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ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide

Paul M. Thompson, Ole A. Andreassen, Alejandro Arias-Vasquez, Carrie E. Bearden, Premika S. Boedhoe, Rachel M. Brouwer, Randy L. Buckner, Jan K. Buitelaar, Kazima B. Bulayeva, Dara M. Cannon, Ronald A. Cohen, Patricia J. Conrod (+59 others)
2017 NeuroImage  
The ENIGMA consortium is discovering factors that consistently affect brain structure and function that will serve as future predictors linking individual brain scans and genomic data.  ...  In some of the largest neuroimaging studies to date - of schizophrenia and major depression - ENIGMA has found replicable disease effects on the brain that are consistent worldwide, as well as factors  ...  Funding for individual consortium authors is listed in Hibar et al., Nature, 2015 and in other papers cited here.  ... 
doi:10.1016/j.neuroimage.2015.11.057 pmid:26658930 pmcid:PMC4893347 fatcat:abs5uh3dmba2ze646vluqdujtu

ENIGMA-Sleep: Challenges, opportunities, and the road map

Masoud Tahmasian, André Aleman, Ole A Andreassen, Zahra Arab, Marion Baillet, Francesco Benedetti, Tom Bresser, Joanna Bright, Michael W L Chee, Daphne Chylinski, Wei Cheng, Michele Deantoni (+65 others)
2021 Journal of Sleep Research  
Recently, we have launched the ENIGMA-Sleep working group with the collaboration of several institutes from 15 countries to perform large-scale worldwide neuroimaging and genetics studies for better understanding  ...  In this introductory review, we describe the details of our currently available datasets and our ongoing projects in the ENIGMA-Sleep group, and discuss both the potential challenges and opportunities  ...  | ENI G MA CON SORTI UM The ENIGMA consortium is a worldwide collaboration of more than 1,400 scientists from more than 200 institutes, across 45 countries, which was started in 2009 and to date have  ... 
doi:10.1111/jsr.13347 pmid:33913199 pmcid:PMC8803276 fatcat:zt3a456gozehznnydp5jf3yuiu

ENIGMA and Global Neuroscience: A Decade of Large-Scale Studies of the Brain in Health and Disease Across More Than 40 Countries

Paul Thompson
2020 Biological Psychiatry  
the human brain in health and disease.  ...  Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide  ...  Acknowledgements The work reported here was supported in part by many public and private agencies across the world. Individual authors' funding is listed in Supplementary Appendix B.  ... 
doi:10.1016/j.biopsych.2020.02.167 fatcat:rcamgpjlcvfgzikfleqbunef3u

The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data

Paul M. Thompson, Jason L. Stein, Sarah E. Medland, Derrek P. Hibar, Alejandro Arias Vasquez, Miguel E. Renteria, Roberto Toro, Neda Jahanshad, Gunter Schumann, Barbara Franke, Margaret J. Wright, Nicholas G. Martin (+277 others)
2014 Brain Imaging and Behavior  
results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging  ...  In fact, most projects study factors that might influence how these disorders affect the brain-medications, geographic factors, and the age and gender of the patient.  ... 
doi:10.1007/s11682-013-9269-5 pmid:24399358 pmcid:PMC4008818 fatcat:ujnpcizkpfdaxg6egpb43sskai

Cortical and Subcortical Brain Morphometry Differences Between Patients With Autism Spectrum Disorder and Healthy Individuals Across the Lifespan: Results From the ENIGMA ASD Working Group

Daan van Rooij, Evdokia Anagnostou, Celso Arango, Guillaume Auzias, Marlene Behrmann, Geraldo F. Busatto, Sara Calderoni, Eileen Daly, Christine Deruelle, Adriana Di Martino, Ilan Dinstein, Fabio Luis Souza Duran (+33 others)
2018 American Journal of Psychiatry  
The authors investigated brain morphometry differences between individuals with ASD and healthy subjects, cross-sectionally across the lifespan, in a large multinational sample from the Enhancing Neuroimaging  ...  Neuroimaging studies show structural differences in both cortical and subcortical brain regions in children and adults with autism spectrum disorder (ASD) compared with healthy subjects.  ...  De Martino is a coauthor of the Italian version of the Social Responsiveness Scale, for which she may receive royalties. Dr. Rubia has received speaking honoraria from Eli Lilly, Medice, and Shire.  ... 
doi:10.1176/appi.ajp.2017.17010100 pmid:29145754 pmcid:PMC6546164 fatcat:5o4jml5hnngnvocjvkblnct4oi

ENIGMA-Viewer

Guohao Zhang, Peter Kochunov, Elliot Hong, Neda Jahanshad, Paul Thompson, Jian Chen
2016 Proceedings of the 7th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics - BCB '16  
Global scale brain research collaborations such as the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) consortium are beginning to collect data in large quantity and to conduct meta-analyses  ...  a common framework though which results can be compared, and combined through unbiased meta-analyses as performed in the ENIGMA (Enhancing  ...  Availability of data and materials The ENIGMA-Viewer program and datasets analyzed during the current study are available in the NITRC repository http://www.nitrc.org/projects/ enigmaviewer_20 and can  ... 
doi:10.1145/2975167.2985689 dblp:conf/bcb/ZhangKHJTC16 fatcat:lbcis47mvzarjgqzenykrfqvuy

ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries

Paul M. Thompson, for the ENIGMA Consortium, Neda Jahanshad, Christopher R. K. Ching, Lauren E. Salminen, Sophia I. Thomopoulos, Joanna Bright, Bernhard T. Baune, Sara Bertolín, Janita Bralten, Willem B. Bruin, Robin Bülow (+159 others)
2020 Translational Psychiatry  
the human brain in health and disease.  ...  Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide  ...  Acknowledgements The work reported here was supported in part by many public and private agencies across the world. Individual authors' funding is listed in Supplementary Appendix B.  ... 
doi:10.1038/s41398-020-0705-1 pmid:32198361 pmcid:PMC7083923 fatcat:b4oftx6e3rg7vhwcuhnjcab7pa

Emerging Global Initiatives in Neurogenetics: The Enhancing Neuroimaging Genetics through Meta-analysis (ENIGMA) Consortium

Carrie E. Bearden, Paul M. Thompson
2017 Neuron  
The Enhancing Neuroimaging Genetics through Meta-analysis (ENIGMA) Consortium is a global team science effort, now including over 800 scientists spread across 340 institutions in 35 countries, with the  ...  shared goal of understanding disease and genetic influences on the brain.  ...  Acknowledgments We thank Agnes McMahon for assistance in figure preparation and all ENIGMA participants worldwide for all their contributions.  ... 
doi:10.1016/j.neuron.2017.03.033 pmid:28426957 pmcid:PMC5918136 fatcat:mu77intw2vgexeir4trkidwkxy

Hippocampal subfield volumes are uniquely affected in PTSD and depression: International analysis of 31 cohorts from the PGC-ENIGMA PTSD Working Group [article]

Lauren E. Salminen, Philipp G. Sämann, Yuanchao Zheng, Emily L. Dennis, Emily K. Clarke, Neda Jahanshad, Juan E. Iglesias, Christopher D. Whelan, Steven E. Bruce, Jasmeet P. Hayes, Soraya Seedat, Christopher L. Averill (+106 others)
2019 bioRxiv   pre-print
However, the hippocampus is heterogeneous, with subregions that may be uniquely affected in individuals with PTSD and depression.  ...  Collectively our results suggest that depression is a stronger predictor of hippocampal volumetry than PTSD, particularly in the CA1, and provide compelling evidence of distinct and more pronounced hippocampal  ...  The mechanisms that underlie this discrepancy likely result from complex individual differences in genetic, environmental, and biopsychosocial factors that differentially influence PTSD susceptibility  ... 
doi:10.1101/739094 fatcat:ui2vauk2vzbonn4gj3zrxxfbd4

ENIGMA MDD: seven years of global neuroimaging studies of major depression through worldwide data sharing

Lianne Schmaal, Elena Pozzi, Tiffany C. Ho, Laura S. van Velzen, Ilya M. Veer, Nils Opel, Eus J. W. Van Someren, Laura K. M. Han, Lybomir Aftanas, André Aleman, Bernhard T. Baune, Klaus Berger (+66 others)
2020 Translational Psychiatry  
The primary aim of ENIGMA MDD is to identify structural and functional brain alterations associated with MDD that can be reliably detected and replicated across cohorts worldwide.  ...  , and predicting who might benefit most from treatments that target specific brain mechanisms.  ...  Acknowledgements ENIGMA MDD work is supported by NIH grants U54 EB020403 (Thompson), R01 MH116147 (Thompson), and R01 MH117601 (Jahanshad & Schmaal)  ... 
doi:10.1038/s41398-020-0842-6 pmid:32472038 pmcid:PMC7260219 fatcat:vayt4cozyzg6tkd7nm2fqeys6u

Novel Neuroimaging Methods to Understand How HIV Affects the Brain

Paul M. Thompson, Neda Jahanshad
2015 Current HIV/AIDS Reports  
Here we review recent developments in brain imaging that reveal how the virus affects the brain.  ...  There is also interest in discovering factors that promote resilience to HIV, and combat its adverse effects in children.  ...  The last 3 years have seen the automatic computation of brain measures on a previously unimaginable scale -the ENIGMA consortium, for example, screened 30,000 brain MRI scans from people in 33 countries  ... 
doi:10.1007/s11904-015-0268-6 pmid:25902966 pmcid:PMC4433315 fatcat:f457wkwagzaxhev6tfq4yy4mni

Brain Aging in Major Depressive Disorder: Results from the ENIGMA Major Depressive Disorder working group [article]

Laura KM Han, Richard Dinga, Tim Hahn, Christopher Ching, Lisa Eyler, Lyubomir Aftanas, Moji Aghajani, Andre Aleman, Bernhard Baune, Klaus Berger, Ivan Brak, Geraldo Busatto Filho (+134 others)
2019 bioRxiv   pre-print
measures separately in 1,147 male and 1,386 female controls from the ENIGMA MDD working group.  ...  The difference between predicted brain age and chronological age was calculated to indicate brain predicted age difference (brain-PAD).  ...  4.0 years 345 versus no significant difference. 6,26 The current study is the first to examine brain aging in over 8,000 346 individuals from the ENIGMA MDD consortium (29 cohorts, 11 countries worldwide  ... 
doi:10.1101/560623 fatcat:6nooqv7gqzg6jekz4q33w6jeh4

Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group

Laura K. M. Han, Richard Dinga, Tim Hahn, Christopher R. K. Ching, Lisa T. Eyler, Lyubomir Aftanas, Moji Aghajani, André Aleman, Bernhard T. Baune, Klaus Berger, Ivan Brak, Geraldo Busatto Filho (+134 others)
2020 Molecular Psychiatry  
separately in 952 male and 1236 female controls from the ENIGMA MDD working group.  ...  The difference between predicted "brain age" and chronological age was calculated to indicate brain-predicted age difference (brain-PAD).  ...  The current study is the first to examine brain aging in over 6900 individuals from the ENIGMA MDD consortium (19 cohorts, 8 countries worldwide), covering almost the entire adult lifespan (18-75 years  ... 
doi:10.1038/s41380-020-0754-0 pmid:32424236 pmcid:PMC8589647 fatcat:7egb6u2nrvbpdoi2h4yhxw4b7m

Non-lesioned subcortical brain volumes are associated with post-stroke sensorimotor behavior across 28 cohorts worldwide: An ENIGMA Stroke Recovery study [article]

Sook-Lei Liew, Artemis Zavaliangos-Petropulu, Nicolas Schweighofer, Neda Jahanshad, Catherine E Lang, Keith R Lohse, Nerisa Banaj, Giuseppe Barisano, Lee A Baugh, Anup K Bhattacharya, Bavrina Bigjahan, Michael R Borich (+58 others)
2020 bioRxiv   pre-print
Methods: We pooled high-resolution T1-weighted MRI brain scans and behavioral data in 828 individuals with unilateral stroke from 28 cohorts worldwide (age: median 63, interquartile range 19 years; 516  ...  Recovery relies on the integrity of spared brain areas to compensate for damaged tissue. Subcortical regions play critical roles in the control and regulation of sensorimotor circuits.  ...  ACKNOWLEDGEMENTS We thank all of the members of the ENIGMA Stroke Recovery working group, all of the participants, as well as Sophia Thomopolous and Bethany Lo for their assistance.  ... 
doi:10.1101/2020.11.04.366856 fatcat:fgwsjzecenhylfgyydlmtvh3je

ENIGMA-Viewer: interactive visualization strategies for conveying effect sizes in meta-analysis

Guohao Zhang, Peter Kochunov, Elliot Hong, Sinead Kelly, Christopher Whelan, Neda Jahanshad, Paul Thompson, Jian Chen
2017 BMC Bioinformatics  
Abstract Background: Global scale brain research collaborations such as the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) consortium are beginning to collect data in large quantity and  ...  a common framework though which results can be compared, and combined through unbiased meta-analyses as performed in the ENIGMA (Enhancing  ...  Availability of data and materials The ENIGMA-Viewer program and datasets analyzed during the current study are available in the NITRC repository http://www.nitrc.org/projects/ enigmaviewer_20 and can  ... 
doi:10.1186/s12859-017-1634-8 pmid:28617224 pmcid:PMC5471941 fatcat:ptoabpt2trhizhjlgzbt32ov5u
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