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Modulation of acute effects of delta-9-tetrahydrocannabinol on psychotomimetic effects, cognition and brain function by previous cannabis exposure

Marco Colizzi, Philip McGuire, Vincent Giampietro, Steve Williams, Mick Brammer, Sagnik Bhattacharyya
2018 European Neuropsychopharmacology  
Some evidence suggests that the acute behavioral and neurocognitive effects of the main active ingredient in cannabis, (−)-trans-Δ9-tetrahydrocannabinol (∆9-THC), might be modulated by previous cannabis  ...  Twenty-four healthy men participated in a double-blind, randomized, placebo-controlled, repeatedmeasures, within-subject, ∆9-THC challenge study.  ...  There was also no significant effect of order of drug administration and no interaction between the effects of drug and order of administration on recall score.  ... 
doi:10.1016/j.euroneuro.2018.04.003 pmid:29935939 fatcat:bhsolowkljak3hd34bqwmalf3e

The effect of cannabis use on memory function: an update

Sagnik Bhattacharyya, Tabea Schoeler
2013 Substance Abuse and Rehabilitation  
While early observational investigations aimed to elucidate the longer-term effects of cannabis use on memory function in humans, findings remained equivocal and pointed to a pattern of interacting factors  ...  impacting on the relationship between cannabis use and memory function, rather than a simple direct effect of cannabis.  ...  Acute effects of cannabis on memory When studying the effects of cannabis on memory function, it is important to be mindful that human memory is not a unitary measurable concept.  ... 
doi:10.2147/sar.s25869 pmid:24648785 pmcid:PMC3931635 fatcat:qvdcmys53nfqxbhzxlq4l5o2wi

Modulation of Mediotemporal and Ventrostriatal Function in Humans by Δ9-Tetrahydrocannabinol

Sagnik Bhattacharyya, Paolo Fusar-Poli, Stefan Borgwardt, Rocio Martin-Santos, Chiara Nosarti, Colin O'Carroll, Paul Allen, Marc L. Seal, Paul C. Fletcher, José A. Crippa, Vincent Giampietro, Andrea Mechelli (+2 others)
2009 Archives of General Psychiatry  
Objectives: To investigate the effects of 2 main psychoactive constituents of C sativa, ⌬9-tetrahydrocannabinol (⌬9-THC) and cannabidiol, on regional brain function during verbal paired associate learning  ...  Design: Subjects were studied on 3 separate occasions using a block design functional magnetic resonance imaging paradigm while performing a verbal paired associate learning task.  ...  17 and memory performance in animals and humans 7, 8, 17 and may reflect increased demands on encoding under the influence of ⌬9-THC.  ... 
doi:10.1001/archgenpsychiatry.2009.17 pmid:19349314 fatcat:6pozfiai7vdenc4p2dagvouyom

Mechanisms contributing to cognitive deficits in cannabis users

Romina Mizrahi, Jeremy J. Watts, Kuei Y. Tseng
2017 Neuropharmacology  
Yet, very few studies have been designed to directly assess the role of CB1 receptors in mediating the effects of cannabis on human brain function.  ...  This perspective review article provides an overview of current state of knowledge on possible neurobiological mechanisms accounting for the detrimental effects of chronic cannabis use on cognition and  ...  Acknowledgments Supported by Rosalind Franklin University and NIH Grant R01-MH105488 to KYT  ... 
doi:10.1016/j.neuropharm.2017.04.018 pmid:28414051 pmcid:PMC5540783 fatcat:asex6bj76fcnvkrjl6g36bvnwy

A systematic review of the antipsychotic properties of cannabidiol in humans

Tabitha A. Iseger, Matthijs G. Bossong
2015 Schizophrenia Research  
Modulation of this system by the main psychoactive component in cannabis, Δ9-tetrahydrocannabinol (THC), induces acute psychotic effects and cognitive impairment.  ...  Here we review studies that investigated the antipsychotic properties of CBD in human subjects.  ...  Appendix A. Supplementary data Supplementary data to this article can be found online at http://dx. doi.org/10.1016/j.schres.2015.01.033.  ... 
doi:10.1016/j.schres.2015.01.033 pmid:25667194 fatcat:5vzue5wzsbc4bfewgrenz4yqg4

Cannabidiol and the Remainder of the Plant Extract Modulate the Effects of Δ9-Tetrahydrocannabinol on Fear Memory Reconsolidation

Anthony Murkar, Pam Kent, Christian Cayer, Jon James, Tony Durst, Zul Merali
2019 Frontiers in Behavioral Neuroscience  
Δ9-Tetrahydrocannabinol (THC, a CB1 receptor agonist) and Cannabidiol (CBD, a non-competitive antagonist of endogenous CB1 and CB2 ligands) are two primary components of Cannabis species, and may modulate  ...  Pharmacological blockade of memory reconsolidation following recall of a conditioned response modulates the expression of learned fear and may represent a viable target for the development of new treatments  ...  One functional magnetic resonance imaging (fMRI) study found CBD and THC had opposite effects on regional activation in the hippocampus, amygdala, superior temporal cortex, and occipital cortex (Bhattacharyya  ... 
doi:10.3389/fnbeh.2019.00174 pmid:31417379 pmcid:PMC6686031 fatcat:7ogm3q77gzalbdrm77safohfo4

The neuropsychopharmacology of cannabis: A review of human imaging studies

Michael A.P. Bloomfield, Chandni Hindocha, Sebastian F. Green, Matthew B. Wall, Rachel Lees, Katherine Petrilli, Harry Costello, M. Olabisi Ogunbiyi, Matthijs G. Bossong, Tom P. Freeman
2019 Pharmacology and Therapeutics  
Acutely, cannabis and THC produce a range of effects on several neurocognitive and pharmacological systems.  ...  The main psychoactive drug in cannabis is Δ9-tetrahydrocannabinol (THC), a partial agonist at the endocannabinoid CB1 receptor.  ...  In a further exploration of this fMRI study on emotional processing, Fusar-Poli et al. (2010) did not show any effects of THC administration on connectivity between the amygdala and ACC.  ... 
doi:10.1016/j.pharmthera.2018.10.006 pmid:30347211 pmcid:PMC6416743 fatcat:g3ynqubp2nfinhciupju7dvvwa

Genetic moderation of the effects of cannabis: Catechol-O-methyltransferase (COMT) affects the impact of Δ9-tetrahydrocannabinol (THC) on working memory performance but not on the occurrence of psychotic experiences

Elizabeth M Tunbridge, Graham Dunn, Robin M Murray, Nicole Evans, Rachel Lister, Katharina Stumpenhorst, Paul J Harrison, Paul D Morrison, Daniel Freeman
2015 Journal of Psychopharmacology  
A functional polymorphism in the catechol-O-methyltransferase (COMT) gene (Val 158 Met) appears to influence the immediate cognitive and psychotic effects of cannabis, or ∆ 9 -tetrahydrocannabinol (THC  ...  The results showed interactive effects of genotype and drug group (THC or placebo) on working memory, assayed using the Digit Span Backwards task.  ...  Funding The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by a UK Medical Research Council (MRC  ... 
doi:10.1177/0269881115609073 pmid:26464454 fatcat:45df6czwbjdfxcvd4geqp3dfay

Recent advances in understanding nicotinic receptor signaling mechanisms that regulate drug self-administration behavior

Luis M. Tuesta, Christie D. Fowler, Paul J. Kenny
2011 Biochemical Pharmacology  
Tobacco smoking is one of the leading causes of disease and premature death in the United States.  ...  Consistent with this possibility, human genome-wide association studies have shown that genetic variation in the CHRNA5-CHRNA3-CHRNB4 gene cluster located in chromosome region 15q25, which encode the α5  ...  Acknowledgments Supported by the National Institute on Drug Abuse (DA020686 to PJK). This is manuscript #21235 from Scripps Florida.  ... 
doi:10.1016/j.bcp.2011.06.026 pmid:21740894 pmcid:PMC3163076 fatcat:c7ojrtgulbb7hecypgezim2l6a

Using the MATRICS to guide development of a preclinical cognitive test battery for research in schizophrenia

Jared W. Young, Susan B. Powell, Victoria Risbrough, Hugh M. Marston, Mark A. Geyer
2009 Pharmacology and Therapeutics  
The rodent tasks are discussed in terms of their validity for probing each cognitive domain as well as a brief overview of the pharmacology and manipulations relevant to schizophrenia for each task.  ...  solving, processing speed, visual learning and memory, verbal learning and memory, and social cognition) and recommended a specific neuropsychological test battery to probe these domains.  ...  Administration of the primary psychoactive constituent of marijuana, delta-9 tetrahydrocannabinol (Δ9-THC), impaired ID and reversal performance at each stage in the ASST without affecting ED shifting  ... 
doi:10.1016/j.pharmthera.2009.02.004 pmid:19269307 pmcid:PMC2688712 fatcat:6pj6622tajhxbfgrvxtgohzbfm

ACNP 55th Annual Meeting: Panels, Mini-Panels and Study Groups

2016 Neuropsychopharmacology  
In adolescent monkeys, repeated exposure to Δ9-tetrahydrocannabinol (THC) blunted the trajectory of accuracy improvements in spatial working memory but did not alter other cognitive functions that mature  ...  Animals were chronically treated with delta-9-tetrahydrocannabinol (Δ9-THC), a major psychoactive ingredient of cannabis, during adolescence.  ...  Recent studies have identified a direct impact of presenilin mutations on the regulation of presynaptic function leading to alterations in synaptic plasticity.  ... 
doi:10.1038/npp.2016.239 fatcat:wg7pyurlzvhp7bvlmlbxtkunl4

ACNP 57th Annual Meeting: Poster Session II

2018 Neuropsychopharmacology  
A composite avoidance score (average of Z-scores across open field, light-dark box, and trauma reminder) demonstrated a main effect of increased avoidance behaviors by two-way ANOVA (Fstress = 9.10, p  ...  Moreover, one prospective study demonstrated that marines who were diagnosed with post-deployment PTSD previously had a twofold higher baseline serum CRP levels prior to deployment (Eraly et al., 2014)  ...  Brain activation during episodic memory encoding was measured with BOLD fMRI during a face-name encoding task.  ... 
doi:10.1038/s41386-018-0267-6 fatcat:febeq6uwefgdzm65ccmzrmjwjy

ACNP 58th Annual Meeting: Panels, Mini-Panels and Study Groups

2019 Neuropsychopharmacology  
Methods: Photoactivatable or "caged" dynorphin derivatives were synthesized and evaluated at heterologously expressed receptors using a functional secreted alkaline phosphatase assay in HEK293 cells and  ...  The kinetics of dynorphin signal activation, duration and spread were characterized in striatum using a combination of photorelease, sensor imaging and electrophysiology.  ...  We recently found that two neutral memories learned within a day share an overlapping neural ensemble in the hippocampus linking the temporally related memories so that recall of one memory triggers recall  ... 
doi:10.1038/s41386-019-0544-z pmid:31801977 pmcid:PMC6957922 fatcat:hjyvf7fcpbf2fhxit6rlhsvg2y

ACNP 59th Annual Meeting: Poster Session I

2020 Neuropsychopharmacology  
Fear memory traces were decreased in the dorsal dentate gyrus and basolateral amygdala following propranolol administration in the ArcCreERT2 x eYFP mice.  ...  and in a self-administration model the stress-CS was sufficient to reinstate cocaine, alcohol and heroin seeking in extinguished animals.  ...  Δ9-Tetrahydrocannabinol Self-Administration Induces Adaptations in the Nucleus Accumbens Core That Are Cell-Type Specific contribute to CUD.  ... 
doi:10.1038/s41386-020-00890-7 pmid:33279934 pmcid:PMC7735198 fatcat:mqfz5f66vfbuvdbnrj7b2jt334

Abstracts of the 15th Annual Meeting of the Israel Society for Neuroscience (Eilat, Israel, December 3–5, 2006)

2007 Neural Plasticity  
The Israel Society for Neuroscience (ISFN) was founded in 1993 by a group of Israeli leading scientists conducting research in the area of neurobiology.  ...  The meeting also offers the opportunity for the researchers to exchange information with each other, often leading to the initiation of collaborative studies.  ...  Acknowledgments: we thank Yael Handler, Mor Nahum, and Sarit Szpiro for their contribution.  ... 
doi:10.1155/2007/73079 fatcat:6ttewkzqh5cmzb433ffyv3t5xi
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