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Effects of severing the corpus callosum on electrical and BOLD functional connectivity and spontaneous dynamic activity in the rat brain

Matthew E Magnuson, Garth John Thompson, Wen-Ju Pan, Shella Dawn Keilholz
2013 Brain Connectivity  
In this work callosotomized rodents are examined, providing a unique platform for evaluating the influence of structural connectivity via the corpus callosum on bilateral resting state functional connectivity  ...  Functional networks, defined by synchronous spontaneous blood oxygenation level-dependent (BOLD) oscillations between spatially distinct brain regions, appear to be essential to brain function and have  ...  We would also like to thank the NIH for two primary funding sources used to fund the research presented in this article (R21NS057718 and T32EB005969).  ... 
doi:10.1089/brain.2013.0167 pmid:24117343 pmcid:PMC3931437 fatcat:sfgtny7wl5g25cdgr4z4sal3em

Evidence for Impaired Plasticity after Traumatic Brain Injury in the Developing Brain

Nan Li, Ya Yang, David P. Glover, Jiangyang Zhang, Manda Saraswati, Courtney Robertson, Galit Pelled
2014 Journal of Neurotrauma  
in layer V of the noninjured S1 by stimulation of the corpus callosum (82% decrease).  ...  The results suggest that post-TBI plasticity can translate into inappropriate neuronal connections and dramatic changes in the function of neuronal networks.  ...  Acknowledgments This work was supported by Johns Hopkins Brain Science Institute and the National Institutes of Health/National Institute of Neurological Disorders and Stroke (grant no. R01NS072171).  ... 
doi:10.1089/neu.2013.3059 pmid:24050267 pmcid:PMC3922417 fatcat:ihgtop7tl5fhvhr3tsoshfiic4

Laminar-specific interhemispheric connectivity mapping with bilateral line-scanning fMRI [article]

Sangcheon Choi, Yi Chen, Hang Zeng, Bharat Biswal, Xin Yu
2021 bioRxiv   pre-print
Despite extensive studies detecting blood-oxygen-level-dependent (BOLD) fMRI signals across two hemispheres to present cognitive processes in normal and diseased brains, the role of corpus callosum (CC  ...  Several studies show maintaining low-frequency fluctuation of resting-state (rs)-fMRI signals in homotopic brain areas of acallosal humans and post-callosotomy animals, raising the question: how can we  ...  ., Effects of severing the corpus callosum on electrical and BOLD functional 391 connectivity and spontaneous dynamic activity in the rat brain. Brain Connect, 2014. 4(1): p. 15-29. 392 14.  ... 
doi:10.1101/2021.03.08.433876 fatcat:fqkmys5gffblljp7hxic6cddo4

White Matter Reorganization and Functional Response after Focal Cerebral Ischemia in the Rat

Chrystelle Po, Daniel Kalthoff, Young Beom Kim, Melanie Nelles, Mathias Hoehn, Christoph Kleinschnitz
2012 PLoS ONE  
Our study shows the influence of the internal capsule reorganization, combined with inter-hemispheric connections though the corpus callosum, on the functional activation of the brain from stroke.  ...  Furthermore, fiber tracking showed a transhemispheric fiber connection through the corpus callosum, which-in the rat without functional recovery-was lost.  ...  Acknowledgments The biological expertise of Andreas Beyrau, the expertise of Michael Diedenhofen during data post-processing and the graphical expertise of Ulla Uhlenküken are gratefully acknowledged.  ... 
doi:10.1371/journal.pone.0045629 pmid:23029148 pmcid:PMC3445514 fatcat:musnl4uw35heveickcqc3fqq4q

Temporal scaling properties and spatial synchronization of spontaneous blood oxygenation level-dependent (BOLD) signal fluctuations in rat sensorimotor network at different levels of isoflurane anesthesia

Kun Wang, Maurits P.A. van Meer, Kajo van der Marel, Annette van der Toorn, Lijuan Xu, Yingjun Liu, Max A. Viergever, Tianzi Jiang, Rick M. Dijkhuizen
2011 NMR in Biomedicine  
In order to obtain more insights into this relationship and, in particular, the effects of anesthesia thereupon, we investigated the spatial and temporal correlations of spontaneous BOLD fluctuations in  ...  Yet, the relationship between functional brain status and the characteristics of spontaneous BOLD fluctuations remains poorly understood.  ...  However, the effect of altered functional status of the brain, such as under anesthesia, on spontaneous BOLD signal fluctuations is still largely unclear.  ... 
doi:10.1002/nbm.1556 pmid:20669170 fatcat:r7tmzicl5fcg7f2qfymawdseuu

Layer-specific interhemispheric functional connectivity in the somatosensory cortex of rats: resting state electrophysiology and fMRI studies

Kwangyeol Baek, Woo Hyun Shim, Jaeseung Jeong, Harsha Radhakrishnan, Bruce R. Rosen, David Boas, Maria Franceschini, Bharat B. Biswal, Young R. Kim
2015 Brain Structure and Function  
We investigated the characteristics of bihemispheric functional connectivity via electrophysiology and rsfMRI in the primary sensory cortex of rats anesthetized by a-chloralose.  ...  Our findings demonstrated the diverse activity patterns of layer-specific electrophysiological substrates and suggest the recruitment of multiple, non-specific brain regions in construction of interhemispheric  ...  The role of the corpus callosum has been demonstrated in previous functional connectivity studies which involved disruption of the corpus callosum connectivity in animals (Mohajerani et al. 2010; Magnuson  ... 
doi:10.1007/s00429-015-1073-0 pmid:26077581 pmcid:PMC4681693 fatcat:f6ovcrie6fbz3brpv4d5xwvzxe

Visual callosal connections: role in visual processing in health and disease

Tommaso Bocci, Marta Pietrasanta, Chiara Cerri, Laura Restani, Matteo Caleo, Ferdinando Sartucci
2014 Reviews in the Neurosciences  
Visual cortical areas in the two sides of the brain are interconnected by interhemispheric fibers passing through the splenium of the corpus callosum.  ...  We also review data highlighting the contribution of callosal input activity to maturation of visual function during early ' critical periods ' in brain development and describe how interhemispheric transfer  ...  Introduction The corpus callosum is the major white matter structure in the brain.  ... 
doi:10.1515/revneuro-2013-0025 pmid:24127537 fatcat:cu7lfzsdwjapdexyfjepnirelm

Workshop on Neurobiology of Epilepsy appraisal: New systemic imaging technologies to study the brain in experimental models of epilepsy

Stefanie Dedeurwaerdere, Sandy R. Shultz, Paolo Federico, Jerome Engel
2014 Epilepsia  
Successful application of functional neuroimaging of the whole brain in the animal laboratory now permits investigations during epileptogenesis and correlation with deep brain electroencephalography (EEG  ...  Modern functional neuroimaging provides opportunities to visualize activity of the entire brain, making it an indispensable diagnostic tool for epilepsy.  ...  We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.  ... 
doi:10.1111/epi.12642 pmid:24836499 pmcid:PMC4057947 fatcat:5q7wx7546rf5nimtya53we36zy

Monkey in the middle: why non-human primates are needed to bridge the gap in resting-state investigations

R. Matthew Hutchison, Stefan Everling
2012 Frontiers in Neuroanatomy  
Resting-state investigations based on the evaluation of intrinsic low-frequency fluctuations of the BOLD fMRI signal have been extensively utilized to map the structure and dynamics of large-scale functional  ...  In addition to increasing our knowledge of normal brain connectivity, disruptions of the spontaneous hemodynamic fluctuations have been suggested as possible diagnostic indicators of neurological and psychiatric  ...  CORRELATES OF SPONTANEOUS BOLD ACTIVITY AND RSNs The BOLD signal is not a direct measure of neural activity as would be recorded in electrophysiological experiments.  ... 
doi:10.3389/fnana.2012.00029 pmid:22855672 pmcid:PMC3405297 fatcat:2hwi3bzqjjcrtlazyjh4ulvipm

Considerations for resting state functional MRI and functional connectivity studies in rodents

Wen-Ju Pan, Jacob C. W. Billings, Joshua K. Grooms, Sadia Shakil, Shella D. Keilholz
2015 Frontiers in Neuroscience  
Resting state functional MRI (rs-fMRI) and functional connectivity mapping have become widely used tools in the human neuroimaging community and their use is rapidly spreading into the realm of rodent  ...  One of the many attractive features of rs-fMRI is that it is readily translatable from humans to animals and back again.  ...  For example, left and right primary somatosensory cortex are directly connected via the corpus callosum and as expected exhibit strong functional connectivity.  ... 
doi:10.3389/fnins.2015.00269 pmid:26300718 pmcid:PMC4525377 fatcat:izgtvld2k5fwdh4jdsqy63vlsm

Neural and metabolic basis of dynamic resting state fMRI

Garth J. Thompson
2018 NeuroImage  
Even an incrementally better understanding of the neurometabolic basis of dynamic rsfMRI would expand rsfMRI's research and clinical utility, and the studies described herein take the first steps on that  ...  and metabolic activity.  ...  The funding sources were not involved in the writing of this review.  ... 
doi:10.1016/j.neuroimage.2017.09.010 pmid:28899744 pmcid:PMC5844792 fatcat:mb36grksezd4rfj55wfkry26ve

Recovery of Sensorimotor Function after Experimental Stroke Correlates with Restoration of Resting-State Interhemispheric Functional Connectivity

M. P. A. van Meer, K. van der Marel, K. Wang, W. M. Otte, S. el Bouazati, T. A. P. Roeling, M. A. Viergever, J. W. Berkelbach van der Sprenkel, R. M. Dijkhuizen
2010 Journal of Neuroscience  
Despite the success of functional imaging to map changes in brain activation patterns after stroke, spatiotemporal dynamics of cerebral reorganization in correlation with behavioral recovery remain incompletely  ...  changes in associated function after unilateral stroke in rats.  ...  Tracing experiments in the current study clearly demonstrated effective transfer of the neuronal tracers manganese, BDA, and PHA-L from contralesional M1 through the corpus callosum toward ipsilesional  ... 
doi:10.1523/jneurosci.5709-09.2010 pmid:20237267 fatcat:plm3ftgz7jdvrf2g5w3u2glrdm

Spatiotemporal dynamics of low frequency fluctuations in BOLD fMRI of the rat

Waqas Majeed, Matthew Magnuson, Shella D. Keilholz
2009 Journal of Magnetic Resonance Imaging  
Keywords functional connectivity; low frequency fluctuations; spontaneous neural activity; spatiotemporal dynamics; rat cortex LOW FREQUENCY FLUCTUATIONS (LFFs) in the blood oxygenation level dependent  ...  The possibility that correlated LFFs reflect the spontaneous "functional connectivity" of the brain has excited the interest of the fMRI and neuroscience communities, and the number of studies using the  ...  ACKNOWLEDGMENTS The authors thank the Laboratory for Functional and Molecular Imaging at the National Institutes of Health for use of the 11.7T animal scanner, with special thanks to Dr.  ... 
doi:10.1002/jmri.21848 pmid:19629982 pmcid:PMC2758521 fatcat:56nxjilsgjezdlq3ht47nf3lbi

Mapping the functional network of medial prefrontal cortex by combining optogenetics and fMRI in awake rats

Zhifeng Liang, Glenn D.R. Watson, Kevin D. Alloway, Gangchea Lee, Thomas Neuberger, Nanyin Zhang
2015 NeuroImage  
This activation pattern was robust, reproducible, and did not depend on the stimulation period in awake rats. BOLD signals, however, were substantially reduced when animals were anesthetized.  ...  Here we combined optogenetic stimulation and functional magnetic resonance imaging (opto-fMRI) to reveal the network of brain regions functionally activated by mPFC outputs in awake rodents.  ...  the National Institute of Neurological Disorders and Stroke.  ... 
doi:10.1016/j.neuroimage.2015.05.036 pmid:26002727 pmcid:PMC4512884 fatcat:4ojeclql2zf4bahgeezwvipxsi

Probing Intrinsic Resting-State Networks in the Infant Rat Brain

Dusica Bajic, Michael M. Craig, David Borsook, Lino Becerra
2016 Frontiers in Behavioral Neuroscience  
Several rs-fMRI studies have been conducted in anesthetized and awake adult rats, reporting consistent patterns of brain activity at the systems level.  ...  However, the evolution to adult patterns of resting-state activity has not yet been evaluated and quantified in the developing rat brain.  ...  The content of the article is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.  ... 
doi:10.3389/fnbeh.2016.00192 pmid:27803653 pmcid:PMC5067436 fatcat:y34rp2qwe5dmhievz44jbuk3ae
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