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Drug-Induced Regulation of Target Expression

Murat Iskar, Monica Campillos, Michael Kuhn, Lars Juhl Jensen, Vera van Noort, Peer Bork, Hiroaki Kitano
2010 PLoS Computational Biology  
To quantify this mechanism systems-wide in an unbiased way, drug-induced differential expression of drug target mRNA was examined in three cell lines using the Connectivity Map.  ...  In 1290 drug-target relations, corresponding to 466 drugs acting on 167 drug targets studied, 8% of the targets are subject to regulation at the mRNA level.  ...  Overington and the members of the Bork group for helpful discussions. Author Contributions  ... 
doi:10.1371/journal.pcbi.1000925 pmid:20838579 pmcid:PMC2936514 fatcat:m4hcwue7gncrtofunif46ufi5a

Impact of microRNAs in Resistance to Chemotherapy and Novel Targeted Agents in Non-Small Cell Lung Cancer

Christian Rolfo, Daniele Fanale, David Hong, Apostolia Tsimberidou, Sarina Piha-Paul, Patrick Pauwels, Jan Meerbeeck, Stefano Caruso, Viviana Bazan, Giuseppe Cicero, Antonio Russo, Elisa Giovannetti
2014 Current Pharmaceutical Biotechnology  
MicroRNAs (miRNAs) are a family of small non-coding RNAs that regulate gene expression by sequence-specific targeting of mRNAs causing mRNA degradation or translational repression.  ...  well as in novel drug targets.  ...  The up-or down-regulation of miRNAs affects the expression of several target proteins involved in drug response, determining changes in drug sensitivity through different molecular mechanisms.  ... 
doi:10.2174/1389201015666140519123219 pmid:24846062 fatcat:ydgqlr3aajdjffq3mjo63avfjq

Regulation of multidrug resistance by microRNAs in anti-cancer therapy

Xin An, Cesar Sarmiento, Tao Tan, Hua Zhu
2017 Acta Pharmaceutica Sinica B  
MicroRNAs (miRNAs) are a new class of small noncoding RNAs that could control the global activity of the cell by post-transcriptionally regulating a large variety of target genes and proteins expression  ...  Although diverse mechanisms of MDR have been well elucidated, such as dysregulation of drugs transporters, defects of apoptosis and autophagy machinery, alterations of drug metabolism and drug targets,  ...  National Institute of Health Grants R01 HL124122, AR067766 and American Heart Association Grant 12SDG12070174.  ... 
doi:10.1016/j.apsb.2016.09.002 pmid:28119807 pmcid:PMC5237711 fatcat:ok67kwh76fhjxjgipth2ktx6ru

New insights into the roles of microRNAs in drug addiction and neuroplasticity

Jean-Luc Dreyer
2010 Genome Medicine  
The funders had no role in study design, decision to publish, or preparation of the manuscript.  ...  Clearly a number of miRNAs may respond specifically to different drugs and thus regulate different pathways in response to a specific drug and differentially affect drug-induced neuroplasticity.  ...  miRNAs are considered to be 'master regulators' of gene expression, and they control the translation of target mRNAs, thereby regulating critical aspects of neuroplasticity and synapse consolidation.  ... 
doi:10.1186/gm213 pmid:21205279 pmcid:PMC3025434 fatcat:ttisrke73ncvlcx2oyja2vy5fa

PXR interaction with p53: a meeting of two masters

D Robbins, J Bakke, M T Cherian, J Wu, T Chen
2016 Cell Death and Disease  
xenobiotic metabolism and disposition. 3-5 PXR exerts its metabolic function by regulating the expression of phase I and II drug-metabolizing enzymes and drug transporters. 6 Agonists of PXR, including  ...  However, emerging evidence suggests PXR is a regulator of apoptosis, with PXR activation correlating with the suppression of expression of apoptotic genes and the promotion of proliferation, drug resistance  ...  Jude Children's Research Hospital, National Institutes of Health grants RO1GM086415 (to TC), RO1GM110034 (to TC), R35GM118041 (to TC), and P30-CA21765, and a United Negro College Fund (UNCF)-Merck Postdoctoral  ... 
doi:10.1038/cddis.2016.122 pmid:27148691 pmcid:PMC4917660 fatcat:jejqnzzovbeutl24jmho4om55u

Drug-inducible and simultaneous regulation of endogenous genes by single-chain nuclear receptor-based zinc-finger transcription factor gene switches

L Magnenat, L J Schwimmer, C F Barbas
2008 Gene Therapy  
Chemically inducible gene switches that regulate expression of endogenous genes have multiple applications for basic gene expression research and gene therapy.  ...  We have also demonstrated that the regulation imposed by these inducible transcription factors is dose dependent, sustainable for at least 11 days and reversible upon cessation of drug treatment.  ...  Acknowledgements This study was supported in part by the National Institute of Health Grant GM065059 to CFB.  ... 
doi:10.1038/gt.2008.96 pmid:18528430 pmcid:PMC2705884 fatcat:5osrn3mh5zd77ogwinxv3tzb44

Post-Transcriptional Controls by Ribonucleoprotein Complexes in the Acquisition of Drug Resistance

Hoin Kang, Chongtae Kim, Heejin Lee, Wook Kim, Eun Lee
2013 International Journal of Molecular Sciences  
Several studies have shown that the acquisition of drug resistance is tightly regulated by post-transcriptional regulators such as RNA binding proteins (RBPs) and microRNAs (miRNAs), which change the stability  ...  Acquisition of drug resistance leads to failure of anti-cancer treatments and therapies.  ...  Conflicts of Interest The authors declare no conflict of interest. Int. J. Mol. Sci. 2013, 14  ... 
doi:10.3390/ijms140817204 pmid:23965981 pmcid:PMC3759960 fatcat:clat7zwcqvddbkdfkbgu37cute

Dihydroartemisinin-regulated mRNAs and lncRNAs in chronic myeloid leukemia

Xiang Li, Yue Gao, Qiang Zhang, Nan Hu, Dong Han, Shangwei Ning, Zhuo Ao
2017 OncoTarget  
Up-or downregulation of these potential DHA targets increased with increasing DHA concentration.  ...  We investigated the effects of an anti-malarial drug, dihydroartemisinin (DHA), on K562 CML cells.  ...  If the entire genome had a total of N genes, of which n were involved with the target genes under investigation, and a total of m DHA candidate genes, of which k were involved with the same drug target  ... 
doi:10.18632/oncotarget.23274 pmid:29416790 pmcid:PMC5788658 fatcat:xiwiwizohberrhwhb3dpi2sehi

A Review of Research Progress in Multidrug-Resistance Mechanisms in Gastric Cancer

Tuo Ruan, Weizhen Liu, Kaixiong Tao, Chuanqing Wu
2020 OncoTargets and Therapy  
For these advanced-stage gastric cancers, combination therapy of surgery, chemotherapy, radiotherapy and target therapy would bring more benefit to the patients.  ...  In this review article, we discuss the mechanisms which have been found in recent years of drug resistance in gastric cancer.  ...  of Hubei Province to Chuanqing Wu (grant WJ2019Q035).  ... 
doi:10.2147/ott.s239336 pmid:32184615 pmcid:PMC7053652 fatcat:sntmvebp4zftfcionesgrbtsai

Non-coding RNA in drug resistance of gastric cancer

Ya-Jun Luo, Qing-Mei Huang, Yan Ren, Zi-Lin Liu, Cheng-Fei Xu, Hao Wang, Jiang-Wei Xiao
2019 World Journal of Gastrointestinal Oncology  
Although the mechanisms of anticancer drug resistance have been broadly studied, the regulation of these mechanisms has not been completely understood.  ...  This review summarizes the current knowledge about the ncRNAs' characteristics, their regulation of the genes involved in chemoresistance and their potential as targeted therapies for personalized treatment  ...  LncRNA UCA1 was upregulated in drug resistant GC cell lines SGC-7901/ADR, SGC-7901/DDP and SGC-7901/Fu, and UCA1 could regulate miR-27b to increase ADR-induced cell apoptosis by decreasing expression of  ... 
doi:10.4251/wjgo.v11.i11.957 pmid:31798777 pmcid:PMC6883183 fatcat:f7gourk6gjf7fc2tvnqtrlufjm

Integrative network analysis of rifampin-regulated miRNAs and their functions in human hepatocytes

Jin Li, Ying Wang, Lei Wang, Hong Liang, Weixing Feng, Xianglian Meng, Wang Cong, Yunlong Liu, Feng Liu, Dong-Hoon Lee, Ricardo Lagoa, Sandeep Kumar
2015 Bio-medical materials and engineering  
In this study, significantly differentially expressed miRNAs (SDEM) were extracted and used to predict the miRNA-regulated co-expression target genes (MCeTG).  ...  Previous studies have shown that rifampin can indirectly influence drug deposition through the regulation of molecular interactions of miRNA, PXR and other genes.  ...  Acknowledgment The authors would like to acknowledge the financial support of the National Key Scientific  ... 
doi:10.3233/bme-151502 pmid:26405974 fatcat:uxcl4alzxjh6hg5qsvy2nzefru

Noncoding RNA in drug resistant sarcoma

Xiaoyang Li, Jacson K. Shen, Francis J. Hornicek, Tao Xiao, Zhenfeng Duan
2017 OncoTarget  
In this review, we discuss the current knowledge of noncoding RNAs characteristics and the regulated genes involved in drug resistant sarcoma, and focus on their therapeutic potential in the future.  ...  Chemotherapy has been extensively used for sarcoma treatment; however, the development of drug resistance is a major obstacle limiting the success of many anticancer agents.  ...  ACKNOWLEDGMENTS CONFLICTS OF INTEREST The authors declare that they have no competing interests.  ... 
doi:10.18632/oncotarget.19029 pmid:28978183 pmcid:PMC5620323 fatcat:u5r5tiy3gzhrvh6tyr3axjmhy4

Recent Progress in Characterizing Long Noncoding RNAs in Cancer Drug Resistance

Wenyuan Zhao, Bin Shan, Dan He, Yuanda Cheng, Bin Li, Chunfang Zhang, Chaojun Duan
2019 Journal of Cancer  
LncRNAs do not affect drug resistance directly; usually, they do so by regulating the expression of some intermediate regulatory factors.  ...  Therefore, lncRNAs provide potential targets for cancer therapies. The lncRNAs involved in cancer drug resistance are attracting interest from an increasing number of researchers.  ...  Acknowledgements This work was supported by the National Natural Science Foundation of China (No.81572281 and No.81702278). And we also thank Dr. Suiyu Chen for the helpful discussion.  ... 
doi:10.7150/jca.30877 pmid:31777598 pmcid:PMC6856905 fatcat:scgkyugdc5fv3arzbr55nz6lgu

Epithelial–Mesenchymal Transition-Mediated Tumor Therapeutic Resistance

Zhimin Xu, Yingxin Zhang, Huanyan Dai, Bing Han
2022 Molecules  
The epithelial–mesenchymal transition (EMT) is essential for tumor drug resistance.  ...  Cancer is one of the world's most burdensome diseases, with increasing prevalence and a high mortality rate threat.  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/molecules27154750 pmid:35897925 pmcid:PMC9331826 fatcat:ujzw5qdcwvc2ng3qrqloycxnwy

The emerging role of microRNAs and long noncoding RNAs in drug resistance of hepatocellular carcinoma

Ling Wei, Xingwu Wang, Liyan Lv, Jibing Liu, Huaixin Xing, Yemei Song, Mengyu Xie, Tianshui Lei, Nasha Zhang, Ming Yang
2019 Molecular Cancer  
Accumulated evidences demonstrate that several deregulated miRNAs and lncRNAs are important regulators in the development of HCC drug resistance which elucidates their potential clinical implications.  ...  A portion of patients with advanced HCC can significantly benefit from treatments with sorafenib, adriamycin, 5-fluorouracil and platinum drugs.  ...  RNA or proteins to form complexes that regulate the expression of target genes [118, [121] [122] [123] [124] [125] [126] [127] [128] [129] [130] .  ... 
doi:10.1186/s12943-019-1086-z pmid:31651347 pmcid:PMC6814027 fatcat:6l7mez6fcvaajclfbzprgc6itq
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