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Distinct profiling of antimicrobial peptide families

Abdullah M. Khamis, Magbubah Essack, Xin Gao, Vladimir B. Bajic
2014 Computer applications in the biosciences : CABIOS  
Antimicrobial peptides (AMPs) exhibit broad-spectrum potent activity against MDR pathogens and kills rapidly, thus giving rise to AMPs being recognized as a potential substitute for conventional antibiotics  ...  Motivation: The increased prevalence of multi-drug resistant (MDR) pathogens heightens the need to design new antimicrobial agents.  ...  This Profiling of antimicrobial peptide families suggests that the features selected based on DAMPD entries discriminate well between different AMP families in the CAMP database.  ... 
doi:10.1093/bioinformatics/btu738 pmid:25388148 pmcid:PMC4380027 fatcat:vujl4sroo5e6nhhdjiyljimhem

Expression, tissue localization and synergy of antimicrobial peptides and proteins in the immune response of the oyster Crassostrea gigas

Paulina Schmitt, Julien de Lorgeril, Yannick Gueguen, Delphine Destoumieux-Garzón, Evelyne Bachère
2012 Developmental and Comparative Immunology  
Highlights ► Oyster antimicrobials display different expression profiles in hemocytes and tissues. ► Hemocytes drive antimicrobials to tissues contributing with their colocalization. ► Oyster antimicrobials  ...  show synergistic activity in vitro. ► Synergy might compensate the low concentration of antimicrobials in oyster tissues.  ...  This work received financial support by the Ifremer, the CNRS, the University of Montpellier 2 and the Languedoc-Roussillon Region ("chercheur(se) d'avenir" REVAResp project).  ... 
doi:10.1016/j.dci.2012.01.004 pmid:22327168 fatcat:wodcw5lpbvbcjcpy5wggydxwxy

Modular determinants of antimicrobial activity in platelet factor-4 family kinocidins

Michael R. Yeaman, Nannette Y. Yount, Alan J. Waring, Kimberly D. Gank, Deborah Kupferwasser, Robert Wiese, Arnold S. Bayer, William H. Welch
2007 Biochimica et Biophysica Acta - Biomembranes  
A consensus peptide domain library representing mammalian PF-4 family members was analyzed to define structural domains contributing to antimicrobial activity against a panel of human pathogens.  ...  Mammalian platelets contain an array of antimicrobial peptides, termed platelet microbicidal proteins (PMPs).  ...  These studies were performed in-part at the Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, and the Department of Biochemistry, University of Nevada, Reno.  ... 
doi:10.1016/j.bbamem.2006.11.010 pmid:17217910 pmcid:PMC2827485 fatcat:rqbl6acxzbcvbpupqns3klfcue

Evidence from peptidomic analysis of skin secretions that the red-legged frogs, Rana aurora draytonii and Rana aurora aurora, are distinct species

J. Michael Conlon, Nadia Al-Ghafari, Laurent Coquet, Jérôme Leprince, Thierry Jouenne, Hubert Vaudry, Carlos Davidson
2006 Peptides  
The authors thank Joe DiDonato and Roger Epperson, East Bay Regional Parks District, and Harry McQuillen of the U.S.  ...  Fish and Wildlife Service for their help in facilitating the collection of specimens and Bency Abraham, U.A.E. University for technical assistance.  ...  of the year, demonstrates that both the HPLC elution profiles (Fig. 1 ) and the mass distribution and amino acid sequences of the antimicrobial peptides (Fig. 3 ) from both species are quite different  ... 
doi:10.1016/j.peptides.2005.10.018 pmid:16307827 fatcat:2kgccckyb5a33d3eibnxdkwuf4

Variations in the expressed antimicrobial peptide repertoire of northern leopard frog (Rana pipiens) populations suggest intraspecies differences in resistance to pathogens

Jacob A. Tennessen, Douglas C. Woodhams, Pierre Chaurand, Laura K. Reinert, Dean Billheimer, Yu Shyr, Richard M. Caprioli, Michael S. Blouin, Louise A. Rollins-Smith
2009 Developmental and Comparative Immunology  
Using a peptidomics approach, we show that the pattern of expressed antimicrobial skin peptides of frogs from three geographically separated populations are distinct, and we report the presence of four  ...  We interpret these differences in expression and activity of antimicrobial peptides as evidence to suggest that each population may have been selected to express a suite of peptides that reflects current  ...  -S. of an NSF Integrated Research Challenges in Environmental Biology (IRCEB) grant DEB-0213851 (J. Collins, P.I.) and NSF grants IOB-0520847, IOB-0619536, and IOS-0843207 (to L.R.-S.).  ... 
doi:10.1016/j.dci.2009.07.004 pmid:19622371 pmcid:PMC2927990 fatcat:cjccgifuyneizgcd4r76jzpmou

The γ-core motif correlates with antimicrobial activity in cysteine-containing kaliocin-1 originating from transferrins

Nannette Y. Yount, María T. Andrés, José F. Fierro, Michael R. Yeaman
2007 Biochimica et Biophysica Acta - Biomembranes  
of transferrin family proteins.  ...  antimicrobial peptides.  ...  Acknowledgments These studies were supported in-part by grants from the National Institutes of Health (AI-39001, AI-48031; MRY), Bethesda, MD, USA, and the Fondo de Investigación Sanitaria (FIS PI052588  ... 
doi:10.1016/j.bbamem.2007.07.024 pmid:17916323 fatcat:gtiu7b6rqvayzmdjtyapwvngae

Functional Divergence among Silkworm Antimicrobial Peptide Paralogs by the Activities of Recombinant Proteins and the Induced Expression Profiles

Wanying Yang, Tingcai Cheng, Mingqiang Ye, Xiaojuan Deng, Huiyu Yi, Yadong Huang, Xiang Tan, Dong Han, Bo Wang, Zhonghuai Xiang, Yang Cao, Qingyou Xia (+1 others)
2011 PLoS ONE  
Four peptides of gloverin family had similar antimicrobial spectrum and activity against tested bacteria. The gloverin family showed similar antimicrobial function and slow evolutionary rates.  ...  They play crucial roles in the innate immune response, but reports on the functional divergence of antimicrobial peptide gene families are rare.  ...  The results showed seven paralogs of drosomycin family revealed obviously different antifungal activity against seven fungal strains [23] , and distinct induced expression profile by four different microbes  ... 
doi:10.1371/journal.pone.0018109 pmid:21479226 pmcid:PMC3066212 fatcat:4ulc33goijgexcdbbdh3eae6xy

Investigating specific bacterial resistance to AMPs by using a magainin I-resistant Escherichia coli model

Keyla C de Almeida, Thais B Lima, Dielle O Motta, Osmar N Silva, Beatriz S Magalhães, Simoni C Dias, Octávio L Franco
2014 Journal of antibiotics (Tokyo. 1968)  
Antimicrobial peptides (AMPs) are multifunctional compounds that may show antimicrobial and immunomodulatory activities.  ...  The other AMPs MICs were 3.4 lM to proline-arginine-rich 39-amino-acid peptide, 43 lM to porcine myeloid antimicrobial 23-amino-acid peptide-23 and 1.2 lM to cecropin P1 for all strains, demonstrating  ...  Table 4 4 MICs of distinct cationic antimicrobial peptides tested in the E. coli strains Abbreviations: ATCC, American Type Culture Collection; PMAP-23, porcine myeloid antimicrobial 23-amino-acid peptide  ... 
doi:10.1038/ja.2014.48 pmid:24802209 fatcat:azw3nysha5ex3ol7zv7rk6iq4i

PREDICTED DISEASE SUSCEPTIBILITY IN A PANAMANIAN AMPHIBIAN ASSEMBLAGE BASED ON SKIN PEPTIDE DEFENSES

Douglas C. Woodhams, Jamie Voyles, Karen R. Lips, Cynthia Carey, Louise A. Rollins-Smith
2006 Journal of Wildlife Diseases  
This taxon has a distinctively thick epidermis, often with a heavily keratinized and roughened structure (Elias and Shapiro, 1957) , and skin peptide profiles of this family are notably less complex than  ...  Individual variation in the peptide profile may indicate novel protective peptides that correspond to antimicrobial potency.  ... 
doi:10.7589/0090-3558-42.2.207 pmid:16870844 fatcat:7pk6xruirraorgpc2xxx27uddm

A23 DIETARY PROTEIN AND AMINO ACID COMPOSITIONS INFLUENCE MICROBIOTA, INTESTINAL PERMEABILITY, AND SUSCEPTIBILITY TO COLITIS

L Rondeau, J Godbout, X Wang, A CAMINERO FERNANDEZ
2021 Journal of the Canadian Association of Gastroenterology  
Its overexpression may incite inflammation by stimulating cytokine signalling through NFκB and modify microbial community structure by regulating antimicrobial peptides.  ...  Cytokine profiling revealed that AAD is associated with significant up-regulation of IL-18 during colitis.  ...  Cytokine profiling revealed that AAD is associated with significant up-regulation of IL-18 during colitis.  ... 
doi:10.1093/jcag/gwab002.022 fatcat:whfgbjpcuzdtddw6r72c6yy33q

Design, synthesis and X-ray crystallographic study of NAmPRTase inhibitors as anti-cancer agents

H. -S. Youn, H. You, I. Im, Y. Lee, M. -H. Bae, S. -K. Lee, H. Ko, Y. -C. Kim, S. H. Eom
2011 Acta Crystallographica Section A Foundations of Crystallography  
The crystal structure revealed that the homodimer assembly of Gr6 mimics the V H -V L heterodimer of immunoglobulin variable domains and the dimerization is, at least partially, attributed to amino acids  ...  To understand this different molecular behavior, we solved the crystal structure of Gr6 to 1.6 Å resolution.  ...  Elucidation of the binding mode of the peptides and characterization of the substrate specificity of DnaK will allow a structure-guided development of peptide inhibitors as antimicrobial agents targeting  ... 
doi:10.1107/s0108767311092336 fatcat:6jdwu4ijmrbatb4o7y324fqmoi

Postsecretory Processing Generates Multiple Cathelicidins for Enhanced Topical Antimicrobial Defense

M. Murakami, B. Lopez-Garcia, M. Braff, R. A. Dorschner, R. L. Gallo
2004 Journal of Immunology  
In mammals, antimicrobial peptides belonging to the cathelicidin family have been shown to be important for the antimicrobial efficacy of neutrophils, macrophages, and mast cells (2) (3) (4) (5) (6) .  ...  In addition, epithelia of lung, gut, urinary bladder, oral mucosa, and skin produce antimicrobial peptides of the defensin and cathelicidin families constitutively or in response to injury (7) (8) (9)  ... 
doi:10.4049/jimmunol.172.5.3070 pmid:14978112 fatcat:u7bl7ktdnzegth5oqitgb2kcyq

The role of amphibian antimicrobial peptides in protection of amphibians from pathogens linked to global amphibian declines

Louise A. Rollins-Smith
2009 Biochimica et Biophysica Acta - Biomembranes  
An effective antimicrobial peptide defense against skin pathogens appears to depend on a diverse array of genes expressing antimicrobial peptides.  ...  The production of antimicrobial peptides may be regulated by signals from the pathogens.  ...  MALDI-TOF analysis of the suite of expressed brevinin-1 peptides in three geographically distinct populations of R. pipiens revealed distinct patterns of expression.  ... 
doi:10.1016/j.bbamem.2009.03.008 pmid:19327341 fatcat:dqh2lq57g5azljiqdxxtcgve64

Structural studies of DnaK in complex with proline-rich antimicrobial peptides

M. Zahn, D. Knappe, N. Ereth, R. Hoffmann, N. Sträter
2011 Acta Crystallographica Section A Foundations of Crystallography  
The crystal structure revealed that the homodimer assembly of Gr6 mimics the V H -V L heterodimer of immunoglobulin variable domains and the dimerization is, at least partially, attributed to amino acids  ...  To understand this different molecular behavior, we solved the crystal structure of Gr6 to 1.6 Å resolution.  ...  Elucidation of the binding mode of the peptides and characterization of the substrate specificity of DnaK will allow a structure-guided development of peptide inhibitors as antimicrobial agents targeting  ... 
doi:10.1107/s0108767311092324 fatcat:y2mghp5xg5dzvaw4pncidj7aky

Defensins and Bioinformatics: In Silico Approaches for Novel Therapeutic Antimicrobial Peptides

Helena C. Castro, Plínio Sathler
2016 Elyns Journal of Microbes  
Therefore, defensins may help as biotechnological prototypes with an antibacterial profile to generate new antimicrobial drugs.  ...  that modulate their biological activity profile.  ...  3D structure-based design of peptide antimicrobials and vaccines, surface coating, delivery systems, and microbial detection devices involving antimicrobial peptides." antimicrobial peptide; bacterial  ... 
doi:10.19104/amb.2015.102 fatcat:rb2wzymcwfe4xogz2nrjxq2yti
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