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Educational attainment polygenic scores are associated with cortical total surface area and regions important for language and memory

Brittany L. Mitchell, Gabriel Cuéllar-Partida, Katrina L. Grasby, Adrian I. Campos, Lachlan T. Strike, Liang-Dar Hwang, Aysu Okbay, Paul M. Thompson, Sarah E. Medland, Nicholas G. Martin, Margaret J. Wright, Miguel E. Rentería
2020 NeuroImage  
This study investigates the association between three global (total surface area (TSA), intra-cranial volume (ICV) and average cortical thickness) and 34 regional cortical measures with educational attainment  ...  At the regional level, we identified seven cortical regions-in the frontal and temporal lobes-that showed variation in surface area and average cortical thickness over-and-above the global effect.  ...  We are very grateful to the twins for their generosity of time and willingness to participate in these studies and thank the many research assistants and support staff who helped with data collection and  ... 
doi:10.1016/j.neuroimage.2020.116691 pmid:32126298 fatcat:zj7jcjl3qvfl5b2cjza2kvz3kq

Educational Attainment Polygenic Scores, Socioeconomic Factors, and Cortical Structure in Children and Adolescents [article]

Emily C Merz, Jordan Strack, Hailee Hurtado, Uku Vainik, Michael Thomas, Alan C Evans, Budhachandra Khundrakpam
2021 bioRxiv   pre-print
Genome-wide polygenic scores for educational attainment (PGS-EA) and socioeconomic factors, which are correlated with each other, have been consistently associated with academic achievement and general  ...  The goal of this study was to examine the unique contributions of PGS-EA and parental education to cortical thickness (CT), cortical surface area (SA), and neurocognitive skills in children and adolescents  ...  Acknowledgements Data used in this study are available through the National Institute of Mental Health (NIMH)  ... 
doi:10.1101/2021.09.17.460810 fatcat:rkfligpvdbavhbu5i4wmkvug4m

Polygenic Score of Intelligence is More Predictive of Crystallized than Fluid Performance Among Children [article]

Robert Loughnan, Clare E. Palmer, Wesley K. Thompson, Anders M. Dale, Terry L. Jernigan, Chun C. Fan
2019 bioRxiv   pre-print
I-GPS was significantly related to total cortical surface area (t=5.3, p=1.4x10-7, 0.3% variance explained), but not mean thickness (t=0.25, p=0.8).  ...  Scores on intelligence tests have been reported to correlate significantly with educational, occupational and health outcomes.  ...  Koester for her assistance in developing a theoretical understanding of computational pipelines for general linear mixed effect models.  ... 
doi:10.1101/637512 fatcat:yomnulzrmngtfnxo6ek5p2jfxu

Assessing the impact of environmental factors on the adolescent brain: the importance of regional analyses and genetic controls

Torkel Klingberg, Nicholas Judd, Bruno Sauce
2022 World Psychiatry  
Initially, we found that both EduYears-PGS and SES were positively correlated with total cortical surface area.  ...  The EduYears-PGS, on the other hand, had an additional regional association with cortical surface area in the right parietal lobe.  ... 
doi:10.1002/wps.20934 pmid:35015364 pmcid:PMC8751551 fatcat:7fkuts4kdzfkvckct3mo4kjryi

Genome-wide association analyses of individual differences in quantitatively assessed reading- and language-related skills in up to 34,000 people [article]

Else Eising, Nazanin Mirza-Schreiber, Eveline L de Zeeuw, Carol A Wang, Dongnhu T Truong, Andrea G Allegrini, Chin Yang Shapland, Gu Zhu, Karen G Wigg, Margot Gerritse, Barbara Molz, Gokberk Alagoz (+78 others)
2021 bioRxiv   pre-print
Genetic correlation analysis of multivariate GWAS results with neuroimaging traits identified association with cortical surface area of the banks of the left superior temporal sulcus, a brain region with  ...  We identified a genome-wide significant association with word reading (rs11208009, p=1.098 x 10-8) independent of known loci associated with intelligence or educational attainment.  ...  Both cortical surface area and mean cortical thickness were selected for brain areas that overlapped regions previously related to language processing, based on literature review [53] [54] [55] [56]  ... 
doi:10.1101/2021.11.04.466897 fatcat:zlkwrbchpfeilcn36lx5oicfcm

Discovery Of 42 Genome-Wide Significant Loci Associated With Dyslexia [article]

Catherine Doust, Pierre Fontanillas, Else Eising, Scott D Gordon, Zhengjun Wang, Gökberk Alagoez, Barbara Molz, Beate St Pourcain, Clyde Francks, Riccardo Marioni, Jingjing Zhao, Silvia Paracchini (+15 others)
2021 medRxiv   pre-print
We identified 42 independent genome-wide significant loci: 17 are in genes linked to or pleiotropic with cognitive ability/educational attainment; 25 are novel and may be more specifically associated with  ...  Reading and writing are crucial for many aspects of modern life but up to 1 in 10 children are affected by dyslexia, which can persist into adulthood.  ...  ACKNOWLEDGEMENTS We thank the research participants and employees of 23andMe Inc, the GenLang Consortium, the Brisbane Adults Reading Study, and the Chinese Reading Study. The following members of the  ... 
doi:10.1101/2021.08.20.21262334 fatcat:riiuc2covzeqvno6wzvrusrule

Genes, Cells and Brain Areas of Intelligence

Natalia A. Goriounova, Huibert D. Mansvelder
2019 Frontiers in Human Neuroscience  
areas involved in intelligence, while genetic associations studies aim to pinpoint genes and genetic loci associated with intelligence.  ...  Finally, we highlight how specific genes that have been identified generate cellular properties associated with intelligence and may ultimately explain structure and function of the brain areas involved  ...  Thus, overall bigger brain volume, when analyzed across multiple studies, is associated with higher intelligence. Which Brain Areas Are Important for Intelligence?  ... 
doi:10.3389/fnhum.2019.00044 pmid:30828294 pmcid:PMC6384251 fatcat:uqwpuvi6anf57hog6q6l6gnlwm

Distinct Regionalization Patterns of Cortical Morphology are Associated with Cognitive Performance Across Different Domains

C E Palmer, W Zhao, R Loughnan, J Zou, C C Fan, W K Thompson, A M Dale, T L Jernigan
2021 Cerebral Cortex  
Here, we show that a distributed configuration of cortical surface area and apparent thickness, when controlling for global imaging measures, is differentially associated with cognitive performance on  ...  be important for improving quality of life.  ...  Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL); Psychiatric Genomics Consortium (PGC).  ... 
doi:10.1093/cercor/bhab054 pmid:33825852 pmcid:PMC8258441 fatcat:xdk7jzhmxffinivf7auppj6krq

Genetic Burden for Late-Life Neurodegenerative Disease and Its Association With Early-Life Lipids, Brain, Behavior, and Cognition

Sander Lamballais, Ryan L. Muetzel, Mohammad Arfan Ikram, Henning Tiemeier, Meike W. Vernooij, Tonya White, Hieab H. H. Adams
2020 Frontiers in Psychiatry  
We did not find evidence that APOE genotype or the polygenic scores impact on childhood nonverbal intelligence, educational attainment, internalizing behavior, and global brain structural measures including  ...  Previous studies have shown evidence for plausible links of apolipoprotein E (APOE), the most important genetic marker for Alzheimer's disease, with early-life cognition and neuroimaging markers.  ...  All authors contributed to manuscript revision, and read and approved the submitted version. All authors agree to be accountable for all of the published work.  ... 
doi:10.3389/fpsyt.2020.00033 pmid:32116848 pmcid:PMC7018686 fatcat:6n6xqtau2fcilnaj4hc6rz2xxa

Probing Brain Developmental Patterns of Myelination and Associations With Psychopathology in Youths Using Gray/White Matter Contrast

Linn B. Norbom, Nhat Trung Doan, Dag Alnæs, Tobias Kaufmann, Torgeir Moberget, Jaroslav Rokicki, Ole A. Andreassen, Lars T. Westlye, Christian K. Tamnes
2019 Biological Psychiatry  
Cerebral myeloarchitecture shows substantial development across childhood and adolescence, and aberrations in these trajectories are relevant for a range of mental disorders.  ...  Differential myelination between intracortical and subjacent white matter can be approximated using signal intensities in T1-weighted magnetic resonance imaging.  ...  There were no association with polygenic scores for neuroticism and any of the multimodal components.  ... 
doi:10.1016/j.biopsych.2018.09.027 pmid:30447910 fatcat:jrm2wgixvnc4xfsgufrhqdffry

Cognitive genomics: Searching for the genetic roots of neuropsychological functioning

Carrie E. Bearden, David C. Glahn
2017 Neuropsychology  
With the complete mapping of the human genome, genome-wide association studies (GWAS) for many complex traits have proliferated; however, the highly polygenic nature of intelligence has made the identification  ...  Increasingly sophisticated analytic tools and ever-larger sample sizes are now facilitating the identification of specific genetic and molecular underpinnings of cognitive abilities, leading to optimism  ...  Jennifer Forsyth for insightful and very helpful feedback on the manuscript draft. This work was supported in part by NIH grants R01MH085953 and U54EB020403.  ... 
doi:10.1037/neu0000412 pmid:29376674 pmcid:PMC5791763 fatcat:lqlgi5nb6vaydjpotd2sgfzhgi

Intelligence as a Developing Function: A Neuroconstructivist Approach

Luca Rinaldi, Annette Karmiloff-Smith
2017 Journal of Intelligence  
Viewing intelligence as a dynamic concept, indeed, implies the need to identify full developmental trajectories, to assess how genes, brain, cognition, and environment interact with each other.  ...  These tendencies, however, are biased by the still limited number of empirical reports taking a developmental perspective on intelligence.  ...  The authors would like to thank Professor Luisa Girelli, Professor Viola Macchi Cassia and four anonymous reviewers for their thoughtful comments and suggestions.  ... 
doi:10.3390/jintelligence5020018 pmid:31162409 pmcid:PMC6526422 fatcat:wuqmdxjjvjdufhua6iabpqeeha

Neurogenetic basis of personality [article]

Sofie Louise Valk, Felix Hoffstaedter, Julia Camilleri, Peter Kochunov, B.T. Thomas Yeo, Simon B. Eickhoff
2019 bioRxiv   pre-print
Quantitative functional decoding indicated regions associated with personality are implicated in (socio-)cognitive and language processing.  ...  Personality traits are influenced by genetic and environmental factors and are related to mental health.  ...  Average surface area sum per parcel and the distribution of 428 total surface area across participants; D) Regional associations between surface area and 429 personality traits.  ... 
doi:10.1101/645945 fatcat:ucri3ahun5bannmjby3qmzhrbi

Early life course processes leading to educational and economic attainment in young adulthood: Contributions of early socioeconomic adversity and education polygenic score

Kandauda A. S. Wickrama, Catherine Walker OˋNeal, Tae Kyoung Lee, Seonhwa Lee, Daniel Romer
2021 PLoS ONE  
from early socioeconomic adversity and education polygenic score (education PGS) as well as potential interactions between them (GxE), which contribute to subsequent young adult socioeconomic outcomes  ...  Additionally, the independent, varying associations among social and genetic predictors, life-stage specific educational outcomes (educational achievement in adolescence and educational attainment, in  ...  , with cooperative funding from 23 other federal agencies and foundations.  ... 
doi:10.1371/journal.pone.0256967 pmid:34634049 pmcid:PMC8504765 fatcat:svkm3spjr5fqhlswxlqp522cqy

Insights into Dyslexia Genetics Research from the Last Two Decades

Florina Erbeli, Marianne Rice, Silvia Paracchini
2021 Brain Sciences  
First, we will briefly outline the clinical and educational presentation and epidemiology of dyslexia.  ...  implicated in many other neurodevelopmental disorders (e.g., developmental language disorder and dyscalculia).  ...  The study also found a correlation between genetics contributing to individual differences in the five measures and cortical surface areas known to process language functions.  ... 
doi:10.3390/brainsci12010027 pmid:35053771 pmcid:PMC8773624 fatcat:fhezlcimyvbn3ggr32tkaopae4
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