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A Novel tDCS Sham Approach Based on Model-Driven Controlled Shunting

Francesco Neri, Lucia Mencarelli, Arianna Menardi, Fabio Giovannelli, Simone Rossi, Giulia Sprugnoli, Alessandro Rossi, Alvaro Pascual-Leone, Ricardo Salvador, Giulio Ruffini, Emiliano Santarnecchi
2019 Brain Stimulation  
Transcranial direct current stimulation (tDCS), a non-invasive brain stimulation technique able to transiently modulate brain activity, is surging as one of the most promising therapeutic solutions in  ...  However, profound limitations exist in current placebo (sham) protocols that limit single- and double-blinding, especially in non-naïve subjects.  ...  Acknowledgements The authors would like to thank all participants who took part in the study and for their efforts. Dr. Pascual-Leone and Dr. Santar-  ... 
doi:10.1016/j.brs.2019.11.004 pmid:31926812 fatcat:yfjqyaaalvf2tbm5qiisffgtdm

Individual Baseline Performance and Electrode Montage Impact on the Effects of Anodal tDCS Over the Left Dorsolateral Prefrontal Cortex

Maike Splittgerber, Ricardo Salvador, Hannah Brauer, Carolin Breitling-Ziegler, Alexander Prehn-Kristensen, Kerstin Krauel, Rafal Nowak, Giulio Ruffini, Vera Moliadze, Michael Siniatchkin
2020 Frontiers in Human Neuroscience  
Anodal transcranial direct current stimulation (tDCS), applied over the left dorsolateral prefrontal cortex (lDLPFC), can produce significant effects on working memory (WM) performance and associated neurophysiological  ...  Our results demonstrate how individual differences in cognitive performance and electrode montages influence effects of tDCS on neuropsychological performance.  ...  The optimization imposed constraints to the maximum current per electrode (I Max Elec = 1.0 mA) and total injected current (the sum of all the positive currents I Max Total = 2.0 mA).  ... 
doi:10.3389/fnhum.2020.00349 pmid:33100989 pmcid:PMC7506510 fatcat:3xlgu7cd5nfzjavq2lr5qk3ady

Technique and Considerations in the Use of 4x1 Ring High-definition Transcranial Direct Current Stimulation (HD-tDCS)

Mauricio F. Villamar, Magdalena Sarah Volz, Marom Bikson, Abhishek Datta, Alexandre F. DaSilva, Felipe Fregni
2013 Journal of Visualized Experiments  
High-definition transcranial direct current stimulation (HD-tDCS) has recently been developed as a noninvasive brain stimulation approach that increases the accuracy of current delivery to the brain by  ...  M1 stimulation, as well as the considerations to be taken for safe and effective stimulation.  ...  Acknowledgements The authors thank Kayleen Weaver for editorial assistance, Alexandre Venturi for volunteering for this video, Dennis Truong for providing one of the figures used in this article, and the  ... 
doi:10.3791/50309 pmid:23893039 pmcid:PMC3735368 fatcat:7ygko2sg7zek3mkheg5btagcv4

Fundamentals of transcranial electric and magnetic stimulation dose: Definition, selection, and reporting practices

Angel V. Peterchev, Timothy A. Wagner, Pedro C. Miranda, Michael A. Nitsche, Walter Paulus, Sarah H. Lisanby, Alvaro Pascual-Leone, Marom Bikson
2012 Brain Stimulation  
or coil configuration parameters: shape, size, position, and electrical properties, as well as the electrode or coil current (or voltage) waveform parameters: pulse shape, amplitude, width, polarity,  ...  The growing use of transcranial electric and magnetic (EM) brain stimulation in basic research and in clinical applications necessitates a clear understanding of what constitutes the dose of EM stimulation  ...  Electric stimulation-Transcranial electric stimulation involves application of current/ voltage to two or more surface electrodes, with at least one of them placed on the scalp.  ... 
doi:10.1016/j.brs.2011.10.001 pmid:22305345 pmcid:PMC3346863 fatcat:4v3bk42hejanpjlszbqot33zli

Slow-Frequency Pulsed Transcranial Electrical Stimulation for Modulation of Cortical Plasticity Based on Reciprocity Targeting with Precision Electrical Head Modeling

Phan Luu, Easwara Moorthy Essaki Arumugam, Erik Anderson, Amanda Gunn, Dennis Rech, Sergei Turovets, Don M. Tucker
2016 Frontiers in Human Neuroscience  
ACKNOWLEDGMENTS We thank Nick Price for his valuable help in the construction of the individual head models and Yasuhiro Tanaka and Steven Shofner for their support with data acquisition.  ...  Maximum current at any given electrode (1 cm 2 ) was limited to 200 µA.  ...  TABLE 1 | 1 Comparisons of transcranial pulsed current stimulation (tPCS) and transcranial direct current stimulation (tDCS) after-effects as a function of total charge.  ... 
doi:10.3389/fnhum.2016.00377 pmid:27531976 pmcid:PMC4969286 fatcat:6ppgwdrk3bcl5m26tv3hc6w2c4

Unification of optimal targeting methods in Transcranial Electrical Stimulation [article]

Mariano Fernandez Corazza, Sergei Turovets, Carlos Horacio Muravchik
2019 bioRxiv   pre-print
One of the major questions in high-density transcranial electrical stimulation (TES) is: given a region of interest (ROI), and given electric current limits for safety, how much current should be delivered  ...  A more complete optimization problem can be stated as follows: maximize directional dose at ROI, limit dose at non-ROI, and constrain total injected current and current per electrode (safety constraints  ...  Keywords: transcranial electrical stimulation (TES), transcranial direct current stimulation (tDCS), optimal electrical stimulation, reciprocity theorem, least squares.  ... 
doi:10.1101/557090 fatcat:6hewf6utknfsbcpwxbicrmowvy

Transcranial Current Brain Stimulation (tCS): Models and Technologies

Giulio Ruffini, Fabrice Wendling, Isabelle Merlet, Behnam Molaee-Ardekani, Abeye Mekonnen, Ricardo Salvador, Aureli Soria-Frisch, Carles Grau, Stephen Dunne, Pedro C. Miranda
2013 IEEE transactions on neural systems and rehabilitation engineering  
Index Terms-Brain stimulation, electrical stimulation, transcranial alternating current (tACS), transcranial current stimulation (tCS), transcranial direct current (tDCS), transcranial random noise current  ...  These techniques are based on the delivery of weak currents through the scalp (with electrode current intensity to area ratios of about 0.3-5 A/m ) at low frequencies (typically 1kHz) resulting in weak  ...  Stecker extended Rush and Driscoll's analytical solution to electrodes of finite size and investigated the effect of size on the current distribution [33] . Miranda et al.  ... 
doi:10.1109/tnsre.2012.2200046 pmid:22949089 fatcat:2yp4xgtnpzhmrcvff2pcucml6a

Cerebellar Lobules Optimal Stimulation (CLOS): A Computational Pipeline to Optimize Cerebellar Lobule-Specific Electric Field Distribution

Zeynab Rezaee, Anirban Dutta
2019 Frontiers in Neuroscience  
Cerebellar transcranial direct current stimulation (ctDCS) is challenging due to the complexity of the cerebellar structure which is reflected by the well-known variability in ctDCS effects.  ...  Three-way analysis of variance (ANOVA) was used to determine the effects of lobules, montage, and head model on the electric field distribution.  ...  the effects of 15min of anodal ctDCS (current density = 0.526 A/m 2 ; electrode size 5 cm × 5 cm) using Celnik and Manto montage on the response time (RT) and root mean square error (RMSE) during isometric  ... 
doi:10.3389/fnins.2019.00266 pmid:31031578 pmcid:PMC6473058 fatcat:auwzvkoydnbzriiuz4mz3inhki

Unification of optimal targeting methods in transcranial electrical stimulation

Mariano Fernández-Corazza, Sergei Turovets, Carlos Muravchik
2019 NeuroImage  
One of the major questions in high-density transcranial electrical stimulation (TES) is: given a region of interest (ROI) and electric current limits for safety, how much current should be delivered by  ...  An extended optimization problem can be stated as follows: maximize the directional intensity at the ROI, limit the electric fields at the non-ROI, and constrain total injected current and current per  ...  The work of the second author, ST, was supported in part by the National Institute of Mental Health (Grant R44MH106421). Authors acknowledge the helpful discussion with Dr.  ... 
doi:10.1016/j.neuroimage.2019.116403 pmid:31862525 pmcid:PMC7110419 fatcat:cd7icsyztbckhm4wrdmweurrh4

An Optimization Approach for Well-Targeted Transcranial Direct Current Stimulation

Sven Wagner, Martin Burger, Carsten H. Wolters
2016 SIAM Journal on Applied Mathematics  
Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique which modifies neural excitability by providing weak currents through scalp electrodes.  ...  For discretization of the proposed minimization problem the finite element method is employed and the existence of at least one minimizer to the discretized optimization problem is shown.  ...  For current density optimization, a multichannel array consisting of 74 fixed electrode locations (the locations of an extended 10-10 EEG electrode system) is used and optimized applied current patterns  ... 
doi:10.1137/15m1026481 fatcat:e4frq7azf5hhdokfbtuhn4qwwq

Acute Effects of High-Definition Transcranial Direct Current Stimulation on Foot Muscle Strength, Passive Ankle Kinesthesia, and Static Balance: A Pilot Study

Songlin Xiao, Baofeng Wang, Xini Zhang, Junhong Zhou, Weijie Fu
2020 Brain Sciences  
This study aimed to examine the effects of single-session anodal high-definition transcranial direct current stimulation (HD-tDCS) on the strength of intrinsic foot muscles, passive ankle kinesthesia,  ...  Nevertheless, these preliminary findings may provide critical knowledge of optimal stimulation parameters, effect size, and power estimation of HD-tDCS for future trials aiming to confirm and expand the  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/brainsci10040246 pmid:32326228 pmcid:PMC7226500 fatcat:fe6bny3i4nhqzmi5nhh7wllzkm

Development of a Non-invasive Deep Brain Stimulator With Precise Positioning and Real-Time Monitoring of Bioimpedance

Heng Wang, Zhongyan Shi, Weiqian Sun, Jianxu Zhang, Jing Wang, Yue Shi, Ruoshui Yang, Chunlin Li, Duanduan Chen, Jinglong Wu, Guo Gongyao, Yifei Xu
2020 Frontiers in Neuroinformatics  
The function of measuring bioimpedance in real time was integrated into the stimulator to improve effectiveness.  ...  Methods by which to achieve non-invasive deep brain stimulation via temporally interfering with electric fields have been proposed, but the precision of the positioning of the stimulation and the reliability  ...  Transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS) are common non-invasive tools that use weak electric currents to painlessly and non-invasively regulate  ... 
doi:10.3389/fninf.2020.574189 pmid:33363461 pmcid:PMC7753039 fatcat:555i6bubmzgifj7bdp3h7uv6ce

Reduction of intratumoral brain perfusion by noninvasive transcranial electrical stimulation

G. Sprugnoli, L. Monti, L. Lippa, F. Neri, L. Mencarelli, G. Ruffini, R. Salvador, G. Oliveri, B. Batani, D. Momi, A. Cerase, A. Pascual-Leone (+3 others)
2019 Science Advances  
Here, we demonstrate that transcranial electrical stimulation (tES) allows to safely and noninvasively reduce intratumoral perfusion in humans.  ...  All patients completed the study and tolerated the procedure without adverse effects, with tES selectively reducing the perfusion of the solid tumor.  ...  For all patients, the maximum electric field (E-field) value never exceeded 1 of 13 of this threshold level, and no adverse effects were observed.  ... 
doi:10.1126/sciadv.aau9309 pmid:31453319 pmcid:PMC6693907 fatcat:sjwn7hbc7fehppsfasz7sycf2u

Examining the Dorsolateral and Ventromedial Prefrontal Cortex Involvement in the Self-Attention Network: A Randomized, Sham-Controlled, Parallel Group, Double-Blind, and Multichannel HD-tDCS Study

Víctor Martínez-Pérez, Guillermo Campoy, Lucía B. Palmero, Luis J. Fuentes
2020 Frontiers in Neuroscience  
Here we went beyond correlational evidence by manipulating cortical activity using high-definition transcranial direct current stimulation (HD-tDCS), a non-invasive brain stimulation method.  ...  We accomplished to overcome different methodological weaknesses of previous studies using different multichannel montages for excitatory and inhibitory effects over both the VMPFC and the DLPFC.  ...  grants: FPU17/00427 and FPU18/00288), and by the Spanish Society of Experimental Psychology (SEPEX).  ... 
doi:10.3389/fnins.2020.00683 pmid:32760241 pmcid:PMC7371986 fatcat:7zdczbveqzgszavfgcngi4a5bm

Accessibility of cortical regions to focal TES: Dependence on spatial position, safety, and practical constraints

Guilherme Bicalho Saturnino, Hartwig Roman Siebner, Axel Thielscher, Kristoffer Hougaard Madsen
2019 NeuroImage  
Transcranial electric stimulation (TES) can modulate intrinsic neural activity in the brain by injecting weak currents through electrodes attached to the scalp.  ...  However, the conductive proprieties of the human head impose inherent physical limitations on how focal the electric fields in the brain produced by multi-electrode TES can be.  ...  Siebner holds a 5-year professorship in precision medicine at the Faculty of Health Sciences and Medicine, University of Copenhagen which is sponsored by the Lundbeck foundation (Grant Nr.  ... 
doi:10.1016/j.neuroimage.2019.116183 pmid:31525498 fatcat:2hc53ufh3rc5llfpfdsucr25ke
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