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Domain-Specific Profiling [chapter]

Alexandre Bergel, Oscar Nierstrasz, Lukas Renggli, Jorge Ressia
2011 Lecture Notes in Computer Science  
Furthermore, we present an infrastructure that enables developers to quickly prototype new profilers for their domain-specific languages and models.  ...  Domain-specific languages and models are increasingly used within general-purpose host languages.  ...  Difficulty of profiling a specific domain This section illustrates two shortcomings of traditional profiling techniques when applied to a specific domain.  ... 
doi:10.1007/978-3-642-21952-8_7 fatcat:5xuefdou5jbpxef7zufo6emvua

Modeling Domain-Specific Profilers

Jorge Ressia, Alexandre Bergel, Oscar Nierstrasz, Lukas Renggli
2012 Journal of Object Technology  
This domain-specific profiler was able to exploit knowledge of Mondrian's domain concepts to gather and present the needed information.  ...  In this paper we detail MetaSpy, an event-based approach for domain-specific profiling. With MetaSpy, a developer specifies the events of interest for a given domain.  ...  Difficulty of profiling a specific domain This section illustrates three shortcomings of traditional profiling techniques when applied to a specific domain.  ... 
doi:10.5381/jot.2012.11.1.a5 fatcat:2jhq2kj2pvf3thbwewwtb4able

Multivariate mixed membership modeling: Inferring domain-specific risk profiles [article]

Massimiliano Russo, Burton H. Singer, David B. Dunson
2019 arXiv   pre-print
Estimation methods yield models with good numerical fits and usually a number of profiles of 20s or higher.  ...  We then introduce a new class of multivariate mixed membership models that take explicit account of the blocks of variables corresponding to the distinct domains and a cross-domain correlation structure  ...  However, if a large set of variables can be meaningfully partitioned into separate subject matter domains, for each of which there is a small number (4 or less) of domain-specific profiles, then experience  ... 
arXiv:1901.05191v2 fatcat:le3qnolgefcpzpg7jhdoeyvzx4

Cinnamon: A Domain-Specific Language for Binary Profiling and Monitoring

Mahwish Arif, Ruoyu Zhou, Hsi-Ming Ho, Timothy M. Jones
2021 2021 IEEE/ACM International Symposium on Code Generation and Optimization (CGO)  
To address this, we introduce Cinnamon, a domain-specific language designed to write programs for binary profiling and monitoring.  ...  Developers often need to write framework-specific boilerplate code and work with low-level and complex programming details.  ...  Summary We have presented Cinnamon, a domain-specific language for binary profiling and monitoring, with a compiler that targets three instrumentation frameworks.  ... 
doi:10.1109/cgo51591.2021.9370313 fatcat:27ei3gw4cjhynadd5inlroxx4e

Profiling the expression domains of a rice-specific microRNA under stress

Neha Sharma, Anita Tripathi, Neeti Sanan-Mishra
2015 Frontiers in Plant Science  
This will help in gaining useful insights on the role of species specific miRs in plant development and abiotic stress response.  ...  In the present study, we have investigated the role of rice-specific Osa-miR820, in indica rice cultivars showing contrasting response to salt stress.  ...  Briefly 500 ng total RNA was used to synthesize cDNA using miR-specific stem-loop primer with Superscript reverse transcriptase III (Invitrogen) as per manufacturer's specifications.  ... 
doi:10.3389/fpls.2015.00333 pmid:26029232 pmcid:PMC4429473 fatcat:nxvz4gyd4vbcxi2zdrlgpfaz6i

Business Process Modeling: Defining Domain Specific Modeling Languages by Use of UML Profiles [chapter]

Steen Brahe, Kasper Østerbye
2006 Lecture Notes in Computer Science  
One tool, called ADSpecializer, can generate a UML profile and its tool support of a given application domain.  ...  We propose using Domain Specific Modeling (DSM) languages to model business processes, such that an enterprise can define its own DSM language(s) capturing its vocabulary and data requirement.  ...  However, using profiles for domain specific modeling in general modeling tools requires good knowledge of both UML and profiles as the general tools do not support modeling directly in domain specific  ... 
doi:10.1007/11787044_19 fatcat:id2mlyc4tbf6pnjrt6makrknxm

NG-meta-profiler: fast processing of metagenomes using NGLess, a domain-specific language [article]

Luis Pedro Coelho, Renato Alves, Paulo Monteiro, Jaime Huerta-Cepas, Ana Teresa Freitas, Peer Bork
2018 bioRxiv   pre-print
NGLess is a domain specific language for describing next-generation sequence processing pipelines. It was developed with the goal of enabling user-friendly computational reproducibility.  ...  Using this framework, we developed 'NG-meta-profiler', a fast profiler for metagenomes which performs sequence preprocessing, mapping to bundled databases, filtering of the mapping results, and profiling  ...  Several tools had already used a domain-specific language to define a computational pipeline.  ... 
doi:10.1101/367755 fatcat:g6tzdy2y6zfhpeqb5dsxsfgcia

On the automation-supported derivation of domain-specific UML profiles considering static semantics

Alexander Kraas
2021 Journal of Software and Systems Modeling  
This enabled us to successfully apply our approach to the two DSLs Test Description Language (TDL) and Specification and Description Language (SDL).  ...  propose a new automated approach for deriving a UML profile from the metamodel of a DSL.  ...  After creating MM Domain , we can automatically derive a DSL-specific UML profile UP Domain in Step (B).  ... 
doi:10.1007/s10270-021-00890-1 fatcat:vyde4lsrhrhldavqr45xsawrdi

Stage-specific protein-domain mutational profile of invasive ductal breast cancer

Ting Yu, Kwok Pui Choi, Ee Sin Chen, Louxin Zhang
2020 BMC Medical Genomics  
Results Our findings suggest that while the spectrum of mutated domains was diverse, mutations were aggregated in Pkinase, Pkinase Tyr, Y-Phosphatase and Src-homology 2 domains, highlighting the genetic  ...  Methods Using the whole-exome sequences and clinical information of 468 patients in the TCGA project data portal, we analyzed mutated protein domains and signaling pathway alterations in order to understand  ...  About this supplement Fig. 1 1 The mutational profiles of significantly mutated genes in IDBC.  ... 
doi:10.1186/s12920-020-00777-y pmid:33087126 fatcat:jn74rsjdazd7nchcd3paxggyka

On the importance of cognitive profiling: A graphical modelling analysis of domain-specific and domain-general deficits after stroke

M. Sofia Massa, Naxian Wang, Wa-Ling Bickerton, Nele Demeyere, M. Jane Riddoch, Glyn W. Humphreys
2015 Cortex  
Domain-specific and domain-general factors.  ...  Here we evaluate whether the cognitive profiling approach, promoted by BCoS, can provide new insights into the nature of domain-specific deficits when domain-general processes are taken into account.  ... 
doi:10.1016/j.cortex.2015.06.006 pmid:26232552 fatcat:2sxkpq2jn5e7nav5sj6fl6imfm

Deuterium NMR of Raft Model Membranes Reveals Domain-Specific Order Profiles and Compositional Distribution

Tomokazu Yasuda, Hiroshi Tsuchikawa, Michio Murata, Nobuaki Matsumori
2015 Biophysical Journal  
(Chol) and successfully acquired deuterium quadrupole coupling profiles of SSM from liquid-ordered (L o ) and liquid-disordered (L d ) domains.  ...  As compared with the reported tie-line analysis of phase diagrams, the merit of our 2 H NMR analysis is that the domain-specific compositional fractions are directly attainable without experimental complexity  ...  In this report, we further applied the site-specifically deuterated SSMs to raft-exhibiting ternary mixtures (SSM/DOPC/Chol) and acquired the quadrupole coupling profiles of SSM from L o and L d domains  ... 
doi:10.1016/j.bpj.2015.04.008 pmid:25992728 pmcid:PMC4457009 fatcat:4t47mejnsjfjjlfr3x26k2kfla

Dissecting Domain-Specific Evolutionary Pressure Profiles of Transient Receptor Potential Vanilloid Subfamily Members 1 to 4

Pau Doñate-Macián, Alex Perálvarez-Marín, Mandë Holford
2014 PLoS ONE  
We have analyzed the selective pressure on specific protein domains, observing a common selective pressure trend for the common TRPV scaffold, consisting of the ankyrin repeat domain, the membrane proximal  ...  Performing evolutionary comparison, we have translated specific channel structural information such as the transmembrane topology, and the interaction between the membrane proximal domain and the TRP box  ...  Refer to the text for specific statistical comparison of the medians. doi:10.1371/journal.pone.0110715.g001 Figure 2 . 2 Domain-specific conservation profile for TRPV channels. A.  ... 
doi:10.1371/journal.pone.0110715 pmid:25333484 pmcid:PMC4204936 fatcat:uds7th7qrvfbzlxb4iailui2kq

NG-meta-profiler: fast processing of metagenomes using NGLess, a domain-specific language

Luis Pedro Coelho, Renato Alves, Paulo Monteiro, Jaime Huerta-Cepas, Ana Teresa Freitas, Peer Bork
2019 Microbiome  
Implementation NGLess, a domain-specific language for NGS processing NGLess is a domain-specific language which was designed specifically for next-generation sequence (NGS) processing.  ...  To this end, we present NG-meta-profiler, a collection of pre-configured pipelines based on the domain-specific language NGLess (Next Generation Language for less effortful analysis).  ... 
doi:10.1186/s40168-019-0684-8 pmid:31159881 pmcid:PMC6547473 fatcat:a44vlibljvebhl2gs7vwfllbnq

The prevalence, development and domain specificity of elementary school students' achievement goal profiles

Joost Jansen in de Wal, Lisette Hornstra, Frans J. Prins, Thea Peetsma, Ineke van der Veen
2015 Educational Psychology  
This study's aim was to examine the prevalence, development and domain specificity of fifthand sixth-grade elementary school students' achievement goal profiles.  ...  Profile membership and transitions between profiles were found to be relatively domain general with 60% overlap between domains.  ...  and (c) to what extent profiles and their development are domain general or domain specific.  ... 
doi:10.1080/01443410.2015.1035698 fatcat:sis6rku6a5grnjm7mfx23bndqa

Profiling the DNA-binding specificities of engineered Cys2His2 zinc finger domains using a rapid cell-based method

Xiangdong Meng, Stacey Thibodeau-Beganny, Tao Jiang, J. Keith Joung, Scot A. Wolfe
2007 Nucleic Acids Research  
Profiling the DNA-binding specificities of engineered Cys2His2 zinc finger domains using a rapid cell-based method. Nucleic Acids Research 35(11): e81.  ...  Published Version ABSTRACT The C 2 H 2 zinc finger is the most commonly utilized framework for engineering DNA-binding domains with novel specificities.  ...  We use this modified B1H system to profile the specificities of 34 engineered zinc-finger domains obtained using a previously described 'bi-partite' zinc finger selection strategy (15) .  ... 
doi:10.1093/nar/gkm385 pmid:17537811 pmcid:PMC1920264 fatcat:e75ex6yxbffunlbvsqo5fgfom4
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