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Regulation of cell migration by amphoterin
2000
Journal of Cell Science
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INTRODUCTION Amphoterin (p30) is a developmentally regulated heparinbinding protein that is abundantly expressed in embryonic brain and in transformed cell lines (Rauvala and Pihlaskari, 1987; Rauvala ...
Extracellular roles in neurite outgrowth, in neuron-glia interactions and in early phases of cell differentiation have been suggested for amphoterin (Rauvala and Pihlaskari, 1987; Rauvala et al., 1988 ...
pmid:10652254
fatcat:qfamd3764rgkhkf3snt6vl5m5a
AMIGO is an auxiliary subunit of the Kv2.1 potassium channel
2011
EMBO Reports
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Circumferential measurement of thoracic wall using a standard respiratory belt
1996
Journal of digital imaging
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Respiratory gating during imaging to reduce imaging artifacts involves the gathering of image data only at the end of the respiratory cycle. This is commonly performed by a pneumatic respiratory belt to monitor thoracic wall motion during respiration. Such gating has been used for magnetic resonance, computerized tomographic, and nuclear medicine imaging. The goal of this study was to measure the performance of a standard belt used for gating imaging studies. The standard respiratory belt
doi:10.1007/bf03168860
pmid:8734577
fatcat:32hev3lsx5crzp4ga4cbvisezy
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... provided with the Magnetom 42 SP MRI scanner (Siemens AG, Erlangen, Germany) was selected. The belt was connected to a microcontroller-based pressure measurement unit that was connected to the standard RS-232C serial port of a computer. The signal was compared with that of a strain gauge respiration transducer. The response of the system was tested in vitro both for isometric and isotonic Ioading. The data measured from the pneumatic belt was linear with different weights of 50 to 1,400 grams with a coefficient of determination (R 2) of 0.999. The system was linear for different amounts of stretching (R 2 of 0.998) within the first 45 mm, which is enough for normal breathing. In vivo the pneumatic system seemed more accurate in measuring the constant stretching in apnea than the strain gauge respiratory belt. The results show that it is possible to use a standard pneumatic belt for accurate measurement of thoracic wall movement during imaging and for other purposes as well.
Fast Network Oscillations in the Newborn Rat HippocampusIn Vitro
2000
Journal of Neuroscience
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deviation of E GABA-A from a calculated E C l-; Kaila 1994) . ...
(E-mail: jpalva@cc.hut.fi). ...
doi:10.1523/jneurosci.20-03-01170.2000
pmid:10648721
fatcat:dlscgr7kerdlzc4yaen3jc24hm
Reproducibility of imaging human knee cartilage by delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) at 1.5 Tesla
2009
Osteoarthritis and Cartilage
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Objective: The purpose of this study was to investigate the day-to-day reproducibility of the delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) measurement at different knee joint surfaces in healthy subjects at 1.5 Tesla (T). Methods: The dGEMRIC experiment was repeated for 10 asymptomatic volunteers three times with an average interval of 5 days between scans. The measurement was performed from a single sagittal slice through the center of the lateral femoral condyle and from the center
doi:10.1016/j.joca.2008.12.001
pmid:19121954
fatcat:xghedqa5unfatgrgpizf7hhfiu
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... f the patella in the axial plane. Cartilage was manually segmented into superficial, deep and full-thickness regions of interests (ROIs) at different topographical locations of the femur, tibia and patella. The reproducibility was evaluated separately for each ROI as well as for the entire bulk cartilage in the slice of each joint surface. Results: The reproducibility at various ROIs expressed by root-mean-square average coefficient of variation (CV RMS ) ranged between 4.7e12.9%. Thirty out of thirty-three ROIs showed a CV RMS less than 10%. Intraclass correlation coefficient (ICC) ranged between 0.45 and 0.98. The CV RMS and ICC for bulk dGEMRIC were 4.2% and 0.95 for femur, 5.5% and 0.87 for tibia, and 4.8% and 0.97 for patella. Conclusions: The dGEMRIC technique showed good day-to-day reproducibility, on the average 8% for small deep or superficial segments, 7% for full-thickness ROIs and 5% for bulk ROIs covering all visible cartilage in a single joint surface. We conclude that dGEMRIC imaging at field strength 1.5 T can be used as a reliable instrument for the assessment of articular cartilage when staff has been carefully trained.
Long-term individual housing in C57BL/6J and DBA/2 mice: assessment of behavioral consequences
2004
Genes, Brain and Behavior
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The aim of the present study was to investigate the effects of individual housing on mouse behavior. The male mice of the C57BL/6J and DBA/2 strains were separated at the age of 4 weeks and kept in individual housing for 7 weeks until behavioral testing began. Their behavior was compared to the group-housed mice in a battery of tests during the following 7 weeks. The single-housed mice were hyperactive and displayed reduced habituation in the tests assessing activity and exploration. Reduced
doi:10.1111/j.1601-183x.2004.00106.x
pmid:15924556
fatcat:gpad64stxberflp54mpsmzvvmi
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... iety was established in the elevated plusmaze, but an opposite effect was observed in the darklight (DL) and hyponeophagia tests. Immobility in the forced swimming test was reduced by social isolation. The DBA mice displayed higher anxiety-like behavior than the B6 mice in the plus-maze and DL exploration test, but hyponeophagia was reduced in the DBA mice. Moreover, all effects of individual housing on the exploratory and emotional behavior were more evident in the DBA than in the B6 mice. Novel object recognition and fear conditioning (FC) were significantly impaired in the single-housed mice, whereas water-maze (WM) learning was not affected. Marked strain differences were established in all three learning tests. The B6 mice performed better in the object recognition and FC tasks. Initial spatial learning in the WM was faster and memory retention slightly enhanced in the B6 mice. The DBA mice displayed lower preference to the new and enhanced preference to the old platform location than the B6 mice after reversal learning in the WM. We conclude that individual housing has strong strain-and test-specific effects on emotional behavior and impairs memory in certain tasks.
Expression of GluK1c underlies the developmental switch in presynaptic kainate receptor function
2012
Scientific Reports
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(e) The effect of ACET (100 nM) on EPSCs, evoked by 5 pulse 50 Hz stimulation in slices expressing GluK1c_EGFP in area CA3. ...
(e) Quantified data on the distribution of GluK1b/c and c splice variants in pyramidal neurons vs. interneurons in different areas of hippocampus. ...
doi:10.1038/srep00310
pmid:22413061
pmcid:PMC3298885
fatcat:b6jeug3x5je3zf5qi3achkul5u
JNK1 controls adult hippocampal neurogenesis and imposes cell-autonomous control of anxiety behaviour from the neurogenic niche
2016
Molecular Psychiatry
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(d, e) The behaviour of retrovirus-infected mice on the EPM is shown, as before. ...
(d, e) Jnk1 − / − mice showed increased head dipping and rearing compared with WT. (f) The average time spent in a light or dark enclosed area is shown. ...
doi:10.1038/mp.2016.203
pmid:27843149
pmcid:PMC5794884
fatcat:bqyjr4g5nfhapmfkvzh7rxdhxa
JNK1 controls adult hippocampal neurogenesis and imposes cell-autonomous control of anxiety behaviour from the neurogenic niche
2017
Molecular Psychiatry
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(d, e) The behaviour of retrovirus-infected mice on the EPM is shown, as before. ...
(d, e) Jnk1 − / − mice showed increased head dipping and rearing compared with WT. (f) The average time spent in a light or dark enclosed area is shown. ...
doi:10.1038/mp.2017.21
pmid:28194007
pmcid:PMC5794892
fatcat:wcsfixobhbh2hc6nu2bfmxmwwu
AMIGO-Kv2.1 Potassium Channel Complex is Associated With Schizophrenia-Related Phenotypes
2015
Schizophrenia Bulletin
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(e) I K currents from CA1 pyramidal neurons from WT (I K WT) and AMIGO KO (I K KO) mice. Ratio of average current densities (I K KO to I K WT) at different membrane potentials. ...
(g) The AMIGO KO mice had reduced PPI compared to the WT littermates
c P(IS families) = .000012, P(AF families) = .15. d P(IS families) = .000022, P(AF families) = .035. e P(IS families) = .78, P(AF ...
doi:10.1093/schbul/sbv105
pmid:26240432
pmcid:PMC4681558
fatcat:bugazrkwabfnloew6e6n2pmcam
The role of heparin-binding growth-associated molecule (HB-GAM) in the postsynaptic induction in cultured muscle cells
1995
Journal of Neuroscience
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; Rauvala et al., 1994) . ...
A, C, E, R-BTX labeling; B, D, F, HB-GAM labeling. ...
doi:10.1523/jneurosci.15-04-03027.1995
pmid:7722643
fatcat:okc47vcqordnxf3kvlkfqsehfa
Amphoterin, the 30-kDa protein in a family of HMG1-type polypeptides. Enhanced expression in transformed cells, leading edge localization, and interactions with plasminogen activation
1993
Journal of Biological Chemistry
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A t n ' G K G D P K K P R G K M S S Y A F F V Q T C R E E H K K K H P D A S V N F p 2 8 ' A K G D P K K P K G K M S A Y A F F V Q T X R E E p29 eX
G K M S A Y A F F V Q T Atn S E F S K K C S E R W K ...
A t n K T Y I P P K G E T K K K F K D P N A P K R P P S A F F L F C S E Y R P K
P P S A F F L F X S E Y R P K P P S A F F L F X S E X R P
A t n I K G E H P G L S I G D V A K K L G E M W N N T A A D ...
pmid:8366113
fatcat:ros24t65gfg7hlrzqyd3h52v34
Reg1ulatory Role and Molecular Interactions of a Cell-Surface Heparan Sulfate Proteoglycan (N-syndecan) in Hippocampal Long-Term Potentiation
1999
Journal of Neuroscience
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Rauvala, unpublished results). ...
., 1996; Rauvala and Peng, 1997) . ...
doi:10.1523/jneurosci.19-04-01226.1999
pmid:9952400
fatcat:7t2iwlzqu5h6jevu4du6qmnd3u
Expression of the heparin-binding cytokines, midkine (MK) and HB-GAM (pleiotrophin) is associated with epithelial-mesenchymal interactions during fetal development and organogenesis
1995
Development
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, 1989; Rauvala et al., 1994) . ...
MK mRNA expression seen in bright-field illumination (A-C) and dark-field illumination (D,E,F). (A,D) Mandibular process (mp), whisker follicles (arrows). (B,E) Soft palate (sp). ...
pmid:7867507
fatcat:6vmsq3pjbvarfcdr34fr5ibode
Mice Deficient in Transmembrane Prostatic Acid Phosphatase Display Increased GABAergic Transmission and Neurological Alterations
2014
PLoS ONE
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Cellular localization of Snapin in WT mouse is more vesicular-like (A, C, E). Scale bar is 10 mm in all figures. ...
(E) PAP 2/2 mice displayed shorter duration of loss of righting reflex after treatment with high dose of diazepam. ...
doi:10.1371/journal.pone.0097851
pmid:24846136
pmcid:PMC4028278
fatcat:mtqrohfxpnaujmz7m65toeycjq
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