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A Comprehensive Analysis of the Dynamic Biological Networks in HCV Induced Hepatocarcinogenesis

Bing He, Hao Zhang, Tieliu Shi, Syed A. Aziz
2011 PLoS ONE  
Hepatocellular carcinoma (HCC) is a primary malignancy of the liver, which is closely related to hepatitis C and cirrhosis.  ...  induced hepatocarcinogenesis, and systematically explored the potentially disease-related mechanisms through a network view.  ...  Conceived and designed the experiments: BH TS. Performed the experiments: BH. Analyzed the data: BH. Contributed reagents/ materials/analysis tools: BH. Wrote the paper: BH HZ TS.  ... 
doi:10.1371/journal.pone.0018516 pmid:21526182 pmcid:PMC3079719 fatcat:wnvp7usa5vfjpp6algkfisuhn4

Bioinformatics analysis of hepatitis C virus genotype 2a-induced human hepatocellular carcinoma in Huh7 cells

Xu P, Wu M, Chen H, Xu J, Wu M, Li M, Qian F, Xu J
2016 OncoTargets and Therapy  
carcinoma (HCC) is a liver cancer that could be induced by hepatitis C virus genotype 2a Japanese fulminant hepatitis-1 (JFH-1) strain.  ...  In total, 173 up and 207 down co-regulated genes were separately identified in JFH-1-infected Huh7 cells compared with those of control cells.  ...  Back to Journals » OncoTargets and Therapy » Volume 9 Bioinformatics analysis of hepatitis C virus genotype 2a-induced human hepatocellular carcinoma in Huh7 cells Authors Xu P, Wu M, Chen H,  ... 
doaj:5355b491454f4954aba11c6d363ae6f9 fatcat:xlxbxxa4nvhexoxqme36eiyvwi

Pathogenesis and prevention of hepatitis C virus-induced hepatocellular carcinoma

Yujin Hoshida, Bryan C. Fuchs, Nabeel Bardeesy, Thomas F. Baumert, Raymond T. Chung
2014 Journal of Hepatology  
Hepatitis C virus (HCV) is one of the major aetiologic agents that causes hepatocellular carcinoma (HCC) by generating an inflammatory, fibrogenic, and carcinogenic tissue microenvironment in the liver  ...  HCV-induced HCC is a rational target for cancer preventive intervention because of the clear-cut high-risk condition, cirrhosis, associated with high cancer incidence (1% to 7% per year).  ...  HCV, hepatitis C virus; HCC, hepatocellular carcinoma; ECM, extracellular matrix.  ... 
doi:10.1016/j.jhep.2014.07.010 pmid:25443348 pmcid:PMC4435677 fatcat:36jjq5zegjb3xblu7ko3yrt534

System biology analysis reveals the role of voltage dependent anion channel (VDAC1) in mitochondrial dysfunction during non-alcoholic fatty liver disease (NAFLD) progression into hepatocellular carcinoma (HCC)

Yanping Zhu, Chao Zhang, Fuyi Xu, Miaoqing Zhao, Jonas Bergquist, Chunhua Yang, Xiuxiu Liu, Ying Tan, Xiang Wang, Shasha Li, Wenguo Jiang, Qunxiang Ong (+3 others)
2020 Cancer Science  
The gene co-expression network analysis indicated that VDAC1 is involved in mitochondria dysfunction in the tumorigenic/tumor progression.  ...  ) with hepatocellular carcinoma (HCC) are unclear.  ...  [23] [24] [25] The results of early-stage hepatocellular carcinoma proteomics showed that hepatocellular carcinoma was related to hepatitis B virus infection (HBV-HCC) and was associated with disrupted  ... 
doi:10.1111/cas.14651 pmid:32945042 fatcat:6zlogmhsxjho3dxrrpeso54ed4

Dynamic edge-based biomarker noninvasively predicts hepatocellular carcinoma with hepatitis B virus infection for individual patients based on blood testing

Yiyu Lu, Zhaoyuan Fang, Meiyi Li, Chen Qian, Tao Zeng, Lina Lu, Qilong Chen, Hui Zhang, Qianmei Zhou, Yan Sun, Xuefeng Xue, Yiyang Hu (+2 others)
2019 Journal of Molecular Cell Biology  
Hepatitis B virus (HBV)-induced hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths in Asia and Africa.  ...  HBV carrier, chronic hepatitis B, cirrhosis, and HCC), we identified a set of 19 candidate genes according to our algorithm of dynamic network biomarkers.  ...  Acknowledgements We thank the study participants for their willingness to engage in this research.  ... 
doi:10.1093/jmcb/mjz025 pmid:30925583 pmcid:PMC6788726 fatcat:3kczsknf7jaifl3ucjcgphmoju

Risk factors and prevention of hepatocellular carcinoma in the era of precision medicine

Naoto Fujiwara, Scott L. Friedman, Nicolas Goossens, Yujin Hoshida
2018 Journal of Hepatology  
Hepatitis B Chronic HBV infection has been the dominant etiology in Southeast Asia and sub-Saharan Africa, although the incidence of HBV-induced HCC is declining. 87 Co-infection with hepatitis delta virus  ...  Chronic fibrotic liver disease caused by viral or metabolic etiologies is a high-risk condition for developing hepatocellular carcinoma (HCC).  ...  Hepatocellular carcinoma screening in patients with compensated hepatitis C virus (HCV)-related cirrhosis aware of their HCV status improves survival: a modeling approach.  ... 
doi:10.1016/j.jhep.2017.09.016 pmid:28989095 pmcid:PMC5818315 fatcat:b6ilafiogba4tltc2jhwrcuin4

Identification of hepatitis B virus and liver cancer bridge molecules based on functional module network

Xiao-Bing Huang, Yong-Gang He, Lu Zheng, Huan Feng, Yu-Ming Li, Hong-Yan Li, Feng-Xia Yang, Jing Li
2019 World Journal of Gastroenterology  
However, there has been little research fully and thoroughly exploring the molecular link between hepatitis B virus (HBV) and hepatocellular carcinoma (HCC).  ...  Second, the protein-protein interaction network based on dysfunctional genes identified a series of dysfunctional modules and significant crosstalk between modules based on the hypergeometric test.  ...  However, there has been little research fully and thoroughly exploring the molecular link between hepatitis B virus (HBV) and hepatocellular carcinoma (HCC).  ... 
doi:10.3748/wjg.v25.i33.4921 pmid:31543683 pmcid:PMC6737318 fatcat:qdm3iw6ayvagdia2ws6xi5b2em

Clinical and Molecular Prediction of Hepatocellular Carcinoma Risk

Naoto Kubota, Naoto Fujiwara, Yujin Hoshida
2020 Journal of Clinical Medicine  
Prediction of hepatocellular carcinoma (HCC) risk becomes increasingly important with recently emerging HCC-predisposing conditions, namely non-alcoholic fatty liver disease and cured hepatitis C virus  ...  In this review, these risk scores and biomarker candidates are overviewed, and strategic issues in their validation and clinical translation are discussed.  ...  HCC develops in chronically diseased livers with infection of hepatitis viruses (e.g., hepatitis B virus (HBV) and hepatitis C virus (HCV)) and metabolic insults such as alcohol abuse and non-alcoholic  ... 
doi:10.3390/jcm9123843 pmid:33256232 fatcat:fbb4b2mfxbeh3p6obbnyijnf7y

Pre-clinical and clinical investigations of metabolic zonation in liver diseases: The potential of microphysiology systems

Alejandro Soto-Gutierrez, Albert Gough, Lawrence A Vernetti, DL Taylor, Satdarshan P Monga
2017 Experimental biology and medicine  
We will discuss how the pathological organ-specific microenvironment affects cell signaling and metabolic liver zonation, especially in steatosis, viral hepatitis, and hepatocellular carcinoma.  ...  Since then, additional molecules have been identified that regulate the pattern of Wnt/b-catenin signaling within a lobule and determine gene expression and function in other hepatic zones.  ...  Metabolic zonation changes, hepatitis C virus infection, and HCC Hepatitis C virus (HCV) is one of the major etiologies of chronic hepatitis and progressive liver fibrosis that lead to development of lethal  ... 
doi:10.1177/1535370217707731 pmid:28467181 pmcid:PMC5661767 fatcat:y5qgypjfbbhjdelf7sxnzqbixq

Identification of diagnostic and prognostic biomarkers, and candidate targeted agents for hepatitis B virus‑associated early stage hepatocellular carcinoma based on RNA‑sequencing data

Zhili Zeng, Zebiao Cao, Ying Tang
2020 Oncology Letters  
The present study aimed to identify potential diagnostic and prognostic biomarkers, and candidate targeted agents for hepatitis B virus (HBV)-associated early stage hepatocellular carcinoma (HCC).  ...  In conclusion, the dysfunction of fat metabolic pathways, the cell cycle, oxidation-reduction processes and viral carcinogenesis may serve critical roles in the occurrence of HBV-associated early stage  ...  A1-AFD018181A29) and Project of Administration of Traditional Chinese Medicine of Guangdong Province of China (Project No. 20201109).  ... 
doi:10.3892/ol.2020.12094 pmid:32968453 pmcid:PMC7499982 fatcat:rf2tk6p57vegdf4c5flb4yi7um

Chronic inflammation: key player and biomarker-set to predict and prevent cancer development and progression based on individualized patient profiles

Shehua Qian, Olga Golubnitschaja, Xianquan Zhan
2019 The EPMA Journal  
of chronic pneumonia, and lung cancer; and between hepatitis virus (mainly hepatitis virus B and C), development of chronic hepatitis, and liver cancer.  ...  A strong relationship exists between tumor and inflammation, which is the hot point in cancer research.  ...  When chronic inflammation induces tumorigenesis and development, some genes, proteins, and metabolites in these signaling pathways might be abnormally expressed, so it may be possible to use these genes  ... 
doi:10.1007/s13167-019-00194-x pmid:31832112 pmcid:PMC6882964 fatcat:zwi3qr6thjdifoczn2zsndhfhy

Interactome of the hepatitis C virus: Literature mining with ANDSystem

Olga V. Saik, Timofey V. Ivanisenko, Pavel S. Demenkov, Vladimir A. Ivanisenko
2016 Virus Research  
The reconstruction and analysis of molecular-genetics networks related to programmed cell death was financially supported from Russian Science Foundation grant "Programmed cell death induced via death  ...  We thank anonymous reviewers for their insightful and highly detailed comments.  ...  Chronic hepatitis C often leads to serious complications, like cirrhosis and hepatocellular carcinoma.  ... 
doi:10.1016/j.virusres.2015.12.003 pmid:26673098 fatcat:xhdcj4qjtbachee4qjbt2jg27u

Cellular based treatment modalities for unresectable hepatocellular carcinoma

Konstantinos Damiris, Hamza Abbad, Nikolaos Pyrsopoulos
2021 World Journal of Clinical Oncology  
Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and is unfortunately associated with an overall poor prognosis and high mortality.  ...  We also provide an up-to-date compilation of ongoing clinical trials investigating CAR-T cells, TCR engineered T cells, cancer vaccines and oncolytic viruses, while discussing strategies that can help  ...  HCC commonly occurs in patients with preexisting liver cirrhosis, chronic hepatitis B virus (HBV), chronic hepatitis C virus (HCV), heavy alcohol consumption, aflatoxin exposure and metabolic associated  ... 
doi:10.5306/wjco.v12.i5.290 pmid:34131562 pmcid:PMC8173328 fatcat:hicu7q3vxvacdlypueiutfhmiu

Liver & Pancreas

2008 Laboratory Investigation  
Our study explored the potential of COX I as an early surrogate biomarker of liver pathogenesis by comparing COX I expression patterns in hepatitis C (HCV) cirrhosis and hepatocellular carcinoma (HCC)  ...  Conclusions: Evaluation of the types may help to predict the clinical course of patients with IPMN. 1388 Can Hepatocellular Carcinoma (HCC) Occur in Chronic Hepatitis B Virus (HBV) in the Absence of  ... 
doi:10.1038/sj.labinvest.3700737 fatcat:tgpudqj3ejc5dlt4feymxsqhgi

Current therapies in alleviating liver disorders and cancers with a special focus on the potential of vitamin D

Shahida Khan, Ashraf Ali, Sarah Khan, Ahmed Bakillah, Ghazi Damanhouri, Aziz Khan, Ahmed Makki, Ibtehal AlAnsari, Naheed Banu
2018 Nutrition & Metabolism  
Vitamin D has gone beyond its role in skeletal disorders by showcasing its associations in other metabolic dysfunctions too.  ...  Vitamin D receptors and alterations in gene expression appear decisive in the development of chronic liver disorders.  ...  Availability of data and materials Data sharing not applicable as no datasets were generated or analyzed during the writing of this review.  ... 
doi:10.1186/s12986-018-0251-5 pmid:29449867 pmcid:PMC5807831 fatcat:52vd2ibebzagpleda3sjrq7vna
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