Filters








504 Hits in 6.4 sec

Dynamical Organization of Syntaxin-1A at the Presynaptic Active Zone

Alexander Ullrich, Mathias A. Böhme, Johannes Schöneberg, Harald Depner, Stephan J. Sigrist, Frank Noé, Kim T. Blackwell
<span title="2015-09-14">2015</span> <i title="Public Library of Science (PLoS)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ch57atmlprauhhbqdf7x4ytejm" style="color: black;">PLoS Computational Biology</a> </i> &nbsp;
Dynamical Organization of Syntaxin-1A at the AZ PLOS Computational Biology |  ...  Although exocytosis mainly occurs at active zones, Syntaxin-1A appears to cover the entire neuronal membrane.  ...  Thus, syntaxins at the active zone may operate at an upper limit of aggregation while still permitting dynamics.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pcbi.1004407">doi:10.1371/journal.pcbi.1004407</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26367029">pmid:26367029</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4569342/">pmcid:PMC4569342</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/c6b36g77t5gp3jamsxhnztxwou">fatcat:c6b36g77t5gp3jamsxhnztxwou</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20171015150242/http://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004407&amp;type=printable" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/65/9e/659e1f8683bb7063350b9fa968fdac771e92c9e7.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pcbi.1004407"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> plos.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569342" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

The SNARE complex in neuronal and sensory cells

Neeliyath A. Ramakrishnan, Marian J. Drescher, Dennis G. Drescher
<span title="">2012</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/uz5ea6gssjh6jmpvh7ayrydqti" style="color: black;">Molecular and Cellular Neuroscience</a> </i> &nbsp;
The main difference rests in how the synaptic complex is organized, with active zones in neuronal cells and ribbon synapses in sensory cells (such as photoreceptors and hair cells).  ...  Transmitter release at synapses ensures faithful chemical coding of information that is transmitted in the sub-second time frame.  ...  Acknowledgments This work was supported by grants from the National Institutes of Health (R01 DC000156 to DGD and R01 DC004076 to MJD) and the Hearing Health Foundation, formerly Deafness Research Foundation  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.mcn.2012.03.009">doi:10.1016/j.mcn.2012.03.009</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/22498053">pmid:22498053</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3570063/">pmcid:PMC3570063</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/vbqk3vv37reojpcz7ngwufsb6i">fatcat:vbqk3vv37reojpcz7ngwufsb6i</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200209072457/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3570063&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/3b/ad/3badb298bcf834ec0ee4c31afa559f65500c365d.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.mcn.2012.03.009"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570063" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Need for speed: Super-resolving the dynamic nanoclustering of syntaxin-1 at exocytic fusion sites

Pranesh Padmanabhan, Adekunle T. Bademosi, Ravikiran Kasula, Elsa Lauwers, Patrik Verstreken, Frédéric A. Meunier
<span title="2019-02-28">2019</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/46dow3ic4jdird3g7urzlpd4cu" style="color: black;">Neuropharmacology</a> </i> &nbsp;
factor (NSF), α-soluble NSF attachment protein (α-SNAP) and SNARE complex assembly on the dynamic nanoscale organization of syntaxin-1.  ...  These techniques are revealing a highly dynamic nature of the nanoscale organization of the exocytic machinery.  ...  Acknowledgements The authors thank Rowan Tweedale (Queensland Brain Institute (QBI)) for critical appraisal of the manuscript, Nick Valmas (QBI) for help with preparing  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuropharm.2019.02.036">doi:10.1016/j.neuropharm.2019.02.036</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30826343">pmid:30826343</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/dg77p4nr3jeydfdfgxpu7bxtci">fatcat:dg77p4nr3jeydfdfgxpu7bxtci</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210429040009/https://lirias2repo.kuleuven.be/bitstream/handle/123456789/635687/Padmanabhan%20et%20al.,%202019.pdf;jsessionid=4CE08B9B0A72F0820B9147183434648D?sequence=2" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/6c/a7/6ca7b0507c8df9e47995701688f35269b541e4f0.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuropharm.2019.02.036"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>

New Insights Into Interactions of Presynaptic Calcium Channel Subtypes and SNARE Proteins in Neurotransmitter Release

Rongfang He, Juan Zhang, Yiyan Yu, Laluo Jizi, Weizhong Wang, Miaoling Li
<span title="2018-07-16">2018</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/uc7xbcwzljashhncrlsxupx3em" style="color: black;">Frontiers in Molecular Neuroscience</a> </i> &nbsp;
Action potential (AP) induces presynaptic membrane depolarization and subsequent opening of Ca 2+ channels, and then triggers neurotransmitter release at the active zone of presynaptic terminal.  ...  Until now, it has not been clear how different subtypes of calcium channels integrally regulate the release of neurotransmitters within 200 µs of the AP arriving at the active zone of synaptic terminal  ...  INTRODUCTION Influx of Ca 2+ through presynaptic calcium channels into presynaptic terminals at active zone is a crucial step in synaptic vesicle exocytosis and rapid neurotransmitter release (Catterall  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fnmol.2018.00213">doi:10.3389/fnmol.2018.00213</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30061813">pmid:30061813</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6054978/">pmcid:PMC6054978</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/6npppiuirffbnoyh7cztal44wy">fatcat:6npppiuirffbnoyh7cztal44wy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190302122042/http://pdfs.semanticscholar.org/9bfd/587e01eabff5291107c4bd9121a03490871d.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/9b/fd/9bfd587e01eabff5291107c4bd9121a03490871d.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fnmol.2018.00213"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> frontiersin.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054978" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

The presynaptic machinery at the synapse of C. elegans

Fernando Calahorro, Patricia G. Izquierdo
<span title="2018-03-12">2018</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/2ywo4j4ppbc7lfpemgpsfkxp4a" style="color: black;">Invertebrate Neuroscience</a> </i> &nbsp;
Here, we review research on the major group of synaptic proteins, involved in the presynaptic machinery in C. elegans, showing a strong conservation between higher organisms and highlight how C. elegans  ...  Although this fact may reflect differences in the function of the homologous proteins in the synapses between these organisms, the most likely interpretation is that many of these components are equally  ...  Acknowledgements We would like to apologize to the colleagues whose work could not be cited due to space constraints.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s10158-018-0207-5">doi:10.1007/s10158-018-0207-5</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/29532181">pmid:29532181</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5851683/">pmcid:PMC5851683</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/w4zpbm62ijgfncrgfpzrfkvf4u">fatcat:w4zpbm62ijgfncrgfpzrfkvf4u</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20181030070239/https://link.springer.com/content/pdf/10.1007%2Fs10158-018-0207-5.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/2e/21/2e21833ac9c05db5e85ed4920d9b7bbb20e356ce.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s10158-018-0207-5"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851683" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Unraveling the Nanoscopic Organization and Function of Central Mammalian Presynapses With Super-Resolution Microscopy

Lia G. Carvalhais, Vera C. Martinho, Elisabete Ferreiro, Paulo S. Pinheiro
<span title="2021-01-08">2021</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/wrk3kouosrhcxiprcbguskdipu" style="color: black;">Frontiers in Neuroscience</a> </i> &nbsp;
Here, we review how these advanced imaging techniques have contributed to unprecedented insight into the nanoscopic organization and function of mammalian neuronal presynapses, revealing new organizational  ...  The complex, nanoscopic scale of neuronal function, taking place at dendritic spines, axon terminals, and other minuscule structures, cannot be adequately resolved using standard, diffraction-limited imaging  ...  ACKNOWLEDGMENTS The authors are grateful to Dr. Eric Hosy, IINS Bordeaux, for critical reading of the manuscript and for helpful suggestions.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fnins.2020.578409">doi:10.3389/fnins.2020.578409</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33584169">pmid:33584169</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7874199/">pmcid:PMC7874199</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/xm4cfpsbpvb6dhstgj2likm6ia">fatcat:xm4cfpsbpvb6dhstgj2likm6ia</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210114095438/https://fjfsdata01prod.blob.core.windows.net/articles/files/578409/pubmed-zip/.versions/1/.package-entries/fnins-14-578409/fnins-14-578409.pdf?sv=2018-03-28&amp;sr=b&amp;sig=XZVeqUT0SWOnHsGMQzyK0xG8eGfMVfsjvdT5uBjngis%3D&amp;se=2021-01-14T09%3A55%3A06Z&amp;sp=r&amp;rscd=attachment%3B%20filename%2A%3DUTF-8%27%27fnins-14-578409.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/80/01/80014e7bdc537d50f8c89c208222ebd377d7e47e.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fnins.2020.578409"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> frontiersin.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874199" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Calcium Channel Regulation and Presynaptic Plasticity

William A. Catterall, Alexandra P. Few
<span title="">2008</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/5lze265mrrcddlccx7zpfjyjwi" style="color: black;">Neuron</a> </i> &nbsp;
We propose that presynaptic Ca 2+ channels serve as the regulatory node in a dynamic, multilayered signaling network that exerts short-term control of neurotransmission in response to synaptic activity  ...  Voltage-gated calcium (Ca 2+ ) channels initiate release of neurotransmitters at synapses, and regulation of presynaptic Ca 2+ channels has a powerful influence on synaptic strength.  ...  No doubt the protein composition of the active zone is dynamic, like the postsynaptic density, but there is no clear evidence for that at present.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuron.2008.09.005">doi:10.1016/j.neuron.2008.09.005</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/18817729">pmid:18817729</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/52s5rj2fsfcivgodizxoisv7oa">fatcat:52s5rj2fsfcivgodizxoisv7oa</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190417100842/https://core.ac.uk/download/pdf/82277199.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/f8/da/f8da0893c1b6eab149add9386cdc82405e7938a3.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuron.2008.09.005"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>

Dysregulations of Synaptic Vesicle Trafficking in Schizophrenia

Chijioke N. Egbujo, Duncan Sinclair, Chang-Gyu Hahn
<span title="2016-07-02">2016</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/dvpogvvzjzfbzasqb3rjxj5unm" style="color: black;">Current Psychiatry Reports</a> </i> &nbsp;
An important segment of these pathways that have been extensively studied for the pathophysiology of schizophrenia is the presynaptic neurotransmitter release mechanism.  ...  This set of molecular events is an evolutionarily well-conserved process that involves vesicle recruitment, docking, membrane fusion and recycling, leading to efficient neurotransmitter delivery at the  ...  via endocytosis at the active zone.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s11920-016-0710-5">doi:10.1007/s11920-016-0710-5</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/27371030">pmid:27371030</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5134737/">pmcid:PMC5134737</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/cfsxrkvhfbb2tgtt3lclxuyxqm">fatcat:cfsxrkvhfbb2tgtt3lclxuyxqm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20191023052610/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5134737&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/5b/8d/5b8dacda278e3d22f7cf63f2d8b27c1b3b4482e5.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s11920-016-0710-5"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134737" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Mobility of Calcium Channels in the Presynaptic Membrane

Romy Schneider, Eric Hosy, Johannes Kohl, Julia Klueva, Daniel Choquet, Ulrich Thomas, Andreas Voigt, Martin Heine
<span title="">2015</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/5lze265mrrcddlccx7zpfjyjwi" style="color: black;">Neuron</a> </i> &nbsp;
Increasing VDCC surface populations by co-expression of the a2d1 subunit did not alter channel mobility but led to enlarged active zones (AZs) rather than higher channel densities.  ...  Highlights d Calcium channels (VDCC) are mobile yet confined within the presynaptic membrane d Intracellular Ca 2+ chelation by BAPTA or EGTA reduces VDCC mobility d Increasing VDCC surface expression  ...  ., 2011) , the synaptic exchange rate for syntaxin-1A molecules appeared high and a fraction of 15% immobile syntaxin-1A::mEOS2 molecules could reflect temporal immobilization of syntaxin-1A in synapses  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuron.2015.03.050">doi:10.1016/j.neuron.2015.03.050</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/25892305">pmid:25892305</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/2wlssyguyjea3nl5kzgfzgb5hi">fatcat:2wlssyguyjea3nl5kzgfzgb5hi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190225073042/https://core.ac.uk/download/pdf/82129832.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/16/db/16db248b2edf6b9ab94f1cefc8a1047e30837fa8.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuron.2015.03.050"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>

Molecular Underpinnings of Synaptic Vesicle Pool Heterogeneity

Devon C. Crawford, Ege T. Kavalali
<span title="2015-03-31">2015</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/236hwyqxjnai3lw6lzbpgsalpq" style="color: black;">Traffic : the International Journal of Intracellular Transport</a> </i> &nbsp;
Chemical neurotransmission is initiated by synaptic vesicle fusion with the presynaptic active zone resulting in release of neurotransmitters.  ...  In this model, functional differences among synaptic vesicle populations are ascribed to their spatial distribution in the synapse with respect to the active zone.  ...  Acknowledgments The authors were supported by National Institutes of Health grants F32MH102915 (D.C.C.) and MH066198 (E.T.K.) and by the Brain and Behavior Research Foundation (E.T.K.).  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1111/tra.12262">doi:10.1111/tra.12262</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/25620674">pmid:25620674</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4578802/">pmcid:PMC4578802</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/o76t54oezjbcdj4qumzwk3jlcq">fatcat:o76t54oezjbcdj4qumzwk3jlcq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200503082627/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4578802&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/64/6b/646b4351f74e626cca9260bdab059d5b40bc3cab.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1111/tra.12262"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578802" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Molecular mechanisms that stabilize short term synaptic plasticity during presynaptic homeostatic plasticity

Jennifer M Ortega, Özgür Genç, Graeme W Davis
<span title="2018-11-13">2018</span> <i title="eLife Sciences Publications, Ltd"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/en4qj5ijrbf5djxx7p5zzpjyoq" style="color: black;">eLife</a> </i> &nbsp;
Our data support a model based on the regulated availability of Unc18 at the presynaptic active zone, a process that is restrained by Syntaxin1A and facilitated by RIM.  ...  As such, regulated vesicle priming/super-priming enables PHP to stabilize both synaptic gain and the activity-dependent transfer of information at a synapse.  ...  Ting Ting Wang for critical reading of the manuscript. Supported by NIH Grant R35NS097212 to GWD. We also acknowledge support of the Kavli Institute for Fundamental Neuroscience at UCSF.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.7554/elife.40385">doi:10.7554/elife.40385</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30422113">pmid:30422113</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6250423/">pmcid:PMC6250423</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/5he5e4q3avh7rpgmn4epzxuccy">fatcat:5he5e4q3avh7rpgmn4epzxuccy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20191212195002/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6250423&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/2a/c3/2ac3fa96669e3fe15671139923ff4848fc12ce7c.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.7554/elife.40385"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elifesciences.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250423" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Presynaptic Calcium Channels

Sumiko Mochida
<span title="2019-05-06">2019</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/3loumxx7kzamnlu4h6x3xoz6ay" style="color: black;">International Journal of Molecular Sciences</a> </i> &nbsp;
For synchronization of efficient neurotransmitter release, synaptic vesicles are targeted by presynaptic Ca2+ channels forming a large signaling complex in the active zone.  ...  This article overviews modulation of the activity of CaV2.1 and CaV2.2 channels in the control of synaptic strength and presynaptic plasticity.  ...  domain of syntaxin-1A [63, 64, 72] .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/ijms20092217">doi:10.3390/ijms20092217</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/4b55c3bbgrfwnkrzfbe4islx4i">fatcat:4b55c3bbgrfwnkrzfbe4islx4i</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200213101352/https://res.mdpi.com/d_attachment/ijms/ijms-20-02217/article_deploy/ijms-20-02217-v2.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/e0/0a/e00a16950c4fed2c589012296d382dc8bb9c231f.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/ijms20092217"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a>

Quantitative Proteomic Analysis Reveals Molecular Adaptations in the Hippocampal Synaptic Active Zone of Chronic Mild Stress-Unsusceptible Rats

Jian Zhou, Zhao Liu, Jia Yu, Xin Han, Songhua Fan, Weihua Shao, Jianjun Chen, Rui Qiao, Peng Xie
<span title="2015-09-12">2015</span> <i title="Oxford University Press (OUP)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/t7zhumcn45gvdefswsettbaxjm" style="color: black;">International Journal of Neuropsychopharmacology</a> </i> &nbsp;
Moreover, through STRING and immunoblotting analysis, membrane-associated GTP-bound Rab3a and Munc18-1 appear to coregulate syntaxin-1/SNAP25/VAMP2 assembly at the hippocampal presynaptic active zone of  ...  Conclusions: The present results support the concept that there is a range of potential protein adaptations in the hippocampal synaptic active zone of unsusceptible rats, revealing new investigative targets  ...  Acknowledgments This work was supported by grants from the National Basic Research Program of China (''973 program'', 2009CB918300), the National Natural Science Foundation of China (81101009, 31570826  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/ijnp/pyv100">doi:10.1093/ijnp/pyv100</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26364272">pmid:26364272</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4772275/">pmcid:PMC4772275</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/kwygp7nbgrdbvfakpmbyqdvcve">fatcat:kwygp7nbgrdbvfakpmbyqdvcve</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190303034048/http://pdfs.semanticscholar.org/ae9e/9335b12a1bc17df8cf6f36dd005a7843a373.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ae/9e/ae9e9335b12a1bc17df8cf6f36dd005a7843a373.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/ijnp/pyv100"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> oup.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772275" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Modulation of neurotransmitter release by the second messenger-activated protein kinases: Implications for presynaptic plasticity

A LEENDERS, Z SHENG
<span title="">2005</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/566qcoq67fbqdpzluwntuadxpi" style="color: black;">Pharmacology and Therapeutics</a> </i> &nbsp;
Here, we present a brief overview of the data on the newly identified candidate targets of the second messenger-activated protein kinases in the presynaptic release machinery and discuss the potential  ...  However, functional evaluation of the activity-dependent phosphorylation events for modulating presynaptic functions still represents a considerable challenge.  ...  Work from the laboratory is supported by the Intramural Research Program of NINDS, NIH (Z.-H.S.).  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.pharmthera.2004.10.012">doi:10.1016/j.pharmthera.2004.10.012</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/15626456">pmid:15626456</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC1804289/">pmcid:PMC1804289</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/7kz6xxijbbdvxemv6tsihwsl4a">fatcat:7kz6xxijbbdvxemv6tsihwsl4a</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200504045940/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC1804289&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/d6/b1/d6b16ccb8f01ee325144aa5f6cb90614dd2b60b1.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.pharmthera.2004.10.012"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1804289" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Intrinsically disordered proteins in synaptic vesicle trafficking and release

David Snead, David Eliezer
<span title="2019-01-30">2019</span> <i title="American Society for Biochemistry &amp; Molecular Biology (ASBMB)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/mryncoafc5cxdicldzfm4vlsze" style="color: black;">Journal of Biological Chemistry</a> </i> &nbsp;
Here, we review the prevalence and functional roles of IDPs and IDRs associated with the release and recycling of synaptic vesicles at nerve terminals, as well as with the architecture of these terminals  ...  vesicle trafficking and exocytosis and in overall synaptic organization.  ...  It is possible, then, that the presynaptic active zone may organize and function through a type of phase transition into a liquid-like dynamic state.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1074/jbc.rev118.006493">doi:10.1074/jbc.rev118.006493</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30700558">pmid:30700558</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6416451/">pmcid:PMC6416451</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/re7nmnqv4nfi7ft2ihdrbdb3fu">fatcat:re7nmnqv4nfi7ft2ihdrbdb3fu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190427193120/http://www.jbc.org/content/294/10/3325.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/52/46/5246e03a5156d7fd3494dbb454fe74f76c1e7e31.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1074/jbc.rev118.006493"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416451" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>
&laquo; Previous Showing results 1 &mdash; 15 out of 504 results