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Dorsal striatum mediates cognitive control, not cognitive effort per se , in decision-making: An event-related fMRI study

Brian D. Robertson, Nole M. Hiebert, Ken N. Seergobin, Adrian M. Owen, Penny A. MacDonald
2015 NeuroImage  
Objective: Whether the dorsal striatum (DS) mediates cognitive control or cognitive effort per se in decision-making is unclear given that these effects are highly correlated.  ...  We implemented a task that disentangled cognitive control and cognitive effort to specify the particular function DS mediates in decision-making.  ...  Acknowledgments This study was supported by a Canada Excellence Research Chair award to Dr.  ... 
doi:10.1016/j.neuroimage.2015.03.082 pmid:25862263 fatcat:76ebipiaurhdvgwecwzdhapdqq

Dorsal striatum mediates cognitive control, not cognitive effort per se, in decision-making: an event-related fMRI study

BD Robertson, NM Hiebert, KN Seergobin, AM Owen, PA MacDonald
2015 Canadian Journal of Neurological Sciences  
Background:Whether the dorsal striatum (DS) mediates cognitive control or cognitive effort per se in decision-making is unclear because as cognitive control requirements of a task intensify, cognitive  ...  support the increasingly accepted notion that DS mediates cognitive control specifically and does not index cognitive effort per se.  ...  E.03 Dorsal striatum mediates cognitive control, not cognitive effort per se, in decision-making: an event-related fMRI study Background: Whether the dorsal striatum (DS) mediates cognitive control or  ... 
doi:10.1017/cjn.2015.94 fatcat:bwzwonokkre7nd2nmp7dh6jpra

Dopamine and effort-based decision making

Irma Triasih Kurniawan
2011 Frontiers in Neuroscience  
Effort-based decision making addresses how we make an action choice based on an integration of action and goal values.  ...  Here we review behavioral and neurobiological data regarding the representation of effort as action cost, and how this impacts on decision making.  ...  More recent fMRI studies have replicated an involvement of striatum in effort-related processes, reporting higher dorsolateral striatal activity for choosing low compared to high-effort options The contribution  ... 
doi:10.3389/fnins.2011.00081 pmid:21734862 pmcid:PMC3122071 fatcat:ragzw2ag7nhnbmh6bngr3isgcm

Learning, Reward, and Decision Making

John P. O'Doherty, Jeffrey Cockburn, Wolfgang M. Pauli
2017 Annual Review of Psychology  
Other Decision Variables: Effort and Uncertainty One variable that is likely to play an important role during decision making is the amount of effort, whether cognitive or physical,  ...  Human fMRI studies of motor sequence learning have reported an increase in activity in the posterior dorsolateral striatum as sequences become overlearned.  ... 
doi:10.1146/annurev-psych-010416-044216 pmid:27687119 pmcid:PMC6192677 fatcat:xdleekt2dbabdjzg4zvk7vsnkm

Emotion and Decision Making: Multiple Modulatory Neural Circuits

Elizabeth A. Phelps, Karolina M. Lempert, Peter Sokol-Hessner
2014 Annual Review of Neuroscience  
This research suggests that the neural mechanisms mediating the relation between affect and choice vary depending on which affective component is engaged and which decision variables are assessed.  ...  Although the prevalent view of emotion and decision making is derived from the notion that there are dual systems of emotion and reason, a modulatory relationship more accurately reflects the current research  ...  risk attitudes per se.  ... 
doi:10.1146/annurev-neuro-071013-014119 pmid:24905597 fatcat:7pplwpbfvzb3letzat65cf3qs4

Categorization=decision making+generalization

Carol A. Seger, Erik J. Peterson
2013 Neuroscience and Biobehavioral Reviews  
We also consider how memory related functions in the hippocampus may be integrated with decision making mechanisms and contribute to categorization.  ...  Next we discuss how value is combined with other factors in decision making, emphasizing the effects of uncertainty.  ...  Cognitive neuroscientists emphasized the importance of decision making in mediating between basic perceptual and memory functions and behavioral choice, and the major role of frontoparietal systems in  ... 
doi:10.1016/j.neubiorev.2013.03.015 pmid:23548891 pmcid:PMC3739997 fatcat:br7gip7fxbhexmpy6sspmdwpgm

The human amygdala encodes value and space during decision making

Olga Therese Ousdal, Karsten Specht, Andres Server, Ole A. Andreassen, Ray J. Dolan, Jimmy Jensen
2014 NeuroImage  
Our data show that the human amygdala integrates information about space and value, an integration of likely importance for assigning cognitive resources towards highly valuable stimuli in our environment  ...  We measured haemodynamic responses (fMRI) in amygdala while manipulating the value and spatial configuration of stimuli in a simple stimulus-reward task.  ...  The authors would like to thank the NORMENT, KG Jebsen Centre for Psychosis Research study group and Anne Hilde Farstad for assisting with data collection.  ... 
doi:10.1016/j.neuroimage.2014.07.055 pmid:25094017 pmcid:PMC4176653 fatcat:k3hxr5h3zrdsvdgjp5aaojjeyq

Examining dorsal striatum in cognitive effort using Parkinson's disease and fMRI

Alex A. MacDonald, Ken N. Seergobin, Ruzbeh Tamjeedi, Adrian M. Owen, Jean-Sebastien Provost, Oury Monchi, Hooman Ganjavi, Penny A. MacDonald
2014 Annals of Clinical and Translational Neurology  
Previously, we claimed that dorsal striatum (DS) mediates cognitive flexibility.  ...  Objective: Understanding cognition mediated by the striatum can clarify cognitive deficits in Parkinson's disease (PD).  ...  Here we show that PD patients are not impaired in making cognitively effortful decisions per se and that performance in selecting between symbolically close versus distant number pairs is not affected  ... 
doi:10.1002/acn3.62 pmid:25356409 pmcid:PMC4184667 fatcat:h3pnyyhmrferzhqllwb2kzfuy4

Binge drinking impacts dorsal striatal response during decision making in adolescents

Scott A. Jones, Anita Cservenka, Bonnie J. Nagel
2016 NeuroImage  
Region of interest (ROI) analysis revealed that during decision making, there was a significant bingedrinking related reduction in brain activation in the dorsal striatum, an effect associated with degree  ...  These results demonstrate how abnormalities in decision-making related circuitry might both lead to and perpetuate alcohol drinking behavior.  ...  Past and current members of the Developmental Brain Imaging Lab are thanked for assisting in participant scheduling and data collection.  ... 
doi:10.1016/j.neuroimage.2016.01.044 pmid:26826511 pmcid:PMC4803619 fatcat:rhfpmxxcdnee5f5rrn2nqusv6e

Arterial tortuosity: an imaging biomarker of childhood stroke pathogenesis?

F Wei, K Diedrich, H Fullerton, G DeVeber, M Wintermark, J Hodge, A Kirton
2015 Canadian Journal of Neurological Sciences  
(VIPS) study (controls from the Calgary Pediatric Stroke Program).  ...  Tortuosity was compared between dissection (spontaneous and traumatic), FCA, moyamoya, meningitis, and cardioembolic, and controls (ANOVA, post-hoc Tukey).Results:A total of 116 children were studied.  ...  E.03 Dorsal striatum mediates cognitive control, not cognitive effort per se, in decision-making: an event-related fMRI study Background: Whether the dorsal striatum (DS) mediates cognitive control or  ... 
doi:10.1017/cjn.2015.93 fatcat:numji3gvqbgnjelmzh53hvpl2i

Design and development of drugs for Alzheimer's dementia as a protein misfolding disorder

C Barden, F Meier-Stephenson, MD Carter, S Banfield, EC Diez, B Kelly, E Lu, A Meek, V Meier-Stephenson, L Pan, GA Simms, B Sweeting (+7 others)
2015 Canadian Journal of Neurological Sciences  
beta-amyloid (plaques) and tau (tangles).Methods:Using large-scale computer simulations, we modelled the misfolding of both beta-amyloid and tau, identifying a common conformational motif (CCM; i.e. an  ...  These were comprehensively screened in a battery of five in vitro protein oligomerization assays.  ...  E.03 Dorsal striatum mediates cognitive control, not cognitive effort per se, in decision-making: an event-related fMRI study Background: Whether the dorsal striatum (DS) mediates cognitive control or  ... 
doi:10.1017/cjn.2015.95 fatcat:jujzjtv53nfi7lhnpe7gboiuli

The detrimental effects of emotional process dysregulation on decision-making in substance dependence

Anna Murphy, Eleanor Taylor, Rebecca Elliott
2012 Frontiers in Integrative Neuroscience  
control, mediate maladaptive decision-making observed in substance dependent individuals such that they continue drug use in spite of negative consequences.  ...  Various cognitive mechanisms have been implicated, including impulsivity, compulsivity, and impaired decision-making.  ...  In these studies, the presentation of a CS that predicted an aversive event did not prevent responding for cocaine.  ... 
doi:10.3389/fnint.2012.00101 pmid:23162443 pmcid:PMC3491319 fatcat:xxuzrpupkva25nff6dbl4dvzdy

Annual Research Review: Transdiagnostic neuroscience of child and adolescent mental disorders - differentiating decision making in attention-deficit/hyperactivity disorder, conduct disorder, depression, and anxiety

Edmund J. S. Sonuga-Barke, Samuele Cortese, Graeme Fairchild, Argyris Stringaris
2015 Journal of Child Psychology and Psychiatry and Allied Disciplines  
initiative in decision making in childhood disorders.  ...  higher order cognitive and behavioral control, and ventral frontostriatal circuits, connecting to brain regions implicated in emotion processing, that control valuation and learning processes.  ...  An fMRI study observed hypoactivation in multiple brain regions in individuals with both CD and substance use disorders (SUDs) during the evaluation phase of decision making (Crowley et al., 2010) .  ... 
doi:10.1111/jcpp.12496 pmid:26705858 pmcid:PMC4762324 fatcat:kkluh4mkxnasjcaxi3qjwzp7eu

Action selection in multi-effector decision making

Seth Madlon-Kay, Bijan Pesaran, Nathaniel D. Daw
2013 NeuroImage  
Decision making and reinforcement learning over movements suffer from the curse of dimensionality: the space of possible movements is too vast to search or even represent in its entirety.  ...  To examine how the brain solves this problem, we used fMRI to compare patterns of BOLD activity in humans during reward learning tasks in which options were selected through either unimanual or bimanual  ...  sometimes the dorsal anterior cingulate in the decision-making literature (Kolling et al., 2012) .  ... 
doi:10.1016/j.neuroimage.2012.12.001 pmid:23228512 pmcid:PMC3580036 fatcat:pihzsxqga5ekvcawfbj7ktu264

What if I Get Busted? Deception, Choice, and Decision-Making in Social Interaction

Kamila E. Sip, Joshua C. Skewes, Jennifer L. Marchant, William B. McGregor, Andreas Roepstorff, Christopher D. Frith
2012 Frontiers in Neuroscience  
Importantly, questions were posed so that, in some conditions, it was possible to be deceptive, while in other conditions it was not.  ...  The condition in which confrontation was not possible was associated with increased activity in subgenual anterior cingulate cortex.  ...  It should also be recalled in this context that our reason for designing the study in this way was that we were not interested in deception in itself as an isolated speech act, but in the social decision-making  ... 
doi:10.3389/fnins.2012.00058 pmid:22529772 pmcid:PMC3328780 fatcat:bwa5oag3kjb4tmwcblpk7ejdg4
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