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Brain hyperintensity location determines outcome in the triad of impaired cognition, physical health and depressive symptoms: A cohort study in late life
2016
Archives of gerontology and geriatrics (Print)
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Acknowledgements The authors would like to thank the participants of the Aberdeen 1936 Birth Cohort (ABC36). Image acquisition and image analysis for ABC36 were funded by the Alzheimer's ...
This association is mediated by white matter hyperintensities (WMH) as evidence of microvascular injury. ...
TS = Total Scheltens's score, WMH = white matter hyperintensities, PVH = perinventricular hyperintensities, GMH = grey matter hyperintensities, ITH = infratentorial hyperintensities. ...
doi:10.1016/j.archger.2015.10.004
pmid:26791171
fatcat:3tccvpk5g5en5immqvds56wkwe
The effect of vascular health factors on white matter microstructure mediates age-related differences in executive function performance
2021
Cortex
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pressure (BP) and white matter hyperintensity (WMH) burden influences this association. ...
Additionally, increased systolic blood pressure and white matter hyperintensity burden within these white matter tracts contribute to worsening white matter health and are important factors underlying ...
We thank Samantha Owens for assistance with white matter hyperintensity measurements and visual inspection. ...
doi:10.1016/j.cortex.2021.04.016
pmid:34130048
fatcat:w264jx4mazbilgu75xkjjlmgju
The effect of vascular health factors on white matter microstructure mediates age-related differences in executive function performance
[article]
2020
bioRxiv
pre-print
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pressure (BP) and white matter hyperintensity (WMH) burden influences this association. ...
Additionally, increased systolic blood pressure and white matter hyperintensity burden within these white matter tracts contribute to worsening white matter health and are important factors underlying ...
Thus, it is essential to quantify regional white matter hyperintensities and include blood pressure measurements in the study of white matter and cognitive aging. was not certified by peer review) is the ...
doi:10.1101/2020.05.14.096677
fatcat:l7lf5eje4nh3nb7kkry2o4d7ru
Baseline white matter microstructural integrity is not related to cognitive decline after 5years: The RUN DMC study
2015
BBA Clinical
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Conclusions: In contrast to cross-sectional studies, in older adults with SVD microstructural integrity of the white matter as assessed with DTI is not related to decline in global cognitive function or ...
Little is known about the association between microstructural integrity of the white matter and changes in cognition. ...
The interconnected neural networks, crucial for cognitive performance, are hypothesized to be disconnected by this damage in the white matter microstructure, also known as the "disconnection syndrome" ...
doi:10.1016/j.bbacli.2015.10.001
pmid:26676146
pmcid:PMC4661735
fatcat:firuqjjiivc2tgeiktidc7cbx4
Large‐scale network dysfunction in vascular cognitive disorder supports connectional diaschisis in advanced arteriosclerosis
2019
European Journal of Neurology
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Our aim was to investigate the associations between FC, white matter damage and cognitive impairment in carotid artery disease. ...
In order to explore the nature of FC changes, their associations with microstructural damage of related white matter tracts and cognitive performance were investigated, followed by mediation analysis. ...
Acknowledgements The authors are grateful to the ICAD participants and the MRI radiographers in the Queen's Medical Centre, Nottingham, for scanning our participants. ...
doi:10.1111/ene.14084
pmid:31505084
fatcat:apphzp76n5fwjj4wwurxkimkr4
Subcortical Hyperintensities Are Associated With Cognitive Decline in Patients With Mild Cognitive Impairment
2007
Stroke
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We aimed to test whether cognitive decline is associated with subcortical hyperintensities in patients with mild cognitive impairment (MCI). ...
Conclusion-White-matter hyperintensities and especially PVH were significantly associated with cognitive decline in MCI patients. ...
, 0 to 84), 4 subtypes of SH were assessed: periventricular hyperintensities (PVH; range, 0 to 6), white-matter hyperintensities (WMH; range, 0 to 24), hyperintensities in the basal ganglia (range, 0 to ...
doi:10.1161/strokeaha.107.488403
pmid:17885256
fatcat:4vowi5ftvjb5pdiofyp5nqsqjy
Structural network efficiency predicts cognitive decline in cerebral small vessel disease
2020
NeuroImage: Clinical
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with lower scores on cognitive performance independent of MRI markers for SVD. ...
White matter network damage is a potentially important mechanism by which SVD causes cognitive impairment. ...
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. ...
doi:10.1016/j.nicl.2020.102325
pmid:32622317
pmcid:PMC7334365
fatcat:a7wkptozbvcmxoqpqjkuiwdaei
Effect of white matter disease on functional connections in the aging brain
1994
Journal of Neurology, Neurosurgery and Psychiatry
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Periventricular white matter hyperintensities (PVHs) seen on T2 weighted MRI studies are common in elderly people and often represent demyelination of fibres. ...
Damage to these fibres could lead to functional disconnection between brain regions. ...
As mentioned earlier, most studies have not detected an effect of hyperintensities on cognition in neurologically normal subjects.1921-23 Severe white matter disease, however, is associated with cognitive ...
doi:10.1136/jnnp.57.11.1347
pmid:7964810
pmcid:PMC1073185
fatcat:znox2jdm7jecdpc5oy6nat2lvm
Sources of disconnection in neurocognitive aging: cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume
2017
Neurobiology of Aging
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We investigated imaging measures of cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume as mediators of the relation between age and fluid cognition ...
Age-related decline in fluid cognition can be characterized as a disconnection among specific brain structures, leading to a decline in functional efficiency. ...
The authors are grateful to Ling Zou, Syam Gadde, Chris Petty, Max Horowitz, and Kristin Sundy for their assistance. ...
doi:10.1016/j.neurobiolaging.2017.01.027
pmid:28389085
pmcid:PMC5401777
fatcat:4krgzbx4ojemlngt7l4yivk46y
Analysis of correlation between cerebral perfusion and KIM score of white matter lesions in patients with Alzheimer's disease
2019
Neuropsychiatric Disease and Treatment
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Montreal cognitive assessment (MoCA) was employed for the assessment of cognition. Cranial MRI was performed, and the KIM scoring system was used to evaluate the white matter hyperintensity. ...
characterize white matter lesions (WMLs) and regional cerebral perfusion, and evaluate their correlations with cognitive deficits in Alzheimer's disease (AD) patients.Patient and methods: One hundred ...
Based on these findings, we speculate that the cognitive impairment in AD patients is associated with the damage to the white matter pathway due to reduced perfusion (especially at PVWML and JVWML), which ...
doaj:cfeb5149f9b2412cb01d082adbce0a7a
fatcat:kxtxvrqi7neixf7koeg2gvqzvm
Dysexecutive syndrome and cerebrovascular disease in non-amnestic mild cognitive impairment: a systematic review of the literature
2012
Dementia & Neuropsychologia
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Executive dysfunction might be associated with disconnection of fronto-parietal-subcortical circuits. ...
Discussion: VaMCI develops with impairment in non-memory domains and subcortical white matter changes on MRI images, which are consistent with clinical and neuroimaging findings in VaD. ...
The authors would like to thank Dr. Evandro Coutinho for technical support and the Conselho Nacional de Pesquisa (CNPq) for supporting Jerson Laks, who is a Researcher 2 of CNPq. ...
doi:10.1590/s1980-57642012dn06030006
pmid:29213788
pmcid:PMC5618961
fatcat:6uciyiez7ngwviqcmfluqo5ore
Subclinical cerebrovascular disease inversely associates with learning ability: The NOMAS
2015
Neurology
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Methods: A clinically stroke-free subset of Northern Manhattan Study participants underwent cognitive testing and brain MRI with quantification of white matter hyperintensity volume (WMHV) and total cerebral ...
Conclusions: White matter hyperintensities, a marker of cerebral small vessel disease, may have an impact on learning slope. ...
Both greater WMHV and smaller cerebral volumes were associated with fewer total words learned over 5 trials, but white matter hyperintensity load, and not lower cerebral volume, was associated with flatter ...
doi:10.1212/wnl.0000000000001657
pmid:26002489
pmcid:PMC4464740
fatcat:2zt4x7isazcr7kczddrnoocq3a
White matter integrity in small vessel disease is related to cognition
2015
NeuroImage: Clinical
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Cerebral small vessel disease, including white matter hyperintensities (WMH) and lacunes of presumed vascular origin, is common in elderly people and is related to cognitive impairment and dementia. ...
In conclusion, cognitive disturbances in subjects with cerebral small vessel disease are related to microstructural integrity of multiple white matter fibers (within WMH and normal-appearing white matter ...
This is supposedly due to the disruption of important white matter (WM) tracts. ...
doi:10.1016/j.nicl.2015.02.003
pmid:25737960
pmcid:PMC4338206
fatcat:asxn3eizhzf4bb3uhy57dmtjii
Reduced glucose uptake and Aβ in brain regions with hyperintensities in connected white matter
2014
NeuroImage
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White matter lesions (WML) disrupt connections between gray matter (GM) regions which in turn changes their activation patterns. ...
Interstitial concentration of amyloid beta (Aß) is positively related to synaptic activity in animal experiments. ...
White matter lesions (WML) manifesting as areas of hyperintense signal on MRI images are, alongside brain atrophy, the most common pathological findings associated with aging [de Leeuw et al., 2001] . ...
doi:10.1016/j.neuroimage.2014.06.060
pmid:24999038
pmcid:PMC4138232
fatcat:somsgszjyndfrbnfagofacwfue
Impaired Structural Network Properties Caused by White Matter Hyperintensity Related to Cognitive Decline
2020
Frontiers in Neurology
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Purpose: There is a high correlation between white matter hyperintensity (WMH) and cognitive impairment (CI) in elderly people. ...
This study aimed to investigate the topological properties of white matter structural network in WMH-related CI. ...
Langen CD, Cremers LGM, de Groot M, White T, Ikram MA, Niessen WJ, et al. Disconnection due to white matter hyperintensities is associated with lower cognitive scores. ...
doi:10.3389/fneur.2020.00250
pmid:32373044
pmcid:PMC7186334
fatcat:7x3wtrvagvgbzdi4rtoyncc5fy
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