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Brain hyperintensity location determines outcome in the triad of impaired cognition, physical health and depressive symptoms: A cohort study in late life

Alison Murray, Chris McNeil, Sima Salarirad, Ian Deary, Louise Phillips, Lawrence Whalley, Roger Staff
2016 Archives of gerontology and geriatrics (Print)  
Acknowledgements The authors would like to thank the participants of the Aberdeen 1936 Birth Cohort (ABC36). Image acquisition and image analysis for ABC36 were funded by the Alzheimer's  ...  This association is mediated by white matter hyperintensities (WMH) as evidence of microvascular injury.  ...  TS = Total Scheltens's score, WMH = white matter hyperintensities, PVH = perinventricular hyperintensities, GMH = grey matter hyperintensities, ITH = infratentorial hyperintensities.  ... 
doi:10.1016/j.archger.2015.10.004 pmid:26791171 fatcat:3tccvpk5g5en5immqvds56wkwe

The effect of vascular health factors on white matter microstructure mediates age-related differences in executive function performance

David A. Hoagey, Linh T.T. Lazarus, Karen M. Rodrigue, Kristen M. Kennedy
2021 Cortex  
pressure (BP) and white matter hyperintensity (WMH) burden influences this association.  ...  Additionally, increased systolic blood pressure and white matter hyperintensity burden within these white matter tracts contribute to worsening white matter health and are important factors underlying  ...  We thank Samantha Owens for assistance with white matter hyperintensity measurements and visual inspection.  ... 
doi:10.1016/j.cortex.2021.04.016 pmid:34130048 fatcat:w264jx4mazbilgu75xkjjlmgju

The effect of vascular health factors on white matter microstructure mediates age-related differences in executive function performance [article]

David A Hoagey, Linh T.T. Lazarus, Karen M Rodrigue, Kristen Michelle Kennedy
2020 bioRxiv   pre-print
pressure (BP) and white matter hyperintensity (WMH) burden influences this association.  ...  Additionally, increased systolic blood pressure and white matter hyperintensity burden within these white matter tracts contribute to worsening white matter health and are important factors underlying  ...  Thus, it is essential to quantify regional white matter hyperintensities and include blood pressure measurements in the study of white matter and cognitive aging. was not certified by peer review) is the  ... 
doi:10.1101/2020.05.14.096677 fatcat:l7lf5eje4nh3nb7kkry2o4d7ru

Baseline white matter microstructural integrity is not related to cognitive decline after 5years: The RUN DMC study

I.W.M. van Uden, H.M. van der Holst, P. Schaapsmeerders, A.M. Tuladhar, A.G.W. van Norden, K.F. de Laat, D.G. Norris, J.A.H.R. Claassen, E.J. van Dijk, E. Richard, R.P.C. Kessels, F.-E. de Leeuw
2015 BBA Clinical  
Conclusions: In contrast to cross-sectional studies, in older adults with SVD microstructural integrity of the white matter as assessed with DTI is not related to decline in global cognitive function or  ...  Little is known about the association between microstructural integrity of the white matter and changes in cognition.  ...  The interconnected neural networks, crucial for cognitive performance, are hypothesized to be disconnected by this damage in the white matter microstructure, also known as the "disconnection syndrome"  ... 
doi:10.1016/j.bbacli.2015.10.001 pmid:26676146 pmcid:PMC4661735 fatcat:firuqjjiivc2tgeiktidc7cbx4

Large‐scale network dysfunction in vascular cognitive disorder supports connectional diaschisis in advanced arteriosclerosis

Dewen Meng, Akram A. Hosseini, Richard J. Simpson, Thomas Welton, Robert A. Dineen, Dorothee P. Auer
2019 European Journal of Neurology  
Our aim was to investigate the associations between FC, white matter damage and cognitive impairment in carotid artery disease.  ...  In order to explore the nature of FC changes, their associations with microstructural damage of related white matter tracts and cognitive performance were investigated, followed by mediation analysis.  ...  Acknowledgements The authors are grateful to the ICAD participants and the MRI radiographers in the Queen's Medical Centre, Nottingham, for scanning our participants.  ... 
doi:10.1111/ene.14084 pmid:31505084 fatcat:apphzp76n5fwjj4wwurxkimkr4

Subcortical Hyperintensities Are Associated With Cognitive Decline in Patients With Mild Cognitive Impairment

S. Debette, S. Bombois, A. Bruandet, X. Delbeuck, S. Lepoittevin, C. Delmaire, D. Leys, F. Pasquier
2007 Stroke  
We aimed to test whether cognitive decline is associated with subcortical hyperintensities in patients with mild cognitive impairment (MCI).  ...  Conclusion-White-matter hyperintensities and especially PVH were significantly associated with cognitive decline in MCI patients.  ...  , 0 to 84), 4 subtypes of SH were assessed: periventricular hyperintensities (PVH; range, 0 to 6), white-matter hyperintensities (WMH; range, 0 to 24), hyperintensities in the basal ganglia (range, 0 to  ... 
doi:10.1161/strokeaha.107.488403 pmid:17885256 fatcat:4vowi5ftvjb5pdiofyp5nqsqjy

Structural network efficiency predicts cognitive decline in cerebral small vessel disease

Esther M. Boot, Esther MC van Leijsen, Mayra I. Bergkamp, Roy P.C. Kessels, David G. Norris, Frank-Erik de Leeuw, Anil M. Tuladhar
2020 NeuroImage: Clinical  
with lower scores on cognitive performance independent of MRI markers for SVD.  ...  White matter network damage is a potentially important mechanism by which SVD causes cognitive impairment.  ...  The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.  ... 
doi:10.1016/j.nicl.2020.102325 pmid:32622317 pmcid:PMC7334365 fatcat:a7wkptozbvcmxoqpqjkuiwdaei

Effect of white matter disease on functional connections in the aging brain

A F Leuchter, J J Dunkin, R B Lufkin, Y Anzai, I A Cook, T F Newton
1994 Journal of Neurology, Neurosurgery and Psychiatry  
Periventricular white matter hyperintensities (PVHs) seen on T2 weighted MRI studies are common in elderly people and often represent demyelination of fibres.  ...  Damage to these fibres could lead to functional disconnection between brain regions.  ...  As mentioned earlier, most studies have not detected an effect of hyperintensities on cognition in neurologically normal subjects.1921-23 Severe white matter disease, however, is associated with cognitive  ... 
doi:10.1136/jnnp.57.11.1347 pmid:7964810 pmcid:PMC1073185 fatcat:znox2jdm7jecdpc5oy6nat2lvm

Sources of disconnection in neurocognitive aging: cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume

David J. Madden, Emily L. Parks, Catherine W. Tallman, Maria A. Boylan, David A. Hoagey, Sally B. Cocjin, Lauren E. Packard, Micah A. Johnson, Ying-hui Chou, Guy G. Potter, Nan-kuei Chen, Rachel E. Siciliano (+3 others)
2017 Neurobiology of Aging  
We investigated imaging measures of cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume as mediators of the relation between age and fluid cognition  ...  Age-related decline in fluid cognition can be characterized as a disconnection among specific brain structures, leading to a decline in functional efficiency.  ...  The authors are grateful to Ling Zou, Syam Gadde, Chris Petty, Max Horowitz, and Kristin Sundy for their assistance.  ... 
doi:10.1016/j.neurobiolaging.2017.01.027 pmid:28389085 pmcid:PMC5401777 fatcat:4krgzbx4ojemlngt7l4yivk46y

Analysis of correlation between cerebral perfusion and KIM score of white matter lesions in patients with Alzheimer's disease

Li RR, He YS, Liu M, Nie ZY, Huang LH, Lu Z, Jin LJ, Li YX
2019 Neuropsychiatric Disease and Treatment  
Montreal cognitive assessment (MoCA) was employed for the assessment of cognition. Cranial MRI was performed, and the KIM scoring system was used to evaluate the white matter hyperintensity.  ...  characterize white matter lesions (WMLs) and regional cerebral perfusion, and evaluate their correlations with cognitive deficits in Alzheimer's disease (AD) patients.Patient and methods: One hundred  ...  Based on these findings, we speculate that the cognitive impairment in AD patients is associated with the damage to the white matter pathway due to reduced perfusion (especially at PVWML and JVWML), which  ... 
doaj:cfeb5149f9b2412cb01d082adbce0a7a fatcat:kxtxvrqi7neixf7koeg2gvqzvm

Dysexecutive syndrome and cerebrovascular disease in non-amnestic mild cognitive impairment: a systematic review of the literature

Felipe Kenji Sudo, Carlos Eduardo Oliveira Alves, Gilberto Sousa Alves, Letice Ericeira-Valente, Chan Tiel, Denise Madeira Moreira, Jerson Laks, Eliasz Engelhardt
2012 Dementia & Neuropsychologia  
Executive dysfunction might be associated with disconnection of fronto-parietal-subcortical circuits.  ...  Discussion: VaMCI develops with impairment in non-memory domains and subcortical white matter changes on MRI images, which are consistent with clinical and neuroimaging findings in VaD.  ...  The authors would like to thank Dr. Evandro Coutinho for technical support and the Conselho Nacional de Pesquisa (CNPq) for supporting Jerson Laks, who is a Researcher 2 of CNPq.  ... 
doi:10.1590/s1980-57642012dn06030006 pmid:29213788 pmcid:PMC5618961 fatcat:6uciyiez7ngwviqcmfluqo5ore

Subclinical cerebrovascular disease inversely associates with learning ability: The NOMAS

H. Glazer, C. Dong, M. Yoshita, T. Rundek, M. S. V. Elkind, R. L. Sacco, C. DeCarli, Y. Stern, C. B. Wright
2015 Neurology  
Methods: A clinically stroke-free subset of Northern Manhattan Study participants underwent cognitive testing and brain MRI with quantification of white matter hyperintensity volume (WMHV) and total cerebral  ...  Conclusions: White matter hyperintensities, a marker of cerebral small vessel disease, may have an impact on learning slope.  ...  Both greater WMHV and smaller cerebral volumes were associated with fewer total words learned over 5 trials, but white matter hyperintensity load, and not lower cerebral volume, was associated with flatter  ... 
doi:10.1212/wnl.0000000000001657 pmid:26002489 pmcid:PMC4464740 fatcat:2zt4x7isazcr7kczddrnoocq3a

White matter integrity in small vessel disease is related to cognition

Anil M. Tuladhar, Anouk G.W. van Norden, Karlijn F. de Laat, Marcel P. Zwiers, Ewoud J. van Dijk, David G. Norris, Frank-Erik de Leeuw
2015 NeuroImage: Clinical  
Cerebral small vessel disease, including white matter hyperintensities (WMH) and lacunes of presumed vascular origin, is common in elderly people and is related to cognitive impairment and dementia.  ...  In conclusion, cognitive disturbances in subjects with cerebral small vessel disease are related to microstructural integrity of multiple white matter fibers (within WMH and normal-appearing white matter  ...  This is supposedly due to the disruption of important white matter (WM) tracts.  ... 
doi:10.1016/j.nicl.2015.02.003 pmid:25737960 pmcid:PMC4338206 fatcat:asxn3eizhzf4bb3uhy57dmtjii

Reduced glucose uptake and Aβ in brain regions with hyperintensities in connected white matter

L. Glodzik, A. Kuceyeski, H. Rusinek, W. Tsui, L. Mosconi, Y. Li, R.S. Osorio, S. Williams, C. Randall, N. Spector, P. McHugh, J. Murray (+4 others)
2014 NeuroImage  
White matter lesions (WML) disrupt connections between gray matter (GM) regions which in turn changes their activation patterns.  ...  Interstitial concentration of amyloid beta (Aß) is positively related to synaptic activity in animal experiments.  ...  White matter lesions (WML) manifesting as areas of hyperintense signal on MRI images are, alongside brain atrophy, the most common pathological findings associated with aging [de Leeuw et al., 2001] .  ... 
doi:10.1016/j.neuroimage.2014.06.060 pmid:24999038 pmcid:PMC4138232 fatcat:somsgszjyndfrbnfagofacwfue

Impaired Structural Network Properties Caused by White Matter Hyperintensity Related to Cognitive Decline

Dan Yang, Lili Huang, Caimei Luo, Mengchun Li, Ruomeng Qin, Junyi Ma, Pengfei Shao, Hengheng Xu, Bing Zhang, Yun Xu, Meijuan Zhang
2020 Frontiers in Neurology  
Purpose: There is a high correlation between white matter hyperintensity (WMH) and cognitive impairment (CI) in elderly people.  ...  This study aimed to investigate the topological properties of white matter structural network in WMH-related CI.  ...  Langen CD, Cremers LGM, de Groot M, White T, Ikram MA, Niessen WJ, et al. Disconnection due to white matter hyperintensities is associated with lower cognitive scores.  ... 
doi:10.3389/fneur.2020.00250 pmid:32373044 pmcid:PMC7186334 fatcat:7x3wtrvagvgbzdi4rtoyncc5fy
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