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Effects of Proton Pump Inhibitors on the Gastrointestinal Microbiota in Gastroesophageal Reflux Disease

Yi-Chao Shi, Shun-Tian Cai, Ya-Ping Tian, Hui-Jun Zhao, Yan-Bing Zhang, Jing Chen, Rong-Rong Ren, Xi Luo, Li-Hua Peng, Gang Sun, Yun-Sheng Yang
2019 Genomics, Proteomics & Bioinformatics  
Proton pump inhibitors (PPIs) are commonly used to lessen symptoms in patients with gastroesophageal reflux disease (GERD).  ...  However, the effects of PPI therapy on the gastrointestinal microbiota in GERD patients remain unclear.  ...  PPI, proton pump inhibitor; GERD, gastroesophageal reflux disease; HC, healthy control; PCoA, principal component analysis.  ... 
doi:10.1016/j.gpb.2018.12.004 pmid:31028880 pmcid:PMC6520915 fatcat:wtvpjqavs5bgxn5tapigtc5j2e

Commentary: The Influence of Proton Pump Inhibitors on the Fecal Microbiome of Infants with Gastroesophageal Reflux-A Prospective Longitudinal Interventional Study

Kelsea M. Drall, Hein M. Tun, Anita L. Kozyrskyj
2018 Frontiers in Cellular and Infection Microbiology  
A Commentary on The Influence of Proton Pump Inhibitors on the Fecal Microbiome of Infants with Gastroesophageal Reflux-A Prospective Longitudinal Interventional Study by Castellani, C., Singer, G., Kashofer  ...  All authors approved the final version of the manuscript for submission. FIGURE 1 | 1 The overlooked effect of proton pump inhibitors on the development of the infant gut microbiota.  ...  Conflict of Interest Statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest  ... 
doi:10.3389/fcimb.2018.00430 pmid:30619776 pmcid:PMC6302613 fatcat:7ufkh53ab5exfcawm2d3ry3g4a

Lactobacillus rhamnosus GG Usage in the Prevention of Gastrointestinal and Respiratory Tract Infections in Children with Gastroesophageal Reflux Disease Treated with Proton Pump Inhibitors: A Randomized Double-Blinded Placebo-Controlled Trial

Piotr Dziechciarz, Katarzyna Krenke, Hania Szajewska, Andrea Horvath
2020 Pediatric Gastroenterology Hepatology & Nutrition  
Proton-pump inhibitors (PPIs) are frequently used to treat gastroesophageal reflux disease (GERD) in children, but recent evidence suggests a potential association between PPI treatment and some types  ...  The aim of this study was to assess the effectiveness of Lactobacillus rhamnosus GG (LGG) for the prevention of gastrointestinal and respiratory tract infections in children with GERD treated with PPI  ...  Conflicts of Interest The authors have no financial conflicts of interest.  ... 
doi:10.5223/pghn.2020.23.3.251 pmid:32483546 pmcid:PMC7231745 fatcat:opdsfwcqrfhhbmyvqkcu4seoyu

Use of proton pump inhibitors in chronic liver diseases

Darrick K. Li, Raymond T. Chung
2017 Clinical Liver Disease  
Abbreviations: EVL, endoscopic variceal ligation; GERD, gastroesophageal reflux disease; GI, gastrointestinal; NSAID, nonsteroidal anti-inflammatory drug; PPI, proton pump inhibitor; SBP, spontaneous bacterial  ...  TABLE 1 . 1 PREVALENCE OF PROTON PUMP INHIBITOR USE IN PATIENTS WITH CIRRHOSIS AS EVIDENCED IN RECENT STUDIES INVESTIGATING THE ASSOCIATION BETWEEN PROTON PUMP INHIBITORS AND SPONTANEOUS BACTERIAL PERITONITIS  ... 
doi:10.1002/cld.678 pmid:30992776 pmcid:PMC6467129 fatcat:zifanlv3rngmlmfuygtwgs3qhy

Gastroesophageal reflux disease and irritable bowel syndrome - prevalence and overlap

Patrycja Kmiotek, Andrzej Materniak
2019 Zenodo  
Gastroesophageal reflux disease and irritable bowel syndrome - prevalence and overlap. Journal of Education, Health and Sport. 2019;9(9):570-577. eISSN 2391-8306.  ...  Gastroesophageal reflux disease and irritable bowel syndrome - prevalence and overlap Name Patrycja Kmiotek ORCID iD Affiliation Medical University of Lublin Country  ...  [22] On the other hand, it's important to remember that long-term proton pump inhibitors therapy can lead to the opposite effect.  ... 
doi:10.5281/zenodo.3444865 fatcat:zu36uzwfmneqpn6humwhrausmq

Distinct Microbiota Dysbiosis in Patients with Non-Erosive Reflux Disease and Esophageal Adenocarcinoma

Jerry Zhou, Prapti Shrestha, Zhiguang Qiu, David G. Harman, Wun-Chung Teoh, Sam Al-Sohaily, Han Liem, Ian Turner, Vincent Ho
2020 Journal of Clinical Medicine  
Non-erosive reflux disease (NERD) and esophageal adenocarcinoma (EAC) are often regarded as bookends in the gastroesophageal reflux disease spectrum.  ...  This study suggests the close relationship between esophageal mucosal microbiota and the appearance of pathologies of this organ.  ...  Effects of Proton Pump Inhibitor on Microbiota and Mucosal Proteome Proton pump inhibitors (PPI) are a mainstay of reflux-disease treatment.  ... 
doi:10.3390/jcm9072162 pmid:32650561 fatcat:gnhzwaaydngznowet6gfvmwnkq

Proton pump inhibitors and dysbiosis: Current knowledge and aspects to be clarified

Giovanni Bruno, Piera Zaccari, Giulia Rocco, Giulia Scalese, Cristina Panetta, Barbara Porowska, Stefano Pontone, Carola Severi
2019 World Journal of Gastroenterology  
Proton pump inhibitors (PPIs) are common medications within the practice of gastroenterology.  ...  The aim of this review is to summarize the recently available data on PPI-related microbiota alterations in each segment of the GI tract and to analyze the possible involvement of PPIs in the pathogenesis  ...  This figure shows the effect of proton pump inhibitor (PPI) treatment on the composition of gut microbiota families.  ... 
doi:10.3748/wjg.v25.i22.2706 pmid:31235994 pmcid:PMC6580352 fatcat:icof4xspezd53aofa53osyagsu

Impact of gastroesophageal reflux in the pathogenesis of tracheal stenosis

Paulo Francisco Guerreiro Cardoso, Helio Minamoto, Benoit Jacques Bibas, Paulo Manuel Pego-Fernandes
2020 Translational Cancer Research  
Despite the frequent finding of pathological gastroesophageal reflux (GER) in benign tracheal stenosis, the cause-and-effect relationship between these two entities and its impact on the outcome of the  ...  stenosis as opposed to the medical management with high dose proton pump inhibitors.  ...  proton pump inhibitors (e.g., omeprazole 80 mg bid).  ... 
doi:10.21037/tcr.2020.03.24 pmid:35117568 pmcid:PMC8799195 fatcat:ms5bjsuhjreazpti2mbjjxhal4

Role of Acid Suppression in Acid-related Diseases: Proton Pump Inhibitor and Potassium-competitive Acid Blocker

Hideki Mori, Hidekazu Suzuki
2019 Journal of Neurogastroenterology and Motility  
Proton pump inhibitors are commonly utilized for the treatment of gastric acid-related diseases, such as gastroesophageal reflux disease, peptic ulcer disease, and Helicobacter pylori infection, and for  ...  Vonoprazan is a first-in-class potassium-competitive acid blocker, which has distinct advantages compared to other conventional proton pump inhibitors in terms of the efficacy for acid suppression.  ...  Figure 2 . 2 Strategy of proton pump inhibitor (PPI)-resistant gastroesophageal reflux disease (GERD) treatment.  ... 
doi:10.5056/jnm18139 pmid:30504527 pmcid:PMC6326200 fatcat:iquwkur32ndfnavu2rzj33qggq

Chronic Lung and Gastrointestinal Diseases: Take a Broader Perspective

Syifa Mustika, Tiar Oktavian Effendi
2022 Jurnal Respirasi  
Vice versa, many cases of gastrointestinal diseases such as gastroesophageal reflux disease (GERD) have developed respiratory dysfunction later.  ...  This includes changes in microbiota, the mucosa-related immune system of both systems, side effects of the therapeutic given, and pathomechanism related to gastrointestinal diseases such as GERD.  ...  Acknowledgments We would like to thank colleagues of Department of Internal Medicine and Department of Pulmonology and Respiratory Medicine, Universitas Brawijaya, for providing all ideas and insight while  ... 
doi:10.20473/jr.v8-i.1.2022.52-59 doaj:0bc6db11d98a40718d6b583153d7e224 fatcat:moe3zbmharesxcjexlqb3dim54

Herbal Preparation STW 5 for Functional Gastrointestinal Disorders: Clinical Experience in Everyday Practice

Tatiana L. Lapina, Alexander S. Trukhmanov
2017 Digestive Diseases  
Summary: Syndromes classified as FGID frequently overlap, and coexist with gastroesophageal reflux disease (GERD). Patients with overlapping symptoms are more likely to seek medical care.  ...  STW 5 reduced concomitant heartburn in FD patients. STW 5 was well tolerated in the examined populations, independent of concomitant diseases and concomitant medication.  ...  The most interesting observation for us was the relief of reflux symptoms in patients with concomitant GERD through treatment with either STW 5 alone or in combination with proton pump inhibitors maintenance  ... 
doi:10.1159/000485411 pmid:29421814 fatcat:2dqyvmiobvghnoxkfz3p4zsngi

Stress and the gut: pathophysiology, clinical consequences, diagnostic approach and treatment options

Peter C Konturek, T Brzozowski, S J Konturek
2011 Journal of Physiology and Pharmacology  
The therapy for these conditions is mainly based on the inhibition of gastric acid by proton pump inhibitors and eradication of Helicobacter pylori-infection.  ...  permeability; 5) negative effects on regenerative capacity of gastrointestinal mucosa and mucosal blood flow; and 6) negative effects on intestinal microbiota.  ...  Therapies of stress-related disorders within the upper GI tract are focused mainly on the inhibition of gastric acid secretion using proton pump inhibitors (PPI), histamine-H 2 blockers, etc.  ... 
pmid:22314561 fatcat:b7aeubvymzdh7hmbn6mas5hm6a

Excess Body Weight and Gastrointestinal Disease

Christoph-Thomas Germer, Hans Scherübl
2021 Visceral Medicine  
Conflict of Interest Statement The authors have no conflicts of interest to declare. Funding Sources There was no funding for this editorial.  ...  Author Contributions Germer C. and Scherübl H. jointly planned, wrote, and revised the editorial.  ...  The authors then discuss the treatment options for gastroesophageal reflux disease beyond proton-pump inhibitors and fundal plication with particular emphasis placed on the merits of gastric bypass surgery  ... 
doi:10.1159/000517251 pmid:34540938 pmcid:PMC8406363 fatcat:bifbraed25e6fa5bqc7md55uoy

Inhibitory pompy protonowej w opiece paliatywnej

Iwona Zaporowska-Stachowiak, Mary-Tiffany Adannia Oduah
2019 Palliative Medicine in Practice  
The mainstay of therapy for peptic ulcer disease, gastroesophageal reflux disease (GERD), and Zollinger-Ellison syndrome is the class of medications known as the proton pump inhibitors (PPIs).  ...  The highly potent blocker of gastric acid secretion, this class of medications exerts their effects via a dose-dependent inhibitory action on hydrogen-potassium ATPase proton pump located on the luminal  ...  Introduction The mainstay of therapy for peptic ulcer disease, gastroesophageal reflux disease (GERD), and Zollinger-Ellison syndrome is the class of medications known as the proton pump inhibitors (PPIs  ... 
doi:10.5603/pmpi.2019.0013 fatcat:fyhc6io7tjgu5jmzr5iqojtghe

The esophageal microbiota in health and disease

Vincenzo Di Pilato, Giancarlo Freschi, Maria Novella Ringressi, Lucia Pallecchi, Gian Maria Rossolini, Paolo Bechi
2016 Annals of the New York Academy of Sciences  
Our understanding of the composition of the esophageal microbiota in health and disease is challenged by the need for invasive sampling procedures and by the dynamic nature of the esophageal environment  ...  reflux disease and is hypothesized to contribute to the evolution of this condition toward Barrett's esophagus (which is the most common esophageal precancerous lesion) and, eventually, adenocarcinoma  ...  Moreover, this study first demonstrated a remarkable effect of proton pump inhibitor (PPI) treatment on the microbiota composition in the esophageal mucosa.  ... 
doi:10.1111/nyas.13127 pmid:27415419 fatcat:s7ibqdhuczc27n4hq7cbfirxia
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