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Urinary metabolomic investigations in vitiligo patients

Wei Liu, Xiao-Yan Liu, Yue-Tong Qian, Dong-Dong Zhou, Jia-Wei Liu, Tian Chen, Wei Sun, Dong-Lai Ma
2020 Scientific Reports  
Urinary metabolomics is a useful non-invasive tool for large-scale screening of disease-related metabolites. However, no comprehensive urinary metabolomic analysis of vitiligo is presently available. To investigate the urine metabolic pattern of vitiligo patients, we conducted a combined cross-sectional and prospective self-control cohort study and an untargeted urinary metabolomic analysis. In the cross-sectional study, 295 vitiligo patients and 192 age‐ and sex‐matched controls were enrolled,
more » ... and 71 differential metabolites between two groups were identified. Pathway enrichment analysis revealed that drug metabolism-cytochrome P450, biopterin metabolism, vitamin B9 (folate) metabolism, selenoamino acid metabolism, and methionine and cysteine metabolism showed significant enrichment in vitiligo patients compared with the status in healthy controls. In the self-control cohort, 46 active vitiligo patients were recruited to analyse the urinary metabolic signatures after treatment. All of these patients were asked to undertake follow-up visits every 2 months three times after first consulting and the disease stage was evaluated compared with that at the last visit. Folate metabolism, linoleate metabolism, leukotriene metabolism, alkaloid biosynthesis, and tyrosine metabolism were predicted to be involved in vitiligo activity. Our study is the first attempt to reveal urinary metabolic signatures of vitiligo patients and provides new insights into the metabolic mechanisms of vitiligo.
doi:10.1038/s41598-020-75135-0 pmid:33093609 fatcat:cezwnsujjndfjbftead56lqw4y

Atomic Force Microscope Deposition Assisted by Electric Field

Zeng Lei Liu, Nian Dong Jiao, Zhi Dong Wang, Zai Li Dong, Lian Qing Liu
2013 Advanced Materials Research  
This paper introduces atomic force microscope (AFM) deposition method to fabricate nanostructures and nanodevices. Field emission theory is introduced in this paper, which provides theoretical explanation for AFM deposition. Dot matrixes are fabricated by AFM deposition on three different substrates, Si, Au and GaAs. Differences of deposition on the three substrates are discussed. AFM deposition has many practical applications. For example, AFM deposition can be used to solder nano components
more » ... gether to improve electrical properties of nanodevices. Besides nanosoldering, AFM deposition can also be used in fabrication of nanodevices. Thus AFM deposition is a valuable research field for future massive applications of nanodevices.
doi:10.4028/ fatcat:ydiuyk4jpvblvm3enpw4eagfqu

Tegaserod Maleate Inhibits Esophageal Squamous Cell Carcinoma Proliferation by Suppressing the Peroxisome Pathway

Xiangyu Wu, Zitong Wang, Yanan Jiang, Yanan Jiang, Yanan Jiang, Yanan Jiang, Hao Zhou, Ang Li, Ang Li, Yaxing Wei, Zhuo Bao, Zhuo Bao (+18 others)
2021 Frontiers in Oncology  
Esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) are the two major types of esophageal cancer (EC). ESCC accounts for 90% of EC. Recurrence after primary treatment is the main reason for poor survival. Therefore, recurrence prevention is a promising strategy for extending the 5-year survival rate. Here, we found tegaserod maleate could inhibit ESCC proliferation both in vivo and in vitro. Proteomics analysis revealed that tegaserod maleate suppressed the peroxisome
more » ... ignaling pathway, in which the key molecules peroxisome membrane protein 11B (PEX11B) and peroxisome membrane protein 13 (PEX13) were downregulated. The immunofluorescence, catalase activity assay, and reactive oxygen species (ROS) confirmed that downregulation of these proteins was related to impaired peroxisome function. Furthermore, we found that PEX11B and PEX13 were highly expressed in ESCC, and knockout of PEX11B and PEX13 further demonstrated the antitumor effect of tegaserod maleate. Importantly, tegaserod maleate repressed ESCC tumor growth in a patient-derived xenograft (PDX) model in vivo. Our findings conclusively demonstrated that tegaserod maleate inhibits the proliferation of ESCC by suppressing the peroxisome pathway.
doi:10.3389/fonc.2021.683241 doaj:99c0be4540c5453d846d9053bdebd56c fatcat:snlyh2tl6ze35fevs2sz7jcycy

Kinesin-12 influences axonal growth during zebrafish neural development

Man Xu, Dong Liu, Zhangji Dong, Xin Wang, Xueqian Wang, Yan Liu, Peter W. Baas, Mei Liu
2014 Cytoskeleton  
, Nadar et al. 2010 , Lin, Liu et al. 2011 , Lin, Liu et al. 2012 .  ...  Introduction During development, the microtubule cytoskeleton is essential to the morphogenesis of an organism (Dong, Deng et al. 2011 , Pramparo, Libiger et al. 2011 .  ... 
doi:10.1002/cm.21193 pmid:25250533 pmcid:PMC4236235 fatcat:wdsom3phpbdz5aea7zj3hxbhii

Study of optical frequency transfer via fiber

Liu Jie, Gao Jing, Xu Guan-Jun, Jiao Dong-Dong, Yan Lu-Lu, Dong Rui-Fang, Jiang Hai-Feng, Liu Tao, Zhang Shou-Gang
2015 Wuli xuebao  
光纤光频传递用户端补偿方案 用户端补偿实验结果 Study of optical frequency transfer via fiber * Liu Jie 1)2)3) Gao Jing 1)3) Xu Guan-Jun 1)3) Jiao Dong-Dong 1)2)3) Yan Lu-Lu 1)3) Dong Rui-Fang 1)3) Jiang Hai-Feng 1)3) Liu  ... 
doi:10.7498/aps.64.120602 fatcat:4nnc4hj4enep5jbnixfmrs4tmq

A Wash-Free Homogeneous Colorimetric Immunoassay Method

Huiqiao Liu, Pengfei Rong, Hongwei Jia, Jie Yang, Bo Dong, Qiong Dong, Cejun Yang, Pengzhi Hu, Wei Wang, Haitao Liu, Dingbin Liu
2016 Theranostics  
Scheme S1. Synthesis of the PEG linker whose one side is thioctic acid and the other side is terminated in N-hydroxysucinimide (NHS)-activated carboxylic acid. (DMAP is the catalyst)
doi:10.7150/thno.13159 pmid:26722373 pmcid:PMC4679354 fatcat:utdlbvuatrdn5lnt77pu2apmne

Liquid Metal‐Enabled Soft Logic Devices

Dong-Dong Li, Tian-Ying Liu, Jiao Ye, Lei Sheng, Jing Liu
2021 Advanced Intelligent Systems  
doi:10.1002/aisy.202000246 fatcat:c3tuwy7ntndodo3lomm2arsck4

Training Neural Networks for Solving 1-D Optimal Piecewise Linear Approximation [article]

Hangcheng Dong, Jingxiao Liao, Yan Wang, Yixin Chen, Bingguo Liu, Dong Ye, Guodong Liu
2021 arXiv   pre-print
Dong) posite of fully connected layers is still continuous piecewise linear mapping [20] [21] [22] , we study the problem so-called onedimensional optimal piecewise linear approximation in least square  ... 
arXiv:2110.08259v1 fatcat:3yudufeuabakzpsomolsikex3e

Two novel norsesquiterpene peroxides from basidiomycete Steccherinum ochraceum

Dong-Ze Liu, Ze-Jun Dong, Fang Wang, Ji-Kai Liu
2010 Tetrahedron Letters  
Two novel 3-nor-methyl-chamigrane sesquiterpene peroxides, named steperoxide A (1) and B (2), have been isolated from basidiomycete Steccherinum ochraceum. This is the first report on the isolation of chamigrane sesquiterpene from higher fungi. The structures of 1 and 2 were established on the basis of spectroscopic data and single-crystal X-ray analysis. Mushrooms have proved to be a rich source of secondary metabolites with unusual structures as well as interesting biological activities.
more » ... te their potential for drug development, few bioactive metabolites have been reported from mushrooms as compared with higher plants and microbes. Over the last 10 years, our main research focus has been secondary metabolites from the untapped resources of higher fungi found in China. 1-5 As a continuation of our studies on structurally interesting and biologically active natural products from higher fungi, chemical investigation on fermentation broth of Steccherinum ochraceum has resulted in the isolation of two rare and novel chamigrane norsesquiterpene peroxides, named steperoxides A (1) and B (2). So far, almost all chamigrane sesquiterpenoids were isolated from marine creatures, and most of them contained at least one halogen. 6-12 This is the first report on the isolation of chamigrane sesquiterpene from higher fungi. We present herein the structural elucidation of these two compounds by spectroscopic data in conjunction with singlecrystal X-ray analysis. Steperoxide A (1) 13 was obtained as colorless crystals (in MeOH) with a molecular formula of C 14 H 22 O 4 as established by HREIMS at m/z 254.1511 [M] + (calcd for 254.1513), requiring 4 degrees of unsaturation. The IR absorptions revealed the presence of hydroxyl (3502 cm À1 ) and carbonyl (1707 cm À1 ) functionalities. The 1 H NMR spectrum (Table 1) showed the presence of three methyls (d H 1.86, 1.20, and 0.93) attached to quaternary carbons, and two oxymethine groups (d H 4.12 and 3.71). The 13 C NMR and HSQC spectra (Table 1) resolved 14 carbon resonances comprising one carbonyl group at d C 208.1, two oxygenated methine carbons at d C 80.2 and 70.1, one oxygenated quaternary carbon at d C 89.6, as well as three methyls (d C 27.2, 25.0, and 23.9), five methylenes (d C 36.6, 35.2, 32.6, 28.0, 25.9), and two quaternary carbons (d C 42.7 and 35.7). Accordingly, a three-ring structure was required for 1 to fulfill the unsaturation requirement.
doi:10.1016/j.tetlet.2010.04.048 fatcat:roqf6ewb4zeelmj6v7yvevhpfi

Antisymmetry of oceanic eddies across the Kuroshio over a shelfbreak

Yu Liu, Changming Dong, Xiaohui Liu, Jihai Dong
2017 Scientific Reports  
Figure 2 . 2 (a) The distribution of eddies detected from the GDP trajectories using Dong et al. 10 eddy detection scheme. Blue and red dots denote cyclonic and anticyclonic eddies, respectively.  ... 
doi:10.1038/s41598-017-07059-1 pmid:28754887 pmcid:PMC5533746 fatcat:s46p4g6ht5h7xkwhaiccuauihi

Experimental Study on the Evolution Mechanism of Landslide with Retaining Wall Locked Segment

Han-Dong Liu, Jia-Xing Chen, Zhi-Fei Guo, Dong-Dong Li, Ya-Feng Zhang, Yi Liu
2022 Geofluids  
Liu et al. [51] Physical model test is an important method to study the mechanism of landslide evolution.  ...  Based on the history of geological evolution, geological environmental conditions, and engineering geological characteristics of western Henan Province in China, Liu et al.  ... 
doi:10.1155/2022/7923448 fatcat:t3i4d2er6nbp7n2ntm2aucqkay

Development and application of communication band narrow linewidth lasers

Jiao Dong-Dong, Gao Jing, Liu Jie, Deng Xue, Xu Guan-Jun, Chen Jiu-Peng, Dong Rui-Fang, Liu Tao, Zhang Shou-Gang
2015 Wuli xuebao  
Development and application of communication band narrow linewidth lasers * Jiao Dong-Dong 1)2)3) Gao Jing 1)3) Liu Jie 1)2)3) Deng Xue 1)3) Xu Guan-Jun 1)3) Chen Jiu-Peng 1)2)3) Dong Rui-Fang 1)3) † Liu  ... 
doi:10.7498/aps.64.190601 fatcat:3oge33fkrzgu5odp32o2k45jvq

Dynamic Sparse R-CNN [article]

Qinghang Hong, Fengming Liu, Dong Li, Ji Liu, Lu Tian, Yi Shan
2022 arXiv   pre-print
Sparse R-CNN is a recent strong object detection baseline by set prediction on sparse, learnable proposal boxes and proposal features. In this work, we propose to improve Sparse R-CNN with two dynamic designs. First, Sparse R-CNN adopts a one-to-one label assignment scheme, where the Hungarian algorithm is applied to match only one positive sample for each ground truth. Such one-to-one assignment may not be optimal for the matching between the learned proposal boxes and ground truths. To
more » ... this problem, we propose dynamic label assignment (DLA) based on the optimal transport algorithm to assign increasing positive samples in the iterative training stages of Sparse R-CNN. We constrain the matching to be gradually looser in the sequential stages as the later stage produces the refined proposals with improved precision. Second, the learned proposal boxes and features remain fixed for different images in the inference process of Sparse R-CNN. Motivated by dynamic convolution, we propose dynamic proposal generation (DPG) to assemble multiple proposal experts dynamically for providing better initial proposal boxes and features for the consecutive training stages. DPG thereby can derive sample-dependent proposal boxes and features for inference. Experiments demonstrate that our method, named Dynamic Sparse R-CNN, can boost the strong Sparse R-CNN baseline with different backbones for object detection. Particularly, Dynamic Sparse R-CNN reaches the state-of-the-art 47.2% AP on the COCO 2017 validation set, surpassing Sparse R-CNN by 2.2% AP with the same ResNet-50 backbone.
arXiv:2205.02101v1 fatcat:b6tomq5fvzfhnkwieakhcohd6a

How to Explain Neural Networks: an Approximation Perspective [article]

Hangcheng Dong, Bingguo Liu, Fengdong Chen, Dong Ye, Guodong Liu
2021 arXiv   pre-print
Hangcheng Dong (, Bingguo Liu, Fengdong Chen, Dong Ye and Guodong Liu ( are with School of Instrumentation Science and Engineering, Harbin Institute of Techonoloy, Harbin  ... 
arXiv:2105.07831v2 fatcat:rbnjj557bza77ovnabe55nvtve

Acid Modification of the Unsupported NiMo Catalysts by Y-Zeolite Nanoclusters

Chengwu Dong, Changlong Yin, Tongtong Wu, Zhuyan Wu, Dong Liu, Chenguang Liu
2019 Crystals  
Unsupported NiMo catalyst has high hydrogenation activity due to its high active site distribution. However, low specific surface area and pore distribution greatly limit the efficient utilization of the active components. The Y-zeolite nanoclusters were hydrothermally synthesized and introduced into the unsupported NiMo catalysts from a layered nickel molybdate complex oxide. The XRD, N2 adsorption-desorption, FT-IR, Py-IR, SEM, NH3-TPD, and TEM were used to characterize all catalysts. The
more » ... nzothiophene (DBT) hydrodesulfurization (HDS) reaction was performed in a continuous high pressure microreactor. The results showed that the specific surface area, pore volume, and average pore size of the unsupported NiMo catalysts were greatly increased by the Y-zeolite nanoclusters, and a more dispersed structure was produced. Furthermore, the Lewis acid and total acid content of the unsupported NiMo catalysts were greatly improved by the Y-zeolite nanoclusters. The HDS results showed that the unsupported NiMo catalysts modified by the nanoclusters had the same high desulfurization efficiency as the unmodified catalyst, but had more proportion of direct desulfurization (DDS) products. The results offer an alternative to reducing hydrogen consumption and save cost in the production of ultra clean diesel.
doi:10.3390/cryst9070344 fatcat:wujzojlowvdhpanhruboqfhzrm
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