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Analysis of membrane bilayer asymmetry using parinaric acid fluorescent probes
1980
FEBS Letters
Acknowledgements This work was supported in part by USPH grant EY00175 (to E.A.D.) and a Postdoctoral Fellowship from the Helen Hay Whitney Foundation (to L.A.S.). ...
This mixture exhibited a thermal phase separation beginning -5°C higher than a typical preparation of disc phosphatidylcholine [5, 7] . ...
The PnA polarization in a dispersion of the total membrane lipids (not shown) has a temperature range which is midway between the dispersions that are models for the 'outer' and 'inner' layers and does ...
doi:10.1016/0014-5793(80)80245-6
pmid:7418878
fatcat:5jzgoueghna5hkalx7thwl3jzq
Deuteron NMR study of ferroelectric transition in VF2/TrFE copolymer
1991
Ferroelectrics (Print)
A calculation is presented for the deuteron quadrupolar NMR spin-lattice relaxation caused by kink-+bond motions along disordered helical chains in the paraelectric phase. ...
Deuteron NMR results on a 70/30 mole Ri random copolymer of deuterated vinylidene fluoride and normal trifluoroethylene are reviewed, for temperatures on both sides of the ferroelectric-paraelectric phase ...
PVFn, is a polymer which exhibits a strong and commercially important piezoelectric effect. ...
doi:10.1080/00150199108222412
fatcat:evvsonot3fbrfmoioif5qg6vge
Revealing protein structures
2002
Proceedings of the sixth annual international conference on Computational biology - RECOMB '02
A recent idea for determining the three-dimensional structure of a protein uses antibody recognition of surface structure and random peptide libraries to map antibody epitope combining sites. ...
The binding site of an antibody is a surface, not just a linear sequence, so the epitope mapping alignment problem is outside the scope of classical string alignment algorithms, such as Smith-Waterman. ...
Input: A probe string s, a target string t (over a common alphabet), a substitution score matrix M, a distance penalty function d, an objective score Q. ...
doi:10.1145/565196.565226
dblp:conf/recomb/MumeyBD02
fatcat:cazfci4ecnacdj4w37mwlo3rym
NMR structure of a receptor-bound G-protein peptide
1997
Nature
A. Leonard and V. A. Best for technical assistance. ...
determined as described 28 Nature 363 , 363 276-280 (1993) ..................................................................................................................................
Ⅺ 1 . 1 Dratz ...
was without effect on adenosine A 1 or A 2 receptors. ...
doi:10.1038/37165
fatcat:swiaddsuvfbndeps5eqokwruzq
Antibody Imprint of a Membrane Protein Surface
1998
Journal of Biological Chemistry
PHE_5:HE a VAL_10:HG a 2.5 3.5 2. PHE_5:HD a VAL_10:HG a 2.5 3.5 3. PHE_5:HN THR_1:HN 2.5 3.5 4. PHE_5:HD a THR_1:HG a 2.5 3.5 5. PHE_5:HE a THR_1:HG a 2.5 3.5 6. PHE_5:HN THR_1:HG a 2.5 3.5 7. ...
Spectra A and B were collected using a standard two-dimensional NOESY pulse sequence with a watergate solvent suppression and a 300 ms mixing time. ...
Bond, Edward A. Dratz ...
doi:10.1074/jbc.273.38.24847
pmid:9733789
fatcat:jvm7tyt7rzgindgavl5m6t6mry
Proteomic analysis of human epileptic neocortex predicts vascular and glial changes in epileptic regions
2018
PLoS ONE
This study is unique in that for each of these six patients the comparison of protein expression was made within the same patient: a more epileptic region was compared to a less epileptic brain region. ...
A total of 397 protein spots of interest (SOI) were clustered by protein expression patterns across all samples. ...
Writing -original draft: Gal Keren-Aviram, Jeffrey A. Loeb, Edward A. Dratz. Writing -review & editing: Gal Keren-Aviram, Fabien Dachet, Jeffrey A. Loeb, Edward A. ...
doi:10.1371/journal.pone.0195639
pmid:29634780
pmcid:PMC5892923
fatcat:gz3z44lf2jelxnrrpdz42bnyvi
Interpretation of 100- and 360-MHz proton magnetic resonance spectra of retinal rod outer segment disk membranes
1977
Biochemistry
The spectra of both the ROS membranes and bilayer vesicles prepared from purified ROS phospholipids (liposomes) appear to represent a superposition of relatively sharp resonance components and a broad, ...
A. Dratz, unpublished) . ...
A. Dratz, in preparation) . ...
doi:10.1021/bi00631a010
pmid:889780
fatcat:pwghha5rljgctelgnyh35gvmuy
Elevating optimal human nutrition to a central goal of plant breeding and production of plant-based foods
2009
Plant Science
In this way we might circumvent a natural tendency for high yield and low production cost to effectively select against the best human nutrition. ...
However, nutrition is currently not an important driver of most plant breeding efforts, and there are only a few well-known efforts to breed crops that are adapted to the needs of optimal human nutrition ...
Acknowledgments We are grateful for the thoughtful remarks and suggestions of the seven reviewers, the editor, Constance Dratz, and our students, Anne Runkel and Brekke Petersen. ...
doi:10.1016/j.plantsci.2009.07.011
pmid:20467463
pmcid:PMC2866137
fatcat:453burzugnajvbvthtjk7jxshy
A New Method for Mapping Discontinuous Antibody Epitopes to Reveal Structural Features of Proteins
2003
Journal of Computational Biology
This paper presents a new method to align these antibody epitopes to discontinuous regions of the one-dimensional amino acid sequence of a target protein. ...
The binding site of an antibody is a surface, not just a continuous linear sequence, so the epitope mapping alignment problem is outside the scope of classical string alignment algorithms, such as Smith-Waterman ...
(Bailey and Dratz, unpublished) . ...
doi:10.1089/10665270360688183
pmid:12935344
fatcat:pxybraomvze33c3nfqn2pjiyfm
Thermotropic behavior of retinal rod membranes and dispersions of extracted phospholipids
1985
Journal of Membrane Biology
ROS disk membranes were found to exhibit a broad peak of excess heat capacity with a maximum at less than about 3~ ascribable to a gel-to-liquid crystalline phase transition of a fraction of the phosphofipids ...
A similar lhermotropic transition was observed for aqueous dispersions of the total extracted and purified ROS phosphofipids. ...
., 1976; Brown, Deese & Dratz, 1982) . ...
doi:10.1007/bf01872007
pmid:4020856
fatcat:co6w3ntccvfk3expubsvoxjjmm
1H-NMR studies of protein-lipid interactions in retinal rod outer segment disc membranes
1976
FEBS Letters
Dratz, in preparation) indicate that our preparations
contain < 2% by weight cholesterol in total ROS lipids.
North-Holland Publishing Company -Amsterdam ...
Supported by a Fight for Sight Fellowship
** Recent analyses in our laboratory (W. L. Stone and
E. A. ...
doi:10.1016/0014-5793(76)80725-9
pmid:992076
fatcat:bsmyxamdjrgb7dqnw7rlrjym7m
A carboxyl-terminal tail peptide of neutrophil chemotactic receptor disrupts its physical complex with G protein
1993
Journal of Leukocyte Biology
The peptide competition was assayed by dissociation of a GTP-sensitive, rapidly sedimenting (78) form of receptor-G protein compla as analyzed by velocity sedimentation on linear sucrose density gradienta ...
A control peptide, with the reverse sequence, rCTUl ( 336 TATDST(lfSDETLAR' 2 2), did not perturb the sedimentation of the reconstituted receptor-G protein complex up to the highest tested concentration ...
This conversion occurred with a GTP"YS EC 50 of approximately 20 nM and appeared to correlate with a reduction in sedimentation rate of G a and ß"Y subunits [18) . ...
doi:10.1002/jlb.54.6.572
pmid:8245709
fatcat:jfvx2czvqzbm3ohmwuh775jptm
The Quantum Biology of Reactive Oxygen Species Partitioning Impacts Cellular Bioenergetics
2016
Scientific Reports
Here, we present results that reveal a novel domain of quantum biology: the control of the biological production of reactive oxygen species (ROS) via coherent spin dynamics in a radical pair (RP) reaction ...
Either O 2 •− is released from the triplet RP state and escapes into the medium, or a hydroperoxy-flavin transient ...
In the perpendicular orientation, we measured a 36% ± 4 reduction of O 2 •− (p < 0.002) and a 21% ± 5 reduction of H 2 O 2 (p < 0.02). ...
doi:10.1038/srep38543
pmid:27995996
pmcid:PMC5172244
fatcat:j2krsiel4vch7fqzy246mcnf7a
Predicting novel histopathological microlesions in human epileptic brain through transcriptional clustering
2014
Brain
, a marker of epileptic activity, in superficial layers. ...
We developed a method to identify cellular changes in human epileptic neocortex using transcriptional clustering. ...
Using a statistical clustering algorithm, we found a subgroup of the differentially-expressed genes arranged into 11 tight clusters, each predicting a change in a specific cell type. ...
doi:10.1093/brain/awu350
pmid:25516101
pmcid:PMC4306820
fatcat:vnolbmblyvhuhje2btqz4sstra
Retinal rod outer segment lipids form bilayers in the presence and absence of rhodopsin: a31P NMR study
1981
FEBS Letters
A. D. During the preliminary stages of this work, M. F. ...
A. J. D. was supported during part of this work by the US National Institutes of Health (5SO7 RR 07135-10). ...
behaviour'; and 'Rhodopsin, being the predominant membrane protein (>85%, w/w), must play a decisive role in organizing the lipids into a bilayer'. ...
doi:10.1016/0014-5793(81)80061-0
pmid:7215559
fatcat:c7rtzdzqvbhdveyurpqg24ltwu
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