A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2018; you can also visit the original URL.
The file type is
Over the follow-up interval, the ε4+ group experienced a greater rate of volume loss in total grey matter, bilateral hippocampi, right hippocampal subfields, bilateral lingual gyri, parahippocampal gyrus ... Rate of change in white matter volumes did not differentiate the groups. ... Acknowledgements Conflict of interest The authors declare no conflict of interest. ...doi:10.3233/jad-160504 pmid:27834774 pmcid:PMC5924681 fatcat:rnn4fuqxkffinamy37nx7nr5vy
One of the presymptomatic hallmarks of AD is the accumulation of beta-amyloid (Aβ) plaques in the human brain. ... We test our method in two independent cohorts, 841 subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and 260 subjects from the Open Access Series of Imaging Studies (OASIS). ... Effects of ApoE-ε4 allele load and age on the rates of grey matter and hippocampal volumes loss in a longitudinal cohort of 1186 healthy elderly persons. ...doi:10.3389/fnins.2021.669595 pmid:34421510 pmcid:PMC8377280 fatcat:kdizw3nygvf77f26qws5illw7i
There are many choices for the measurement of each biomarker and a detailed understanding of the methodology and underlying biology is important when making decisions for implementation in clinical trials ... P-tau is measured using isoform specific assays (181, 217, or 231) that may also differ in the location of the tau epitope in sandwich ELISA or Immunoprecipitation methods. ... ACTC is funded by a Cooperative Agreement from the National Institute on Aging, National Institutes of Health (ACTC grant (NIH/NIA U24 AG057437, Aisen / Sperling / Petersen, Multi-PI) and IMPACT-AD is ...doi:10.14283/jpad.2021.57 pmid:34773455 pmcid:PMC8589633 fatcat:rr2dy6mzxjfa3auv3npl2gixry