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Nonlinear Imaging of Microbubble Contrast Agent Using the Volterra Filter: In Vivo Results

Juan Du, Dalong Liu, Emad S. Ebbini
2016 IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control  
We also report in vivo results from imaging UCA activity in an implanted LNCaP tumor with heterogeneous perfusion.  ...  A nonlinear filtering approach to imaging the dynamics of microbubble ultrasound contrast agents (UCA) in microvessels is presented.  ...  John Bischof, Prof. of Biomedical Engineering at Minnesota for collaboration on the in vivo tumor imaging using CEUS. We are grateful for Dr. Jeunghwan Choi and Dr.  ... 
doi:10.1109/tuffc.2016.2614430 pmid:27705855 pmcid:PMC5759042 fatcat:vnyxqvohk5ch7kskkobyxjvoaa

Initial results of in vivo non-invasive cancer imaging in the human breast using near-infrared photoacoustics

Srirang Manohar, Susanne E. Vaartjes, Johan C. G. van Hespen, Joost M. Klaase, Frank M. van den Engh, Wiendelt Steenbergen, Ton G. van Leeuwen
2007 Optics Express  
The results show that photoacoustic imaging may have potential in visualizing certain breast cancers based on intrinsic optical absorption contrast.  ...  Near-infrared photoacoustic images of regions-of-interest in 4 of the 5 cases of patients with symptomatic breasts reveal higher intensity regions which we attribute to vascular distribution associated  ...  Finally, ring patterns have been reported in dynamic magnetic resonance (MR) imaging of contrast agent uptake in breast carcinomas [21] with rim enhancement correlating well with ratios of tumor periphery-core  ... 
doi:10.1364/oe.15.012277 pmid:19547596 fatcat:kdlbahku3fhctomix33btjpkde

Optical Verification of Microbubble Response to Acoustic Radiation Force in Large Vessels With In Vivo Results

Shiying Wang, Claudia Y. Wang, Sunil Unnikrishnan, Alexander L. Klibanov, John A. Hossack, F. William Mauldin
2015 Investigative Radiology  
beam sequence designs or signal processing routines for enhanced ultrasound molecular imaging.  ...  Objective: The objective of this study was to optically verify the dynamic behaviors of adherent microbubbles in large blood vessel environments in response to a new ultrasound technique using modulated  ...  design or developments of signal processing methods for enhanced ultrasound molecular imaging.  ... 
doi:10.1097/rli.0000000000000185 pmid:26135018 pmcid:PMC4598275 fatcat:bukvb23xfzhydjtx4vqqkbh6ta

Evolution of contrast agents for ultrasound imaging and ultrasound-mediated drug delivery

Vera Paefgen, Dennis Doleschel, Fabian Kiessling
2015 Frontiers in Pharmacology  
This review summarizes important steps in the development of US CAs and introduces the current clinical applications of contrast-enhanced US.  ...  Citation: Paefgen V, Doleschel D and Kiessling F (2015) Evolution of contrast agents for ultrasound imaging and ultrasound-mediated drug delivery.  ...  Introduction Ultrasound (US) imaging enables cheap, non-invasive imaging in real-time with a high soft tissue contrast and without exposing the patient to radiation.  ... 
doi:10.3389/fphar.2015.00197 pmid:26441654 pmcid:PMC4584939 fatcat:bljkwrnozrhm7if2gjd3pe5vhy

Use of Ultrasound to Assess Drug Efficacy in Orthotopic Rat Models of HCC [chapter]

Cedo M., Terri Swanson, Theresa Tuthill
2011 Ultrasound Imaging - Medical Applications  
Assessment of tumor perfusion using contrast imaging Within the past decade, ultrasound contrast agents have been increasingly used to characterize vascular dynamics.  ...  Two methods are available when using the contrast agent to assess tumor perfusion; power Doppler and dynamic contrast imaging: Use of power Doppler.  ...  Use of Ultrasound to Assess Drug Efficacy in Orthotopic Rat Models of HCC, Ultrasound Imaging -Medical Applications, Prof.  ... 
doi:10.5772/20650 fatcat:765ad3lderevxnrs6l5mxb25r4

scVEGF Microbubble Ultrasound Contrast Agents

Christopher R. Anderson, Joshua J. Rychak, Marina Backer, Joseph Backer, Klaus Ley, Alexander L. Klibanov
2010 Investigative Radiology  
A murine model of colon adenocarcinoma was used to assess retention of scVEGF-MB with contrast ultrasound imaging during tumor angiogenesis in vivo.  ...  In an in vivo model of tumor angiogenesis, scVEGF MB showed significantly higher ultrasound contrast signal enhancement in tumors (8.46 ± 1.61 dB) compared with nontargeted control MB (1.58 ± 0.83 dB).  ...  preferentially binds to recombinant VEGFR-2 and VEGFR-2-expressing endothelial cells in vitro, and enhance ultrasound imaging of tumor angiogenesis in vivo.  ... 
doi:10.1097/rli.0b013e3181efd581 pmid:20733505 pmcid:PMC3426362 fatcat:iuuxwfvrtjanpfsqyzfefua54i

Targeted imaging using ultrasound contrast agents

S.H. Bloch, P.A. Dayton, K.W. Ferrara
2004 IEEE Engineering in Medicine and Biology Magazine  
(b) Image of time to 80% replenishment of ultrasound contrast agent within the tumor. (c) Contrast-enhanced CT image of the same tumor. (d) CT image of time to 80% replenishment within the tumor.  ...  Parametric imaging of time to 80% contrast enhancement in the microvasculature of a subcutaneously implanted mammary adenocarcinoma in a rat model. (a) B-mode ultrasound image of an implanted tumor.  ... 
doi:10.1109/memb.2004.1360405 pmid:15565796 fatcat:rgsz6pnftbe6vdyztjpr7v6oqq

Thermal Ablation and High-Resolution Imaging Using a Back-to-Back (BTB) Dual-Mode Ultrasonic Transducer: In Vivo Results

Hae Gyun Lim, Hyunhee Kim, Kyungmin Kim, Jeongwoo Park, Yeonggeun Kim, Jinhee Yoo, Dasom Heo, Jinhwan Baik, Sung-Min Park, Hyung Ham Kim
2021 Sensors  
Images were obtained in vivo mice before and after treatment and compared to identify the treated region.  ...  The optic fibers were embedded in the HIFU focal region of ex vivo chicken breasts and the temperature change was measured.  ...  To the best of our knowledge, the current paper is the first to demonstrate the use of high-frequency in vivo imaging to monitor the dynamics of lesion formation using color-scale imaging after HIFU treatment  ... 
doi:10.3390/s21051580 pmid:33668260 pmcid:PMC7956793 fatcat:ydsof6gafbgehm7yvqds4y6vry

Contrast-enhanced Ultrasound Imaging: State of the Art

Ji-Bin Liu, Gervais Wansaicheong, Daniel A. Merton, Flemming Forsberg, Barry B. Goldberg
2005 Journal of Medical Ultrasound  
KEY WORDS -harmonic imaging, microbubble, tumor diagnosis, ultrasound contrast agents, ultrasound imaging technology ■ J Med Ultrasound 2005;13(3):109-126 ■  ...  Contrast-enhanced imaging using micro-flow imaging Contrast-enhanced imaging using micro-flow imaging d mode shows a high resolution depiction of normally perfused kidney parenchyma in an animal model.  ...  Contrast-enhanced ultrasound has the potential to be very useful as it allows real-time assessment of lesion vascularity [36] and is similar to dynamic CT in its sensitivity and specificity [37, 38]  ... 
doi:10.1016/s0929-6441(09)60100-4 fatcat:3pcave2cyjb5nounks3stxpnvq

Tumor Functional and Molecular Imaging Utilizing Ultrasound and Ultrasound-Mediated Optical Techniques

Baohong Yuan, Joshua Rychak
2013 American Journal of Pathology  
This review introduces tumor functional and molecular imaging using microbubble-based ultrasound and ultrasound-mediated optical imaging techniques. (Am J Pathol 2013, 182: 305e311; http://dx.  ...  inexpensive contrast agents, and comparable maximum-imaging depth.  ...  recently. 6, 10 In this review, microbubble-enhanced ultrasound tumor imaging will be introduced first.  ... 
doi:10.1016/j.ajpath.2012.07.036 pmid:23219728 pmcid:PMC3969505 fatcat:ax3a7q4ogzhezfsnxc6f2rkvvi

Novel contrast-enhanced ultrasound imaging in prostate cancer

Martijn Smeenge, Massimo Mischi, M. Pilar Laguna Pes, Jean J. M. C. H. de la Rosette, Hessel Wijkstra
2011 World journal of urology  
With the introduction of contrast-enhanced ultrasound (CEUS), perfusion imaging of the microvascularization became available.  ...  Purpose The purposes of this paper were to present the current status of contrast-enhanced transrectal ultrasound imaging and to discuss the latest achievements and techniques now under preclinical testing  ...  Clinically, contrast-enhanced ultrasound is now mainly used for perfusion measurement of the heart and for the detection of liver malignancies [18, 19] .  ... 
doi:10.1007/s00345-011-0747-3 pmid:21847656 pmcid:PMC3189413 fatcat:z6crulc3yng47gpvgco6dpdwu4

Recent developments in dynamic contrast-enhanced ultrasound imaging of tumor angiogenesis

Reshu Saini, Kenneth Hoyt
2014 Imaging in Medicine  
There is tremendous interest in the development of noninvasive methods for imaging tumor angiogenesis, and ultrasound (US) is an emerging platform technology to address this challenge.  ...  The introduction of intravascular microbubble contrast agents not only allows real-time visualization of tumor perfusion during an US examination, but they can be functionalized with specific ligands to  ...  With the advent of microbubble (MB) contrast agents, characterization of tissue perfusion and vascular volume is possible with the application of a dynamic contrast-enhanced US (DCE-US) imaging session  ... 
doi:10.2217/iim.13.74 pmid:25221623 pmcid:PMC4160124 fatcat:5wswf7oikbg4tothyy3vhsyaza

The Evolution of Ultrasound Technologies; from Anatomic to Physiologic,Histologic, and Molecular Imaging

Wayne L Monsky
2013 Anatomy & Physiology  
Contrast Enhanced Ultrasound Contrast enhanced MRI and CT have been primary cross sectional imaging modalities.  ...  as chemoembolization [7] and radiofrequency ablation [8] were intra-procedural dynamic imaging of tumor perfusion can be used to determine the completeness of therapeutic vascular embolization and  ... 
doi:10.4172/2161-0940.1000e133 fatcat:5ojdcngi45e2hifuxsnlejewru

Nanobubbles for enhanced ultrasound imaging of tumors

Rongqin Zheng, Tinghui Yin, Ping Wang, Rongqin Zheng, Bowen Zheng, Du Cheng, Xinling Zhang, Xin-Tao Shuai
2012 International Journal of Nanomedicine  
We have demonstrated the ability to fabricate NBs that can be used for the in vivo contrast-enhanced imaging of tumor tissue and that have potential for drug/gene delivery.  ...  In this work, we fabricated a lipid NBs contrast-enhanced ultrasound agent and evaluated its passive targeting ability in vivo.  ...  Disclosure The authors report no conflicts of interest in this work.  ... 
doi:10.2147/ijn.s28830 pmid:22393289 pmcid:PMC3289446 fatcat:dog5dhpmt5aqlhc2jy4h6vfoti

Radioembolization of Hepatocellular Carcinoma with Built-In Dosimetry: First in vivo Results with Uniformly-Sized, Biodegradable Microspheres Labeled with 188Re

José Carlos De La Vega, Pedro Luis Esquinas, Cristina Rodríguez-Rodríguez, Mehrdad Bokharaei, Igor Moskalev, David Liu, Katayoun Saatchi, Urs O. Häfeli
2019 Theranostics  
We also thank Jovan Gill and Nicole Sarden for their help during the ultrasound-guided injections as well as Zeynab Nosrati for help during the administration of 188 Re-MS.  ...  the limited resolution and the low contrast difference in the CT images of the rats did not allow us to distinguish with confidence the boundaries of the tumor and the healthy liver tissue.  ...  The interactions of β¯ particles with tissue result in Bremsstrahlung photons which can be used to create images using single photon emission computed tomography (SPECT).  ... 
doi:10.7150/thno.29381 fatcat:qnjulh7wara4jmamazujnhfzse
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