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Drug Target Commons 2.0: a community platform for systematic analysis of drug–target interaction profiles

ZiaurRehman Tanoli, Zaid Alam, Markus Vähä-Koskela, Balaguru Ravikumar, Alina Malyutina, Alok Jaiswal, Jing Tang, Krister Wennerberg, Tero Aittokallio
2018 Database: The Journal of Biological Databases and Curation  
Drug Target Commons 2.0: a community platform for systematic analysis of drug-target interaction profiles.  ...  Abstract Drug Target Commons (DTC) is a web platform (database with user interface) for community-driven bioactivity data integration and standardization for comprehensive mapping, reuse and analysis of  ...  We also thank John-Olof Hansson and Kari Tuomainen for providing IT support at FIMM.  ... 
doi:10.1093/database/bay083 pmid:30219839 pmcid:PMC6146131 fatcat:d572uzhyr5h7rnvxlxv7obzew4

Identification of Common Biological Pathways and Drug Targets Across Multiple Respiratory Viruses Based on Human Host Gene Expression Analysis

Steven B. Smith, William Dampier, Aydin Tozeren, James R. Brown, Michal Magid-Slav, Krzysztof Pyrc
2012 PLoS ONE  
Given the genetic diversity of respiratory viruses and the emergence of drug resistant strains, the targeted disruption of human host-virus interactions is a potential therapeutic strategy for treating  ...  The availability of large-scale genomic datasets focused on host-pathogen interactions can be used to discover novel drug targets as well as potential opportunities for drug repositioning.  ...  Acknowledgments We thank Vinod Kumar for his assistance in computational analysis. Author Contributions  ... 
doi:10.1371/journal.pone.0033174 pmid:22432004 pmcid:PMC3303816 fatcat:yt74vddq7jhevh3zuitlf4jsta

SZGR 2.0: a one-stop shop of schizophrenia candidate genes

Peilin Jia, Guangchun Han, Junfei Zhao, Pinyi Lu, Zhongming Zhao
2016 Nucleic Acids Research  
SZGR 2.0 is a comprehensive resource of candidate variants and genes for schizophrenia, covering genetic, epigenetic, transcriptomic, translational and many other types of evidence.  ...  In summary, SZGR 2.0 provides a onestop shop of schizophrenia variants and genes and their function and regulation, providing an important resource in the schizophrenia and other mental disease community  ...  Hua Sun, Yuan Cao and Pora Kim for valuable assistance in this project.  ... 
doi:10.1093/nar/gkw902 pmid:27733502 pmcid:PMC5210619 fatcat:ffvz46hpyfad3pqo6v6rrkdpqm

iNetModels 2.0: an interactive visualization and database of multi-omics data

Muhammad Arif, Cheng Zhang, Xiangyu Li, Cem Güngör, Buğra Çakmak, Metin Arslantürk, Abdellah Tebani, Berkay Özcan, Oğuzhan Subaş, Wenyu Zhou, Brian Piening, Hasan Turkez (+7 others)
2021 Nucleic Acids Research  
Here, we present iNetModels, an interactive database and visualization platform of Multi-Omics Biological Networks (MOBNs).  ...  This platform allows the user to interactively explore a single feature's association with other omics data and customize its particular context (e.g. male/female specific).  ...  The data used for the  ... 
doi:10.1093/nar/gkab254 pmid:33849075 pmcid:PMC8262747 fatcat:cllw4hb2vjbctjgef3hlzimzky

ADMETlab 2.0: an integrated online platform for accurate and comprehensive predictions of ADMET properties

Guoli Xiong, Zhenxing Wu, Jiacai Yi, Li Fu, Zhijiang Yang, Changyu Hsieh, Mingzhu Yin, Xiangxiang Zeng, Chengkun Wu, Aiping Lu, Xiang Chen, Tingjun Hou (+1 others)
2021 Nucleic Acids Research  
Here, we announced the release of ADMETlab 2.0, a completely redesigned version of the widely used AMDETlab web server for the predictions of pharmacokinetics and toxicity properties of chemicals, of which  ...  Because undesirable pharmacokinetics and toxicity of candidate compounds are the main reasons for the failure of drug development, it has been widely recognized that absorption, distribution, metabolism  ...  ACKNOWLEDGEMENTS We would like to thank the user community for using AD-METlab and providing us with valuable suggestions regarding further improvement of this tool.  ... 
doi:10.1093/nar/gkab255 pmid:33893803 pmcid:PMC8262709 fatcat:x2ogifzupffdbghwcjanpurnke

Innovation through Web 2.0 to support English language learning

Kristian Armando Pineda Castillo
2022 Sinéctica  
This investigation had the purpose of understanding how the use of a website created by the teacher-researcher contributed to an improvement in the educational experience in English language teaching with  ...  in the study of English.  ...  atmosphere without a possibility of cheating; some examples of platforms which allow such interaction are Kahoot!  ... 
doi:10.31391/s2007-7033(2022)0059-005 doaj:adffd37b011342bfa261503c2569ed64 fatcat:yufex4q2fng4jgnzru7mutq62i

Learning 2.0 Promoting Innovation in Formal Education and Training in Europe [chapter]

Christine Redecker, Yves Punie
2010 Lecture Notes in Computer Science  
social computing applications. vision for guiding developments: A major obstacle for the broader implementation and take up of Learning 2.0 approaches is the lack of communication and common understanding  ...  Targeted use and tailored integration, respecting learners' needs: For Web 2.0 tools, it is essential that they support learning in a targeted way and are not used in a self-serving way.  ... 
doi:10.1007/978-3-642-16020-2_21 fatcat:wklfzfwch5g45laaycl3qfa22u

Propaganda 2.0: Herman and Chomsky's Propaganda Model in the Age of the Internet, Big Data and Social Media in the Age of the Internet, Big Data and Social Media [chapter]

Christian Fuchs, University of Westminster, GB
2018 The Propaganda Model Today: Filtering Perception and Awareness  
Empirical analysis shows that in protests, social media communication tends to interact with other forms of political communication, especially face-toface-communication. 40 Revolutions and protests  ...  I find the PM a useful model for the analysis of power structures in media systems, as this chapter demonstrates.  ... 
doi:10.16997/book27.f fatcat:aoxujjczwzgzdlpaxp3ql7xbhy

CRM 2.0 within E-Health Systems: Towards Achieving Health Literacy & Customer Satisfaction

Muhammad Anshari, Mohammad Nabil Almunawar, Patrick Kim Cheng Low
2012 IJID (International Journal on Informatics for Development)  
We draw the conclusion that the CRM 2.0 in healthcare technologies has brought a possibility to extend the services of e-health by enabling patients, patients families, and community at large to participate  ...  At the same time, the advancement of Web technology known as Web 2.0 plays a significant part in the CRM transition which drives social change that impacts all institutions including business and healthcare  ...  The next emerging trend in HIS is to use Web 2.0 technologies, which use the Internet as a working platform.  ... 
doi:10.14421/ijid.2012.01201 fatcat:5gheyogyebby3pq6n2ofhg5dju

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

Nathalie Percie du Sert, Viki Hurst, Amrita Ahluwalia, Sabina Alam, Marc T. Avey, Monya Baker, William J. Browne, Alejandra Clark, Innes C. Cuthill, Ulrich Dirnagl, Michael Emerson, Paul Garner (+17 others)
2020 PLoS Biology  
This division facilitates improved reporting of animal research by supporting a stepwise approach to implementation.  ...  They consist of a checklist of information to include in publications describing in vivo experiments to enable others to scrutinise the work adequately, evaluate its methodological rigour, and reproduce  ...  A key aspect of the revision was to develop this explanation and elaboration document to provide background and rationale for each of the 21 items of ARRIVE 2.0.  ... 
doi:10.1371/journal.pbio.3000410 pmid:32663219 fatcat:qzlrm33ugzfeppyjmac2drgmre

Discourse 2.0: Language and new mediaTannenDeborahTresterAnna Marie (eds), Discourse 2.0: Language and new media, Georgetown University Press: Washington, DC, 2013; 258 pp.: ISBN 9781589019546, $44.95 (pbk)

Karen Correia Da Silva
2014 New Media & Society  
ACKNOWLEDGMENTS We thank the participants in our study and audience members of our workshop at GURT 2011 for their input and feedback.  ...  ACKNOWLEDGEMENTS I am grateful to all the students in my classes who helped me understand their own and their peers' uses of digital media in their personal interactions, especially those whose examples  ...  Media convergence is also resulting in a trend for multiple modes of verbal communication to coexist in the same platform.  ... 
doi:10.1177/1461444814524163b fatcat:lix7m4khk5ep3f7d3ftd3psx3q

Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0

Nathalie Percie du Sert, Amrita Ahluwalia, Sabina Alam, Marc T. Avey, Monya Baker, William J. Browne, Alejandra Clark, Innes C. Cuthill, Ulrich Dirnagl, Michael Emerson, Paul Garner, Stephen T. Holgate (+17 others)
2020 PLoS Biology  
It provides further information about each of the 21 items in ARRIVE 2.0, including the rationale and supporting evidence for their inclusion in the guidelines, elaboration of details to report, and examples  ...  Improving the reproducibility of biomedical research is a major challenge.  ...  A key aspect of the revision was to develop this explanation and elaboration document to provide background and rationale for each of the 21 items of ARRIVE 2.0.  ... 
doi:10.1371/journal.pbio.3000411 pmid:32663221 fatcat:wgeagtfdxvgzrhb5m5r23fbdre

Computational and Experimental Advances in Drug Repositioning for Accelerated Therapeutic Stratification

Khader Shameer, Ben Readhead, Joel T. Dudley
2015 Current Topics in Medicinal Chemistry  
Molecular profiling and more sophisticated analysis of longitudinal clinical data are refining definitions of human diseases, creating needs and opportunities to re-target or reposition approved drugs  ...  Efficient tools are now available for systematic drug-repositioning methods using large repositories of compounds with biological activities.  ...  Mantra 2.0 Web-based collaborative resource for drug mode of action and repositioning by network analysis Assess similarities between drug-induced transcriptional profiles NCGC pharmaceutical collection  ... 
doi:10.2174/1568026615666150112103510 pmid:25579574 fatcat:uryq36httvcwrfub36lstr6tw4

Computational Tools; Indispensable Armamentarium of Medical Biotechnology

, Nutan, Swapnil Jain, , Shilpa, Akanksha Tomar, Harish Changotra, Jitendraa Vashistt
2016 Indian Journal of Science and Technology  
Objective: Computational infrastructure of medical biotechnology provides insight into elements of genomics, proteomics for understanding diseases and biological systems in a more comprehensive and systematic  ...  Method and Analysis: Methodology adopted for study included analysis of online literature through Google Scholar, Pub-med, and Science Direct by searching with comprehensive input like computational tools  ...  In another case, drug target interaction analysis is performed by integrated network system approach using DReSMin, an algorithm for mining semantically-rich networks for occurrences of a given semantic  ... 
doi:10.17485/ijst/2016/v9i32/100745 fatcat:ozwp56se75bjxl7tbvblkps2gi

Identification of New Toxicity Mechanisms in Drug-Induced Liver Injury through Systems Pharmacology

Aurelio A. Moya-García, Andrés González-Jiménez, Fernando Moreno, Camilla Stephens, María Isabel Lucena, Juan A. G. Ranea
2022 Genes  
drugtarget interactions.  ...  We have leveraged drug polypharmacology, i.e., the ability of a drug to bind multiple targets and thus perturb several biological processes, to develop a systems pharmacology platform that integrates all  ...  Acknowledgments: The authors thank the Supercomputing and Bioinnovation Center (SCBI) of the University of Malaga for their provision of computational resources and technical support.  ... 
doi:10.3390/genes13071292 pmid:35886075 pmcid:PMC9315637 fatcat:unl4zudnsvee5gdnijrj5qrelq
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