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Dopamine increases in striatum do not elicit craving in cocaine abusers unless they are coupled with cocaine cues

Nora D. Volkow, Gene-Jack Wang, Frank Telang, Joanna S. Fowler, Jean Logan, Anna-Rose Childress, Millard Jayne, Yeming Ma, Christopher Wong
2008 NeuroImage  
Imaging studies have shown an association between dopamine increases in striatum and cue induced craving in cocaine abusers.  ...  dopamine in striatum, did not induce craving unless subjects were concomitantly exposed to cocaine-cues (video scenes of subjects self-administering cocaine).  ...  In this study oral MP decreased binding in ventral striatum in the cocaine abusers when coupled with the neutral-cue video but not when coupled with the cocaine-cue video.  ... 
doi:10.1016/j.neuroimage.2007.09.059 pmid:18024160 pmcid:PMC3170090 fatcat:mg36tbjavberxfz63m6vec35ga

Neurocircuitry of Addiction

George F Koob, Nora D Volkow
2009 Neuropsychopharmacology  
The transition to addiction involves neuroplasticity in all of these structures that may begin with changes in the mesolimbic dopamine system and a cascade of neuroadaptations from the ventral striatum  ...  involving the orbitofrontal cortex-dorsal striatum, prefrontal cortex, basolateral amygdala, hippocampus, and insula involved in craving and the cingulate gyrus, dorsolateral prefrontal, and inferior frontal  ...  We thank Michael Arends and Ruben Baler for their assistance with paper preparation.  ... 
doi:10.1038/npp.2009.110 pmid:19710631 pmcid:PMC2805560 fatcat:7gu2vbom7bfoheapzs2t6gbk54

Neuroimaging and drug taking in primates

Kevin S. Murnane, Leonard L. Howell
2011 Psychopharmacology  
Results The study of drug interactions with dopamine and serotonin transporters in vivo has identified pharmacological mechanisms of action associated with the abuse liability of stimulants.  ...  Dysregulation of dopamine function and brain metabolic changes in areas involved in reward circuitry have been linked to drug taking behavior, cognitive impairment, and treatment response.  ...  Acknowledgments Research from the laboratory of the authors and preparation of the manuscript were supported in part by US Public Health Service Grants DA10344, DA12514, DA16589, DA00517, and RR00165 (  ... 
doi:10.1007/s00213-011-2222-7 pmid:21360099 pmcid:PMC3232674 fatcat:v7563edthnglfimtqcfdeaovnm

Aberrant learning and memory in addiction

Mary M. Torregrossa, Philip R. Corlett, Jane R. Taylor
2011 Neurobiology of Learning and Memory  
or interferes with functioning in other facets of life.  ...  Long-lasting alterations in brain function have been found in neural circuits that are known to be responsible for normal appetitive learning and memory processes and it has been hypothesized that drugs  ...  Positron emission tomography (PET) scans with radiolabelled tracers sensitive to dopamine binding reveal dopamine release in the dorsal striatum in cocaine users in response to cocaine associated cues  ... 
doi:10.1016/j.nlm.2011.02.014 pmid:21376820 pmcid:PMC3138832 fatcat:lpj6goj7jbebdmzf773x5qtkdq

Drug Addiction as a Pathology of Staged Neuroplasticity

Peter W Kalivas, Charles O'Brien
2007 Neuropsychopharmacology  
response to drug-associated cues and simultaneous reports of drug craving.  ...  There appears to be plasticity associated with the addiction phenomenon in general as well as changes produced by addiction to a specific class of addicting drugs.  ...  ACKNOWLEDGEMENTS This work was supported in part by USPHS Center Grants P50 DA015369 and P60 DA01586.  ... 
doi:10.1038/sj.npp.1301564 pmid:17805308 fatcat:hwaxidwhk5ctdbx6x5kjgdpqyu

Phosphodiesterase 4 inhibitors and drugs of abuse: current knowledge and therapeutic opportunities

Christopher M. Olsen, Qing-Song Liu
2016 Frontiers in Biology  
There is a promising possibility to repurpose these PDE4 inhibitors for the treatment of drug addiction as they are safe and well-tolerated in patients.  ...  It is expressed in several brain regions that regulate the reinforcing effects of drugs of abuse.  ...  Stimuli that are commonly used to reinstate drug seeking include drugassociated cues, stress, or a priming dose of the drug itself. These stimuli are known to also elicit craving in human drug users.  ... 
doi:10.1007/s11515-016-1424-0 pmid:28974957 pmcid:PMC5617368 fatcat:t6kyvm34r5bfhjarxd4mvh6hmq

Factors modulating neural reactivity to drug cues in addiction: A survey of human neuroimaging studies

Agnes J. Jasinska, Elliot A. Stein, Jochen Kaiser, Marcus J. Naumer, Yavor Yalachkov
2014 Neuroscience and Biobehavioral Reviews  
Cocaine abusers reported an increase in cue-elicited craving in the no-inhibition but not in the cognitive-inhibition condition relative to the baseline with no drug cues presented.  ...  mechanism, of most if not all drugs of abuse is that they increase extracellular dopamine (DA) concentration in the mesocorticolimbic system, including the ventral striatum (VS), extended amygdala, hippocampus  ... 
doi:10.1016/j.neubiorev.2013.10.013 pmid:24211373 pmcid:PMC3913480 fatcat:5wqntoo3cjc2dicu6x5e24xw5i

Role of Prefrontal Cortex Dopamine and Noradrenaline Circuitry in Addiction [chapter]

Ezio Carboni, Roberto Cadeddu, Anna Rosa
2012 Addictions - From Pathophysiology to Treatment  
they are required to inhibit craving.  ...  Adolescents respond to the effects of alcohol distinctly from adults in fact they are less sensitive to negative effects of alcohol, they do no perceive cues that may suggest reduction of intake, but are  ... 
doi:10.5772/51221 fatcat:wngwaw7qyzf7pf5fsyokubdkce

The neural basis of drug craving: An incentive-sensitization theory of addiction

T Robinson
1993 Brain Research Reviews  
The first is: why do addicts crave drugs? Thar is, what is the psychological. and neurobiologicat basis of drug craving?  ...  The sensitization of dopamine systems is gated by associative learning, which causes excessive incentive salience to be attributed to the act of drug taking and to stimuli associated with drug taking.  ...  An earlier version of this theory was first presented at a UCLA/N'IDA conference on The Biological Basis of Substance Abuse, Santa Monica, CA, January 9-12, 1991.  ... 
doi:10.1016/0165-0173(93)90013-p pmid:8401595 fatcat:fanavracsbcr5a5qqvxkjka26e

Evidence for sugar addiction: Behavioral and neurochemical effects of intermittent, excessive sugar intake

Nicole M. Avena, Pedro Rada, Bartley G. Hoebel
2008 Neuroscience and Biobehavioral Reviews  
Cocaine cues and dopamine ventral tegmentum shared by palatable food (Fonzies) and non- in dorsal striatum: mechanism of craving in cocaine addiction.  ...  a decrease in accumbens DA release coupled with an rats do for cocaine (Deroche-Gamonet et al., 2004). increase in ACh release (Colantuoni et al., 2002).  ... 
doi:10.1016/j.neubiorev.2007.04.019 pmid:17617461 pmcid:PMC2235907 fatcat:ikj3cez2era67hecwvdsy6mmkm

D1 receptor hypersensitivity in mice with low striatal D2 receptors facilitates select cocaine behaviors

Lauren K. Dobbs, Alanna R. Kaplan, Roland Bock, Khanhky Phamluong, J. Hoon Shin, Miriam E. Bocarsly, Lindsay Eberhart, Dorit Ron, Veronica A. Alvarez
2018 Neuropsychopharmacology  
Vulnerability for cocaine abuse in humans is associated with low dopamine D2 receptor (D2R) availability in the striatum. The mechanisms driving this vulnerability are poorly understood.  ...  We found evidence that littermate control mice develop D1R hypersensitivity after they are sensitized to cocaine.  ...  ACKNOWLEDGEMENTS We are grateful to the members of the Alvarez laboratory for providing valuable feedback on this manuscript.  ... 
doi:10.1038/s41386-018-0286-3 fatcat:tljn6nnnwnehlfkuzga5gmtsq4

Mechanisms of Locomotor Sensitization to Drugs of Abuse in a Two-Injection Protocol

Emmanuel Valjent, Jesus Bertran-Gonzalez, Benjamin Aubier, Paul Greengard, Denis Hervé, Jean-Antoine Girault
2009 Neuropsychopharmacology  
These results combined with previous ones show that TIPS in mouse is a context-dependent response, which involves an increase in extracellular dopamine, stimulation of D1 and NMDA receptors, regulation  ...  A single injection of the selective dopamine transporter blocker GBR12783 was sufficient to activate extracellular signal-regulated kinase (ERK) in the striatum to the same level as cocaine and to induce  ...  We thank Anne-Gaëlle Corbillé for her help with some experiments and Alice Rousseau and Philippe Bernard for their help with the mutant mice.  ... 
doi:10.1038/npp.2009.143 pmid:19759531 pmcid:PMC2794893 fatcat:62w3hrnferawhauacpdnxjq22a

Mechanisms of the psychostimulant effects of caffeine: implications for substance use disorders

Sergi Ferré
2016 Psychopharmacology  
effects of caffeine and its possible increase in the vulnerability to develop SUD.  ...  Highlights-The model can explain the caffeine-induced rotational behavior in rats with unilateral striatal dopamine denervation and the ability of caffeine to reverse the adipsic-aphagic syndrome in dopamine-deficient  ...  Similarly, humans also develop taste preference with caffeine, but a consistent finding is that they do not develop preference for a caffeine-paired flavor unless they are at least moderate daily caffeine  ... 
doi:10.1007/s00213-016-4212-2 pmid:26786412 pmcid:PMC4846529 fatcat:2xb35jqftbfwbjxjzts267z6fe

The cue-reactivity paradigm: An ensemble of networks driving attention and cognition when viewing drug-related and natural-reward stimuli [article]

Lauren D. Hill-Bowen, Michael C. Riedel, Ranjita Poudel, Taylor Salo, Jessica S. Flannery, Julia A. Camilleri, Simon B. Eickhoff, Angela R. Laird, Matthew T. Sutherland
2020 bioRxiv   pre-print
When considering cue-reactivity collectively, across both drug and natural studies, activity convergence was observed in the dorsal striatum, limbic, insula, parietal, occipital, and temporal regions.  ...  Further, we demonstrated that these elements are supported by perceptual, sensorimotor, tripartite, and affective networks, which are essential to understanding the neural mechanisms involved in the development  ...  ., Dopamine increases in striatum do not elicit craving in cocaine abusers unless they are coupled with cocaine cues. Neuroimage, 2008. 39(3): p. 1266-73. 25.  ... 
doi:10.1101/2020.02.26.966549 fatcat:kdvw5bq5qjezvkkuvsrdwg5tsu

Environmental enrichment protects against the acquisition of cocaine self-administration in adult male rats, but does not eliminate avoidance of a drug-associated saccharin cue

Matthew D. Puhl, Joshua S. Blum, Stefany Acosta-Torres, Patricia S. Grigson
2012 Behavioural Pharmacology  
Acknowledgments The authors would like to thank the National Institute on Drug Abuse for generously supplying the cocaine HCl used in this study.  ...  . ↑ indicates an increase in magnitude of the behavioral parameter shown, while ↓ indicates a decrease in magnitude of the behavioral parameter shown. Behav Pharmacol.  ...  Low drug-takers, then, are not unmotivated. Instead, they are well motivated, but to take only a small amount of drug.  ... 
doi:10.1097/fbp.0b013e32834eb060 pmid:22157144 pmcid:PMC3650841 fatcat:qxu66ekuszcjdbs7dumsj43la4
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