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Pten and Dicer1 loss causes poorly-differentiated endometrial adenocarcinoma in mice [article]

Xiyin Wang, Jillian Wendel, Robert E Emerson, Russell R. Broaddus, Chad J. Creighton, Doug Rusch, Aaron M Buechlein, Francesco J DeMayo, John P Lydon, Shannon Hawkins
2020 bioRxiv   pre-print
Endometrial cancer remains the most common gynecological malignancy in the United States. While the loss of the tumor suppressor, PTEN (phosphatase and tensin homolog), is well studied in endometrial cancer, recent studies suggest that DICER1, the endoribonuclease responsible for miRNA genesis, also plays a significant role in endometrial adenocarcinoma. In an endometrial adenocarcinoma mouse model, which has a conditional uterine deletion of Pten, Dicer1 was also conditionally deleted.
more » ... nal uterine deletion of Dicer1 and Pten resulted in high-penetrance, poorly-differentiated endometrial adenocarcinomas. Poorly-differentiated endometrial adenocarcinomas expressed known markers of clear-cell adenocarcinoma, including Napsin A and HNF1B (hepatocyte nuclear factor 1 homeobox B). Adenocarcinomas were hormone-independent, and treatment with long-term progesterone did not mitigate poorly-differentiated adenocarcinoma, nor did it affect adnexal metastasis. Transcriptomic analyses of uteri or Ishikawa cells with deletion of DICER1 revealed unique transcriptomic profiles and global downregulation of miRNAs. Integration of downregulated miRNAs with upregulated mRNA targets revealed deregulated let-7 and miR-16 target genes, similar to published human DICER1-mutant endometrial cancers from TCGA (The Cancer Genome Atlas). Importantly, these miRNA-target genes, involved in ephrin-receptor and transforming growth factor-beta signaling, represent potential clinical targets for rare, yet deadly, poorly-differentiated endometrial adenocarcinomas in women. This mouse model represents poorly-differentiated endometrial adenocarcinoma and will allow for the discovery of novel mechanisms of hormone-independent endometrial adenocarcinoma from atrophic endometrium.
doi:10.1101/2020.03.12.989087 fatcat:yvphrpybqfhbtfmjflzlaoart4

Environmental Management of Asthma at Massachusetts Managed Care Organizations

Doug Brugge, Loretta Carranza, Suzanne Steinbach, Arthur Wendel, James Hyde
2001 Journal of Public Health Management and Practice  
Environmental Management of Asthma at Massachusetts Managed Care Organizations Doug Brugge, Loretta Carranza, Suzanne Steinbach, Arthur Wendel, and James Hyde Asthma management staff at eight Massachusetts  ...  Health;* Loretta Carranza, MS, is a former student in the Health Communication Program;* Suzanne Steinbach, MD, is a pediatrician;' Arthur Wendel is a student in the Department of Family Medicine and  ... 
doi:10.1097/00124784-200107050-00006 pmid:11680029 fatcat:cc2eas2rpfambofbjmkicwkiiq

Meeting report of the RNA Ontology Consortium January 8-9, 2011

Amanda Birmingham, Jose C. Clemente, Narayan Desai, Jack Gilbert, Antonio Gonzalez, Nikos Kyrpides, Folker Meyer, Eric Nawrocki, Peter Sterk, Jesse Stombaugh, Zasha Weinberg, Doug Wendel (+4 others)
2011 Standards in Genomic Sciences  
This report summarizes the proceedings of the structure mapping working group meeting of the RNA Ontology Consortium (ROC), held in Kona, Hawaii on January 8-9, 2011. The ROC hosted this workshop to facilitate collaborations among those researchers formalizing concepts in RNA, those developing RNA-related software, and those performing genome annotation and standardization. The workshop included three software presentations, extended round-table discussions, and the constitution of two new
more » ... ng groups, the first to address the need for better software integration and the second to discuss standardization and benchmarking of existing RNA annotation pipelines. These working groups have subsequently pursued concrete implementation of actions suggested during the discussion. Further information about the ROC and its activities can be found at http://roc.bgsu.edu/.
doi:10.4056/sigs.1724282 pmid:21677862 pmcid:PMC3111981 fatcat:rwizei7ftjgujcouzyk5q4bfhi

The Biological Observation Matrix (BIOM) format or: how I learned to stop worrying and love the ome-ome

Daniel McDonald, Jose C Clemente, Justin Kuczynski, Jai Ram Rideout, Jesse Stombaugh, Doug Wendel, Andreas Wilke, Susan Huse, John Hufnagle, Folker Meyer, Rob Knight, J Gregory Caporaso
2012 GigaScience  
Attached please find our revised manuscript and response to the reviewer's comments. As we discussed, I approached Jonathan Eisen about writing a commentary on our paper, and specifically on the "ome-ome" idea and the proliferation of "omics terms" in the biomedical literature. He mentioned that he is interested in principle, so we have left our discussion of this in the text. If it's OK with you, I'd like to send him this draft of the manuscript. At that point I'll confirm his interest in
more » ... ng a commentary, and he can use this draft to base his commentary on. We have pasted the full text of the reviewers' comment below, and provided our responses in red. Thank you again for considering our manuscript for publication in GigaScience. Sincerely, J. Gregory Caporaso Reviewer: Frederick Matsen Minor essential revision: I have one real suggestion, which is to separate the description of the format from its implementation in Python. The history of formats that are defined wholly or partially by a reference implementation is not pretty. The description on http://www.biom-format.org/documentation/biom_format.html seems complete to me, and I think that link should be given in this manuscript as the specification. Similarly, I'm a bit surprised by the decision to tie the BIOM format version to the version number of the biom-format software. If the goal is to parsers in lots of languages, won't they at some point be at different versions? I think that versioning the spec is the appropriate thing to do here. We see the reviewer's point about decoupling the version of the biom-format package and the version of the specification, and will act on that suggestion. We have updated the text describing this point in the paper. If it acceptable to the reviewer and the editor, we would like to synchronize the change to the software and specification with the publication of the paper. At that time, we will create a 1.0.0 version of the BIOM specification, which will be under independent versioning from the biom-format project. The reason we would like to wait until the publication of the paper is that we are already planning a 1.0.0 release of the biom-format project at that time, and, given that several software development groups either have or are in the process of integrating the BIOM format into their tools, we feel that doing a release now and an additional release in the near future will be disruptive of that process (and could thus hinder the adoption of BIOM). We thank the reviewer for this very valuable suggestion. Discretionary revisions: Abstract:(1) "JSON-derived": I would prefer "JSON-based" rather than "JSONderived" as the latter makes it sound like you are extending JSON in some way. Modified as requested. (2) "bioinformatics bottleneck": I would prefer something more precise like "the file format incompatibility problem". We have opted to keep this terminology for consistency with the cited references in this section.
doi:10.1186/2047-217x-1-7 pmid:23587224 pmcid:PMC3626512 fatcat:mvod5riw6zhfbmutpxpnodtgva

MIxS-BE: a MIxS extension defining a minimum information standard for sequence data from the built environment

Elizabeth M Glass, Yekaterina Dribinsky, Pelin Yilmaz, Hal Levin, Robert Van Pelt, Doug Wendel, Andreas Wilke, Jonathan A Eisen, Sue Huse, Anna Shipanova, Mitch Sogin, Jason Stajich (+3 others)
2013 The ISME Journal  
doi:10.1038/ismej.2013.176 pmid:24152717 pmcid:PMC3869023 fatcat:5veec22mfrd35pcateehsocqqe

Londonderry Board of Directors

Wendell Coleman, Charlie Chairperson, Carrie Cave, Esther Chalmers, Doug Fishman, Debra Friant, Jim Lyneis, Andrea Mooney, Dianne Ogden, Jeanne Yelton, Nancy Zammataro, David Westlund (+1 others)
2010 Business Manager   unpublished
The member school districts of the Mountain Towns RED have worked increasingly over the past several years to consolidate management and educational services, master employee contracts and to otherwise bring about effective and efficient operating procedures and practices. Through this process, both formal and informal agreements, management systems and operating procedures have evolved between and among these member school districts, laying a foundation for the creation of the Mountain Towns
more » ... gional School District. Article 3 The Mountain Towns RED will operate grades K-8 and offer parental choice for grades 9-12, and will offer Pre-K education as determined by the Mountain Towns RED Board. 9 Article 4 Beginning _July 1, 2013, the Mountain Towns RED Board will be responsible for adopting policies regarding the transportation of the publicly-funded students of the district consistent with the centralization of transportation provision of Act 153. Article 5 The RED will honor all pre-existing master and individual contracts that are in place for the forming school districts on July 1, 2013. These master and individual agreements will continue until their respective specified termination dates. Article 6 The combining/forming districts of the RED recognize their obligations, pursuant to Act 153 of 2010, Section 9, to standardize curricula, and to otherwise standardize their operations within existing Supervisory Unions boundaries, on or before July 1, 2013. Article 7 Any and all operating deficits and/or surpluses of any of the combining/forming districts shall become the property, and/or the obligation, of the RED on or before June 30, 2013.
fatcat:dfuy554y75cr7k4qwtl7tmfguy

Page 36 of Journal of Public Health Management and Practice Vol. 7, Issue 5 [page]

2001 Journal of Public Health Management and Practice  
Environmental Management of Asthma at Massachusetts Managed Care Organizations Doug Brugge, Loretta Carranza, Suzanne Steinbach, Arthur Wendel, and James Hyde Asthma management staff at eight Massachusetts  ...  Health;* Loretta Carranza, MS, is a former student in the Health Communication Program;* Suzanne Steinbach, MD, is a pediatrician;' Arthur Wendel is a student in the Department of Family Medicine and  ... 

Page 1155 of Guernsey Breeders' Journal Vol. 103, Issue 12 [page]

1959 Guernsey Breeders' Journal  
Wendell C. Locke and James C. VC'alker m nomination tor election as members ot the Fxecutive Commit¬ tee.  ...  Doug- laston Manor Farm, Pulaski, N. Y.. and John Lyman maile the presentation to R H. McMurtrie. Huntingburg, Imliana.  ... 

Page 445 of The New England Magazine Vol. 3, Issue 4 [page]

1890 The New England Magazine  
And here, when driven from Tremont Temple by a Pro-Slavery mob, Wendell Phillips once led his supporters and made his speec h. Frederick Doug lass, who was present, gives in a letter to  ... 

Page 729 of The New England Magazine Vol. 27, Issue 6 [page]

1903 The New England Magazine  
WENDELL PHILLIPS AT FIFTY Miss Anthony’s reminiscence on this occasion gave a different pic- ture from that suggested by Doug- lass, but the man of whom she told was the same in old age as Douglass had  ...  REMINISCENCES OF WENDELL PHILLIPS 729 frank eagerness over a box of flow- ers which was brought to her, and before I left, she got up on her feet for a few minutes.  ... 

Page 344 of Kansas Bar Association. The Journal of the Kansas Bar Association Vol. 28, Issue 3 [page]

1960 Kansas Bar Association. The Journal of the Kansas Bar Association  
Doug Myers of Dodge City has a new comer suite in the Bank Building. The office is modern in design, and well done. Doug says he likes it.  ...  Wendell Doggett is the latest addition to the Liberal Bar. He is general counsel for the Anadarko Production Company, a subsidiary of Panhandle Eastern.  ... 

Page 344 of Kansas Bar Association. The Journal of the Kansas Bar Association Vol. 28, Issue 3 [page]

1960 Kansas Bar Association. The Journal of the Kansas Bar Association  
Doug Myers of Dodge City has a new comer suite in the Bank Building. The office is modern in design, and well done. Doug says he likes it.  ...  Wendell Doggett is the latest addition to the Liberal Bar. He is general counsel for the Anadarko Production Company, a subsidiary of Panhandle Eastern.  ... 

Page 665 of Alabama. Supreme Court. Reports Vol. 21, Issue [page]

1852 Alabama. Supreme Court. Reports  
Lyme, Doug. 159; Brosius v. Beuter, 1 Harr. & Johns. 557. 8. The Commissioners’ Court should have been called on to audit the claim of Tarver, before it could be called on to make the allowance.  ...  Throop, 12 Wendell, 183. 10. The pleadings in the case on the part of the defendants, are not contradictory. There is no one defence which sub- stantially denies the other.  ... 

Comparison of chloroplast and nuclear phylogeny in the autogamous annualMicroseris douglasii (Asteraceae: Lactuceae)

Dick Roelofs, Konrad Bachmann
1997 Plant Systematics and Evolution  
1993 , WENDEL & al. 1993 ) and hybridization followed by the exclusion of the maternal nuclear genome.  ...  RIESEBERG & WENDEL (1993) reviewed 37 examples of "chloroplast capture", SOLTIS & KUZOFF (1995) put the number at "well above 50".  ... 
doi:10.1007/bf00982531 fatcat:gvztbrwoxjad5g75zftvhg32xm

Page 20 of Black History Bulletin Vol. 14, Issue 1 [page]

1950 Black History Bulletin  
During the spring of 1850 Doug- lass did not want for signs and por- tents of the slave conspiracy.  ...  Doug- lass was accosted by Rynders but was spared from physical violence by his remarkable display of cool- ness and wit.  ... 
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