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Dynamics of a neuron–glia system: the occurrence of seizures and the influence of electroconvulsive stimuli

André H. Erhardt, Kent-Andre Mardal, Jakob E. Schreiner
2020 Journal of Computational Neuroscience  
In this paper, we investigate the dynamics of a neuron-glia cell system and the underlying mechanism for the occurrence of seizures.  ...  In addition, we will study potassium dynamics of the model by considering a reduced version and we will show how both mechanisms are linked to each other.  ...  Furthermore, the authors wish to thank the anonymous referees for their careful reading of the original manuscript and their comments that eventually led to an improved presentation.  ... 
doi:10.1007/s10827-020-00746-5 pmid:32399790 fatcat:jrdqqk65b5halfnkgmtw62ylj4

Neurobiology of Major Depressive Disorder

Rosa Villanueva
2013 Neural Plasticity  
axis; the production of neurotrophins and growth factors; the expression of miRNAs; the production of proinflammatory cytokines; and, even, the abnormal delivery of gastrointestinal signaling peptides  ...  Clinically, descriptive gene and protein expression analysis and genetic and functional studies revised here show that individual alterations of a complex signaling network, which includes the hypothalamic-pituitary-adrenal  ...  The expression of the BDNF receptor TrkB is also upregulated by chronic electroconvulsive seizure and antidepressant drug treatments [39] .  ... 
doi:10.1155/2013/873278 pmid:24222865 pmcid:PMC3810062 fatcat:fge4d7foyjdofiu53nqt4xqfha

Toward rational design of electrical stimulation strategies for epilepsy control

Sridhar Sunderam, Bruce Gluckman, Davide Reato, Marom Bikson
2010 Epilepsy & Behavior  
Then the experimental perspective is presented, with the biophysical mechanisms and modalities of open-loop electrical stimulation, and the potential benefits of closed-loop control for epilepsy.  ...  Its attractions are temporal and spatial specificity of action, flexibility of waveform parameters and timing, and the perception that its effects are reversible unlike resective surgery.  ...  Acknowledgments The writing of this article was supported in part by NIH, (grants  ... 
doi:10.1016/j.yebeh.2009.10.017 pmid:19926525 pmcid:PMC2818293 fatcat:nw73rjfhobfstkkw53o6flvckq

Therapeutic devices for epilepsy

Robert S. Fisher
2012 Annals of Neurology  
Responsive neurostimulation, which delivers stimuli to one or two seizure foci in response to a detected seizure, recently completed a successful multicenter trial.  ...  Controlled studies of TMS split on efficacy, and may depend on whether a seizure focus is near a possible region for stimulation.  ...  Fisher consults with or holds stock options in NeuroVista (seizure prediction), ICVRx (CSF perfusion of drugs), Cyberonics (vagus nerve stimulation), Intelli-vision (seizure alert). We thank Dr.  ... 
doi:10.1002/ana.22621 pmid:22367987 pmcid:PMC3296971 fatcat:nq57govhkjhelenradz2m4ogzq

Adult neurogenesis, human after all (again): classic, optimized, and future approaches

Paul J. Lucassen, Carlos P. Fitzsimons, Evgenia Salta, Mirjana Maletic-Savatic
2019 Behavioural Brain Research  
, of new neurons in the adult and aged human hippocampus.  ...  In this perspective article, we reflect on the recent debate about the existence of human neurogenesis and discuss direct, and also indirect, support for the ongoing formation, and functional relevance  ...  the dentate gyrus declined sharply during the first years of life, and only few young neurons were observed by 7 and 13 years of age.  ... 
doi:10.1016/j.bbr.2019.112458 pmid:31899214 fatcat:tdr7icowbzhcjcakhmnf7f3keq

The influence of DNA methylation on gene expression involved in the etiology and treatment of psychiatric disorders [article]

Mads Dyrvig
2015 The PhD Series of theThe PhD Series of the Faculty of Medicine  
This work was supported by the Danish Medical Research Council, NeuroSearch A/S, A.P. Møller Foundation and the NOVO Nordisk Foundation. The authors declare no conflict of interest. Appendix A.  ...  Acknowledgments This work was supported by The Obel Family Foundation and Fonden til Laegevidenskabens Fremme.  ...  The Npy system is regulated after both ECS and seizures (Husum et al., 1998; Mikkelsen et al., 1994) .  ... 
doi:10.5278/vbn.phd.med.00024 fatcat:hmjtdawr5fcjlc6j3cq5z5x5ty

Excitation-Neurogenesis Coupling in Adult Neural Stem/Progenitor Cells

Karl Deisseroth, Sheela Singla, Hiroki Toda, Michelle Monje, Theo D Palmer, Robert C Malenka
2004 Neuron  
and (4) what are the computational advannew neurons is influenced by a variety of environmental tages of coupling excitation to neurogenesis for the and behavioral conditions (Brown et al., 2003; McEwen  ...  For example, brief NMDA receptor blockade in vivo increases precur-A wide variety of in vivo manipulations influence neurosor proliferation and subsequent neuron production genesis in the adult hippocampus  ...  Ca 2؉ Channels and Activity Influence Neurogenesis in Intact Systems Excitation Induces NeuroD, a Regulator of Neuronal Differentiation, in Proliferating NPCs The use of an in vitro culture preparation  ... 
doi:10.1016/s0896-6273(04)00266-1 pmid:15157417 fatcat:f7jlppxaqjea5mpddfcrnn4bde

Pathophysiogenesis of Mesial Temporal Lobe Epilepsy: Is Prevention of Damage Antiepileptogenic?

G. Curia, C. Lucchi, J. Vinet, F. Gualtieri, C. Marinelli, A. Torsello, L. Costantino, G. Biagini
2014 Current Medicinal Chemistry  
Besides loss of principal neurons and of specific interneurons, network rearrangement caused by axonal sprouting and neurogenesis are well known phenomena that are integrated by changes in receptor and  ...  Although prevention of hippocampal damage and epileptogenesis after a primary event could be a key innovative approach to TLE, the lack of clear data on the pathophysiological mechanisms leading to TLE  ...  In addition, celecoxib reduced the occurrence of spontaneous recurrent seizures after pilocarpine-induced prolonged seizures, prevented neuronal death and microglia activation in the hilus of dentate gyrus  ... 
doi:10.2174/0929867320666131119152201 pmid:24251566 pmcid:PMC4101766 fatcat:3le4pb3vs5exlmzglvfz3mvi2m

Neuroplasticity: from MRI to depressive symptoms

Philippe Fossati, Andrei Radtchenko, Patrice Boyer
2004 European Neuropsychopharmacology  
of such a phenomenon are manifold: apoptosis and neurotrophic deficits could explain most of the symptoms of depression depending on the regions concerned; the resulting alterations in neuroplasticity  ...  For example, communication between the hippocampus and the prefrontal cortex could be re-established, enabling in a way the cognitive processes to be breset.Q From a clinical point of view, the consequences  ...  Acknowledgement PF is supported by a Young Narsad Investigator Award (2003).  ... 
doi:10.1016/j.euroneuro.2004.09.001 pmid:15550349 fatcat:7i45wba33zaxrkbdew2wztcmre

Insights into Potential Targets for Therapeutic Intervention in Epilepsy

Cecilia Zavala-Tecuapetla, Manola Cuellar-Herrera, Hiram Luna-Munguia
2020 International Journal of Molecular Sciences  
All of them have demonstrated a certain degree of efficacy not only in controlling seizures but also in displaying neuroprotective activity and in modifying the progression of epilepsy.  ...  of drug-resistant epilepsy and develop new antiseizure therapies for the treatment of epilepsy.  ...  Gutierrez-Lerma for English review and improvement. Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/ijms21228573 pmid:33202963 pmcid:PMC7697405 fatcat:xqztcatnz5hkbau3o6cjwgjqie

Neuroimaging studies of mood disorders

Wayne C Drevets
2000 Biological Psychiatry  
Dysfunction involving these regions is thus hypothesized to play a role in the pathogenesis of depressive symptoms.  ...  Neuroimaging studies of major depression have identified neurophysiologic abnormalities in multiple areas of the orbital and medial prefrontal cortex, the amygdala, and related parts of the striatum and  ...  Because these phasic, burst firing patterns of dopamine neurons are thought to encode information regarding stimuli that predict reward and deviations between such predictions and the actual occurrence  ... 
doi:10.1016/s0006-3223(00)01020-9 pmid:11063977 fatcat:sfymlkhqbrdspngzv3mru2puwm

The Endocannabinoid System as an Emerging Target of Pharmacotherapy

P. Pacher
2006 Pharmacological Reviews  
We are indebted to Kimberly Bochniak for help with the list of references. P.P. dedicates this review to his beloved mother, Iren.  ...  Based on the above, one might hypothesize that A␤ deposition induces the release of endocannabinoids from neurons and glia, which activate CB 1 -mediated neuroprotective pathways and modulate the release  ...  , a key step in endocannabinoid production by glia .  ... 
doi:10.1124/pr.58.3.2 pmid:16968947 pmcid:PMC2241751 fatcat:2jj7ndilondzfmp6zpriecu5oq

Vascular growth factors in neuropsychiatry

Samuel S. Newton, Neil M. Fournier, Ronald S. Duman
2013 Cellular and Molecular Life Sciences (CMLS)  
neurons and vasculature.  ...  Obtaining insight into the behavioral, cellular and molecular actions of multi-functional trophic factors has the potential to open new and transformative therapeutic approaches.  ...  We showed that electroconvulsive seizure (ECS), which is one the most effective options for the treatment of refractory depression, resulted in a rapid and robust upregulation of VEGF expression in the  ... 
doi:10.1007/s00018-013-1281-9 pmid:23475069 pmcid:PMC3951730 fatcat:ze5vzw3n5rayrgju75kg3wrrum

Abstracts of the 15th Annual Meeting of the Israel Society for Neuroscience (Eilat, Israel, December 3–5, 2006)

2007 Neural Plasticity  
The Israel Society for Neuroscience (ISFN) was founded in 1993 by a group of Israeli leading scientists conducting research in the area of neurobiology.  ...  Both the number of members of the society and of those participating in the annual meeting is constantly increasing, and it is anticipated that this year about 600 scientists will convene at the Princess  ...  Acknowledgments: we thank Yael Handler, Mor Nahum, and Sarit Szpiro for their contribution.  ... 
doi:10.1155/2007/73079 fatcat:6ttewkzqh5cmzb433ffyv3t5xi

Major channels involved in neuropsychiatric disorders and therapeutic perspectives

Paola Imbrici, Diana Conte Camerino, Domenico Tricarico
2013 Frontiers in Genetics  
The cyclic activation of these channels influences neurotransmitter release, neuron excitability, gene transcription, and plasticity, providing distinct brain areas with unique physiological and pharmacological  ...  Voltage-gated ion channels are important mediators of physiological functions in the central nervous system.  ...  Three sodium channel genes encoding distinct α-subunit isoforms SCN1A, SCN2A, SCN3A are highly expressed in neurons and glia throughout the central nervous system (CNS) and peripheral nervous system.  ... 
doi:10.3389/fgene.2013.00076 pmid:23675382 pmcid:PMC3646240 fatcat:ro6b4xpnijgcznok62oxvrjuxy
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