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Dynamics of Electrical Activity in Epileptic Brain and Induced Changes due to Interictal Epileptiform Discharges

Ahmed Hossam Mohammed, Ulyana Morar, Mercedes Cabrerizo, Hoda Rajaei, Alberto Pinzon, Ilker Yaylali, Malek Adjouadi
2021 IEEE Access  
Understanding functional connectivity (FC) patterns of epileptic brain networks as they relate to the presence or absence of interictal epileptiform discharges (IEDs) can enhance machine learning (ML)  ...  Conclusions: FC maps intrinsically reflect the significant changes occurring in the dynamics of the epileptic brain.  ...  Due to the challenging state of randomness of seizure activity within an epileptic brain, FC maps produced by interictal epileptiform discharges (IEDs) can prove to be beneficial in bringing our attention  ... 
doi:10.1109/access.2021.3138385 fatcat:dyicw5anxfcwpdvejxqlufke4e

How do we use in vitro models to understand epileptiform and ictal activity? A report of the TASK1-WG4 group of the ILAE/AES Joint Translational Task Force

Chris G. Dulla, Damir Janigro, Premysl Jiruska, Joseph V. Raimondo, Akio Ikeda, Chou-Ching K. Lin, Howard P. Goodkin, Aristea S. Galanopoulou, Christophe Bernard, Marco de Curtis
2018 Epilepsia Open  
A great deal of knowledge about how brain networks generate various forms of epileptiform activity has been gained, but due to the multiple in vitro models and manipulations used, there is a need for a  ...  Preparations from both rodent and human postsurgical tissue have been utilized to generate in vitro electrical activity similar to electrographic activity seen in patients with epilepsy.  ...  Uwe was a true leader in the field of epilepsy research. We would also like to acknowledge Lauren-Harte-Hargrove for assistance during the preparation of this manuscript.  ... 
doi:10.1002/epi4.12277 pmid:30525115 pmcid:PMC6276782 fatcat:3x5uyuq4qbfydn4ffjqip6or3u

Hippocampus and epilepsy: Findings from human tissues

G. Huberfeld, T. Blauwblomme, R. Miles
2015 Revue neurologique (Paris)  
Interictal discharges thus depend on both GABAergic and glutamatergic signaling.  ...  Slices of tissue from patient with these syndromes retain functional neuronal networks and may generate epileptic activities.  ...  Finally, tissue slice microenvironment can be modified to mimic changes in brain extra-cellular medium to induce specific activities or for pharmacological investigation.  ... 
doi:10.1016/j.neurol.2015.01.563 pmid:25724711 pmcid:PMC4409112 fatcat:keilneu3ejcirpuuhgn3vewmj4

Models of drug-induced epileptiform synchronization in vitro

Massimo Avoli, John G.R. Jefferys
2016 Journal of Neuroscience Methods  
Overall, the analysis of the epileptiform activity induced in brain tissue in vitro has played a major role in advancing our understanding of the cellular and network mechanisms of epileptiform synchronization  ...  More complex slices including extensive networks and/or several connected brain structures can provide insights into the dynamics of long range connections during epileptic activity.  ...  Acknowledgments Original experimental data shown in this review were supported by the Canadian Institutes of Health Research (CIHR grants 8109 and 74609) to MA.  ... 
doi:10.1016/j.jneumeth.2015.10.006 pmid:26484784 pmcid:PMC4878885 fatcat:efvw3urqobe6npca5sv7unerp4

Mechanisms of Epileptiform Synchronization in Cortical Neuronal Networks

M. Avoli
2014 Current Medicinal Chemistry  
However, excessive neuronal synchronization is often the hallmark of epileptic activity in both generalized and partial epileptic disorders.  ...  This epileptic disorder can be reproduced in animals by topical or systemic injection of pilocarpine or kainic acid, or by repetitive electrical stimulation; these procedures induce an initial status epilepticus  ...  A: Changes induced by Schaffer collateral cut on the epileptiform activity recorded from the CA3 and entorhinal cortex from a combined mouse brain slice.  ... 
doi:10.2174/0929867320666131119151136 pmid:24251567 pmcid:PMC4880466 fatcat:fw3itiqw5ngvpm4n7veffv67ze

Evolving Mechanistic Concepts of Epileptiform Synchronization and their Relevance in Curing Focal Epileptic Disorders

Maxime Lévesque, David Ragsdale, Massimo Avoli
2019 Current Neuropharmacology  
Excessive synchronization can, however, lead to focal epileptiform activity characterized by interictal and ictal discharges in epileptic patients and animal models.  ...  For each mechanism, we discuss the actions of antiepileptic drugs that are presumably modulating excitatory or inhibitory signaling and voltage-gated currents to prevent seizures in epileptic patients.  ...  Perreault, to the experiments from which the figures shown in this review originate; these experiments were performed at the MNI between 1987 and 2007. We also thank Dr. M.  ... 
doi:10.2174/1570159x17666181127124803 pmid:30479217 pmcid:PMC7052840 fatcat:c4sxhjz7wjejjaljnxjshdx7oq

Extracellular potassium dynamics in the hyperexcitable state of the neuronal ictal activity

Gerson Florence, Tiago Pereira, Jürgen Kurths
2012 Communications in nonlinear science & numerical simulation  
This paper reviews experimental evidences and computational studies concerning effects of the extracellular potassium dynamics on the cellular excitability within the neuronal ictal activity.  ...  It remains unclear, however, how the extracellular potassium variation could affect the generation and persistence of epileptiform bursting within the ictal phase, that is, during the epileptic seizure  ...  Acknowledgements This work was supported by the Fundação Universidade Federal do ABC-UFABC (GF), and by CNPq grant 474647/2009-9 (T.P.).  ... 
doi:10.1016/j.cnsns.2011.06.023 fatcat:sbsfcqxldndhpjbqegoazhchxy

Seizure Initiation and Termination☆ [chapter]

J.L. Stringer
2017 Reference Module in Neuroscience and Biobehavioral Psychology  
The presence of interictal activity is also proposed to lead to the formation of new, or abnormal, excitatory connections, promoting further changes in the brain.  ...  Yet, despite all of the possible changes in an epileptic brain, the seizures remain episodic. They still start and stop.  ... 
doi:10.1016/b978-0-12-809324-5.00222-4 fatcat:fjpa2sbfnjbsxd2boghn2ay3je

Basic Electroencephalogram and It Is Common Clinical Applications in Children [chapter]

Raafat Hammad Seroor Jadah
2020 Electroencephalography [Working Title]  
Electroencephalography (EEG) is a non-invasive neurophysiological study that monitors electrical activity of the brain.  ...  EEG is an essential investigational tool to analyze and record electrical impulses of the brain and considered to be the gold standard electrophysiological test which can be used to help diagnose epilepsy  ...  of cerebral electrical activity in patients with brain death [4, 5] .  ... 
doi:10.5772/intechopen.94247 fatcat:xa7adz5hurh43nkmj2y2wwmyzy

GABAergic synchronization in the limbic system and its role in the generation of epileptiform activity

Massimo Avoli, Marco de Curtis
2011 Progress in Neurobiology  
Finally, we will consider the role of altered inhibition in the human epileptic brain along with the ability of GABA A receptor-mediated conductances to generate synchronous depolarizing events that may  ...  lead to ictogenesis in human epileptic disorders as well.  ...  Acknowledgments The original studies reviewed in this paper were supported by grants from the Canadian Institutes of Health Research, the Savoy Foundation, CURE, the Piergiorgio and Luisa Mariani Foundation  ... 
doi:10.1016/j.pneurobio.2011.07.003 pmid:21802488 pmcid:PMC4878907 fatcat:m7lsxzzfovewrcvdmryfmymw3a

The Impact of EEG/MEG Signal Processing and Modeling in the Diagnostic and Management of Epilepsy

F.H. Lopes da Silva
2008 IEEE Reviews in Biomedical Engineering  
ACKNOWLEDGMENT The author would like to thank J. C. de Munck and S.  ...  Kalitzin and their groups at the Free University Medical Center of Amsterdam, and at the Foundation of Epilepsy Institutions of The Netherlands at Heemstede, respectively, for the many discussions that  ...  In order to analyze this question deeper, it is relevant to discuss the general theoretical framework of the dynamics of brain activity that may account both for normal and epileptic neuronal activities  ... 
doi:10.1109/rbme.2008.2008246 pmid:22274902 fatcat:zacjnz3fr5bjrj7ojtxrmau5lu

Presynaptic GABAB receptors underlie the antiepileptic effect of low-frequency electrical stimulation in the 4-aminopyridine model of epilepsy in brain slices of young rats

Elena Y. Smirnova, Anton V. Chizhov, Aleksey V. Zaitsev
2020 Brain Stimulation  
Using the 4-aminopyridine (4-AP) model of epileptiform activity in juvenile rat brain slices, we found that LFES increased the interval between ictal discharges (IDs) in the entorhinal cortex.  ...  The blockade of GABAA, GABAB, AMPA, or NMDA synaptic receptors strongly affected the characteristics of epileptiform discharges in slices.  ...  Acknowledgment The reported study was funded by RFBR (project number 19-315-60016) and RSF (project number 17-75-10082).  ... 
doi:10.1016/j.brs.2020.07.013 pmid:32717394 fatcat:bqadw2q7bbd6xn64r7xyz542ja

Reduced signal complexity of intracellular recordings: a precursor for epileptiform activity?

Guido Widman, Dieter Bingmann, Klaus Lehnertz, Christian E. Elger
1999 Brain Research  
of neurons primarily involved in generation of epileptiform discharges.  ...  To test the existence of such dependencies, Ž . the transition from normal to epileptiform activity EA of CA3-neurons in hippocampal slices was analyzed in four epilepsy models, using a time windowed computation  ...  Epileptiform discharges are often characterized by synchronous activity in extended neuronal networks, maintained by PSP of chemical or electrical synapses, volatile Ž . signals NO or CO , electrical fields  ... 
doi:10.1016/s0006-8993(99)01647-9 pmid:10415414 fatcat:6apeymr2ivgmhcqkh3wpyl5hha

Antiepileptic Effects of a Novel Non-invasive Neuromodulation Treatment in a Subject With Early-Onset Epileptic Encephalopathy: Case Report With 20 Sessions of HD-tDCS Intervention

Oded Meiron, Rena Gale, Julia Namestnic, Odeya Bennet-Back, Nigel Gebodh, Zeinab Esmaeilpour, Vladislav Mandzhiyev, Marom Bikson
2019 Frontiers in Neuroscience  
A 73% decrease in interictal epileptic discharges (IEDs) frequency was also observed immediately after the intervention period, compared to IED frequency at 3 days prior to intervention.  ...  Seizures and epileptiform activity were monitored and quantified using video-EEG over multiple days of baseline, intervention, and post-intervention periods.  ...  DISCUSSION The efficacy of tDCS to suppress epileptiform activity and epileptic seizures was demonstrated in animal models (Nitsche and Paulus, 2009 ) and patient populations with focal epilepsy due to  ... 
doi:10.3389/fnins.2019.00547 pmid:31191235 pmcid:PMC6548848 fatcat:46cb6bznh5dofallq46k5po5oq

Computational models of epileptiform activity

Fabrice Wendling, Pascal Benquet, Fabrice Bartolomei, Viktor Jirsa
2016 Journal of Neuroscience Methods  
, seizure initiation, seizure propagation, spike-wave discharge, status epilepticus )*(+,$%-./'$0-,( Epileptiform activity refers to brain activity recorded during epileptic phenomena that cover not only  ...  We reviewed computer models that have been developed to reproduce and explain epileptiform activity.  ...  Raineteau for providing the hippocampal slice confocal image in Figure 1 .  ... 
doi:10.1016/j.jneumeth.2015.03.027 pmid:25843066 fatcat:altbj3ga5faj7dzlqla2pixwpq
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