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Regulation of cell migration by amphoterin

C Fages, R Nolo, H J Huttunen, E Eskelinen, H Rauvala
2000 Journal of Cell Science  
INTRODUCTION Amphoterin (p30) is a developmentally regulated heparinbinding protein that is abundantly expressed in embryonic brain and in transformed cell lines (Rauvala and Pihlaskari, 1987; Rauvala  ...  Extracellular roles in neurite outgrowth, in neuron-glia interactions and in early phases of cell differentiation have been suggested for amphoterin (Rauvala and Pihlaskari, 1987; Rauvala et al., 1988  ... 
pmid:10652254 fatcat:qfamd3764rgkhkf3snt6vl5m5a

AMIGO is an auxiliary subunit of the Kv2.1 potassium channel

Marjaana A Peltola, Juha Kuja-Panula, Sari E Lauri, Tomi Taira, Heikki Rauvala
2011 EMBO Reports  
doi:10.1038/embor.2011.204 pmid:22056818 pmcid:PMC3245694 fatcat:obv76mz5tndtzng6desjzbk5wi

Circumferential measurement of thoracic wall using a standard respiratory belt

E. Rauvala, L. Jyrkinen, A. Koivula, K. Suominen, O. Tervonen
1996 Journal of digital imaging  
Respiratory gating during imaging to reduce imaging artifacts involves the gathering of image data only at the end of the respiratory cycle. This is commonly performed by a pneumatic respiratory belt to monitor thoracic wall motion during respiration. Such gating has been used for magnetic resonance, computerized tomographic, and nuclear medicine imaging. The goal of this study was to measure the performance of a standard belt used for gating imaging studies. The standard respiratory belt
more » ... provided with the Magnetom 42 SP MRI scanner (Siemens AG, Erlangen, Germany) was selected. The belt was connected to a microcontroller-based pressure measurement unit that was connected to the standard RS-232C serial port of a computer. The signal was compared with that of a strain gauge respiration transducer. The response of the system was tested in vitro both for isometric and isotonic Ioading. The data measured from the pneumatic belt was linear with different weights of 50 to 1,400 grams with a coefficient of determination (R 2) of 0.999. The system was linear for different amounts of stretching (R 2 of 0.998) within the first 45 mm, which is enough for normal breathing. In vivo the pneumatic system seemed more accurate in measuring the constant stretching in apnea than the strain gauge respiratory belt. The results show that it is possible to use a standard pneumatic belt for accurate measurement of thoracic wall movement during imaging and for other purposes as well.
doi:10.1007/bf03168860 pmid:8734577 fatcat:32hev3lsx5crzp4ga4cbvisezy

Fast Network Oscillations in the Newborn Rat HippocampusIn Vitro

J. Matias Palva, Karri Lamsa, Sari E. Lauri, Heikki Rauvala, Kai Kaila, Tomi Taira
2000 Journal of Neuroscience  
deviation of E GABA-A from a calculated E C l-; Kaila 1994) .  ...  (E-mail: jpalva@cc.hut.fi).  ... 
doi:10.1523/jneurosci.20-03-01170.2000 pmid:10648721 fatcat:dlscgr7kerdlzc4yaen3jc24hm

Reproducibility of imaging human knee cartilage by delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) at 1.5 Tesla

J. Multanen, E. Rauvala, E. Lammentausta, R. Ojala, I. Kiviranta, A. Häkkinen, M.T. Nieminen, A. Heinonen
2009 Osteoarthritis and Cartilage  
Objective: The purpose of this study was to investigate the day-to-day reproducibility of the delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) measurement at different knee joint surfaces in healthy subjects at 1.5 Tesla (T). Methods: The dGEMRIC experiment was repeated for 10 asymptomatic volunteers three times with an average interval of 5 days between scans. The measurement was performed from a single sagittal slice through the center of the lateral femoral condyle and from the center
more » ... f the patella in the axial plane. Cartilage was manually segmented into superficial, deep and full-thickness regions of interests (ROIs) at different topographical locations of the femur, tibia and patella. The reproducibility was evaluated separately for each ROI as well as for the entire bulk cartilage in the slice of each joint surface. Results: The reproducibility at various ROIs expressed by root-mean-square average coefficient of variation (CV RMS ) ranged between 4.7e12.9%. Thirty out of thirty-three ROIs showed a CV RMS less than 10%. Intraclass correlation coefficient (ICC) ranged between 0.45 and 0.98. The CV RMS and ICC for bulk dGEMRIC were 4.2% and 0.95 for femur, 5.5% and 0.87 for tibia, and 4.8% and 0.97 for patella. Conclusions: The dGEMRIC technique showed good day-to-day reproducibility, on the average 8% for small deep or superficial segments, 7% for full-thickness ROIs and 5% for bulk ROIs covering all visible cartilage in a single joint surface. We conclude that dGEMRIC imaging at field strength 1.5 T can be used as a reliable instrument for the assessment of articular cartilage when staff has been carefully trained.
doi:10.1016/j.joca.2008.12.001 pmid:19121954 fatcat:xghedqa5unfatgrgpizf7hhfiu

Long-term individual housing in C57BL/6J and DBA/2 mice: assessment of behavioral consequences

V. Võikar, A. Polus, E. Vasar, H. Rauvala
2004 Genes, Brain and Behavior  
The aim of the present study was to investigate the effects of individual housing on mouse behavior. The male mice of the C57BL/6J and DBA/2 strains were separated at the age of 4 weeks and kept in individual housing for 7 weeks until behavioral testing began. Their behavior was compared to the group-housed mice in a battery of tests during the following 7 weeks. The single-housed mice were hyperactive and displayed reduced habituation in the tests assessing activity and exploration. Reduced
more » ... iety was established in the elevated plusmaze, but an opposite effect was observed in the darklight (DL) and hyponeophagia tests. Immobility in the forced swimming test was reduced by social isolation. The DBA mice displayed higher anxiety-like behavior than the B6 mice in the plus-maze and DL exploration test, but hyponeophagia was reduced in the DBA mice. Moreover, all effects of individual housing on the exploratory and emotional behavior were more evident in the DBA than in the B6 mice. Novel object recognition and fear conditioning (FC) were significantly impaired in the single-housed mice, whereas water-maze (WM) learning was not affected. Marked strain differences were established in all three learning tests. The B6 mice performed better in the object recognition and FC tasks. Initial spatial learning in the WM was faster and memory retention slightly enhanced in the B6 mice. The DBA mice displayed lower preference to the new and enhanced preference to the old platform location than the B6 mice after reversal learning in the WM. We conclude that individual housing has strong strain-and test-specific effects on emotional behavior and impairs memory in certain tasks.
doi:10.1111/j.1601-183x.2004.00106.x pmid:15924556 fatcat:gpad64stxberflp54mpsmzvvmi

Expression of GluK1c underlies the developmental switch in presynaptic kainate receptor function

Aino Vesikansa, Prasanna Sakha, Juha Kuja-Panula, Svetlana Molchanova, Claudio Rivera, Henri J. Huttunen, Heikki Rauvala, Tomi Taira, Sari E. Lauri
2012 Scientific Reports  
(e) The effect of ACET (100 nM) on EPSCs, evoked by 5 pulse 50 Hz stimulation in slices expressing GluK1c_EGFP in area CA3.  ...  (e) Quantified data on the distribution of GluK1b/c and c splice variants in pyramidal neurons vs. interneurons in different areas of hippocampus.  ... 
doi:10.1038/srep00310 pmid:22413061 pmcid:PMC3298885 fatcat:b6jeug3x5je3zf5qi3achkul5u

JNK1 controls adult hippocampal neurogenesis and imposes cell-autonomous control of anxiety behaviour from the neurogenic niche

H Mohammad, F Marchisella, S Ortega-Martinez, P Hollos, K Eerola, E Komulainen, N Kulesskaya, E Freemantle, V Fagerholm, E Savontous, H Rauvala, B D Peterson (+2 others)
2016 Molecular Psychiatry  
(d, e) The behaviour of retrovirus-infected mice on the EPM is shown, as before.  ...  (d, e) Jnk1 − / − mice showed increased head dipping and rearing compared with WT. (f) The average time spent in a light or dark enclosed area is shown.  ... 
doi:10.1038/mp.2016.203 pmid:27843149 pmcid:PMC5794884 fatcat:bqyjr4g5nfhapmfkvzh7rxdhxa

JNK1 controls adult hippocampal neurogenesis and imposes cell-autonomous control of anxiety behaviour from the neurogenic niche

H Mohammad, F Marchisella, S Ortega-Martinez, P Hollos, K Eerola, E Komulainen, N Kulesskaya, E Freemantle, V Fagerholm, E Savontous, H Rauvala, B D Peterson (+2 others)
2017 Molecular Psychiatry  
(d, e) The behaviour of retrovirus-infected mice on the EPM is shown, as before.  ...  (d, e) Jnk1 − / − mice showed increased head dipping and rearing compared with WT. (f) The average time spent in a light or dark enclosed area is shown.  ... 
doi:10.1038/mp.2017.21 pmid:28194007 pmcid:PMC5794892 fatcat:wcsfixobhbh2hc6nu2bfmxmwwu

AMIGO-Kv2.1 Potassium Channel Complex is Associated With Schizophrenia-Related Phenotypes

Marjaana A. Peltola, Juha Kuja-Panula, Johanna Liuhanen, Vootele Võikar, Petteri Piepponen, Tero Hiekkalinna, Tomi Taira, Sari E. Lauri, Jaana Suvisaari, Natalia Kulesskaya, Tiina Paunio, Heikki Rauvala
2015 Schizophrenia Bulletin  
(e) I K currents from CA1 pyramidal neurons from WT (I K WT) and AMIGO KO (I K KO) mice. Ratio of average current densities (I K KO to I K WT) at different membrane potentials.  ...  (g) The AMIGO KO mice had reduced PPI compared to the WT littermates c P(IS families) = .000012, P(AF families) = .15. d P(IS families) = .000022, P(AF families) = .035. e P(IS families) = .78, P(AF  ... 
doi:10.1093/schbul/sbv105 pmid:26240432 pmcid:PMC4681558 fatcat:bugazrkwabfnloew6e6n2pmcam

The role of heparin-binding growth-associated molecule (HB-GAM) in the postsynaptic induction in cultured muscle cells

HB Peng, AA Ali, Z Dai, DF Daggett, E Raulo, H Rauvala
1995 Journal of Neuroscience  
; Rauvala et al., 1994) .  ...  A, C, E, R-BTX labeling; B, D, F, HB-GAM labeling.  ... 
doi:10.1523/jneurosci.15-04-03027.1995 pmid:7722643 fatcat:okc47vcqordnxf3kvlkfqsehfa

Amphoterin, the 30-kDa protein in a family of HMG1-type polypeptides. Enhanced expression in transformed cells, leading edge localization, and interactions with plasminogen activation

J Parkkinen, E Raulo, J Merenmies, R Nolo, E O Kajander, M Baumann, H Rauvala
1993 Journal of Biological Chemistry  
A t n ' G K G D P K K P R G K M S S Y A F F V Q T C R E E H K K K H P D A S V N F p 2 8 ' A K G D P K K P K G K M S A Y A F F V Q T X R E E p29 eX G K M S A Y A F F V Q T Atn S E F S K K C S E R W K  ...  A t n K T Y I P P K G E T K K K F K D P N A P K R P P S A F F L F C S E Y R P K P P S A F F L F X S E Y R P K P P S A F F L F X S E X R P A t n I K G E H P G L S I G D V A K K L G E M W N N T A A D  ... 
pmid:8366113 fatcat:ros24t65gfg7hlrzqyd3h52v34

Reg1ulatory Role and Molecular Interactions of a Cell-Surface Heparan Sulfate Proteoglycan (N-syndecan) in Hippocampal Long-Term Potentiation

S. E. Lauri, S. Kaukinen, T. Kinnunen, A. Ylinen, S. Imai, K. Kaila, T. Taira, H. Rauvala
1999 Journal of Neuroscience  
Rauvala, unpublished results).  ...  ., 1996; Rauvala and Peng, 1997) .  ... 
doi:10.1523/jneurosci.19-04-01226.1999 pmid:9952400 fatcat:7t2iwlzqu5h6jevu4du6qmnd3u

Expression of the heparin-binding cytokines, midkine (MK) and HB-GAM (pleiotrophin) is associated with epithelial-mesenchymal interactions during fetal development and organogenesis

T A Mitsiadis, M Salmivirta, T Muramatsu, H Muramatsu, H Rauvala, E Lehtonen, M Jalkanen, I Thesleff
1995 Development  
, 1989; Rauvala et al., 1994) .  ...  MK mRNA expression seen in bright-field illumination (A-C) and dark-field illumination (D,E,F). (A,D) Mandibular process (mp), whisker follicles (arrows). (B,E) Soft palate (sp).  ... 
pmid:7867507 fatcat:6vmsq3pjbvarfcdr34fr5ibode

Mice Deficient in Transmembrane Prostatic Acid Phosphatase Display Increased GABAergic Transmission and Neurological Alterations

Heidi O. Nousiainen, Ileana B. Quintero, Timo T. Myöhänen, Vootele Voikar, Jelena Mijatovic, Mikael Segerstråle, Annakaisa M. Herrala, Natalia Kulesskaya, Anitta E. Pulkka, Tanja Kivinummi, Usama Abo-Ramadan, Tomi Taira (+4 others)
2014 PLoS ONE  
Cellular localization of Snapin in WT mouse is more vesicular-like (A, C, E). Scale bar is 10 mm in all figures.  ...  (E) PAP 2/2 mice displayed shorter duration of loss of righting reflex after treatment with high dose of diazepam.  ... 
doi:10.1371/journal.pone.0097851 pmid:24846136 pmcid:PMC4028278 fatcat:mtqrohfxpnaujmz7m65toeycjq
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