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Modeling the effects of HIV-1 virions and proteins on Fas-induced apoptosis of infected cells [article]

John Jack, Andrei Paun
2007 arXiv   pre-print
We report a first in modeling and simulation of the effects of the HIV proteins on the (caspase dependent) apoptotic pathway in infected cells.  ...  Using the model obtained we have then run the simulations for the infected memory T cells, called also latent T cells, which, at the moment, represent the major obstacle to finding a cure for HIV.  ...  In this paper, we focus on simulating the effects on the Fas-induced apoptosis caused by the HIV-1 strand R5 proteins. We report a simulation for the Fas-mediated pathway in HIV-1 infected cells.  ... 
arXiv:0705.2032v1 fatcat:hdnt25j4drbmvedu4clwlswkni

DISCRETE NONDETERMINISTIC MODELING OF THE FAS PATHWAY

JOHN JACK, ALFONSO RODRÍGUEZ-PATÓN, OSCAR H. IBARRA, ANDREI PĂUN
2008 International Journal of Foundations of Computer Science  
Results of our discrete simulation of the type I and type II Fas-mediated apoptotic signaling cascade are illustrated and compared with two approaches: one based on ordinary differential equations and  ...  We present a refined approach for the discrete modeling of protein interactions within the environment of a single cell.  ...  Acknowledgements We gratefully acknowledge support in part from a NSF GK-12 Ph.D. fellowship, support from NSF Grants CCF-0430945, CCF-0523572 and CCF-0524136, support from LA BoR RSC grant LEQSF (2004  ... 
doi:10.1142/s0129054108006194 fatcat:2ycyhf5kj5b5bfdy4r7fp2w6mi

Human Immunodeficiency Virus Type 1 Protease Cleaves Procaspase 8 In Vivo

Z. Nie, G. D. Bren, S. R. Vlahakis, A. A. Schimnich, J. M. Brenchley, S. A. Trushin, S. Warren, D. J. Schnepple, C. M. Kovacs, M. R. Loutfy, D. C. Douek, A. D. Badley
2007 Journal of Virology  
Human immunodeficiency virus type 1 (HIV-1) infection causes apoptosis of infected CD4 T cells as well as uninfected (bystander) CD4 and CD8 T cells.  ...  These data indicate that casp8p41 independently induces apoptosis and is a specific product of HIV-1 protease which may contribute to death of HIV-1-infected cells.  ...  We gratefully acknowledge the administrative expertise of Teresa Hoff, the technical assistance of Robert Brown, the assistance with coordination and shipment of patient blood samples from Roberta Halpenny  ... 
doi:10.1128/jvi.02798-06 pmid:17442709 pmcid:PMC1933285 fatcat:kybf5ilkovhw7j77hlwfy6tbwe

Gene Array Studies in HIV-1 Infection

Rajeev Mehla, Velpandi Ayyavoo
2011 Current HIV/AIDS Reports  
HIV-1-infected individuals exhibit remarkable variation in the onset of disease.  ...  Gene set enrichment analysis has revealed gene signatures linked to disease progression involving pathways related to metabolism, apoptosis, cell-cycle dysregulation, and T-cell signaling.  ...  HIV-1-infected resting memory T cells are a major latent reservoir for infection and pose a hurdle to eradicating the virus.  ... 
doi:10.1007/s11904-011-0100-x pmid:22184032 pmcid:PMC3968537 fatcat:35sfzjawnnfbpljxdikzdssrae

Comparative Analysis of Tat-Dependent and Tat-Deficient Natural Lentiviruses

Deepanwita Bose, Jean Gagnon, Yahia Chebloune
2015 Veterinary Sciences  
SRLVs only replicate productively in monocytes/macrophages in infected animals but not in CD4+ T cells.  ...  Results may also help develop new strategies based on the attenuation of SRLVs to control the highly pathogenic HIV-1 in humans.  ...  Acknowledgments We thank the National Institute of Health, AIDS Research and Reference Reagent Program for providing HIV and SIV overlapping peptides and cell lines.  ... 
doi:10.3390/vetsci2040293 pmid:29061947 pmcid:PMC5644649 fatcat:caziewlxufgdhcctexuohjqify

Viral Control of Mitochondrial Apoptosis

Lorenzo Galluzzi, Catherine Brenner, Eugenia Morselli, Zahia Touat, Guido Kroemer, B. Brett Finlay
2008 PLoS Pathogens  
Throughout the process of pathogen-host co-  ...  or CD4/CCR5) on the surface of uninfected cells.  ...  [S155] HIV-1 Vpr CD4 + lymphocytes ANT/VDAC Dy m loss, IMS proteins release, caspase cascade activation [24;S41,S113,S115] HTLV-1 p13(II) Lymphocytes Rapid flux of K+ and Ca 2+ across IM,  ... 
doi:10.1371/journal.ppat.1000018 pmid:18516228 pmcid:PMC2376094 fatcat:gih4tmf64jefrhkwlfsvbnukz4

Molecular and Cellular Mechanisms Associated with Autoimmune Diseases

Wellington Ayensu, Paul Tchounwou, Robert McMurray
2004 International Journal of Environmental Research and Public Health  
Emphasis is laid on the role of T and B cell receptor/ligand interactions, functions and malfunctions due to structural and quantitative alterations in T-B-cell cluster of antigen determinants.  ...  As a result, the cost to public health from clinical management of autoimmune conditions is on the rise.  ...  Acknowledgments: This research was financially supported, by two grants from National Institutes of  ... 
doi:10.3390/ijerph2004010039 pmid:16696180 fatcat:zq7g76ysurdstcu4g42b6v2g6i

Prime, Shock, and Kill: Priming CD4 T Cells from HIV Patients with a BCL-2 Antagonist before HIV Reactivation Reduces HIV Reservoir Size

Nathan W. Cummins, Amy M. Sainski, Haiming Dai, Sekar Natesampillai, Yuan-Ping Pang, Gary D. Bren, Maria Cristina Miranda de Araujo Correia, Rahul Sampath, Stacey A. Rizza, Daniel O'Brien, Joseph D. Yao, Scott H. Kaufmann (+2 others)
2016 Journal of Virology  
HIV killing of CD4 T cells that replicate HIV can involve HIV protease-mediated cleavage of procaspase 8 to generate a fragment (Casp8p41) that directly binds and activates the mitochondrial proapoptotic  ...  infection is incurable due to a long-lived reservoir of HIV+memory CD4 T cells, and no clinically relevant interventions have been identified that reduce the number of these HIV DNA-containing cells.  ...  I ntense activity is focused on identifying a clinical intervention that results in a long term, drug free remission of HIV-1 infection.  ... 
doi:10.1128/jvi.03179-15 pmid:26842479 pmcid:PMC4810548 fatcat:rmfsfisntncvxlzj3axxqgcsoe

Constitutive NF- B activation, normal Fas-induced apoptosis, and increased incidence of lymphoma in human herpes virus 8 K13 transgenic mice

P. Chugh, H. Matta, S. Schamus, S. Zachariah, A. Kumar, J. A. Richardson, A. L. Smith, P. M. Chaudhary
2005 Proceedings of the National Academy of Sciences of the United States of America  
HHV-8-encoded viral Fas-associated death domain-like IL-1-converting enzyme inhibitory protein (vFLIP) is one of the few viral proteins to be expressed in latently infected cells and plays a key role in  ...  Collectively, our results demonstrate that HHV-8 vFLIP is an oncogenic protein that mimics the signaling activities of caspase 8 during antigen receptor signaling and could contribute to the development  ...  Dennis Willerford for providing the pHSE3Ј construct. This work was supported by National Institutes of Health Grants CA85177 and AI͞AR47230 and the Mario Lemieux Foundation.  ... 
doi:10.1073/pnas.0408577102 pmid:16120683 pmcid:PMC1200255 fatcat:ukuijdpzifby3mfzhuuiktikl4

Impact of human immunodeficiency virus on pulmonary vascular disease

Ashok Kumar, Aatish Mahajan, Ethan A Salazar, Kevin Pruitt, Christian Arce Guzman, Matthias A Clauss, Sharilyn Almodovar, Navneet K Dhillon
2021 Global Cardiology Science & Practice  
Although chronic HIV-1 infection is independently associated with the development of pulmonary arterial hypertension, PH in people living with HIV may also be the outcome of various co-morbidities commonly  ...  We also examine the interactions of HIV proteins, including Nef, Tat, and gp120 in the pulmonary vasculature and how these proteins alter the endothelial and smooth muscle function by transforming them  ...  Besides its effects on co-stimulatory signals, chronic HIV infection also causes an increase in the expression of co-inhibitory molecules, such as programmed death 1 (PD-1) on CD8+ T cells.  ... 
doi:10.21542/gcsp.2021.12 pmid:34285903 pmcid:PMC8272407 fatcat:5qsatipqmbftlipwq2wiv4umti

P-C4 Associating HIV-1 Env trimer structures with functional Env conformational states by smFRET analysis

Maolin Lu, Xiaochu Ma, Luis Castillo-Menendez, Jason Gorman, James Munro, Peter Kwong, Scott Blanchard, Joseph Sodroski, Walther Mothes
2018 Journal of Acquired Immune Deficiency Syndromes  
We found that these GSK-3 inhibitors potently activate latent HIV-1 in both a tissue-based model of HIV latency formed in primary CD4 T cells, and in CD4 T cells isolated from HIV-infected patients.  ...  The first approach is the systemic activation of HIV followed by a polyvalent "swarm" of HIV-gp120 bi-specific CAR CD4+/ CD8+ T-cells.  ...  P-G3 Unravelling Adult T-cell leukemia-lymphoma (ATL) is a leukemia of mature CD4 T cells that develops after long-term infection of human T-cell leukemia virus (HTLV-1).  ... 
doi:10.1097/01.qai.0000532510.14481.56 fatcat:zedvdor4nnbmjaznnff6itlbgu

Abstracts from the 14th International Symposium on NeuroVirology October 25–28, 2016, Toronto, Ontario, Canada

2016 Journal of Neurovirology  
A majority of these mediators as P7 HIV-1 Vpr sequence variants associate specifically with co-linear genetic determinants of viral co-receptor phenotype G r e g o r y A n t e l l 1 , Wi ll ia m D a m  ...  The underlying mechanism of cognitive impairment and b r a i n i n j u r y i n p a t i e n t s w i t h H I V-a s s o c i a t e d neurocognitive disorder (HAND) on suppressive antiretroviral therapy are  ...  5' and 3' LTRs of integrated HIV-1 proviral DNA copies from latently infected human CD4+ T-cells.  ... 
doi:10.1007/s13365-016-0478-8 pmid:27678092 fatcat:dxph35wjxzbmrnyhdcwnjlbmzq

Proceedings of the Frontiers of Retrovirology Conference 2016

Irena Zurnic, Sylvia Hütter, Ute Lehmann, Nicole Stanke, Juliane Reh, Tobias Kern, Fabian Lindel, Gesche Gerresheim, Martin Hamann, Erik Müllers, Paul Lesbats, Peter Cherepanov (+639 others)
2016 Retrovirology  
Viral subtyping was done using online tools and drug resistannce mutations were screened using the Stanford University HIV Drug Resistance Database for Interpretation and the International AIDS Society-USA  ...  Our 205 cohort samples with a viral load above 2000 copies/ml were amplified by PCR and sequenced.  ...  Latent infection of long-lived memory CD4+ T cells is a major barrier to the eradication of HIV-1.  ... 
doi:10.1186/s12977-016-0294-5 fatcat:4oldvixbkjfkdfkl3ouqlrrxka

The Strengths, Weaknesses, Opportunities and Threats (SWOT) Analysis of HIV Type-1

Babalola Michael Oluyemi
2012 IOSR Journal of Pharmacy (IOSRPHR)  
These include: the requirement for CCR5 and CXCR4 chemokine co-receptors for fusion prior to internalization, presence on HIV-1 envelope of conserved determinants that mediate CD4 binding, the Achilles  ...  heel of HIV is a tiny stretch of amino acids numbered 421 to 423 on gp 120, the capsid proteins reveal potential weakness at the inner core of the virus, HIV proteins retain virus internal carbohydrate  ...  HIV-1 induced killing is the predominant cause of CD4+ T-cell death and is caused by a necrotic, not an apoptotic, mechanism.  ... 
doi:10.9790/3013-2440416 fatcat:oajepxznyvcsjam6g4japvgo2u

Herpes Simplex Virus Infection Downmodulates NKG2D Ligand Expression

D. Schepis, M. D'Amato, M. Studahl, T. Bergström, K. Kärre, L. Berg
2009 Scandinavian Journal of Immunology  
The role of different components of the immune system were addressed, ranging from innate factors, such as IFNα and NK cells, to the adaptive immune system, represented by T-cells.  ...  The results are discussed with respect to the various possible levels of interaction between the innate and the adaptive immune systems.  ...  than the one needed to activate CD4 + T-cells.  ... 
doi:10.1111/j.1365-3083.2009.02241.x pmid:19508374 fatcat:erip6uaqcvdqpnl7cjzf4wwnfy
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