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A Case of Idiopathic Eosinophilic Cholecystitis Treated with Steroids

Hyun Jun Kang, Min Ho Choi, Ho Tae Kim, Tae Yeong Kwak, Hyun Chaol Lee, Yeong Sung Kim, Dong Hyup Kwak
2012 Korean Journal of Medicine  
Eosinophilic cholecystitis is a rare disease characterized by transmural leukocyte infiltration composed of more than 90% eosinophils. Eosinophilic cholecystitis is clinically indistinguishable from ordinary cholecystitis, and as a rule it leads to cholecystectomy. We report a case of idiopathic eosinophilic cholecystitis treated with steroids. A 75-year-old woman presented with a classic history of acute cholecystitis and a peripheral eosinophilia of 41.8%. There was no evidence of allergy or
more » ... arasitic infestation. An abdominal ultrasonography and computed tomography (CT) scan showed an edematous, thickened gallbladder wall, but no gallstones. There was no evidence of eosinophilic infiltration in other organs. Cholecystectomy was not performed because the patient refused surgical management. However, fever, abdominal pain, and peripheral eosinophilia persisted despite antibiotic and conservative therapy. Therefore, we attempted treatment with prednisolone. A week later, the symptoms disappeared and the peripheral eosinophilia normalized. (Korean J Med 2012;83:342-346)
doi:10.3904/kjm.2012.83.3.342 fatcat:i6usrwcy35dejgfqp2hsvo7tj4

The Korean Pregnancy Outcome Study (KPOS): Study Design and Participants

Hansol Choi, Dong Wook Kwak, Min Hyoung Kim, Su Young Lee, Jin Hoon Chung, You Jung Han, Hee Jin Park, Moon Young Kim, Dong Hyun Cha, Seul Koo, Joong-Yeon Lim, Hyun Mee Ryu (+1 others)
2020 Journal of Epidemiology  
The Korean Pregnancy Outcome Study (KPOS) was established to investigate the determinants of adverse pregnancy outcomes among Korean women. We recruited 4,537 pregnant women between 2013 and 2017 from two tertiary centers located in Seoul, Korea, and a total of 4,195 Korean women met inclusion criteria in the baseline analysis. A range of data on socio-demographics, past medical histories, reproductive information, health-related behaviors, psychological health and clinical information were
more » ... ined using interviewer-based questionnaires and clinical assessment at 12, 24, and 36 gestational weeks (GW), delivery and 6-8 weeks postpartum. Blood samplings were performed at 12, 24 and 36 GW, and placental tissues were obtained after delivery. The main outcome of this study was pregnancy-related complications including gestational diabetes mellitus (GDM), gestational hypertension, and screening positive for peripartum depression. Depression was assessed using the Korean version of the Edinburgh Postnatal Depression Scale, and a score of ≥10 indicated a positive screen for depression. Among 4,195 eligible pregnant women with a median age of 33.0 years, 3,565 (85.0%) pregnancy outcomes were available in this study, including 30 miscarriages, 16 stillbirths, and 3,519 deliveries. Mean gestational age was 38.8 GW, and mean birth weight was 3,236 gram. The prevalence of pregnancy complications such as GDM, hypertensive disorders, and screening positive of depression during pregnancy and postpartum was 7.0%, 1.4%, 27.8%, and 16.6%, respectively. We designed KPOS to identify the determinants of pregnancy-related outcomes, and it may provide effective strategies for the prevention of pregnancy complications in Korean pregnant women.
doi:10.2188/jea.je20200055 pmid:32595182 pmcid:PMC8126675 fatcat:ouxjlckxubgl5hkqj3a3uxsyti

A Case of Thyroid Papillary Carcinoma With Pulmonary Tumor Embolism

Jung Gyu Lee, Dong Shin Kwak, Jae Ha Kim, Yoo Mi Yeo, Sang Heon Kim, Jang Won Sohn, Ho Joo Yoon, Dong Ho Shin, Sung Soo Park, Hyun Jung Kwak
2013 Journal of the Korean Geriatrics Society  
The tumor embolism is defined as tumor cells within the vascular system such as pulmonary artery that is not contiguous with the other metastatic foci. The incidence of tumor embolism varies widely ranging from 3% to 26% among seve ral studies; whereas lung cancer, prostate cancer, colorectal cancer, breast cancer, pancreas cancer are associated with high risks for tumor embolism. However thyroid cancer is rarely associated with tumor embolism. Among the rare cases, tumor embolism was reported
more » ... s being mostly of follicular carcinoma or undifferentiated carcinoma, but few of papillary carcinoma. We report an unusual presentation that pulmonary tumor embolism from thyroid papillary carcinoma was diagnosed with positron emission tomography/computed tomography (CT) and chest CT.
doi:10.4235/jkgs.2013.17.3.143 fatcat:mu5ccvo2efduhekozzij2xmrnm

Association between Bethesda categories and tumor characteristics of conventional papillary thyroid carcinoma

Vivian Youngjean Park, Eun-Kyung Kim, Dong Hyun Kim, Jin Young Kwak, Jung Hyun Yoon, Hee Jung Moon
2017 Ultrasonography  
ORCID: Vivian Youngjean Park: http://orcid.org/0000-0002-5135-4058; Eun-Kyung Kim: http://orcid.org/0000-0002-3368-5013; Jin Young Kwak: http://orcid.org/0000-0002-6212-1495; Jung Hyun Yoon: http://orcid.org  ... 
doi:10.14366/usg.17053 pmid:29361659 pmcid:PMC6177694 fatcat:p7kg6ave2rfxjinmrnfbhai5w4

Techno-Economic Study on Non-Capture CO2Utilization Technology

Ji Hyun Lee, Dong Woog Lee, No-Sang Kwak, Jung Hyun Lee, Jae-Goo Shim
2016 KEPCO Journal on Electric Power and Energy  
Techno-economic evaluation of Non-Capture CO2 Utilization (NCCU) technology for the production of high-value-added products using greenhouse gas (CO2) was performed. The general scheme of NCCU process is composed of CO2 carbonation and brine electrolysis process. Through a carbonation reaction with sodium hydroxide that is generated from brine electrolysis and CO2 of the flue gas, it is possible to get high-value-added products such as sodium bicarbonate, sodium hydroxide, hydrogen & chloride
more » ... d also to reduce the CO2 emission simultaneously. For the techno-economic study on NCCU technology, continuous operation of bench-scale facility which could treat 2 kgCO2/day was performed. and based on the key performance data evaluated, the economic evaluation analysis targeted on the commercial chemical plant, which could treat 6 tons CO2 per day, was performed using the net present value (NPV) metrics. The results showed that the net profit obtained during the whole plant operation was about 7,890 mKRW (million Korean Won) on NPV metrics and annual CO2 reduction was estimated as about 2,000 tCO2. Also it was found that the energy consumption of brine electrolysis is one of the key factors which affect the plant operation cost (ex. electricity consumption) and the net profit of the plant. Based on these results, it could be deduced that NCCU technology of this study could be one of the cost-effective CO2 utilization technology options.
doi:10.18770/kepco.2016.02.01.109 fatcat:3qgtqpgj6jdavagmntxjw3vxzu

Short-term prognostic value of CRP in the patients with acute coronary syndrome

Tae Ik Kim, Shung Chull Chae, Dong Hun Yang, Seong Chull Shin, Ho Sang Bae, Dong Hun Kwak, Jong Hyun Hwang, Yong Geun Cho, Jae Eun Jun, Wee Hyun Park
2000 Korean Circulation Journal  
and Objectives Acute coronary syndrome occurs most commonly in the setting of atherosclerotic coronary artery disease, but there is little information concerning the mechanism responsible for the transition from stable to unstable coronary atherosclerotic plaque. Hypothetically, several microorganism Chlamydia pneumonia, Cytomegalovirus and Helicobacter pylori and their inflammatory reaction have been suggested as a causative motive in progression of acute coronary syndrome. Although it is
more » ... ar whether the serum level of CRP as an inflammatory parameter is concerned with previous inflammatory change or myocardial necrosis, CRP appears to be predictive of higher risk for cardiac event in the patients with acute coronary syndrome. Our objective was to evaluate whether the inflammatory parameters CRP, ESR and WBC count are useful in predicting the short-term cardiac risk within 30 days. Materials and Method One hundred and ten patients with acute coronary syndrome were enrolled from April 1998 through August 1998. Blood samples were collected at 1st hour, 24th hour, 48th hour and 7th day and tested for CRP, ESR, WBC count and CK-MB level. Values of 323 normal were used as control. All patients were followed up for 30 days and assessed for the presence of cardiac complications. Results Peak CRP value of the patients with acute myocardial infarction 3.4 3.85 mg/dL, n 62 was higher than that of the patients with unstable angina 0.7 0.93 mg/dL, n 48, p 0.05 and controls 0.3 0.48 mg/dL, n 323, p 0.05 . Peak CRP value of patients with cardiac complication was higher than that of patients without complication 7.7 4.77 mg/dL, n 15 vs 1.3 1.74 mg/dL, n 95 p 0.05 . In multivariate analysis, peak CRP value was the only predictive parameter for development of cardiac complications in the patients with acute coronary syndrome Odds ratio 4.893, 95% confidence interval 1.212 19.756, p value 0.026 . In the high-CRP group 2 mg/dL, n 30 , the cardiac complication rate was higher than the low-CRP group 2 mg/dL, n 80 43.3% vs 2.5%, p 0.05 . Peak CRP value was correlated with age r 0.191, p 0.045 , pulse rate r 0.186, p 0.008), left ventricular ejection fraction r 0.384, p 0. 001 , peak ESR r 0.383, p 0.001 and peak WBC count r 0.307, p 0.001 , but not with peak CK-MB level. Conclusion Elevated CRP level in patients with acute coronary syndrome seems to be a valuable
doi:10.4070/kcj.2000.30.11.1387 fatcat:7yhc3pmfijb6tfo7p7oo5fa6se

A Case of Carcinosarcoma of the Parotid Gland

Dong Uk Park, Bo Kyung Kwak, Joo-Hyun Woo, Dong Young Kim
2012 Korean Journal of Otorhinolaryngology - Head and Neck Surgery  
Carcinosarcoma is an extremely rare tumor, composed of a mixture of both carcinomatous and sarcomatous elements. The two-thirds are derived from the parotid gland. Because carcinosarcoma is highly aggressive malignant tumor with high local recurrence and poor survival rates, the combination of radical surgical excision and chemotherapy or radiotherapy is regarded as treatment of choice. However, treatment protocol has not been established. A 73-year-old man presented with a painful mass in the
more » ... eft parotid gland that had been rapidly enlarging for 2 weeks. Fine-needle aspiration biopsy was performed and it showed atypical epithelium. Superficial parotidectomy and modified radical neck dissection were performed for the left parotid gland cancer. The pathological diagnosis was carcinosarcoma and sequential chemoradiotherapy was performed. After a clinical follow-up of 30 months, he has remained free of disease. Based on our experience, we suggest that conservative surgical procedure could be one of the effective therapies.
doi:10.3342/kjorl-hns.2012.55.2.118 fatcat:pvwtcayfzjgrrl6e2xfgt7i6du

Enzymatic Weight Update Algorithm for DNA-Based Molecular Learning

Christina Baek, Sang-Woo Lee, Beom-Jin Lee, Dong-Hyun Kwak, Byoung-Tak Zhang
2019 Molecules  
Recent research in DNA nanotechnology has demonstrated that biological substrates can be used for computing at a molecular level. However, in vitro demonstrations of DNA computations use preprogrammed, rule-based methods which lack the adaptability that may be essential in developing molecular systems that function in dynamic environments. Here, we introduce an in vitro molecular algorithm that 'learns' molecular models from training data, opening the possibility of 'machine learning' in wet
more » ... ecular systems. Our algorithm enables enzymatic weight update by targeting internal loop structures in DNA and ensemble learning, based on the hypernetwork model. This novel approach allows massively parallel processing of DNA with enzymes for specific structural selection for learning in an iterative manner. We also introduce an intuitive method of DNA data construction to dramatically reduce the number of unique DNA sequences needed to cover the large search space of feature sets. By combining molecular computing and machine learning the proposed algorithm makes a step closer to developing molecular computing technologies for future access to more intelligent molecular systems.
doi:10.3390/molecules24071409 fatcat:abccu57ltjhcjhvthedhltq3xe

Maternal total cell-free DNA in preeclampsia with and without intrauterine growth restriction

Dong Wook Kwak, Shin Young Kim, Hyun Jin Kim, Ji Hyae Lim, Young-Han Kim, Hyun Mee Ryu
2020 Scientific Reports  
Elevation of total cell-free DNA (cfDNA) in patients with preeclampsia is well-known; however, whether this change precedes the onset of symptoms remains inconclusive. Here, we conducted a nested case-control study to determine the elevation of cfDNA levels in women who subsequently developed preeclampsia. Methylated HYP2 (m-HYP2) levels were determined in 68 blood samples collected from women with hypertensive disorders of pregnancy, along with 136 control samples, using real-time quantitative
more » ... PCR. The measured m-HYP2 levels were converted to multiples of the median (MoM) values for correction of maternal characteristics. The m-HYP2 levels and MoM values in patients with preeclampsia were significantly higher than in controls during the third trimester (P < 0.001, both), whereas those for women who subsequently developed preeclampsia did not differ during the second trimester. However, when patients with preeclampsia were divided based on the onset-time of preeclampsia or 10th percentile birth weight, both values were significantly higher in women who subsequently developed early-onset preeclampsia (P < 0.05, both) and preeclampsia with small-for-gestational-age (SGA) neonate (P < 0.01, both) than controls. These results suggested that total cfDNA levels could be used to predict early-onset preeclampsia or preeclampsia with SGA neonate.
doi:10.1038/s41598-020-68842-1 pmid:32678284 fatcat:nzvp2c6mjnbtnnkjticfxxy5oy

Genome-wide gene expression analysis in the placenta from fetus with trisomy 21

Ji Hyae Lim, You Jung Han, Hyun Jin Kim, Dong Wook Kwak, So Yeon Park, Sun-Hee Chun, Hyun Mee Ryu
2017 BMC Genomics  
We performed whole human genome expression analysis in placenta tissue (normal and T21) samples in order to investigate gene expression into the pathogenesis of trisomy 21 (T21) placenta. We profiled the whole human genome expression of placental samples from normal and T21 fetuses using the GeneChip Human Genome U133 plus 2.0 array. Based on these data, we predicted the functions of differentially expressed genes using bioinformatics tools. Results: A total of 110 genes had different
more » ... patterns in the T21 placentas than they did in the normal placentas. Among them, 77 genes were up-regulated in the T21 placenta and 33 genes were down-regulated compared to their respective levels in normal placentas. Over half of the up-regulated genes (59.7%, n = 46) were located on HSA21. Up-regulated genes in the T21 placentas were significantly associated with T21 and its complications including mental retardation and neurobehavioral manifestations, whereas down-regulated genes were significantly associated with diseases, such as cystitis, metaplasia, pathologic neovascularization, airway obstruction, and diabetes mellitus. The interactive signaling network showed that 53 genes (40 up-regulated genes and 13 downregulated genes) were an essential component of the dynamic complex of signaling (P < 1.39e-08). Conclusions: Our findings provide a broad overview of whole human genome expression in the placentas of fetuses with T21 and a possibility that these genes regulate biological pathways that have been involved in T21 and T21 complications. Therefore, these results could contribute to future research efforts concerning gene involvement in the disease's pathogenesis.
doi:10.1186/s12864-017-3993-y pmid:28899343 pmcid:PMC5596874 fatcat:xyquqjndu5hvngclj5ads5olqy

Safety Profile of Adenosine Myocardial Perfusion Imaging

Jeong Gyoon Kim, Byeong Cheol Ahn, Kyung Ah Chun, Dong Woo Hyun, Young Hak Lee, Sun Geun Bae, Dong Suck Kwak, Jin Yong Hwang, Yong Keun Cho, Shung Chull Chae, Jae Eun Jun, Wee Hyun Park (+3 others)
1997 Korean Circulation Journal  
Myocardial perfusion scintigraphy with intravenous adenosine has proved efficacy for the diagnosis and risk stratification of coronary artery disease. To determine the safety of adenosine infusion in conjunction with radionuclide imaging, we evaluated pro-spectively 1,093 patients who underwent myocardial perfusion study. Methods Informations on safety and adverse events during and immediately after adenosine infusion were collected and statistical analysis was performed. Results The adverse
more » ... nts were reported in 730 patients 66.8% , but no death or myocardial infarction. These adverse events were well tolerated and no prolonged effect was noted. Chest pain occurred in 223 patients 20.4% and facial flushing and dyspnea were reported by 246 patients 22.5% and 253 patients 23.1% , respectively. ECG changes, such as mild arrhythmia, ST depression and AV block were checked in 230 patients 21.0% . The infusion was prematurely terminated in 32 patients 2.9% , due to severe chest pain, severe brochospasm, or third degree AV block. Higher frequency of chest pain was reported in women compare to men p 0.05 , and ST segment depression was more frequent in patients with abnormal myocardial perfusion scintigraphic findings p 0.05 . Conclusion These results demonstrate that intravenous infusion of adenosine is relatively safe, and myocardial perfusion scintigraphy with intravenous adenosine is feasible technique in the evaluation of the coronary artery disease patients unable to exercise. KEY WORDS Adenosine stress testing·Safety·Side effects·Coronary artery disease.
doi:10.4070/kcj.1997.27.2.189 fatcat:iw7kmtgxonhfrbedrpexa3erfe

Clinical Experiences of Molecular Genetic Evaluation of Achondroplasia in Prenatal and Neonatal Cases

Dong Wook Kwak, Hyun Jin Kim, So Yeon Park, Hyun Suk Ahn, Yong Hwa Chae, Moon Young Kim, Young Ho Lee, Hyun Mee Ryu
2013 Journal of Genetic Medicine  
facial features of frontal bossing and mid-face hypoplasia, exaggerated lumbar lordosis, genu varum and trident hands. 3) ACH is inherited as an autosomal dominant trait with 100% penetrance. More than 90% of affected individuals have de novo mutations associated with increased paternal age. 4, 5) The gene responsible for achondroplasia, fibroblast growth factor receptor (Print) 2233-9108(Online) Purpose: The purpose of this study was to assess the characteristics of achondroplasia (ACH)
more » ... ed in fetuses or neonates and to evaluate the usefulness of a molecular genetic testing to confirm ACH. Materials and Methods: The medical and ultrasonographic records of 16 pregnant women, who had molecular genetic testing for ACH performed on their fetus or neonate at the Cheil General Hospital between February 1999 and April 2013, were retrospectively analyzed. Detection of G1138A and G1138C mutations of the fibroblast growth factor receptor 3 (FGFR3) gene was accomplished by polymerase chain reaction -restriction fragment length polymorphism analysis. Results: Of the eight fetuses and two neonates who were suspected of having ACH during pregnancy, four fetuses and one neonate was confirmed to have ACH and they all carried the heterozygous G1138A mutation. Out of 6 cases which had a history of ACH in prior pregnancies, three had genetic information for the previous fetuses while the other three did not. All six fetuses had no mutations at G380R. However, the one fetus of pregnant woman with non-confirmed ACH showed shortened long bone on ultrasound thereafter and the fetus was identified as having oto-spondylo-megaepiphyseal dysplasia after birth. Conclusion: Korean patients with achondroplasia have the heterozygous G1138A mutation that is most commonly defined in other countries. Molecular genetic evaluations of ACH are helpful not only for establishing diagnosis but for appropriate counseling with subsequent pregnancies.
doi:10.5734/jgm.2013.10.1.38 fatcat:tz5r2trlqjgrjlr6u5ysrnjuym

Multimodal Residual Learning for Visual QA [article]

Jin-Hwa Kim, Sang-Woo Lee, Dong-Hyun Kwak, Min-Oh Heo, Jeonghee Kim, Jung-Woo Ha, Byoung-Tak Zhang
2016 arXiv   pre-print
Deep neural networks continue to advance the state-of-the-art of image recognition tasks with various methods. However, applications of these methods to multimodality remain limited. We present Multimodal Residual Networks (MRN) for the multimodal residual learning of visual question-answering, which extends the idea of the deep residual learning. Unlike the deep residual learning, MRN effectively learns the joint representation from vision and language information. The main idea is to use
more » ... nt-wise multiplication for the joint residual mappings exploiting the residual learning of the attentional models in recent studies. Various alternative models introduced by multimodality are explored based on our study. We achieve the state-of-the-art results on the Visual QA dataset for both Open-Ended and Multiple-Choice tasks. Moreover, we introduce a novel method to visualize the attention effect of the joint representations for each learning block using back-propagation algorithm, even though the visual features are collapsed without spatial information.
arXiv:1606.01455v2 fatcat:42t6jwgju5bvtijonsfbtuzb3q

Micro-Objective Learning : Accelerating Deep Reinforcement Learning through the Discovery of Continuous Subgoals [article]

Sungtae Lee, Sang-Woo Lee, Jinyoung Choi, Dong-Hyun Kwak and Byoung-Tak Zhang
2017 arXiv   pre-print
Recently, reinforcement learning has been successfully applied to the logical game of Go, various Atari games, and even a 3D game, Labyrinth, though it continues to have problems in sparse reward settings. It is difficult to explore, but also difficult to exploit, a small number of successes when learning policy. To solve this issue, the subgoal and option framework have been proposed. However, discovering subgoals online is too expensive to be used to learn options in large state spaces. We
more » ... pose Micro-objective learning (MOL) to solve this problem. The main idea is to estimate how important a state is while training and to give an additional reward proportional to its importance. We evaluated our algorithm in two Atari games: Montezuma's Revenge and Seaquest. With three experiments to each game, MOL significantly improved the baseline scores. Especially in Montezuma's Revenge, MOL achieved two times better results than the previous state-of-the-art model.
arXiv:1703.03933v1 fatcat:murlzmc4fvfgljpzozhu5wyi34

Prenatal diagnosis of 4p deletion syndrome: A case series report

Dong Wook Kwak, Hyun Kyong Ahn
2017 Journal of Genetic Medicine  
doi:10.5734/jgm.2017.14.1.38 fatcat:o5i56zauyrbnhgltb2ohdusvym
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