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Ventricular tachyarrhythmia as a primary presentation of sarcoidosis

P. Uusimaa, K. Ylitalo, O. Anttonen, T. Kerola, V. Virtanen, E. Paakko, P. Raatikainen
2008 Europace  
Aims Sarcoidosis is a multisystem, granulomatous disease with occasional cardiac manifestations. The clinical course of patients with ventricular tachyarrhythmias as a primary presentation of sarcoidosis is mostly unknown. Methods and results We describe nine patients (four males and five females) in whom sarcoidosis manifested as ventricular tachycardia (VT). The age of the patients was 53 + 10 years (range 33-68). The disease was diagnosed by endomyocardial biopsy in eight patients and by
more » ... h node biopsy in one patient. The presenting arrhythmia varied from non-sustained VT to incessant VT and ventricular fibrillation. All patients received implantable cardioverter defibrillator (ICD) and anti-arrhythmic medication. High-dose steroid treatment was used in eight cases. During the follow-up (50 + 34 months), five patients underwent appropriate ICD therapies and non-sustained VT episodes were detected in four patients. Two patients developed incessant VT, which was treated by catheter ablation. One patient was referred for heart transplantation. Conclusion Our data indicate that sarcoidosis can manifest as VT without any detectable systemic findings. This makes sarcoidosis an important diagnostic consideration in patients with VT of unknown origin. Arrhythmia control in cardiac sarcoidosis is difficult, and all modern treatments including high-dose steroids, anti-arrhythmic drugs, ICD, and catheter ablation are needed to suppress the arrhythmias.
doi:10.1093/europace/eun110 pmid:18456644 fatcat:wi6aqoyuabf4dcoowarddxru6i

Association of bronchiolitis with connective tissue disorders

M Hakala, P Paakko, S Sutinen, E Huhti, O Koivisto, M Tarkka
1986 Annals of the Rheumatic Diseases  
Among 173 consecutive open lung biopsies, nine gave a histopathological diagnosis of bronchiolitis. Seven of these patients had some connective tissue disorder (CTD), six of whom are presented in this report; two had classical and one possible rheumatoid arthritis (RA), one ankylosing spondylitis, one scleroderma, and one developed classical RA four years after biopsy. Four of the patients were smokers, most suffered from breathlessness and cough. In terms of lung function three patients had
more » ... truction, one both restriction and obstruction and three a decreased diffusion capacity. For control purposes peripheral lung tissue was studied histologically from 24 consecutive smoking patients without CTD who underwent a lobectomy for cancer. Intraluminal plugs and mucosal lymphoplasmocytic infiltration of the bronchiolar walls were more prevalent and abundant in the CTD patients than in the controls (p<0-02 and p<O-OOl respectively). Two CTD patients also showed some obliterative bronchiolitis. Corticosteroids were effective in one out of four patients treated. One patient improved and the others did not show any progression during the follow up. The results suggest that smoking alone does not explain the lesions of the small airways found in CTD patients, and that bronchiolitis may be specifically associated with the basic disorder in such cases.
doi:10.1136/ard.45.8.656 pmid:3740995 pmcid:PMC1001963 fatcat:c5cdqlhosbbxvjsiajr66aoahe

Prospective population-based study on the survival of patients with lung cancer

R. Makitaro, P. Paakko, E. Huhti, R. Bloigu, V.L. Kinnula
2002 European Respiratory Journal  
Pääkko, E. Huhti, R. Bloigu, V.L. Kinnula. #ERS Journals Ltd 2002.  ... 
doi:10.1183/09031936.02.00048302 pmid:12108861 fatcat:w3t3t3niv5cibohvpyi746kln4

A prospective pilot study on MRI visibility of iron oxide-impregnated polyvinylidene fluoride mesh after ventral rectopexy

K. E. Laitakari, J. K. Mäkelä-Kaikkonen, E. Pääkkö, P. Ohtonen, T. T. Rautio
2019 Techniques in Coloproctology  
junction (mm) b The position of the insertion point to the right levator muscle c The position of the insertion point to the left levator muscle d Length of insertion to the anterior rectal wall (mm) e  ...  63 3 24 Enterocele Incontinence RVMR 86 20 B 56 2 22 Enterocele ODS RVMR 90 400 C 88 3 22 Prolapse Prolapse RVMR 121 0 D 53 2 23 Enterocele Incontinence RVMR a 174 0 E  ... 
doi:10.1007/s10151-019-02022-w pmid:31270653 pmcid:PMC6692291 fatcat:zwx3grqfnfhktevlhbrcavigd4

Manganese superoxide dismutase as a diagnostic marker for malignant pleural mesothelioma

K Kahlos, P Pääkkö, E Kurttila, Y Soini, V L Kinnula
2000 British Journal of Cancer  
doi:10.1054/bjoc.1999.1037 pmid:10737384 pmcid:PMC2374425 fatcat:xpphamshdjaafiuzkkhhkdsl5e

An epidemiological study of lung cancer: history and histological types in a general population in northern Finland

R. Makitaro, P. Paakko, E. Huhti, R Bloigu, V.l. Kinnula
1999 European Respiratory Journal  
Pa Èa Èkko È).  ... 
doi:10.1034/j.1399-3003.1999.13b36.x fatcat:qwxlbiwtlbfhbbg3smxvvvelr4

Information value of magnetic resonance imaging in shunted hydrocephalus

E Paakko, T Lopponen, A L Saukkonen, J Pyhtinen, J Laitinen, W Serlo, M Knip
1994 Archives of Disease in Childhood  
Commentary Paakko et al have reported new and interesting observations about the MRI scan of shunted hydrocephalic children.  ... 
doi:10.1136/adc.70.6.530 pmid:8048826 pmcid:PMC1063406 fatcat:qkdqpudpcfcvrp7ryqvat3vxoy

Inducible nitric oxide synthase expression, apoptosis, and angiogenesis in in situ and invasive breast carcinomas

M Vakkala, K Kahlos, E Lakari, P Pääkkö, V Kinnula, Y Soini
2000 Clinical Cancer Research  
Kahlos, E. Lakari, P. Pääkkö, and V. Kinnula. Expression of inducible and endothelial nitric oxide synthase in healthy pleura and in malignant mesothelioma, submitted for publication.  ...  The diagnosis of all of the cases were based on light microscopic examination by the conventional H&E stain (15, 16) .  ... 
pmid:10873093 fatcat:sqobccxotvgodoc2sdzc4n66ka

195 Prenatal Inflammation, Brain Damage and Two-Year Neurologic Outcome in Very Preterm Infants

T Kaukola, R Herva, M Perhomaa, E Pääkkö, S Kingsmore, L Vainionpää, M Hallman
2005 Pediatric Research  
Bacteria cultured included Group B streptococcus, Bacteroides, Enterobacter cloacae, E. coli, Klebsiella, Morganella morganii and a coliform.  ... 
doi:10.1203/00006450-200508000-00224 fatcat:ex2njaf3wffeve3hkengbxxg4m

Expression of inducible nitric oxide synthase in healthy pleura and in malignant mesothelioma

Y Soini, K Kahlos, A Puhakka, E Lakari, M Säily, P Pääkkö, V Kinnula
2000 British Journal of Cancer  
E. Another metastatic adenocarcinoma showing only weak positivity for the polyclonal iNOS anitbody.  ...  positive immunostaining for iNOS in most of the cases; 28/38 (74%) of malignant pleural mesotheliomas (Fig. 1B, C) and 24/25 (96%) of metastatic pleural adenocarcinomas were iNOS positive ( Fig. 1 D, E)  ... 
doi:10.1054/bjoc.2000.1384 pmid:10970689 pmcid:PMC2374678 fatcat:4ci2fo547feuvct7e2u63he56u

An epidemiological study of lung cancer: history and histological types in a general population in northern Finland

R. Mäkitaro, P. Pääkkö, E. Huhti, R. Bloigu, V.L. Kinnula
1999 European Respiratory Journal  
Pa Èa Èkko È).  ... 
doi:10.1183/09031936.99.13243699 pmid:10065694 fatcat:m4npawilpbfdvjz3rfavnvwjau

Apoptosis and expression of apoptosis regulating proteins bcl-2, mcl-1, bcl-X, and bax in malignant mesothelioma

Y Soini, V Kinnula, R Kaarteenaho-Wiik, E Kurttila, K Linnainmaa, P Pääkkö
1999 Clinical Cancer Research  
32 0.00 0 0.22 Ϫ ϩϩϩϩ ϩϩϩ ϩϩϩϩ 57 F B 21 33 0.00 0 2.76 Ϫ ϩ ϩ ϩϩϩ 70 M B 14 34 0.00 0 0.24 Ϫ ϩϩ ϩϩ ϩϩϩ 68 M B 2 35 0.00 0 N Ϫ ϩϩ ϩϩϩ ϩϩϩϩ 57 M B 24 a E,  ... 
pmid:10589765 fatcat:k7v62hvu6rervndaty4zzu7nrm

Carboxyterminal propeptide of type I procollagen in ELF: elevation in asbestosis, but not in pleural plaque disease

L. Lammi, L. Ryhänen, E. Lakari, J Risteli, P Pääkkö, M. Ruotsalainen, S Lähde, V.l. Kinnula
1999 European Respiratory Journal  
Markers of collagen metabolism may possibly be used in the assessment of pulmonary involvement in asbestosis-related pulmonary diseases. In this study the levels of the carboxyterminal propeptide of type I procollagen (PICP) and the aminoterminal propeptide of type III procollagen (PIIINP) were evaluated in bronchoalveolar lavage fluid (BALF), epithelial lining fluid (ELF) and serum from patients with asbestos related pulmonary and pleural involvement. Forty-two consecutive patients with
more » ... ional exposure to asbestos fibres, who underwent bronchoscopy and bronchoalveolar lavage (BAL) at the time of the diagnosis were investigated. Five patients were diagnosed as having asbestosis, while 37 showed no parenchymal involvement. Of the latter group, 25 had pleural plaques, while 12 had no detectable changes in chest radiographs. The patients were followedup for an average of 7 yrs. The PICP in BALF and ELF was detectable in all patients with asbestosis and in 8/ 37 subjects without parenchymal involvement. The levels of PICP in BALF and ELF were significantly higher in the asbestosis group compared to the patients without asbestosis (9.81.8 mg . L -1 versus 0.61.3 mg . L -1 , p<0.001 and 488.9208.8 mg . L -1 versus 22.650.6 mg . L -1 , p<0.001, respectively). Only 1 patient with asbestosis and 3 patients without parenchymal involvement had detectable levels of PIIINP in BALF. The serum levels of PICP and PIIINP did not differ between the patients with asbestosis and those with exposure to asbestos fibres without asbestosis and were within the normal range. None of the 37 patients exposed to asbestos fibres without parenchymal involvement at the baseline developed asbestosis during the follow-up period of 7 yrs. In conclusion, the data show that the carboxyterminal propeptide of procollagen type I, but not the aminoterminal propeptide of type III procollagen is highly elevated in bronchoalveolar lavage fluid and epithelial lining fluid in patients with asbestosis, but not in those without parenchymal involvement. This suggests that the determination of carboxyterminal propeptide of procollagen type I in bronchoalveolar lavage fluid could be used as a marker of parenchymal involvement in patients exposed to asbestos fibres. Eur Respir J 1999; 14: 560±564.
doi:10.1034/j.1399-3003.1999.14c13.x pmid:10543275 fatcat:gdkvzxuxwncezfbcucbwegi7ny

Justification of CT examinations in young adults and children can be improved by education, guideline implementation and increased MRI capacity

P Tahvonen, H Oikarinen, E Pääkkö, A Karttunen, R Blanco Sequeiros, O Tervonen
2013 British Journal of Radiology  
These recommendations were distributed by e-mail to the Radiology Department staff and the referring practitioners, after which they continued to be available on the hospital intranet.  ... 
doi:10.1259/bjr.20130337 pmid:23934962 pmcid:PMC3755402 fatcat:knxvz65ozvesxifln6z3myy7hm

High Body Mass Index Increases the Risk for Osteonecrosis in Children With Acute Lymphoblastic Leukemia

Riitta A. Niinimäki, Arja H. Harila-Saari, Airi E. Jartti, Raija M. Seuri, Pekka V. Riikonen, Eija L. Pääkkö, Merja I. Möttönen, Marjatta Lanning
2007 Journal of Clinical Oncology  
Harila-Saari, Airi E. Jartti, Eija L. Paakko Manuscript writing; Riitta A. Niinimaki, Arja H. Harila-Saari, Airi E. Jartti, Raija M. Seuri, Pekka V. Riikonen, Eija L. Paakk6, Merja I.  ...  Ojala AE, Paakko E, Lanning FP, et al: Bone marrow changes on MRI in children with acute lymphoblastic leukaemia 5 years after treatment. Clin Radiol 53:131-136, 1998 17.  ... 
doi:10.1200/jco.2006.06.2539 pmid:17442991 fatcat:43nimnxnkrgvnk2sxbus4xnjfm
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