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Nonlinear Imaging of Microbubble Contrast Agent Using the Volterra Filter: In Vivo Results
2016
IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control
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We also report in vivo results from imaging UCA activity in an implanted LNCaP tumor with heterogeneous perfusion. ...
A nonlinear filtering approach to imaging the dynamics of microbubble ultrasound contrast agents (UCA) in microvessels is presented. ...
John Bischof, Prof. of Biomedical Engineering at Minnesota for collaboration on the in vivo tumor imaging using CEUS. We are grateful for Dr. Jeunghwan Choi and Dr. ...
doi:10.1109/tuffc.2016.2614430
pmid:27705855
pmcid:PMC5759042
fatcat:vnyxqvohk5ch7kskkobyxjvoaa
Initial results of in vivo non-invasive cancer imaging in the human breast using near-infrared photoacoustics
2007
Optics Express
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The results show that photoacoustic imaging may have potential in visualizing certain breast cancers based on intrinsic optical absorption contrast. ...
Near-infrared photoacoustic images of regions-of-interest in 4 of the 5 cases of patients with symptomatic breasts reveal higher intensity regions which we attribute to vascular distribution associated ...
Finally, ring patterns have been reported in dynamic magnetic resonance (MR) imaging of contrast agent uptake in breast carcinomas [21] with rim enhancement correlating well with ratios of tumor periphery-core ...
doi:10.1364/oe.15.012277
pmid:19547596
fatcat:kdlbahku3fhctomix33btjpkde
Optical Verification of Microbubble Response to Acoustic Radiation Force in Large Vessels With In Vivo Results
2015
Investigative Radiology
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beam sequence designs or signal processing routines for enhanced ultrasound molecular imaging. ...
Objective: The objective of this study was to optically verify the dynamic behaviors of adherent microbubbles in large blood vessel environments in response to a new ultrasound technique using modulated ...
design or developments of signal processing methods for enhanced ultrasound molecular imaging. ...
doi:10.1097/rli.0000000000000185
pmid:26135018
pmcid:PMC4598275
fatcat:bukvb23xfzhydjtx4vqqkbh6ta
Evolution of contrast agents for ultrasound imaging and ultrasound-mediated drug delivery
2015
Frontiers in Pharmacology
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This review summarizes important steps in the development of US CAs and introduces the current clinical applications of contrast-enhanced US. ...
Citation: Paefgen V, Doleschel D and Kiessling F (2015) Evolution of contrast agents for ultrasound imaging and ultrasound-mediated drug delivery. ...
Introduction Ultrasound (US) imaging enables cheap, non-invasive imaging in real-time with a high soft tissue contrast and without exposing the patient to radiation. ...
doi:10.3389/fphar.2015.00197
pmid:26441654
pmcid:PMC4584939
fatcat:bljkwrnozrhm7if2gjd3pe5vhy
Use of Ultrasound to Assess Drug Efficacy in Orthotopic Rat Models of HCC
[chapter]
2011
Ultrasound Imaging - Medical Applications
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Assessment of tumor perfusion using contrast imaging Within the past decade, ultrasound contrast agents have been increasingly used to characterize vascular dynamics. ...
Two methods are available when using the contrast agent to assess tumor perfusion; power Doppler and dynamic contrast imaging: Use of power Doppler. ...
Use of Ultrasound to Assess Drug Efficacy in Orthotopic Rat Models of HCC, Ultrasound Imaging -Medical Applications, Prof. ...
doi:10.5772/20650
fatcat:765ad3lderevxnrs6l5mxb25r4
scVEGF Microbubble Ultrasound Contrast Agents
2010
Investigative Radiology
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A murine model of colon adenocarcinoma was used to assess retention of scVEGF-MB with contrast ultrasound imaging during tumor angiogenesis in vivo. ...
In an in vivo model of tumor angiogenesis, scVEGF MB showed significantly higher ultrasound contrast signal enhancement in tumors (8.46 ± 1.61 dB) compared with nontargeted control MB (1.58 ± 0.83 dB). ...
preferentially binds to recombinant VEGFR-2 and VEGFR-2-expressing endothelial cells in vitro, and enhance ultrasound imaging of tumor angiogenesis in vivo. ...
doi:10.1097/rli.0b013e3181efd581
pmid:20733505
pmcid:PMC3426362
fatcat:iuuxwfvrtjanpfsqyzfefua54i
Targeted imaging using ultrasound contrast agents
2004
IEEE Engineering in Medicine and Biology Magazine
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(b) Image of time to 80% replenishment of ultrasound contrast agent within the tumor. (c) Contrast-enhanced CT image of the same tumor. (d) CT image of time to 80% replenishment within the tumor. ...
Parametric imaging of time to 80% contrast enhancement in the microvasculature of a subcutaneously implanted mammary adenocarcinoma in a rat model. (a) B-mode ultrasound image of an implanted tumor. ...
doi:10.1109/memb.2004.1360405
pmid:15565796
fatcat:rgsz6pnftbe6vdyztjpr7v6oqq
Thermal Ablation and High-Resolution Imaging Using a Back-to-Back (BTB) Dual-Mode Ultrasonic Transducer: In Vivo Results
2021
Sensors
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Images were obtained in vivo mice before and after treatment and compared to identify the treated region. ...
The optic fibers were embedded in the HIFU focal region of ex vivo chicken breasts and the temperature change was measured. ...
To the best of our knowledge, the current paper is the first to demonstrate the use of high-frequency in vivo imaging to monitor the dynamics of lesion formation using color-scale imaging after HIFU treatment ...
doi:10.3390/s21051580
pmid:33668260
pmcid:PMC7956793
fatcat:ydsof6gafbgehm7yvqds4y6vry
Contrast-enhanced Ultrasound Imaging: State of the Art
2005
Journal of Medical Ultrasound
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KEY WORDS -harmonic imaging, microbubble, tumor diagnosis, ultrasound contrast agents, ultrasound imaging technology ■ J Med Ultrasound 2005;13(3):109-126 ■ ...
Contrast-enhanced imaging using micro-flow imaging Contrast-enhanced imaging using micro-flow imaging d mode shows a high resolution depiction of normally perfused kidney parenchyma in an animal model. ...
Contrast-enhanced ultrasound has the potential to be very useful as it allows real-time assessment of lesion vascularity [36] and is similar to dynamic CT in its sensitivity and specificity [37, 38] ...
doi:10.1016/s0929-6441(09)60100-4
fatcat:3pcave2cyjb5nounks3stxpnvq
Tumor Functional and Molecular Imaging Utilizing Ultrasound and Ultrasound-Mediated Optical Techniques
2013
American Journal of Pathology
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This review introduces tumor functional and molecular imaging using microbubble-based ultrasound and ultrasound-mediated optical imaging techniques. (Am J Pathol 2013, 182: 305e311; http://dx. ...
inexpensive contrast agents, and comparable maximum-imaging depth. ...
recently. 6, 10 In this review, microbubble-enhanced ultrasound tumor imaging will be introduced first. ...
doi:10.1016/j.ajpath.2012.07.036
pmid:23219728
pmcid:PMC3969505
fatcat:ax3a7q4ogzhezfsnxc6f2rkvvi
Novel contrast-enhanced ultrasound imaging in prostate cancer
2011
World journal of urology
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With the introduction of contrast-enhanced ultrasound (CEUS), perfusion imaging of the microvascularization became available. ...
Purpose The purposes of this paper were to present the current status of contrast-enhanced transrectal ultrasound imaging and to discuss the latest achievements and techniques now under preclinical testing ...
Clinically, contrast-enhanced ultrasound is now mainly used for perfusion measurement of the heart and for the detection of liver malignancies [18, 19] . ...
doi:10.1007/s00345-011-0747-3
pmid:21847656
pmcid:PMC3189413
fatcat:z6crulc3yng47gpvgco6dpdwu4
Recent developments in dynamic contrast-enhanced ultrasound imaging of tumor angiogenesis
2014
Imaging in Medicine
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There is tremendous interest in the development of noninvasive methods for imaging tumor angiogenesis, and ultrasound (US) is an emerging platform technology to address this challenge. ...
The introduction of intravascular microbubble contrast agents not only allows real-time visualization of tumor perfusion during an US examination, but they can be functionalized with specific ligands to ...
With the advent of microbubble (MB) contrast agents, characterization of tissue perfusion and vascular volume is possible with the application of a dynamic contrast-enhanced US (DCE-US) imaging session ...
doi:10.2217/iim.13.74
pmid:25221623
pmcid:PMC4160124
fatcat:5wswf7oikbg4tothyy3vhsyaza
The Evolution of Ultrasound Technologies; from Anatomic to Physiologic,Histologic, and Molecular Imaging
2013
Anatomy & Physiology
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Contrast Enhanced Ultrasound Contrast enhanced MRI and CT have been primary cross sectional imaging modalities. ...
as chemoembolization [7] and radiofrequency ablation [8] were intra-procedural dynamic imaging of tumor perfusion can be used to determine the completeness of therapeutic vascular embolization and ...
doi:10.4172/2161-0940.1000e133
fatcat:5ojdcngi45e2hifuxsnlejewru
Nanobubbles for enhanced ultrasound imaging of tumors
2012
International Journal of Nanomedicine
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We have demonstrated the ability to fabricate NBs that can be used for the in vivo contrast-enhanced imaging of tumor tissue and that have potential for drug/gene delivery. ...
In this work, we fabricated a lipid NBs contrast-enhanced ultrasound agent and evaluated its passive targeting ability in vivo. ...
Disclosure The authors report no conflicts of interest in this work. ...
doi:10.2147/ijn.s28830
pmid:22393289
pmcid:PMC3289446
fatcat:dog5dhpmt5aqlhc2jy4h6vfoti
Radioembolization of Hepatocellular Carcinoma with Built-In Dosimetry: First in vivo Results with Uniformly-Sized, Biodegradable Microspheres Labeled with 188Re
2019
Theranostics
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We also thank Jovan Gill and Nicole Sarden for their help during the ultrasound-guided injections as well as Zeynab Nosrati for help during the administration of 188 Re-MS. ...
the limited resolution and the low contrast difference in the CT images of the rats did not allow us to distinguish with confidence the boundaries of the tumor and the healthy liver tissue. ...
The interactions of β¯ particles with tissue result in Bremsstrahlung photons which can be used to create images using single photon emission computed tomography (SPECT). ...
doi:10.7150/thno.29381
fatcat:qnjulh7wara4jmamazujnhfzse
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