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Disrupted brain networks in the aging HIV+ population
2012
Brain Connectivity
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Neural network deficiencies in HIV + populations exceed those typical of normal aging, and are worse in those genetically predisposed to brain degeneration. ...
We set out to determine selective virus-associated disruptions in the brain's structural network. All individuals in this study were aged 60-80, with full access to antiretroviral therapy. ...
Acknowledgments This study was supported by the following grants:
Author Disclosure Statement No competing financial interests exist.
342 JAHANSHAD ET AL. ...
doi:10.1089/brain.2012.0105
fatcat:5wt2zawnjvbfxlymygvwu3qf34
Disrupted Brain Networks in the Aging HIV+ Population
2012
Brain Connectivity
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Neural network deficiencies in HIV + populations exceed those typical of normal aging, and are worse in those genetically predisposed to brain degeneration. ...
We set out to determine selective virus-associated disruptions in the brain's structural network. All individuals in this study were aged 60-80, with full access to antiretroviral therapy. ...
Acknowledgments This study was supported by the following grants:
Author Disclosure Statement No competing financial interests exist.
342 JAHANSHAD ET AL. ...
doi:10.1089/brain.2012.0105-rev
pmid:23240599
pmcid:PMC3621327
fatcat:jtsmjesdcnb7ncn7npxmpsh3ie
Topological Organization of Whole-Brain White Matter in HIV Infection
2017
Brain Connectivity
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Results from this study indicate disruption to brain network integrity in treatment-limited HIV+ young adults with corresponding abnormalities in cognitive performance. ...
As such, we examined structural whole-brain white matter connectivity patterns and cognitive performance in 29 HIV+ young adults (mean age = 25.9) with limited or no HIV treatment history. ...
Acknowledgments This study was supported by the National Institute of Mental Health (MH085604). Dr. Stein was supported by the Medical Research Council of South Africa. ...
doi:10.1089/brain.2016.0457
pmid:28076974
pmcid:PMC5359681
fatcat:hsbe2c53xfgrxkiknk5vkik6k4
Effect of HAART on Brain Organization and Function in HIV-Negative Subjects
2015
Journal of Neuroimmune Pharmacology
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Our results suggests that previous changes in functional connectivity and cerebral blood flow in HIV infected individuals receiving HAART may largely due to the virus and remaining reservoirs and less ...
A potential confound in previous studies of HIV-associated cognitive dysfunction is that HAART may be neurotoxic. Thus, observed effects, attributed to HIV, may be in part due to HAART. ...
Funding was also provided by the Alzheimer's Association NIRP-12-257747 (BMA). ...
doi:10.1007/s11481-015-9634-9
pmid:26446778
pmcid:PMC4662631
fatcat:5tmpo3l2k5g55otktxzjkgeymi
Weighted brain networks in disease: centrality and entropy in human immunodeficiency virus and aging
2015
Neurobiology of Aging
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HIV and age were associated with divergent measures when evaluated at the whole graph level, within individual functional networks, and at the level of individual nodes. ...
HIV was primarily associated with differences in measures of centrality, and age was primarily associated with differences in diversity. ...
Cognition can deteriorate in the HIV+ population but remains relatively intact in healthy HIV-individuals across the age-range analyzed in this study (Jacobs et al., 2012) . ...
doi:10.1016/j.neurobiolaging.2014.06.019
pmid:25034343
pmcid:PMC4268260
fatcat:fyguht5ek5ekbgznqgvo5sekg4
Whole-brain computational modeling reveals disruption of microscale brain dynamics in HIV infected individuals
[article]
2020
medRxiv
pre-print
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The results show that untreated HIV-infected individuals have disrupted local brain dynamics that in part correlate with network topological measurements. ...
Notably, after 12 weeks of cART, both the microscale brain dynamics and the network topological measurements improved and were closer to those in the healthy brain. ...
Funding This work was supported by the National Institutes of Health [grant numbers R01 MH099921, R01 AG054328, R01MH118020 and UL1TR002001]; ...
doi:10.1101/2020.04.29.20084558
fatcat:4r54k32gibbqbhrmzxcixjlupi
Apolipoprotein E ε4 genotype status is not associated with neuroimaging outcomes in a large cohort of HIV+ individuals
2016
Journal of Neurovirology
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Previous neuroimaging studies suggest a negative relationship between the apolipoprotein (ApoE) ε4 allele and brain integrity in HIV-infected (HIV+) individuals, although the presence of this relationship ...
The purpose of this study is to clarify the discrepancies using a large, diverse group of HIV+ individuals and multiple imaging modalities sensitive to HIV. ...
Acknowledgments The CNS HIV Anti-Retroviral Therapy Effects Research (CHARTER; https://www.charterresource.ucsd.edu) is supported by awards N01 MH22005, HHSN271201000036C and HHSN271201000030C from the ...
doi:10.1007/s13365-016-0434-7
pmid:27021072
pmcid:PMC5040614
fatcat:ddo6nkbtrzdm7goyjsslrqryiy
Novel Neuroimaging Methods to Understand How HIV Affects the Brain
2015
Current HIV/AIDS Reports
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In much of the developed world, the HIV epidemic has largely been controlled by anti-retroviral treatment. ...
Here we review recent developments in brain imaging that reveal how the virus affects the brain. ...
In one study [39] , the integrity of connections in the brain's anatomical network was lower in HIV+ patients versus controls, and was further disrupted in people with prolonged HIV exposure and with ...
doi:10.1007/s11904-015-0268-6
pmid:25902966
pmcid:PMC4433315
fatcat:f457wkwagzaxhev6tfq4yy4mni
Page 3514 of Psychological Abstracts Vol. 89, Issue 9
[page]
2002
Psychological Abstracts
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Gender, age, marital status, and education may influence social support needs and social network size. ...
—This paper reviews the literature on the psychological adjustment and quality of life in children who survive brain tumors. A total of 31 studies were reviewed. ...
The potential role of vagus-nerve stimulation in the treatment of HIV-associated depression: a review of literature
2017
Neuropsychiatric Disease and Treatment
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VN stimulation (VNS) and its benefits as a treatment for depression have been well documented, but remain unexplored in the HIV population. ...
Estimates suggest that the prevalence rate for depression among HIV-infected individuals is three times that of the general population. ...
In support, the fMRI results corresponded to increased functional connectivity in the default-mode network of the brain (known to be decreased in depression). ...
doi:10.2147/ndt.s136065
pmid:28721049
pmcid:PMC5499939
fatcat:emmmj7wa65ctznzglk7wji6ixa
Functional MRI Correlates of Sleep Quality in HIV
2021
Nature and Science of Sleep
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Furthermore, the relationship between these networks and PSQI is different in the HIV+ and HIV- populations. ...
To examine resting-state functional MRI (rs-fMRI) networks related to sleep in the context of HIV infection. rs-fMRI data were collected in 40 HIV-infected (HIV+) individuals at baseline (treatment-naive ...
Acknowledgments We would like to acknowledge the subjects that took part in this study. In addition, we acknowledge Dr. ...
doi:10.2147/nss.s291544
pmid:33688288
pmcid:PMC7936696
fatcat:4jmzy4tdffgpxe5avd76vybm3u
HIV Infection Is Associated with Attenuated Frontostriatal Intrinsic Connectivity: A Preliminary Study
2015
Journal of the International Neuropsychological Society
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Intrinsic connectivity of this network may therefore serve as a marker of the deleterious effects of HIV infection on the brain, possiblyviaHIV-associated dopaminergic abnormalities. ...
The current study aimed to assess the association of HIV infection with functional connections within the frontostriatal network, circuitry hypothesized to be highly vulnerable to HIV infection. ...
intrinsic central executive network (Vincent, Kahn, Snyder, Raichle, & Buckner, 2008) that is disrupted in HIV positive individuals . ...
doi:10.1017/s1355617715000156
pmid:25824201
pmcid:PMC4400233
fatcat:ujoledcxhrh6rmv6376xgvo2be
Common gene-network signature of different neurological disorders and their potential implications to neuroAIDS
2017
PLoS ONE
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The neurological complications of AIDS (neuroAIDS) during the infection of human immuno- ...
Acknowledgments This work was supported in part by grants R01DA040537, R01DA034547, and 1R03DA037782 from the National Institute of Health. ...
This may be correlated with the atrophy of grey and white matter in the brain of HIV patients [39] . ...
doi:10.1371/journal.pone.0181642
pmid:28792504
pmcid:PMC5549695
fatcat:oclsbv5bbrd5ljjarsr3klymia
Altered intrinsic local activity and cognitive dysfunction in HIV patients: A resting-state fMRI study
2018
PLoS ONE
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The orbitofrontal cortex and primary sensorimotor area were more disrupted in HAND relative to HIV-IC and correlated with behavioral performance, suggesting these areas are relevant to cognitive impairment ...
Correlation analyses were performed between rsfMRI values and neuropsychological tests. rsfMRI analyses revealed decreased rsfMRI values in the frontal areas, and increases in the posterior brain regions ...
in HIV patients, they might be more relevant to cognitive impairment in this population. ...
doi:10.1371/journal.pone.0207146
pmid:30496203
pmcid:PMC6264476
fatcat:vrvygdob5vd5topa54q2qjy4qa
Astrocytes, HIV and the Glymphatic System: A Disease of Disrupted Waste Management?
2020
Frontiers in Cellular and Infection Microbiology
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Similar to AD, HIV infection of the CNS contributes to abnormal aging with altered AQP4 localization, accumulation of pTau and chronic neuroinflammation. ...
The discovery of the glial-lymphatic or glymphatic fluid clearance pathway in the rodent brain led researchers to search for a parallel system in humans and to question the implications of this pathway ...
In this context, decreased glymphatic clearance may increase the risk of neurodegenerative changes contributing to cognitive decline in the aging population or in age-related CNS diseases (Rainey-Smith ...
doi:10.3389/fcimb.2020.523379
pmid:33134185
pmcid:PMC7550659
fatcat:am4c52v5knhujmjgptre5zt4ta
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