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Five-Year Longitudinal Brain Volume Change in Healthy Elders at Genetic Risk for Alzheimer's Disease

Katherine Reiter, Kristy A. Nielson, Sally Durgerian, John L. Woodard, J. Carson Smith, Michael Seidenberg, Dana A. Kelly, Stephen M. Rao, Mark Bondi
2016 Journal of Alzheimer's Disease  
Over the follow-up interval, the ε4+ group experienced a greater rate of volume loss in total grey matter, bilateral hippocampi, right hippocampal subfields, bilateral lingual gyri, parahippocampal gyrus  ...  Rate of change in white matter volumes did not differentiate the groups.  ...  Acknowledgements Conflict of interest The authors declare no conflict of interest.  ... 
doi:10.3233/jad-160504 pmid:27834774 pmcid:PMC5924681 fatcat:rnn4fuqxkffinamy37nx7nr5vy

Predicting Brain Amyloid Using Multivariate Morphometry Statistics, Sparse Coding, and Correntropy: Validation in 1,101 Individuals From the ADNI and OASIS Databases

Jianfeng Wu, Qunxi Dong, Jie Gui, Jie Zhang, Yi Su, Kewei Chen, Paul M. Thompson, Richard J. Caselli, Eric M. Reiman, Jieping Ye, Yalin Wang
2021 Frontiers in Neuroscience  
One of the presymptomatic hallmarks of AD is the accumulation of beta-amyloid (Aβ) plaques in the human brain.  ...  We test our method in two independent cohorts, 841 subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and 260 subjects from the Open Access Series of Imaging Studies (OASIS).  ...  Effects of ApoE-ε4 allele load and age on the rates of grey matter and hippocampal volumes loss in a longitudinal cohort of 1186 healthy elderly persons.  ... 
doi:10.3389/fnins.2021.669595 pmid:34421510 pmcid:PMC8377280 fatcat:kdizw3nygvf77f26qws5illw7i

Abstract: Symposia, Conferences, Oral communications: 14th Clinical Trials on Alzheimer's Disease (CTAD) November 9-12, 2021

2021
There are many choices for the measurement of each biomarker and a detailed understanding of the methodology and underlying biology is important when making decisions for implementation in clinical trials  ...  P-tau is measured using isoform specific assays (181, 217, or 231) that may also differ in the location of the tau epitope in sandwich ELISA or Immunoprecipitation methods.  ...  ACTC is funded by a Cooperative Agreement from the National Institute on Aging, National Institutes of Health (ACTC grant (NIH/NIA U24 AG057437, Aisen / Sperling / Petersen, Multi-PI) and IMPACT-AD is  ... 
doi:10.14283/jpad.2021.57 pmid:34773455 pmcid:PMC8589633 fatcat:rr2dy6mzxjfa3auv3npl2gixry