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Short-term prognostic value of CRP in the patients with acute coronary syndrome

Tae Ik Kim, Shung Chull Chae, Dong Hun Yang, Seong Chull Shin, Ho Sang Bae, Dong Hun Kwak, Jong Hyun Hwang, Yong Geun Cho, Jae Eun Jun, Wee Hyun Park
2000 Korean Circulation Journal  
and Objectives Acute coronary syndrome occurs most commonly in the setting of atherosclerotic coronary artery disease, but there is little information concerning the mechanism responsible for the transition from stable to unstable coronary atherosclerotic plaque. Hypothetically, several microorganism Chlamydia pneumonia, Cytomegalovirus and Helicobacter pylori and their inflammatory reaction have been suggested as a causative motive in progression of acute coronary syndrome. Although it is
more » ... ar whether the serum level of CRP as an inflammatory parameter is concerned with previous inflammatory change or myocardial necrosis, CRP appears to be predictive of higher risk for cardiac event in the patients with acute coronary syndrome. Our objective was to evaluate whether the inflammatory parameters CRP, ESR and WBC count are useful in predicting the short-term cardiac risk within 30 days. Materials and Method One hundred and ten patients with acute coronary syndrome were enrolled from April 1998 through August 1998. Blood samples were collected at 1st hour, 24th hour, 48th hour and 7th day and tested for CRP, ESR, WBC count and CK-MB level. Values of 323 normal were used as control. All patients were followed up for 30 days and assessed for the presence of cardiac complications. Results Peak CRP value of the patients with acute myocardial infarction 3.4 3.85 mg/dL, n 62 was higher than that of the patients with unstable angina 0.7 0.93 mg/dL, n 48, p 0.05 and controls 0.3 0.48 mg/dL, n 323, p 0.05 . Peak CRP value of patients with cardiac complication was higher than that of patients without complication 7.7 4.77 mg/dL, n 15 vs 1.3 1.74 mg/dL, n 95 p 0.05 . In multivariate analysis, peak CRP value was the only predictive parameter for development of cardiac complications in the patients with acute coronary syndrome Odds ratio 4.893, 95% confidence interval 1.212 19.756, p value 0.026 . In the high-CRP group 2 mg/dL, n 30 , the cardiac complication rate was higher than the low-CRP group 2 mg/dL, n 80 43.3% vs 2.5%, p 0.05 . Peak CRP value was correlated with age r 0.191, p 0.045 , pulse rate r 0.186, p 0.008), left ventricular ejection fraction r 0.384, p 0. 001 , peak ESR r 0.383, p 0.001 and peak WBC count r 0.307, p 0.001 , but not with peak CK-MB level. Conclusion Elevated CRP level in patients with acute coronary syndrome seems to be a valuable
doi:10.4070/kcj.2000.30.11.1387 fatcat:7yhc3pmfijb6tfo7p7oo5fa6se

Clinical Characteristics of the Patients with Myocardial Rupture after Acute Myocardial Infarction

Eui Ryong Cheong, Hun Sik Park, Dong Heon Yang, Young Bae Seo, Bong Ryeol Lee, Dong Hun Kwak, Jung Jo Heo, Man Ki Park, Yong Geun Jo, Shung Chull Chae, Jae Eun Jun, Wee Hyun Park
2002 Korean Circulation Journal  
doi:10.4070/kcj.2002.32.6.467 fatcat:5ytj4fw44ff5rai4ckijtbvura

Antimicrobial Activity of Zabofloxacin against Clinically Isolated Streptococcus pneumoniae

Hee-Soo Park, Sang-Hun Oh, Hye-Shin Kim, Dong-Rack Choi, Jin-Hwan Kwak
2016 Molecules  
Author Contributions: Hee-Soo Park, Sang-Hun Oh and Hye Shin Kim designed and performed the experiments; Hee-Soo Park analyzed the data; Hee-Soo Park, and Jin-Hwan Kwak wrote the paper; and Jin-Hwan Kwak  ...  Acknowledgments: This research was supported by Dong Hwa Pharmaceutical Industry Ltd.  ...  Experimental Section Antimicrobial Agents Zabofloxacin was provided by Dong Wha Pharmaceutical Co. Ltd. (Anyang, Korea).  ... 
doi:10.3390/molecules21111562 pmid:27869677 fatcat:dn45x5uitbdtdfr36p7fwcjuni

A Osteoma of the External Auditory Canal
외이도 골종

Jong Dam Lee, Ho Sun Park, Dong Hun Kwak, Sang Ho Youn
2002 Journal of Clinical Otolaryngology  
doi:10.35420/jcohns.2002.13.2.213 fatcat:ho7xqwj66bb7ffqiomb2l4gbai

Synthetic redesign of Escherichia coli for cadaverine production from galactose

Dong Hun Kwak, Hyun Gyu Lim, Jina Yang, Sang Woo Seo, Gyoo Yeol Jung
2017 Biotechnology for Biofuels  
With increasing concerns over the environment, biological production of cadaverine has been suggested as an alternative route to replace polyamides generated from the petroleum-based process. For an ideal bioprocess, cadaverine should be produced with high yield and productivity from various sugars abundant in biomass. However, most microorganisms are not able to efficiently metabolize other biomass-derived sugars as fast as glucose. This results in reduced growth rate and low carbon flux
more » ... the production of desired bio-chemicals. Thus, redesign of microorganisms is necessary for utilizing those carbon sources with enhanced carbon flux and product formation. Results: In this study, we engineered Escherichia coli to produce cadaverine with rapid assimilation of galactose, a promising future feedstock. To achieve this, genes related to the metabolic pathway were maximally expressed to amplify the flux toward cadaverine production via synthetic expression cassettes consisting of predictive and quantitative genetic parts (promoters, 5′-untranslated regions, and terminators). Furthermore, the feedback inhibition of metabolic enzymes and degradation/re-uptake pathways was inactivated to robustly produce cadaverine. Finally, the resultant strain, DHK4, produced 8.80 g/L cadaverine with high yield (0.170 g/g) and productivity (0.293 g/L/h) during fed-batch fermentation, which was similar to or better than the previous glucose fermentation. Conclusions: Taken together, synthetic redesign of a microorganism with predictive and quantitative genetic parts is a prerequisite for converting sugars from abundant biomass into desired platform chemicals. This is the first report to produce cadaverine from galactose. Moreover, the yield (0.170 g/g) was the highest among engineered E. coli systems.
doi:10.1186/s13068-017-0707-2 pmid:28127401 pmcid:PMC5251296 fatcat:cjc6yyiz5rgztivgsuze37ohc4

Morphology-dependent phase transformation of γ-Al 2 O 3

Jaekyoung Lee, Himchan Jeon, Dong Gun Oh, Janos Szanyi, Ja Hun Kwak
2015 Applied Catalysis A : General  
The phase transformations of platelet-and rod-shaped γ-Al 2 O 3 were investigated and compared to that of a commercial sample by XRD, BET surface area measurements, Transmission Electron Microscopy (TEM), solid state 27 Al-NMR and ethanol temperature programmed desorption (TPD) after sequential annealing in air up to 1100 o C. After annealing at 1100 o C, commercial γ-Al 2 O 3 mostly transformed into α-Al 2 O 3 with drastic surface area reduction (from 200 m 2 /g to 25 m 2 /g). Interestingly,
more » ... atelet-and rod-shaped γ-Al 2 O 3 which showed exactly the same XRD patterns transformed into different phases upon the high temperature calcinations. Platelet-shaped γ-Al 2 O 3 transformed into θ-phase while the rod-shaped γ-Al 2 O 3 transformed into the δ-phase and not to the α-polymorph. Both plateletand rod-shaped aluminas retained significantly higher surface area (~60 m 2 /g) than the commercial one after the same treatment at 1100 o C. These results suggest that the phase transformation in γ-Al 2 O 3 is strongly affected by not only the crystal structure of the starting material, but its morphology as well. Ethanol TPD from platelet-and rod-shaped alumina after 1100 o C annealing, showed significantly different desorption profiles which suggest different surface characteristics even though they had almost the same surface areas. These © 2015. This manuscript version is made available under the Elsevier user license http://www.elsevier.com/open-access/userlicense/1.0/ 2 different phase transformations were also supported by solid state 27 Al-NMR. After 1100 o C annealing commercial alumina showed the presence of mostly octahedral Al 3+ ions, but the other two samples displayed even higher number of tetrahedral Al 3+ ions than the initial γ-Al 2 O 3 . Morphological changes were also confirmed by TEM. All these results consistently suggest the morphology-dependent phase transformations of γ-Al 2 O 3 and the improved thermal stability of platelet-and rod-shaped γ-Al 2 O 3 in comparison to a commercial γ-Al 2 O 3 .
doi:10.1016/j.apcata.2015.03.040 fatcat:3c54pcufrzaxpktjqxpmwbdkqu

Characterization for pyrolysis of thermoplastic polyurethane by thermal analyses

Suk-Hwan Kang, Dong-Cheol Ku, Jung-Hun Lim, Yun-Kyu Yang, Noh-Seok Kwak, Taek-Sung Hwang
2005 Macromolecular Research  
doi:10.1007/bf03219054 fatcat:miqgopftdbg35g55ewtazjt4bq

Role of exercise in age-related sarcopenia

Su-Zi Yoo, Mi-Hyun No, Jun-Won Heo, Dong-Ho Park, Ju-Hee Kang, So Hun Kim, Hyo-Bum Kwak
2018 Journal of Exercise Rehabilitation  
Sarcopenia is an age-associated decline of skeletal muscle mass and function and is known to lead to frailty, cachexia, osteoporosis, metabolic syndromes, and death. Notwithstanding the increasing incidence of sarcopenia, the molecular and cellular mechanisms driving age-related sarcopenia are not completely understood. This article reviews current definitions of sarcopenia, its potential mechanisms, and effects of exercise on sarcopenia. The pathogenesis of age-related sarcopenia is
more » ... ial and includes myostatin, inflammatory cytokines, and mitochondria-derived problems. Especially, age-induced mitochondrial dysfunction triggers the production of reactive oxygen species (ROS) by mitochondria, impedes mitochondrial dynamics, interrupts mitophagy, and leads to mitochondria-mediated apoptosis. Aerobic exercise provides at least a partial solution to sarcopenia as it ameliorates mitochondria-derived problems, and resistance exercise strengthens muscle mass and function. Furthermore, combinations of these exercise types provide the benefits of both. Collectively, this review summarizes potential mechanisms of age-related sarcopenia and emphasizes the use of exercise as a therapeutic strategy, suggesting that combined exercise provides the most beneficial means of combating age-related sarcopenia.
doi:10.12965/jer.1836268.134 pmid:30276173 pmcid:PMC6165967 fatcat:swn7sayvxnfeza7u2yrzz64x7y

Simultaneous Vertebral Artery Dissection and Contralateral Posterior Inferior Cerebellar Artery Dissecting Aneurysm

Young-Seok Kwak, Dong-Hun Kang, Hyun-Jin Woo
2012 Journal of Cerebrovascular and Endovascular Neurosurgery  
The optimal treatment and appropriate follow-up period for an unruptured vertebral artery (VA) and/or posterior inferior cerebellar artery (PICA) dissection have not been established. Decisions regarding treatment of these vascular lesions are usually based on the manifesting symptoms and changes in radiologic findings during the follow-up period. We experienced a patient who had a simultaneous unruptured VA dissection and a contralateral PICA dissecting aneurysm. We did not find such a case in other literature.
doi:10.7461/jcen.2012.14.3.228 pmid:23210052 pmcid:PMC3491219 fatcat:ewoejgfrx5hi7mdk76jy32pupu

Phase control of iridium and iridium oxide thin films in atomic layer deposition

Sung-Wook Kim, Se-Hun Kwon, Dong-Kee Kwak, Sang-Won Kang
2008 Journal of Applied Physics  
The atomic layer deposition of iridium ͑Ir͒ and iridium oxide ͑IrO 2 ͒ films was investigated using an alternating supply of ͑ethylcyclopentadienyl͒͑1,5-cyclooctadiene͒ iridium and oxygen gas at temperatures between 230 and 290°C. The phase transition between Ir and IrO 2 occurred at the critical oxygen partial pressure during the oxygen injection pulse. The oxygen partial pressure was controlled by the O 2 / ͑Ar+ O 2 ͒ ratio or deposition pressures. The resistivity of the deposited Ir and IrO
more » ... films was about 9 and 120 ⍀ cm, respectively. In addition, the critical oxygen partial pressure for the phase transition between Ir and IrO 2 was increased with increasing the deposition temperature. Thus, the phase of the deposited film, either Ir or IrO 2 , was controlled by the oxygen partial pressure and the deposition temperature. However, the formation of a thin Ir layer was detected between the IrO 2 and SiO 2 substrate. To remove this interfacial layer, the oxygen partial pressure is increased to a severe condition. And the impurity contents were below the detection limit of Auger electron spectroscopy in both Ir and IrO 2 films.
doi:10.1063/1.2836965 fatcat:dj7uf475sjfj7nbixxtbt7guae

Cyclin-dependent Kinase 5 (Cdk5) Regulates the Function of CLOCK Protein by Direct Phosphorylation

Yongdo Kwak, Jaehoon Jeong, Saebom Lee, Young-Un Park, Seol-Ae Lee, Dong-Hee Han, Joung-Hun Kim, Toshio Ohshima, Katsuhiko Mikoshiba, Yoo-Hun Suh, Sehyung Cho, Sang Ki Park
2013 Journal of Biological Chemistry  
Cdk5 is a kinase involved in the various neuronal processes. Results: Cdk5 directly phosphorylates CLOCK and regulates its transcriptional activity in association with altered stability and subcellular distribution. Conclusion: Cdk5 functions as a regulator of CLOCK protein. Significance: Our findings may provide mechanistic links between diverse Cdk5-mediated brain functions and the molecular clock. Circadian rhythm is a biological rhythm governing physiology and behavior with a period of ϳ24
more » ... . At the molecular level, circadian output is controlled by a molecular clock composed of positive and negative feedback loops in transcriptional and post-translational processes. CLOCK is a transcription factor known as a central component of the molecular clock feedback loops generating circadian oscillation. Although CLOCK is known to undergo multiple post-translational modifications, the knowledge of their entities remains limited. Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine-threonine kinase that is involved in various neuronal processes. Here, we report that Cdk5 is a novel regulator of CLOCK protein. Cdk5 phosphorylates CLOCK at the Thr-451 and Thr-461 residues in association with transcriptional activation of CLOCK. The Cdk5-dependent regulation of CLOCK function is mediated by alterations of its stability and subcellular distribution. These results suggest that Cdk5 is a novel regulatory component of the core molecular clock machinery.
doi:10.1074/jbc.m113.494856 pmid:24235147 pmcid:PMC3873547 fatcat:f57u54pbvjcyzb2a6j2t5ukgeq

A Case of Metastatic Renal Cell Carcinoma of Parotid Gland

Seul Gi Kwak, Choon Dong Kim, Hun Hee Baek, Jun Yeon Hwang
2014 Korean Journal of Otorhinolaryngology - Head and Neck Surgery  
Park과 Hlivko A B A Case of mRCC of Parotid Gland █ Kwak SG, et al. www.jkorl.org 859 되지 않았다(Fig. 1).  ... 
doi:10.3342/kjorl-hns.2014.57.12.858 fatcat:kzcdkmf74vc4bk2ntg3uvjzphm

Should Cerebral Angiography Be Avoided within Three Hours after Subarachnoid Hemorrhage?

Hong An, Jaechan Park, Dong-Hun Kang, Wonsoo Son, Young-Sup Lee, Youngseok Kwak, Boram Ohk
2019 Journal of Korean Neurosurgical Society  
While the risk of aneurysmal rebleeding induced by catheter cerebral angiography is a serious concern and can delay angiography for a few hours after a subarachnoid hemorrhage (SAH), current angiographic technology and techniques have been much improved. Therefore, this study investigated the risk of aneurysmal rebleeding when using a recent angiographic technique immediately after SAH. Patients with acute SAH underwent immediate catheter angiography on admission. A four-vessel examination was
more » ... onducted using a biplane digital subtraction angiography (DSA) system that applied a low injection rate and small volume of a diluted contrast, along with appropriate control of hypertension. Intra-angiographic aneurysmal rebleeding was diagnosed in cases of extravasation of the contrast medium during angiography or increased intracranial bleeding evident in flat-panel detector computed tomography scans. In-hospital recurrent hemorrhages before definitive treatment to obliterate the ruptured aneurysm occurred in 11 of 266 patients (4.1%). Following a univariate analysis, a multivariate analysis using a logistic regression analysis revealed that modified Fisher grade 4 was a statistically significant risk factor for an in-hospital recurrent hemorrhage (p =0.032). Cerebral angiography after SAH was performed on 88 patients ≤3 hours, 74 patients between 3-6 hours, and 104 patients >6 hours. None of the time intervals showed any cases of intra-angiographic rebleeding. Moreover, even though the DSA ≤3 hours group included more patients with a poor clinical grade and modified Fisher grade 4, no case of aneurysmal rebleeding occurred during erebral angiography. Despite the high risk of aneurysmal rebleeding within a few hours after SAH, emergency cerebral angiography after SAH can be acceptable without increasing the risk of intra-angiographic rebleeding when using current angiographic techniques and equipment.
doi:10.3340/jkns.2018.0238 pmid:31484228 pmcid:PMC6732357 fatcat:2rnugyw5wfcy7ivfqrs7wwn2um

A Case of Lobular Capillary Hemangioma on the Nasal Septum
비중격에 원발한 소엽성 모세관 혈관종(화농성 육아종) 1례

Geun Seob Lee, Dong Hun Kwak, Sun Woo Kim, Jong Dam Lee
1999 Journal of Clinical Otolaryngology  
doi:10.35420/jcohns.1999.10.2.277 fatcat:uulrlvkqlffujanz66nc3r7r24

Value and utility of North Korean studies in Romania

Dong Hun Kwak
2021 Bulletin of the Transilvania University of Brașov. Series IV, Philology & Cultural Studies  
For third-year students of the department of Korean language and literature at Babeş-Bolyai University, the 'North Korean Society and Culture' course was launched in 2011 by assistant professor Dong Hun  ...  Kwak to introduce the history of North Koreans, their guiding ideology, and their culture.  ... 
doi:10.31926/but.pcs.2021.63.14.1.2 fatcat:yf4jukjn7vdjpp5xgdxe7fkrzm
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