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Disentangling in vivo the effects of iron content and atrophy on the ageing human brain

S. Lorio, A. Lutti, F. Kherif, A. Ruef, J. Dukart, R. Chowdhury, R.S. Frackowiak, J. Ashburner, G. Helms, N. Weiskopf, B. Draganski
2014 NeuroImage  
We interpret our findings as direct evidence for the impact of ageing-related brain tissue property changes on automated tissue classification of brain structures using SPM12.  ...  The reliable delineation of cortex and basal ganglia using automated computational anatomy methods based on T1-weighted images remains challenging, which results in controversies in the literature.  ...  the Novartis Foundation for medical-biological research and the German Research Council (DFG, KFO 247).  ... 
doi:10.1016/j.neuroimage.2014.09.044 pmid:25264230 pmcid:PMC4263529 fatcat:qcxvnbe7vna3hmyw5ot4flqct4

Disentangling molecular alterations from water-content changes in the aging human brain using quantitative MRI

Shir Filo, Oshrat Shtangel, Noga Salamon, Adi Kol, Batsheva Weisinger, Sagiv Shifman, Aviv A. Mezer
2019 Nature Communications  
However, qMRI measurements change in response to both molecular composition and water content.  ...  Quantitative magnetic resonance imaging (qMRI) provides biophysical parametric measurements allowing for non-invasive mapping of the aging human brain.  ...  We thank Inbal Goshen for assigning research lab space and advising on the protein and ion samples as well as the porcine brain experiments.  ... 
doi:10.1038/s41467-019-11319-1 pmid:31363094 pmcid:PMC6667463 fatcat:wscp6yfkwndsnin2wcxd4hkvlq

Brain Aging and Its Modifiers: Insights from in Vivo Neuromorphometry and Susceptibility Weighted Imaging

N. RAZ, K. M RODRIGUE, E. M. HAACKE
2007 Annals of the New York Academy of Sciences  
Future research on brain aging would benefit from combining structural and metabolic techniques in a longitudinal design, as such studies will allow examination of leading-trailing effects of those factors  ...  Cross-sectional studies of brain volume reveal greater age-related shrinkage of the prefrontal cortex (PFC) and the hippocampus than in the entorhinal and primary visual cortex.  ...  ACKNOWLEDGMENT This work was supported in part by a grant R37-AG-11230 from the National Institute on Aging. We thank Y-C.N. Chang for stimulating discussion of the topics covered in this article.  ... 
doi:10.1196/annals.1379.018 pmid:17413014 pmcid:PMC2630248 fatcat:g5j7gnjrzbeo7drfesqswc5w6a

Widespread age-related differences in the human brain microstructure revealed by quantitative magnetic resonance imaging

Martina F. Callaghan, Patrick Freund, Bogdan Draganski, Elaine Anderson, Marinella Cappelletti, Rumana Chowdhury, Joern Diedrichsen, Thomas H.B. FitzGerald, Peter Smittenaar, Gunther Helms, Antoine Lutti, Nikolaus Weiskopf
2014 Neurobiology of Aging  
This study aims to characterize the spatial pattern and age-related differences of biologically relevant measures in vivo over the course of normal aging.  ...  This whole-brain pattern of age-associated microstructural differences in the asymptomatic population provides insight into the neurobiology of aging.  ...  Foundation for medicalebiological research, and Deutsche Forschungsgemeinschaft (Kfo 247 [Bogdan Draganski]); the Royal Society Dorothy Hodgkin Fellowship and Project Grant (Marinella Cappelletti).  ... 
doi:10.1016/j.neurobiolaging.2014.02.008 pmid:24656835 pmcid:PMC4024196 fatcat:rzbnvfoj5fhwhdgucbsopv3a2m

Neuroimaging, nutrition, and iron-related genes

Neda Jahanshad, Priya Rajagopalan, Paul M. Thompson
2013 Cellular and Molecular Life Sciences (CMLS)  
Finally, we outline some recent discoveries regarding the genetics of iron and its effects on the brain, suggesting the promise of neuroimaging in revealing how dietary factors affect the brain.  ...  human brain changes dynamically throughout life, and profound changes occur from childhood to old age, and, in particular, with the progression of disease.  ...  Acknowledgments we are very grateful for the support of our colleagues and co-authors at the UCLA School of Medicine and the University of Queensland who helped to design and perform many of the brain  ... 
doi:10.1007/s00018-013-1369-2 pmid:23817740 pmcid:PMC3827893 fatcat:sygiub6vnnbe5he6jzpffvv544

Uncovering molecular iron compounds in the living human brain [article]

Shir Filo, Rona Shaharabani, Daniel Bar Hanin, Masha Adam, Eliel Ben-David, Hanan Schoffman, Nevo Margalit, Naomi Habib, Tal Shahar, Aviv Mezer
2022 bioRxiv   pre-print
In the in vivo human brain, we validate our approach against ex vivo iron compounds quantification and gene expression.  ...  Therefore, our approach may allow for non-invasive research and diagnosis of iron homeostasis in living human brains.  ...  R2* mapping for brain iron: Associations with cognition in normal aging. 29. Lorio, S. et al. Disentangling in vivo the effects of iron content and atrophy on the ageing human brain. 34.  ... 
doi:10.1101/2022.05.02.490254 fatcat:npwquwgztjfnjgxjw5lsi35fti

Iron Level and Myelin Content in the Ventral Striatum Predict Memory Performance in the Aging Brain

T. K. Steiger, N. Weiskopf, N. Bunzeck
2016 Journal of Neuroscience  
As iron accumulates, a degeneration of myelin sheaths has been observed in the elderly, but the relationship between both and their impact on memory performance in healthy elderly humans remain important  ...  As expected, we observed a decrease in gray matter volume and myelin, and an increase of iron in the elderly relative to the young subjects within widespread brain regions, including the basal ganglia.  ...  In summary, we provide novel in vivo evidence that healthy aging is associated with higher levels of iron within the basal ganglia and a negative correlation between iron and myelin.  ... 
doi:10.1523/jneurosci.3617-15.2016 pmid:27013683 pmcid:PMC4804012 fatcat:qj7p6c3cmfgctj7w7rbtnyqw7a

Contribution of normal aging to brain atrophy in MS

Christina J. Azevedo, Steven Y. Cen, Amir Jaberzadeh, Ling Zheng, Stephen L. Hauser, Daniel Pelletier
2019 Neurology: Neuroimmunology & Neuroinflammation  
To identify the top brain regions affected by MS-specific atrophy (i.e., atrophy in excess of normal aging) and to test whether normal aging and MS-specific atrophy increase or decrease in these regions  ...  This may have substantial implications to understand the biology of brain atrophy in MS.  ...  All authors had full access to the data and take responsibility for the content of this article.  ... 
doi:10.1212/nxi.0000000000000616 pmid:32330116 pmcid:PMC6807662 fatcat:mwygixtsafdd7nyfy2c4aaxwnq

The whole-brain pattern of magnetic susceptibility perturbations in Parkinson's disease

Julio Acosta-Cabronero, Arturo Cardenas-Blanco, Matthew J. Betts, Michaela Butryn, Jose P. Valdes-Herrera, Imke Galazky, Peter J. Nestor
2016 Brain  
analysis, subcortical volumetry and tract-based diffusion tensor analysis; confirming the potential of whole-brain quantitative susceptibility mapping as an in vivo biomarker in Parkinson's disease.  ...  In addition to whole-brain analysis, a regional study including sub-segmentation of the substantia nigra into dorsal and ventral regions and qualitative assessment of susceptibility maps in single subjects  ...  Acknowledgements We are very grateful to all the participants who made this research possible. We also thank Mrs Urte Schneider, Parkinson's disease magnetostatics BRAIN 2017: 140; 118-131 | 129  ... 
doi:10.1093/brain/aww278 pmid:27836833 fatcat:6ffoto2mbna4xfets2qnru3diy

Neurobiological origin of spurious brain morphological changes: A quantitative MRI study

Sara Lorio, Ferath Kherif, Anne Ruef, Lester Melie-Garcia, Richard Frackowiak, John Ashburner, Gunther Helms, Antoine Lutti, Bodgan Draganski
2016 Human Brain Mapping  
Our findings highlight the impact of microstructural properties of brain tissue-myelination, iron, and water content-on automated measures of brain morphology and show that microstructural tissue changes  ...  We acquired quantitative maps of the MRI parameters that determine signal intensities in T1-weighted images (R 1 (51/T1), R 2 *, and PD) in a large cohort of healthy subjects (n 5 120, aged 18-87 years  ...  We attribute this effect to the sensitivity of R 2 * to iron concentration, which increases with age in the basal ganglia.  ... 
doi:10.1002/hbm.23137 pmid:26876452 pmcid:PMC4855623 fatcat:qzeocfxclzefnofdaapzjbs6je

Genetics and Pathophysiology of Neurodegeneration with Brain Iron Accumulation (NBIA)

Susanne A. Schneider, Petr Dusek, John Hardy, Ana Westenberger, Joseph Jankovic, Kailash P. Bhatia
2013 Current Neuropharmacology  
We then focus on clinical features and investigational findings in NBIA and summarize therapeutic results reviewing reports of iron chelation therapy and deep brain stimulation.  ...  Our understanding of the syndromes of Neurodegeneration with Brain Iron Accumulation (NBIA) continues to grow considerably.  ...  None of the funders had any input into the writing of this manuscript. We also thank W. Christie for useful discussion.  ... 
doi:10.2174/157015913804999469 pmid:23814539 pmcid:PMC3580793 fatcat:l2ouzjhmgjgmfn2npzpzrqyg3y

Striatal Iron Content Predicts Its Shrinkage and Changes in Verbal Working Memory after Two Years in Healthy Adults

A. M. Daugherty, E. M. Haacke, N. Raz
2015 Journal of Neuroscience  
The accumulation of non-heme iron in the brain has been proposed as a harbinger of neural and cognitive decline in aging and neurodegenerative disease, but support for this proposal has been drawn from  ...  Here, we present longitudinal evidence of subcortical iron accumulation in healthy human adults (age 19 -77 at baseline).  ...  These factors should be considered in investigating the role of iron in the brain and in cognitive aging.  ... 
doi:10.1523/jneurosci.4717-14.2015 pmid:25926451 pmcid:PMC4412893 fatcat:lfuywvrvcjg2vacczyjjsvh33u

Systematic Review: Quantitative Susceptibility Mapping (QSM) of Brain Iron Profile in Neurodegenerative Diseases

Parsa Ravanfar, Samantha M. Loi, Warda T. Syeda, Tamsyn E. Van Rheenen, Ashley I. Bush, Patricia Desmond, Vanessa L. Cropley, Darius J. R. Lane, Carlos M. Opazo, Bradford A. Moffat, Dennis Velakoulis, Christos Pantelis
2021 Frontiers in Neuroscience  
As a general pattern, QSM revealed increased magnetic susceptibility (suggestive of increased iron content) in the brain regions associated with the pathology of each disorder, such as the amygdala and  ...  Iron has been increasingly implicated in the pathology of neurodegenerative diseases.  ...  For the reasons mentioned above, in vivo evaluation of brain iron has been of great interest in neurodegenerative diseases.  ... 
doi:10.3389/fnins.2021.618435 pmid:33679303 pmcid:PMC7930077 fatcat:jkqbluctcja3pjbh7je4ttocpu

Imaging outcome measures of neuroprotection and repair in MS

Jiwon Oh, Daniel Ontaneda, Christina Azevedo, Eric C. Klawiter, Martina Absinta, Douglas L. Arnold, Rohit Bakshi, Peter A. Calabresi, Ciprian Crainiceanu, Blake Dewey, Leorah Freeman, Susan Gauthier (+23 others)
2019 Neurology  
To summarize current and emerging imaging techniques that can be used to assess neuroprotection and repair in multiple sclerosis (MS), and to provide a consensus opinion on the potential utility of each  ...  technique in clinical trial settings.  ...  tissue abnormalities (US Patent 9607392) issued, and a patent method of analyzing multi-sequence MRI data for analyzing brain abnormalities in a subject (US20150045651A1) pending.  ... 
doi:10.1212/wnl.0000000000007099 pmid:30787160 pmcid:PMC6511106 fatcat:btpd5d5crzgkhowxxmoob6eiyy

Vitamin C, Aging and Alzheimer's Disease

2017 Nutrients  
iron, copper, and zinc, and on the suppression of amyloid-beta peptide (Aβ) fibrillogenesis.  ...  Growing in vivo evidence supports the role of ascorbic acid in ameliorating factors linked to Alzheimer's disease (AD) pathogenesis, although evidence in humans yielded equivocal results.  ...  So far, there is inconsistent data on epigenetic modifications in the human brain.  ... 
doi:10.3390/nu9070670 pmid:28654021 pmcid:PMC5537785 fatcat:vacrb6z4gfa7ndvpqr7yp4pgmy
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