Filters








167 Hits in 7.6 sec

Tissue and electrode capacitance reduce neural activation volumes during deep brain stimulation

Christopher R. Butson, Cameron C. McIntyre
2005 Clinical Neurophysiology  
In this study we evaluate the effects of the tissue and electrode capacitance on the volume of tissue activated (VTA) during deep brain stimulation (DBS).  ...  Neural activation volumes are calculated as a function of the stimulation parameters and magnitude of the capacitive components of the electrode-tissue interface.  ...  The purpose of this study was to determine the role of capacitance on the volume of axonal tissue activated with clinically relevant deep brain stimulation parameters.  ... 
doi:10.1016/j.clinph.2005.06.023 pmid:16125463 pmcid:PMC3653320 fatcat:v4qjmyxlerddfalthcn2ryptae

Artificial neural network based characterization of the volume of tissue activated during deep brain stimulation

Ashutosh Chaturvedi, J Luis Luján, Cameron C McIntyre
2013 Journal of Neural Engineering  
The volume of tissue activated (VTA) represents a metric used to estimate the spatial extent of DBS for a given parameter setting.  ...  Clinical deep brain stimulation (DBS) systems can be programmed with thousands of different stimulation parameter combinations (e.g. electrode contact(s), voltage, pulse width, frequency).  ...  Acknowledgments This work was funded by the National Institutes of Health (NIH R01 NS059736).  ... 
doi:10.1088/1741-2560/10/5/056023 pmid:24060691 pmcid:PMC4115460 fatcat:ybajwprklrgjrgmrjoayuszm5a

Role of electrode design on the volume of tissue activated during deep brain stimulation

Christopher R Butson, Cameron C McIntyre
2005 Journal of Neural Engineering  
The fundamental goal of this study was to develop a theoretical understanding of the impact of changes in the DBS electrode contact geometry on the volume of tissue activated (VTA) during stimulation.  ...  Deep brain stimulation (DBS) is an established clinical treatment for a range of neurological disorders.  ...  Acknowledgments This work was supported by grants from the American Parkinson Disease Association, the Ohio Biomedical Research and Technology Transfer Partnership and the National Institutes of Health  ... 
doi:10.1088/1741-2560/3/1/001 pmid:16510937 pmcid:PMC2583360 fatcat:ejnvgd6375ggpiwkas2sfi34ve

Accelerating the computation of the volume of tissue activated during deep brain stimulation using Gaussian processes

Iván De La Pava Panche, Viviana Gómez-Orozco, Mauricio Alexander Álvarez-López, Óscar Alberto Henao-Gallo, Genaro Daza-Santacoloma, Álvaro Ángel Orozco-Gutiérrez
2017 Revista Facultad de Ingeniería  
The volume of tissue activated (VTA) is a well-established approach to model the direct effect of deep brain stimulation (DBS) on neural tissue.  ...  It combines multicompartment axon models coupled to the stimulating electric field with a Gaussian process classifier (GPC), following the premise that computing the VTA from a field of axons is in essence  ...  We would like to thank Hernan Dario Vargas Cardona for providing us the brain conductivity tensors used in this study. 7.  ... 
doi:10.17533/udea.redin.n84a03 fatcat:ic5tyssgczfzpdqs7effgiyipa

The Use of Stimulation Field Models for Deep Brain Stimulation Programming

Christopher R. Butson, Cameron C. McIntyre
2015 Brain Stimulation  
Attention must be paid to the study inclusion criteria, selection of outcome measures, the method of data synthesis and calculation of the effect size. Acknowledgments We would like to thank Drs.  ...  Specifically, we have focused much of our effort on the development of biophysically-based estimators for stimulation spread, or the volume of tissue activated (VTA), which are also known as stimulation  ...  Introduction Computational models of deep brain stimulation (DBS) have proven useful for predicting and visualizing its effects on a patient-specific basis.  ... 
doi:10.1016/j.brs.2015.06.005 pmid:26358487 fatcat:ox4ce7ru2rapjneqfjmywm7rpy

Computational modeling of deep brain stimulation [chapter]

Cameron C. Mcintyre, Thomas J. Foutz
2013 Handbook of Clinical Neurology  
Acknowledgments This work was supported by grants from the National Institutes of Health (R01 NS047388, R01 NS059736). MCINTYRE and FOUTZ Page 6 Handb Clin Neurol.  ...  (C) Overlap of volumes of tissue activated (VTAs) from 163 different stimulation parameter settings. Fig. 5 . 4 . 54 Clinical testing of patient-specific deep brain stimulation (DBS) models.  ...  (B) Model-defined stimulation parameter settings and volume of tissue activated (VTA) (red volume) defined to match the target volume.  ... 
doi:10.1016/b978-0-444-53497-2.00005-x pmid:24112884 pmcid:PMC5570759 fatcat:2rkdvqejyjhnvdqand5y2vsbmm

Neural Selectivity, Efficiency, and Dose Equivalence in Deep Brain Stimulation through Pulse Width Tuning and Segmented Electrodes

Collin J. Anderson, Daria Nesterovich Anderson, Stefan M. Pulst, Christopher R. Butson, Alan D. Dorval
2020 Brain Stimulation  
We analyzed axon activation profiles and calculated volumes of tissue activated.  ...  Further, the precise effects of pulse width tuning are unknown, and recent reports of the effects of pulse width tuning on neural selectivity are at odds with classic biophysical studies.  ...  axon models to quantify neuron response to extracellular stimulation 28 and used these results to compute the volume of tissue activated 16 (VTA) and spread of activation, applying 29 what we recently  ... 
doi:10.1016/j.brs.2020.03.017 pmid:32278715 pmcid:PMC7308191 fatcat:rzmdsmtnx5d4fpsojlpatm4sci

Neuropsychiatric Side Effects of Deep Brain Stimulation in Parkinson's Disease [chapter]

Christine Daniels, Jens Volkmann
2012 Deep Brain Stimulation  
the volume of tissue activated (VTA) during DBS.  ...  The results demonstrate that the estimates of the VTA are consistent with the observations within the desired region of the brain while avoiding side effects and reducing power consumption by 13% on average  ...  Sheng-Tzung Tsai in the Department of Neurosurgery, Division of Functional Neuroscience, at Tzu-Chi General Hospital for helpful discussions and providing clinical data and Prof.  ... 
doi:10.1007/978-3-642-30991-5_15 fatcat:v7wuwaxjjvaxpnutm66ks3efwu

Modeling of a Segmented Electrode for Desynchronizing Deep Brain Stimulation

J. Buhlmann, L. Hofmann, P. A. Tass, C. Hauptmann
2011 Frontiers in Neuroengineering  
We created a finite element model (FEM) of the electrode and analyzed the volume of tissue activated for this electrode design.  ...  Deep brain stimulation (DBS) is an effective therapy for medically refractory movement disorders like Parkinson's disease.  ...  The potential values of the electric field were used to predict the volume of tissue activated (VTA) by applying the methods proposed by Rattay (1986) .  ... 
doi:10.3389/fneng.2011.00015 pmid:22163220 pmcid:PMC3233722 fatcat:xn56u7t7v5dqhbrkwov74xvlfu

Investigating the depth electrode–brain interface in deep brain stimulation using finite element models with graded complexity in structure and solution

Nada Yousif, Xuguang Liu
2009 Journal of Neuroscience Methods  
These finite element models differ in complexity, each highlighting a different feature of the EBI's effect on the DBS induced electric field.  ...  Deep brain stimulation (DBS) is an increasingly used surgical therapy for a range of neurological disorders involving the long-term electrical stimulation of various regions of the human brain in a disorder-specific  ...  Acknowledgments This study was partially supported by a research grant (grant ID 71766) awarded to X Liu, and N Yousif was supported by a research fellowship (grant ID 78512), from the Medical Research Council of  ... 
doi:10.1016/j.jneumeth.2009.07.005 pmid:19596028 pmcid:PMC2754374 fatcat:ckwpt4s6fvfhzg3c3vxxpfwsau

Computational Models of Neuromodulation [chapter]

Christopher R. Butson
2012 International review of neurobiology  
He is a shareholder of Intelect Medical and has authored intellectual property related to computational modeling of DBS and SCS.  ...  A concept that emerged from these studies was the volume of tissue activated (VTA) in the brain during DBS in individual patients (Butson et al., 2007; McIntyre, Mori, Sherman, Thakor, & Vitek, 2004)  ...  One idea that came from these models was the idea of a VTA produced during DBS.  ... 
doi:10.1016/b978-0-12-404706-8.00002-4 pmid:23206676 fatcat:5bh5ak2uwbfedmrjzivtwmzqve

EFFECT OF REALISTIC MODELING OF DEEP BRAIN STIMULATION ON THE PREDICTION OF VOLUME OF ACTIVATED TISSUE

Laleh Golestanirad, Alberto Pradas Izquierdo, Simon J. Graham, Juan Ramon Mosig, Claudio Pollo
2012 Electromagnetic Waves  
We propose a new technique called multi-resolution FEM modeling, which may improve the accuracy of the prediction of volume of activated tissue and yet be computationally tractable on personal computers  ...  Numerous computational models, mostly based on the Finite Element Method (FEM) approach have been suggested to investigate the biophysical mechanisms of electromagnetic wave-tissue interaction during DBS  ...  We also have studied the effect of uncertainties in the actual values of tissue conductivities on the accuracy of predicted activation volume.  ... 
doi:10.2528/pier12013108 fatcat:idiujonparatph34s375rximb4

Quantifying axonal responses in patient-specific models of subthalamic deep brain stimulation

Kabilar Gunalan, Bryan Howell, Cameron C. McIntyre
2018 NeuroImage  
In general, three types of PAMs are used to estimate activation: 1) field-cable (FC) models, 2) driving force (DF) models, and 3) volume of tissue activated (VTA) models.  ...  Medical imaging has played a major role in defining the general anatomical targets for deep brain stimulation (DBS) therapies.  ...  Noecker and Ashutosh Chaturvedi for assistance with the models. This work was supported by the National Institutes of Health (NIH) (R01 NS085188; F32 NS096839).  ... 
doi:10.1016/j.neuroimage.2018.01.015 pmid:29331449 pmcid:PMC5910209 fatcat:vf55rxebnnbzvkoolkkt365gka

Neural Selectivity, Efficiency, and Dose Equivalence in Deep Brain Stimulation through Pulse Width Tuning and Segmented Electrodes [article]

Collin J Anderson, Daria Nesterovich Anderson, Stefan M Pulst, Christopher R. Butson, Alan D Dorval
2019 bioRxiv   pre-print
We analyzed axon activation profiles and calculated volumes of tissue activated.  ...  Achieving deep brain stimulation (DBS) dose equivalence is challenging, especially with pulse width tuning and directional contacts. Further, the precise effects of pulse width tuning are unknown.  ...  Introduction Rigorous efficacy testing of different deep brain stimulation (DBS) parameters requires some notion of stimulation dose equivalence.  ... 
doi:10.1101/613133 fatcat:edymthdomzcuxnx743eihq56ly

Stereotactic neurosurgical planning, recording, and visualization for deep brain stimulation in non-human primates

Svjetlana Miocinovic, Jianyu Zhang, Weidong Xu, Gary S. Russo, Jerrold L. Vitek, Cameron C. McIntyre
2007 Journal of Neuroscience Methods  
activated (VTA) as a function of the stimulation parameters.  ...  Cicerone allows for analysis of co-registered magnetic resonance images (MRI), computed tomography (CT) scans, 3D brain atlases, MER data, and DBS electrode(s) with predictions of the volume of tissue  ...  Acknowledgements This project was supported by the National Institutes of Health (T32 GM07250; R01 NS-37019; R01 NS047388) and the Ohio Biomedical Research and Technology Transfer Partnership.  ... 
doi:10.1016/j.jneumeth.2006.12.007 pmid:17275094 pmcid:PMC2075353 fatcat:54n3xv4pu5bizjlf2f4iajiuuu
« Previous Showing results 1 — 15 out of 167 results