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Specific phobia of illness:

Russell Noyes, Caroline P Carney, Douglas R Langbehn
2004 Journal of Anxiety Disorders  
comparison and factor analytic studies established separate dimensions of disease phobia and disease conviction within hypochondriasis (Kellner, 1985; Pilowsky, 1967) , and both DSM-III and DSM-III-R  ... 
doi:10.1016/s0887-6185(03)00041-0 pmid:15149712 fatcat:ehmie4x6undhbgmpxqzkaxyyxu

Clinical Outcomes and Selection Criteria for Prodromal Huntington's Disease Trials

Douglas R. Langbehn, Steven Hersch
2020 Movement Disorders  
S C H P R O D R O M A L L A N G B E H N A N D H E R S C H  ...  Word Test (interference condition); Verbal-C, cat- egorical verbal fluency test; Movement Disorders, Vol. 35, No. 12, 2020 Movement Disorders, Vol. 35, No. 12, 2020 L A N G B E H N A N D H E R  ... 
doi:10.1002/mds.28222 pmid:32686867 fatcat:6tur74rmkvhttn57cnytplvdf4

Impact of Binge Drinking During College on Resting State Functional Connectivity [article]

Tien T Tong, Jatin G Vaidya, John R Kramer, Samuel T Kuperman, Douglas R Langbehn, Daniel S OLeary
2021 bioRxiv   pre-print
Douglas R. Langbehn: Conceptualization, Funding acquisition, Investigation, Methodology, Writing -review & editing. Daniel S.  ...  R. .  ... 
doi:10.1101/2021.02.09.430381 fatcat:sv2vpjxdcbdknngz7r7zimygqu

Earliest functional declines in Huntington disease

Leigh J. Beglinger, Justin J.F. O'Rourke, Chiachi Wang, Douglas R. Langbehn, Kevin Duff, Jane S. Paulsen
2010 Psychiatry Research  
This criterion has been used in prior analyses attempting to capture the earliest signs of disease in a pre-diagnosed sample (Langbehn and Paulsen, 2007) .  ...  The one cognitive test with a motor component, the SDMT, was also associated with ability to shop for groceries and use public transportation, consistent with previous research from our group (Langbehn  ... 
doi:10.1016/j.psychres.2010.04.030 pmid:20471695 pmcid:PMC3629818 fatcat:prxszo6odzajhjx7lo4y6upssi

Validation of a prognostic index for Huntington's disease

Jeffrey D. Long, Douglas R. Langbehn, Sarah J. Tabrizi, Bernhard G. Landwehrmeyer, Jane S. Paulsen, John Warner, Cristina Sampaio
2016 Movement Disorders  
Background-The aim was to develop a prognostic index for motor diagnosis in Huntington's disease and examine its predictive performance in external observational studies. Methods-The pre-diagnosis Neuro-biological Predictors of Huntington's Disease study (N=945 gene-positive) was used to select a Cox regression model for computing a prognostic index. Crossvalidation was used for selecting a model with good internal validity performance using the research sites as natural splits of the data set.
more » ... Then the external predictive performance was assessed using pre-diagnosis data from three additional observational studies, The Cooperative Huntington Observational Research Trial (N=358), TRACK-HD (N=118), and REGISTRY (N=480). Results-Model selection yielded a prognostic index computed as the weighted combination of the UHDRS total motor score, symbol digit modalities test, baseline age, and cytosine-adenineguanine expansion. External predictive performance was very good for the first two of the three studies, with the third being a much more progressed cohort than the other studies. The databases were pooled and a final Cox regression model was estimated. The regression coefficients were scaled to produce the prognostic index for Huntington's disease, and a normed version, which is scaled relative to a 10-year 50% probability of motor diagnosis.
doi:10.1002/mds.26838 pmid:27892614 pmcid:PMC5318276 fatcat:24npjtwpuvhiddcunnejgd4g7u

Hypertension Is Associated with an Earlier Age of Onset of Huntington's Disease

Jordan L. Schultz, Lyndsay A. Harshman, Douglas R. Langbehn, Peg C. Nopoulos
2020 Movement Disorders  
We included tobacco use as a H Y P E R T E N S I O N H A S T E N S S Y M P T O M O N S E T O F H D covariate given that this has been shown to be associated with an earlier ADx 7, 23 and the known relationship  ... 
doi:10.1002/mds.28062 pmid:32339315 fatcat:32ahma4a7zde7fwtpk7vtdyjfu

Cerebral cortex structure in prodromal Huntington disease

Peggy C. Nopoulos, Elizabeth H. Aylward, Christopher A. Ross, Hans J. Johnson, Vincent A. Magnotta, Andrew R. Juhl, Ronald K. Pierson, James Mills, Douglas R. Langbehn, Jane S. Paulsen
2010 Neurobiology of Disease  
five years were calculated using a CAG-and-age based predictive model developed from a worldwide sample of 2,913 and validated with nearly 100 prospectively diagnosed patients from the PREDICT-HD study Langbehn  ... 
doi:10.1016/j.nbd.2010.07.014 pmid:20688164 pmcid:PMC2955824 fatcat:2ho6dgavbbcdja3wpyc6yayl5m

Changes in cognition in Huntington's disease and its relationship to future cognition

Kevin Duff, Leigh J. Beglinger, David J. Moser, Douglas R. Langbehn, Jane S. Paulsen
2005 Alzheimer's & Dementia  
Newman et al. (2001) noted that subtle changes in cognition of patients undergoing CABG surgery were predictive of cognition 5-years later. To our knowledge, similar comparisons have not been made in patients with neurodegenerative disorders, like Huntington's disease (HD). Objective(s): The current study examined the relationship between shortterm changes in cognition and future cognitive functioning. Methods: One hundred seventy adults, who had been previously diagnosed with HD, were followed
more » ... clinically on an "as needed" basis. The clinical visit included three cognitive tasks: 1) Digit Symbol, 2) verbal fluency, and 3) Stroop Color Word Test. The amount of time between Time 1 and Time 2 averaged 7 months, and the amount of time between Time 2 and the follow-up point, Time 3, averaged 29 months. Partial correlations were used to assess the relationship between short-term changes in cognition (Time 2 -Time 1) and cognitive outcome (Time 3), while controlling for baseline functioning (Time 1). Results: Digit Symbol practice effects were significantly related to Time 3 Digit Symbol scores (pr[158] ϭ .56, pϽ.01) after controlling for Time 1 Digit Symbol scores. Digit Symbol practice effects were also related to other cognitive scores, but to a lesser degree (verbal fluency: pr[158] ϭ .29, pϽ.01; Stroop Interference: pr[154] ϭ .37, pϽ.01). The other cognitive tasks showed similar, but weaker, relationships. Conclusions: Changes in test performance on repeated assessments were related to long-term cognitive performance in this large sample of patients with manifest HD. Digit Symbol showed the strongest relationship between short-term change and 29 month follow-up, possibly because of its more prominent motor component than the other cognitive tests and the underlying neuropathology of HD. This short-term change variable might offer a simple, convenient, and non-invasive marker for monitoring longterm changes in an individual patient's cognitive status. This value might also serve as an outcome variable in clinical trials.
doi:10.1016/j.jalz.2005.06.088 fatcat:5ty7imliubfxbl5b6fwvdcojpm

Distinct Contributions of Conduct and Oppositional Defiant Symptoms to Adult Antisocial Behavior

Douglas R. Langbehn, Remi J. Cadoret, William R. Yates, Edward P. Troughton, Mark A. Stewart
1998 Archives of General Psychiatry  
Reprints: Douglas R. Langbehn, MD, PhD, Psychiatry Service, 9W-20 VA Hospital, Highway 6, Iowa City, IA 52246.  ...  ), University of Iowa (Drs Langbehn, Cadoret, and Stewart and Mr Troughton), Iowa City; and University of Oklahoma College of Medicine, Tulsa (Dr Yates).  ...  Component Symptoms Biological parent ASPD † 0.81 0.37 to 1.26 3.63 Ͻ.001 R 2 = 0.08 R 2 = 0.34 Intercept AAES ‡ Conduct Component, R 2 = 0.08 −0.32 −0.63 to 0.02 0.20 0.06 to 0.34 Adult Antisocial Symptoms  ... 
doi:10.1001/archpsyc.55.9.821 pmid:9736009 fatcat:mftonv6hjzemjnr3g7ywbrkd3i

Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington's disease patients

Edward J. Wild, Roberto Boggio, Douglas Langbehn, Nicola Robertson, Salman Haider, James R.C. Miller, Henrik Zetterberg, Blair R. Leavitt, Rainer Kuhn, Sarah J. Tabrizi, Douglas Macdonald, Andreas Weiss
2015 Journal of Clinical Investigation  
G L G R G L ÙÖ ½º µ × Ø × ×Ø Ø Ò Ø Ó ×Ô Ì ÐÓ Û Ö ÖÓÛ Ö Ð ØÖÓÒ ×Ø Ø × Ò « Ö ÒØ × Ø × Û Ø ÒÓ Ô ÓÒÓÒ× Ò Ø Û ÐÐ¸Ø × Ø × Ò Ð Ö Ò Ø ÖÖ Ö׺ À Ö ÖÓÛ× ÓÖÖ ×ÔÓÒ ØÓ Ö ÒÙÑ Ö Ó Ô ÓÒÓÒ׺ ËØÖ Ø Ð Ò × Ö ÓÔÔ Ò × Ò Û ÚÝ  ...  Ð ÓÖ Ø ÊÌ × ÒØÖ Ð × Ø Û ÐÝ ÓÙÔÐ ØÓ Ø Ð × Ø Ø ÒØ Ö Ø Û Ø Ø Ô ÓÒÓÒ×´× ½´ µµº Ì Ò¸ ¼ × Ø Û ÐÐ³× ÖÓÙÒ ×Ø Ø Û × × Ø Ý Ø Ð ¹ ØÖ ¬ Ð Ò Î ¼ ½ Î Ê Ò Î ½ ¼ Î Ä´ÎĴʵ Î µ Û ¬Ü Ø ØÙÒÒ Ð Ò Ö Ø × Ø ÖÓÙ Ø ÖÖ Ö׺ G R  ... 
doi:10.1172/jci80743 pmid:25844897 pmcid:PMC4463213 fatcat:qq5cyrkf6fgfjb2yr5swluvvgq

Abnormal Brain Structure in Children With Isolated Clefts of the Lip or Palate

Peg Nopoulos, Douglas R. Langbehn, John Canady, Vincent Magnotta, Lynn Richman
2007 Archives of Pediatrics & Adolescent Medicine  
b Cortical gray and cerebral white matter were nearly collinear (Pearson r = −.998).  ... 
doi:10.1001/archpedi.161.8.753 pmid:17679656 fatcat:t2t7arztarbcdkwxvrxn5hz2ye

Operationalizing compensation over time in neurodegenerative disease

Sarah Gregory, Jeffrey D. Long, Stefan Klöppel, Adeel Razi, Elisa Scheller, Lora Minkova, Marina Papoutsi, James A. Mills, Alexandra Durr, Blair R. Leavitt, Raymund A. C. Roos, Julie C. Stout (+4 others)
2017 Brain  
doi:10.1093/brain/awx022 pmid:28334888 pmcid:PMC5382953 fatcat:rpnkblvhnnbhdh5gitcz5balpe

fMRI biomarker of early neuronal dysfunction in presymptomatic Huntington's Disease

Jane S Paulsen, Janice L Zimbelman, Sean C Hinton, Douglas R Langbehn, Catherine L Leveroni, Michelle L Benjamin, Norman C Reynolds, Stephen M Rao
2004 American Journal of Neuroradiology  
Interrater reliability was high (r ϭ 0.91).  ... 
pmid:15569736 pmcid:PMC8148746 fatcat:ivvy3cowonazbccq3i6fh4cnei

Self-paced timing detects and tracks change in prodromal Huntington disease

Kelly C. Rowe, Jane S. Paulsen, Douglas R. Langbehn, Kevin Duff, Leigh J. Beglinger, Chiachi Wang, Justin J. F. O'Rourke, Julie C. Stout, David J. Moser
2010 Neuropsychology  
, alternating-thumbs condition R 2 = .26.  ...  Participants with higher estimated probability of diagnosis (based on age and CAG repeat length, Langbehn et al., 2004 ) performed less accurately and had different patterns of activation than participants  ... 
doi:10.1037/a0018905 pmid:20604618 pmcid:PMC2900808 fatcat:3rpxzpm5bvenbj4uzm4iihqnce

Neurocognitive signs in prodromal Huntington disease

Julie C. Stout, Jane S. Paulsen, Sarah Queller, Andrea C. Solomon, Kathryn B. Whitlock, J. Colin Campbell, Noelle Carlozzi, Kevin Duff, Leigh J. Beglinger, Douglas R. Langbehn, Shannon A. Johnson, Kevin M. Biglan (+1 others)
2011 Neuropsychology  
Method-For each of 738 HD CAG-expanded participants, we computed estimated years to clinical diagnosis and probability of diagnosis in five years, based on age and CAG repeat expansion number (Langbehn  ...  covariates adjusted R 2 = 0.42, F[36,300] = 7.75, p < 0.0001).  ...  diagnosis (as defined by the presence of unequivocal motor signs of HD), and the probability of diagnosis in five years, based on the participant's age and the number of CAG repeats on the expanded allele Langbehn  ... 
doi:10.1037/a0020937 pmid:20919768 pmcid:PMC3017660 fatcat:jp6b4qjsvbekjntr3cuaghlxqe
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