  
Collectively, these cyclases represent a point of cross-talk between the cAMP-and Ca 2+ -dependent signalling pathways.  ...  However, a significant number of transcripts belonging, for instance, to categories of G protein-coupled receptors (GPCR) or serine-threonine kinases exhibit high expression levels but remain unassigned  ...  11.01 mitogen-activated protein kinase 14 Mapk14 10.53 11.07 calcium/calmodulin-dependent protein kinase kinase 2, beta Camkk2 10.40 11.59 mitogen-activated protein kinase kinase 7 Map2k7  ... 
doi:10.1007/s00424-010-0863-8 pmid:20686783 fatcat:ctzwid32ofebxhzdmrijiavjnm

Expression profiling in neuropsychiatric disorders: Emphasis on glutamate receptors in bipolar disorder

Stephen D. Ginsberg, Scott E. Hemby, John F. Smiley
2012 Pharmacology, Biochemistry and Behavior  
Genome-wide association studies (GWAS) have attempted to identify valid candidate genes through single nucleotide polymorphism (SNP) analysis.  ...  Although functional genomic assessment of BP is in its infancy, results to date point towards a dysregulation of GluRs that bear some similarity to schizophrenia (SZ), although the pattern is complex,  ...  We also express our appreciation to the families of the patients studied here who made this research possible.  ... 
doi:10.1016/j.pbb.2011.09.015 pmid:22005598 pmcid:PMC3253885 fatcat:audb4nialrhvlnijxfwtt4t43m

TRPM3_miR-204: a complex locus for eye development and disease

Alan Shiels
2020 Human Genomics  
Activation of TRPM3 channels at the cell membrane elicits a signal transduction cascade of mitogen-activated kinases and stimulus response transcription factors.  ...  Activators of TRPM3 channels include the neurosteroid pregnenolone sulfate, calmodulin, phosphoinositides, and heat, whereas inhibitors include certain drugs, plant-derived metabolites, and G-protein subunits  ...  This work was supported by NIH/NEI grants EY028899 (to A.S.) and EY02687 (Core Grant for Vision Research) and an unrestricted grant to the Department of Ophthalmology and Visual Sciences from Research  ... 
doi:10.1186/s40246-020-00258-4 pmid:32070426 fatcat:fm4hkfsykjb67heq5nnug7eo3e

Induction of Olfaction and Cancer-Related Genes in Mice Fed a High-Fat Diet as Assessed through the Mode-of-Action by Network Identification Analysis

Youngshim Choi, Cheol-Goo Hur, Taesun Park, Richard L. Eckert
2013 PLoS ONE  
ranked genes at each time point in the 3 different tissues of mice fed the HFD were considered in the present study.  ...  To gain more insight into the genetic mediators associated with the onset and progression of diet-induced obesity and metabolic diseases, we studied the molecular changes in response to a high-fat diet  ...  Previous studies identified several single nucleotide polymorphisms in this gene associated with type 2 diabetes in different populations, including Caucasians and Chinese [39] .  ... 
doi:10.1371/journal.pone.0056610 pmid:23555558 pmcid:PMC3608641 fatcat:llhsdsoc6bftfe5uipvqc53naa

Mechanisms of specificity in neuronal activity-regulated gene transcription

Michelle R. Lyons, Anne E. West
2011 Progress in Neurobiology  
Since the neurotransmitter-dependent regulation of Fos transcription was first discovered nearly 25 years ago, a wealth of studies have enriched our understanding of the molecular pathways that mediate  ...  The brain is a highly adaptable organ that is capable of converting sensory information into changes in neuronal function.  ...  Distinct Ser133 kinases including PKA, Ca 2+ /calmodulin (CaM)-dependent protein kinases (CaMKs), MAPK, and Akt (also known as protein kinase B, PKB) mediate phosphorylation of CREB in response to different  ... 
doi:10.1016/j.pneurobio.2011.05.003 pmid:21620929 pmcid:PMC3134613 fatcat:42cd3r7sivg4zpg3zcvgdcm4jq

Award Winners and Abstracts of the 31st Annual Symposium of The Protein Society, Montreal, Canada, July 24-27, 2017

2017 Protein Science  
In the present study, we aimed to improve the ExM method for imaging of proteins in human clinical tissue samples, for diagnostic pathology and research.  ...  ExPath enables morphological and protein imaging and analysis of tissue microarrays, by providing $70nm resolution imaging of proteins in any type of human tissues, using optical microscopes (currently  ...  CaMKK2 (Ca21/calmodulin-dependent protein kinase kinase 2) is a member of CaMK signaling cascades that detect changes in intracellular concentration of calcium ions and transduce this signal by activation  ... 
doi:10.1002/pro.3349 pmid:29280217 fatcat:jrxtwzblare37gxsvc5szbwuhu

Steroid Receptors in Breast Cancer: Understanding of Molecular Function as a Basis for Effective Therapy Development

Wojciech Kowalczyk, Grzegorz Waliszczak, Robert Jach, Joanna Dulińska-Litewka
2021 Cancers  
Over the past decades, huge amount of data was obtained in multiple studies exploring this field, therefore in this review we attempt to summarize the current knowledge in a comprehensive way.  ...  SRs are involved in a vast variety of interactions with other proteins, including extensive crosstalk with each other.  ...  Acknowledgments: This work was supported by a grant from Ministry of Science & Higher Education (MNiSW) through Jagiellonian University Medical College (N41/DBS/000431).  ... 
doi:10.3390/cancers13194779 pmid:34638264 fatcat:jxhmszpak5bkpmoika3r4i6vki

Target Identification for CNS Diseases by Transcriptional Profiling

C Anthony Altar, Marquis P Vawter, Stephen D Ginsberg
2008 Neuropsychopharmacology  
target early growth response 1, Nurr-1, and signaling through protein kinase C and RAS pathways.  ...  Studies in schizophrenia identify robust decreases in genes for GABA function, including glutamic acid decarboxylase, HINT1, glutamate transport and GluRs, BDNF and TrkB, numerous 14-3-3 protein family  ...  The genes recently updated for BPD by the CFG approach include lysophospholipase I (LYPLA I), myocyte enhancer factor 2C (MEF2C), calcium/calmodulin-dependent protein kinase kinase 2, b (CAMKK2), cyclin-dependent  ... 
doi:10.1038/npp.2008.172 pmid:18923405 pmcid:PMC2675576 fatcat:qkc37jvh4ne6vpcgg72cnv2oyi
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