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Disrupted brain networks in the aging HIV+ population

Neda Jahanshad, Victor G Valcour, Talia M Nir, Omid Kohannim, Edgar Busovaca, Krista Nicolas, Paul Thompson
2012 Brain Connectivity  
Neural network deficiencies in HIV + populations exceed those typical of normal aging, and are worse in those genetically predisposed to brain degeneration.  ...  We set out to determine selective virus-associated disruptions in the brain's structural network. All individuals in this study were aged 60-80, with full access to antiretroviral therapy.  ...  Acknowledgments This study was supported by the following grants: Author Disclosure Statement No competing financial interests exist. 342 JAHANSHAD ET AL.  ... 
doi:10.1089/brain.2012.0105 fatcat:5wt2zawnjvbfxlymygvwu3qf34

Disrupted Brain Networks in the Aging HIV+ Population

Neda Jahanshad, Victor G. Valcour, Talia M. Nir, Omid Kohannim, Edgar Busovaca, Krista Nicolas, Paul M. Thompson
2012 Brain Connectivity  
Neural network deficiencies in HIV + populations exceed those typical of normal aging, and are worse in those genetically predisposed to brain degeneration.  ...  We set out to determine selective virus-associated disruptions in the brain's structural network. All individuals in this study were aged 60-80, with full access to antiretroviral therapy.  ...  Acknowledgments This study was supported by the following grants: Author Disclosure Statement No competing financial interests exist. 342 JAHANSHAD ET AL.  ... 
doi:10.1089/brain.2012.0105-rev pmid:23240599 pmcid:PMC3621327 fatcat:jtsmjesdcnb7ncn7npxmpsh3ie

Topological Organization of Whole-Brain White Matter in HIV Infection

Laurie M. Baker, Sarah A. Cooley, Ryan P. Cabeen, David H. Laidlaw, John A. Joska, Jacqueline Hoare, Dan J. Stein, Jodi M. Heaps-Woodruff, Lauren E. Salminen, Robert H. Paul
2017 Brain Connectivity  
Results from this study indicate disruption to brain network integrity in treatment-limited HIV+ young adults with corresponding abnormalities in cognitive performance.  ...  As such, we examined structural whole-brain white matter connectivity patterns and cognitive performance in 29 HIV+ young adults (mean age = 25.9) with limited or no HIV treatment history.  ...  Acknowledgments This study was supported by the National Institute of Mental Health (MH085604). Dr. Stein was supported by the Medical Research Council of South Africa.  ... 
doi:10.1089/brain.2016.0457 pmid:28076974 pmcid:PMC5359681 fatcat:hsbe2c53xfgrxkiknk5vkik6k4

Effect of HAART on Brain Organization and Function in HIV-Negative Subjects

Matthew R. Brier, Qian Wu, Aaron B. Tanenbaum, Elizabeth T. Westerhaus, Evan D. Kharasch, Beau M. Ances
2015 Journal of Neuroimmune Pharmacology  
Our results suggests that previous changes in functional connectivity and cerebral blood flow in HIV infected individuals receiving HAART may largely due to the virus and remaining reservoirs and less  ...  A potential confound in previous studies of HIV-associated cognitive dysfunction is that HAART may be neurotoxic. Thus, observed effects, attributed to HIV, may be in part due to HAART.  ...  Funding was also provided by the Alzheimer's Association NIRP-12-257747 (BMA).  ... 
doi:10.1007/s11481-015-9634-9 pmid:26446778 pmcid:PMC4662631 fatcat:5tmpo3l2k5g55otktxzjkgeymi

Weighted brain networks in disease: centrality and entropy in human immunodeficiency virus and aging

Jewell B. Thomas, Matthew R. Brier, Mario Ortega, Tammie L. Benzinger, Beau M. Ances
2015 Neurobiology of Aging  
HIV and age were associated with divergent measures when evaluated at the whole graph level, within individual functional networks, and at the level of individual nodes.  ...  HIV was primarily associated with differences in measures of centrality, and age was primarily associated with differences in diversity.  ...  Cognition can deteriorate in the HIV+ population but remains relatively intact in healthy HIV-individuals across the age-range analyzed in this study (Jacobs et al., 2012) .  ... 
doi:10.1016/j.neurobiolaging.2014.06.019 pmid:25034343 pmcid:PMC4268260 fatcat:fyguht5ek5ekbgznqgvo5sekg4

Whole-brain computational modeling reveals disruption of microscale brain dynamics in HIV infected individuals [article]

Yuchuan Zhuang, Zhengwu Zhang, Madalina Tivarus, Xing Qiu, Jianhui Zhong, Giovanni Schifitto
2020 medRxiv   pre-print
The results show that untreated HIV-infected individuals have disrupted local brain dynamics that in part correlate with network topological measurements.  ...  Notably, after 12 weeks of cART, both the microscale brain dynamics and the network topological measurements improved and were closer to those in the healthy brain.  ...  Funding This work was supported by the National Institutes of Health [grant numbers R01 MH099921, R01 AG054328, R01MH118020 and UL1TR002001];  ... 
doi:10.1101/2020.04.29.20084558 fatcat:4r54k32gibbqbhrmzxcixjlupi

Apolipoprotein E ε4 genotype status is not associated with neuroimaging outcomes in a large cohort of HIV+ individuals

Sarah A. Cooley, Robert H. Paul, Christine Fennema-Notestine, Erin E. Morgan, Florin Vaida, Qianqian Deng, Jie Ashley Chen, Scott Letendre, Ronald Ellis, David B. Clifford, Christina M. Marra, Ann C. Collier (+7 others)
2016 Journal of Neurovirology  
Previous neuroimaging studies suggest a negative relationship between the apolipoprotein (ApoE) ε4 allele and brain integrity in HIV-infected (HIV+) individuals, although the presence of this relationship  ...  The purpose of this study is to clarify the discrepancies using a large, diverse group of HIV+ individuals and multiple imaging modalities sensitive to HIV.  ...  Acknowledgments The CNS HIV Anti-Retroviral Therapy Effects Research (CHARTER; is supported by awards N01 MH22005, HHSN271201000036C and HHSN271201000030C from the  ... 
doi:10.1007/s13365-016-0434-7 pmid:27021072 pmcid:PMC5040614 fatcat:ddo6nkbtrzdm7goyjsslrqryiy

Novel Neuroimaging Methods to Understand How HIV Affects the Brain

Paul M. Thompson, Neda Jahanshad
2015 Current HIV/AIDS Reports  
In much of the developed world, the HIV epidemic has largely been controlled by anti-retroviral treatment.  ...  Here we review recent developments in brain imaging that reveal how the virus affects the brain.  ...  In one study [39] , the integrity of connections in the brain's anatomical network was lower in HIV+ patients versus controls, and was further disrupted in people with prolonged HIV exposure and with  ... 
doi:10.1007/s11904-015-0268-6 pmid:25902966 pmcid:PMC4433315 fatcat:f457wkwagzaxhev6tfq4yy4mni

Page 3514 of Psychological Abstracts Vol. 89, Issue 9 [page]

2002 Psychological Abstracts  
Gender, age, marital status, and education may influence social support needs and social network size.  ...  —This paper reviews the literature on the psychological adjustment and quality of life in children who survive brain tumors. A total of 31 studies were reviewed.  ... 

The potential role of vagus-nerve stimulation in the treatment of HIV-associated depression: a review of literature

William C Nicholson, Mirjam-Colette Kempf, Linda Moneyham, David E Vance
2017 Neuropsychiatric Disease and Treatment  
VN stimulation (VNS) and its benefits as a treatment for depression have been well documented, but remain unexplored in the HIV population.  ...  Estimates suggest that the prevalence rate for depression among HIV-infected individuals is three times that of the general population.  ...  In support, the fMRI results corresponded to increased functional connectivity in the default-mode network of the brain (known to be decreased in depression).  ... 
doi:10.2147/ndt.s136065 pmid:28721049 pmcid:PMC5499939 fatcat:emmmj7wa65ctznzglk7wji6ixa

Functional MRI Correlates of Sleep Quality in HIV

Arun Venkataraman, Yuchuan Zhuang, Jennifer Marsella, Madalina E Tivarus, Xing Qiu, Lu Wang, Jianhui Zhong, Giovanni Schifitto
2021 Nature and Science of Sleep  
Furthermore, the relationship between these networks and PSQI is different in the HIV+ and HIV- populations.  ...  To examine resting-state functional MRI (rs-fMRI) networks related to sleep in the context of HIV infection. rs-fMRI data were collected in 40 HIV-infected (HIV+) individuals at baseline (treatment-naive  ...  Acknowledgments We would like to acknowledge the subjects that took part in this study. In addition, we acknowledge Dr.  ... 
doi:10.2147/nss.s291544 pmid:33688288 pmcid:PMC7936696 fatcat:4jmzy4tdffgpxe5avd76vybm3u

HIV Infection Is Associated with Attenuated Frontostriatal Intrinsic Connectivity: A Preliminary Study

Jonathan C. Ipser, Gregory G. Brown, Amanda Bischoff-Grethe, Colm G. Connolly, Ronald J. Ellis, Robert K. Heaton, Igor Grant
2015 Journal of the International Neuropsychological Society  
Intrinsic connectivity of this network may therefore serve as a marker of the deleterious effects of HIV infection on the brain, possiblyviaHIV-associated dopaminergic abnormalities.  ...  The current study aimed to assess the association of HIV infection with functional connections within the frontostriatal network, circuitry hypothesized to be highly vulnerable to HIV infection.  ...  intrinsic central executive network (Vincent, Kahn, Snyder, Raichle, & Buckner, 2008) that is disrupted in HIV positive individuals .  ... 
doi:10.1017/s1355617715000156 pmid:25824201 pmcid:PMC4400233 fatcat:ujoledcxhrh6rmv6376xgvo2be

Common gene-network signature of different neurological disorders and their potential implications to neuroAIDS

Vidya Sagar, S. Pilakka-Kanthikeel, Paola C. Martinez, V. S. R. Atluri, M. Nair, Eliseo A Eugenin
2017 PLoS ONE  
The neurological complications of AIDS (neuroAIDS) during the infection of human immuno-  ...  Acknowledgments This work was supported in part by grants R01DA040537, R01DA034547, and 1R03DA037782 from the National Institute of Health.  ...  This may be correlated with the atrophy of grey and white matter in the brain of HIV patients [39] .  ... 
doi:10.1371/journal.pone.0181642 pmid:28792504 pmcid:PMC5549695 fatcat:oclsbv5bbrd5ljjarsr3klymia

Altered intrinsic local activity and cognitive dysfunction in HIV patients: A resting-state fMRI study

Yunjin Bak, Sunyoung Jun, Jun Yong Choi, Youngjoon Lee, Seung-Koo Lee, Sanghoon Han, Na-Young Shin
2018 PLoS ONE  
The orbitofrontal cortex and primary sensorimotor area were more disrupted in HAND relative to HIV-IC and correlated with behavioral performance, suggesting these areas are relevant to cognitive impairment  ...  Correlation analyses were performed between rsfMRI values and neuropsychological tests. rsfMRI analyses revealed decreased rsfMRI values in the frontal areas, and increases in the posterior brain regions  ...  in HIV patients, they might be more relevant to cognitive impairment in this population.  ... 
doi:10.1371/journal.pone.0207146 pmid:30496203 pmcid:PMC6264476 fatcat:vrvygdob5vd5topa54q2qjy4qa

Astrocytes, HIV and the Glymphatic System: A Disease of Disrupted Waste Management?

Caitlin Tice, Jane McDevitt, Dianne Langford
2020 Frontiers in Cellular and Infection Microbiology  
Similar to AD, HIV infection of the CNS contributes to abnormal aging with altered AQP4 localization, accumulation of pTau and chronic neuroinflammation.  ...  The discovery of the glial-lymphatic or glymphatic fluid clearance pathway in the rodent brain led researchers to search for a parallel system in humans and to question the implications of this pathway  ...  In this context, decreased glymphatic clearance may increase the risk of neurodegenerative changes contributing to cognitive decline in the aging population or in age-related CNS diseases (Rainey-Smith  ... 
doi:10.3389/fcimb.2020.523379 pmid:33134185 pmcid:PMC7550659 fatcat:am4c52v5knhujmjgptre5zt4ta
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