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Editorial: Complexity in genomes
2014
Computational biology and chemistry
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The C in "low complexity" (e.g. Wootton and Federhen, 1993) regions and the C in "more complex" genomes (e.g. ...
In the literature, the term complexity (C) in genomes is used with several meanings. Some people use the number of genes in a genome to measure its complexity (Hahn and Wray, 2002) . ...
doi:10.1016/j.compbiolchem.2014.08.003
pmid:25239778
fatcat:qakbbg2xdjd3pgyxaihi4hhe7u
Editorial [Hot Topic: Genetics Dissection of Complex Traits in the Genomic Era (Guest Editor: Bernardo Ordas)]
2012
Current Genomics
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EDITORIAL Genetics Dissection of Complex Traits in the Genomic Era There is a renewed interest for Quantitative genetics since the genomic revolution. ...
This is in agreement with the principles of genomic selection, although the success of prediction methods for complex diseases will be limited by the disease prevalence and the heritability. ...
doi:10.2174/138920212800543075
pmid:23115519
pmcid:PMC3382272
fatcat:hjzwxlpoenekrfd4pkatiryngq
Genetic pleiotropy in complex traits and diseases: implications for genomic medicine
2016
Genome Medicine
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Editorial summary Several recent papers have used summary results from genome-wide association studies to characterize genetic overlap between human complex traits and common diseases. ...
Here, we review key advances from these papers that enable more in-depth investigations of pleiotropy, and we discuss their implications for genomic medicine. ...
Acknowledgements We thank members of the Center for Neurogenetics and Statistical Genomics at the University of Queensland for helpful discussions. ...
doi:10.1186/s13073-016-0332-x
pmid:27435222
pmcid:PMC4952057
fatcat:2vrcjgxd6bbyplnawcjhz4qeeu
Genomic Diversity of the Major Histocompatibility Complex in Health and Disease
2019
Cells
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The human Major Histocompatibility Complex (MHC) genes are part of the supra‐locus onchromosome 6p21 known as the human leukocyte antigen (HLA) system [...] ...
office, and especially Daniela Zhang for her friendly and accommodating editorial assistance. ...
Acknowledgments: We thank all the authors, reviewers, editors and assistant editors for their efforts and timely submissions and patience during the review process for this Special Issue, the staff of Cells' editorial ...
doi:10.3390/cells8101270
pmid:31627481
pmcid:PMC6830316
fatcat:pqwz5xjrxbhzrm6db4domd2blu
Dimensional phenotypes in psychiatric genetics: lessons from genome-wide association studies of alcohol use phenotypes
2021
Complex Psychiatry
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Over the past decade, genome-wide association studies (GWASs) have proved to be useful tools for advancing our knowledge of genetic influences on complex traits like AUD. ...
Conflict of Interest Statement SSR is an editorial board member for Complex Psychiatry but has no other conflicts of interest to declare. TTM has no conflicts of interest to declare. ...
doi:10.1159/000518863
pmid:35083441
pmcid:PMC8739983
fatcat:drggt4lqofgifnviq4nymtnv4y
Synaptic dysfunction in complex psychiatric disorders: from genetics to mechanisms
2018
Genome Medicine
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Dysregulated synaptic development, properties, and plasticity have been hypothesized to underlie altered neuronal function in complex neuropsychiatric disorders, such as schizophrenia (SCZ) and autism ...
Editorial summary Breakthroughs on many fronts have provided strong evidence to support synaptic dysfunction as a causal factor for neuropsychiatric diseases. ...
Abbreviations ASD: Autism spectrum disorder; GWAS: Genome-wide association study; iPSC: Induced pluripotent stem cell; MHC: Major histocompatibility complex; PDE: Phosphodiesterase; SCZ: Schizophrenia; ...
doi:10.1186/s13073-018-0518-5
pmid:29386063
pmcid:PMC5793422
fatcat:r4mvb2a73nbu7pgrd4xrmoyhra
The Validity of Brief Phenotyping in Population Biobanks for Psychiatric Genome-Wide Association Studies on the Biobank Scale
2021
Complex Psychiatry
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Conflict of Interest Statement J.R.I.C. is an editorial board member for Complex Psychiatry but has no other conflicts of interest to declare. ...
Some such phenotyping has been achieved through medical record linkage, which has numerous complexities beyond the scope of this editorial [21, 22] . ...
In this editorial, I will discuss some of these challenges with a particular focus on the use of brief phenotyping measures. ...
doi:10.1159/000516837
pmid:34883499
pmcid:PMC8443942
fatcat:glwcsjlxzzb4bjf5be4apxj5be
Systematic analysis of essential yeast TAFs in genome-wide transcription and preinitiation complex assembly
2003
EMBO Journal
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This work was supported in part by grants from the NIH (M.R.G.) and the Leukemia and Lymphoma Society (W.-C.S.). ...
Acknowledgements We thank P.Anthony Weil for the anti-TAF antibodies; Lynne Apone for helpful discussions; Jin Wang and Lynn Jones for technical assistance; and Sara Evans for editorial assistance. ...
complex (PIC). ...
doi:10.1093/emboj/cdg336
pmid:12840001
pmcid:PMC165660
fatcat:akwhtk4n3zeitdza466prl73cy
Purine-rich low complexity regions are potential RNA binding hubs in the human genome
2019
F1000Research
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The universal TTSs were enriched with the purine-rich low complexity regions. Nowadays, the role of the chromatin bound RNAs in the formation of 3D chromatin structure is actively discussed. ...
While the universal TTSs were quite rare in the human genome (around 0.5%), they were more frequent (>15%) among the MEG3 binding sites (ChOP-seq peaks) and especially among the shared Capture-seq peaks ...
We have updated the title of the article to: 'Purine-rich low complexity regions are potential RNA binding hubs in the human genome'. ...
doi:10.12688/f1000research.13522.2
fatcat:ezu67fhiuva6nalccpuhih7zmq
Ethical implications of array comparative genomic hybridization in complex phenotypes: points to consider in research
2007
Genetics in Medicine
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These considerations are especially important in the use of array comparative genome hybridization to study complex and common traits. ...
We examined recent publications on autism as an example of the application of array comparative genome hybridization to a complex phenotype. ...
ACKNOWLEDGMENTS The authors were supported by Grant P50HG003389 from the National Human Genome Research Institute. ...
doi:10.1097/gim.0b013e3181485688
pmid:17873651
pmcid:PMC2220022
fatcat:y7rkcmbysbf35l3trvivntufhq
Eleven Densely Clustered Genes, Six of them Novel, in 176 kb of Mouse t-complex DNA
2000
Genome Research
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Finally, we thank Serafino Pantano for the use of his Tce1 Northern blot data, Shoshana Stern for assistance in the analysis, and Kristen Keener for editorial consultation. ...
The publication costs of this article were defrayed in part by payment of page charges. ...
About 1% of the mouse genome is included in the t-complex region of chromosome 17, which is known to encode genes involved in embryonic development, distortion of male transmission ratio, male sterility ...
doi:10.1101/gr.10.7.916
pmid:10899141
pmcid:PMC310918
fatcat:rzogdhmk4fanfm4xa7lflec2uy
Modeling the genetic complexity of Parkinson's disease by targeted genome edition in iPS cells
2017
Current Opinion in Genetics and Development
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Division of the subject into sections The subject of Genetics and Development is divided into six themed sections, each of which is reviewed once a year: • Cancer Genomics • Genome Architecture and Expression ...
The Editorial Board provides support to the Editors and the Section Editors with their comments and suggestions on names and topics. ...
In order to ensure that your video or animation material is directly usable, please provide the file in one of our recommended file formats with a preferred maximum size of 150 MB per file, 1 GB in total ...
doi:10.1016/j.gde.2017.06.002
pmid:28759872
fatcat:jvshgo2u4rbdrnmv6spks52d3e
CellWalker integrates single-cell and bulk data to resolve regulatory elements across cell types in complex tissues
2021
Genome Biology
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Single-cell and bulk genomics assays have complementary strengths and weaknesses, and alone neither strategy can fully capture regulatory elements across the diversity of cells in complex tissues. ...
noisy scATAC-seq and annotates cell type-specific regulatory elements in bulk data. ...
We were able to define cell types in a complex tissue and annotate genomic loci with the cell types in which they are active. ...
doi:10.1186/s13059-021-02279-1
pmid:33583425
pmcid:PMC7883575
fatcat:gfznxmk52zfhnoagecztt3f4gu
Debutant iOS app and gene-disease complexities in clinical genomics and precision medicine
2019
Clinical and Translational Medicine
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This tool with accelerate users' abilities to understand the genetic basis of human complex diseases and by assimilating genomic and phenotypic data will support future work to identify gene-specific designer ...
Adopting NGS with Whole-Genome and RNA sequencing in a diagnostic context has the potential to improve disease-risk detection in support of precision medicine and drug discovery. ...
Christopher Bonin for providing editorial support. We are grateful to the Ahmed lab at UConn Health, School of Medicine, Department of Genetics and Genome Sciences. We thank The Jackson Labora- ...
doi:10.1186/s40169-019-0243-8
pmid:31586224
pmcid:PMC6778157
fatcat:exkuwafqvballajb4zwhbbnjii
Genomic Complexity of the Variable Region-Containing Chitin-Binding Proteins in Amphioxus
2008
BMC Genetics
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In this report, we describe VCBP genomic organization and characterize adjacent and intervening genetic features which may influence both their polymorphism and complex transcriptional repertoire. ...
In at least one haplotype, inverted repeats occur more frequently than elsewhere in the genome. ...
Acknowledgements We would like to thank, Robert Hubley for informatics support running the RepeatModeler and RepeatMasker software on the amphioxus genome; Barbara Pryor for editorial assistance; Bruce ...
doi:10.1186/1471-2156-9-78
pmid:19046437
pmcid:PMC2632668
fatcat:xpvhy7i7k5bnpj2lbo5bpkptdu
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