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Direct Parametric Image Reconstruction of Rapid Multi-tracer PET [chapter]

Xiaoyin Cheng, Nassir Navab, Sibylle I. Ziegler, Kuangyu Shi
2013 Lecture Notes in Computer Science  
This study developed a novel direct parametric reconstruction method by integrating a multi-tracer model with reduced number of fitting parameters into image reconstruction.  ...  The algorithm was validated on realistic simulation phantoms and real rapid [ 18 F]FDG and [ 18 F]FLT PET imaging of mice with lymphoma mouse tumor.  ...  The better consistency of the results Conclusion This study proposed a novel direct rapid multi-tracer PET reconstruction algorithm which can robustly retrieve single tracer images from overlapped  ... 
doi:10.1007/978-3-642-40760-4_20 fatcat:kl3guftlsra4pnbboebcrqml6q

Towards enhanced PET quantification in clinical oncology

Habib Zaidi, Nicolas Karakatsanis
2018 British Journal of Radiology  
(4D) parametric imaging methods in clinical oncology.  ...  PET image quantification enables to ascertain a direct link between the time-varying activity concentration in organs/tissues and the fundamental parameters portraying the biological processes at the cellular  ...  AdvANced strAteGies For iNdirect ANd direct PArAMetric wHole-bodY iMAGiNG Parametric PET imaging involves the spatiotemporal or dynamic (4D) acquisition of the administered PET tracer activity distribution  ... 
doi:10.1259/bjr.20170508 pmid:29164924 fatcat:7gtiavdgtzad3g6q7sos2orhx4

Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking

Evan D. Morris, Su Jin Kim, Jenna M. Sullivan, Shuo Wang, Marc D. Normandin, Cristian C. Constantinescu, Kelly P. Cosgrove
2013 Journal of Visualized Experiments  
Conventional methods for PET analysis estimate time-invariant kinetic model parameters which cannot capture short-term fluctuations in neurotransmitter release.  ...  Because our model is also linear in parameters, it is practical, computationally, to apply at the voxel level.  ...  Acknowledgements The authors thank the members of the Yale PET Center chemistry team for tracer synthesis, the imaging team for tracer injection and image acquisition and Ms.  ... 
doi:10.3791/50358 pmid:23963311 pmcid:PMC4046621 fatcat:bcismsqe6necbkv6z457kvpcua

Dynamic whole-body PET parametric imaging: I. Concept, acquisition protocol optimization and clinical application

Nicolas A Karakatsanis, Martin A Lodge, Abdel K Tahari, Y Zhou, Richard L Wahl, Arman Rahmim
2013 Physics in Medicine and Biology  
Here, we pursue a transition to dynamic whole-body PET parametric imaging, by presenting, within a unified framework, clinically feasible multi-bed dynamic PET acquisition protocols and parametric imaging  ...  Alternative PET protocols involving dynamic acquisition of temporal images have been implemented in the research setting, allowing quantification of tracer dynamics, an important capability for tumor characterization  ...  Furthermore, we would also like to acknowledge Dr Joyce Mhlanga and John Crandall for assistance in recruiting patients for our clinical studies, Andy Crabb for computational support, and Hassan Mohy-ud-Din  ... 
doi:10.1088/0031-9155/58/20/7391 pmid:24080962 pmcid:PMC3941007 fatcat:usorxqsr3na55bbrlz76ds5gxi

CALIPER: A software for blood-free parametric Patlak mapping using PET/MRI input function [article]

Praveen Dassanayake, Lumeng Cui, Elizabeth Finger, Matthew Kewin, Jennifer Hadaway, Andrea Soddu, Bjoern Jakoby, Sven Zuehlsdorff, Keith S St Lawrence, Gerald Moran, Udunna C Anazodo
2021 bioRxiv   pre-print
CALIPER generates regional values or parametric maps of net influx rate (Ki) for tracers using reconstructed dynamic PET images and anatomical MRI for IDIF vessel delineation.  ...  Overall, CALIPER is a promising tool for irreversible PET tracer quantification and can simplify the ability to perform parametric analysis in clinical settings without the need for blood sampling.  ...  The authors acknowledge the contribution of Pei-Shan Wei in implementing the input function fitting routine.  ... 
doi:10.1101/2021.07.08.451713 fatcat:qgem6d7glrevtfs3lw6r3mnnpm

Generalized whole-body Patlak parametric imaging for enhanced quantification in clinical PET

Nicolas A Karakatsanis, Yun Zhou, Martin A Lodge, Michael E Casey, Richard L Wahl, Habib Zaidi, Arman Rahmim
2015 Physics in Medicine and Biology  
As such, we recommend gPatlak for highly quantitative imaging tasks, while, for tasks emphasizing lesion detectability (e.g.  ...  In general, hPatlak was seen to outperform all methods in terms of target-to-background ratio (TBR) and CNR for all ROIs.  ...  Acknowledgments The authors would like to thank Dr Abdel K Tahari and John Crandall for assistance in recruiting patients.  ... 
doi:10.1088/0031-9155/60/22/8643 pmid:26509251 pmcid:PMC4710061 fatcat:g2fv3nnekjfx7e3qxebm7jqbqa

Quantitative assessment of dynamic PET imaging data in cancer imaging

Mark Muzi, Finbarr O'Sullivan, David A. Mankoff, Robert K. Doot, Larry A. Pierce, Brenda F. Kurland, Hannah M. Linden, Paul E. Kinahan
2012 Magnetic Resonance Imaging  
Dynamic PET imaging output parameters, particularly transport (flow) and overall metabolic rate, have provided imaging endpoints for clinical trials at single center institutions for years.  ...  Purpose-Clinical imaging in PET is often performed using single time point estimates of tracer uptake or static imaging that provides a spatial map of regional tracer concentration.  ...  Acknowledgments This work is supported in part by grants from the National Institutes of Health: U01-CA148131, P01-CA042045, R01-CA164371.  ... 
doi:10.1016/j.mri.2012.05.008 pmid:22819579 pmcid:PMC3466344 fatcat:66wf6qgkdrb4xfdlbsv4itrf24

Methodology for Quantitative Rapid Multi-Tracer PET Tumor Characterizations

Dan J. Kadrmas, John M. Hoffman
2013 Theranostics  
Rapid multi-tracer PET techniques have great potential for both research and clinical cancer imaging applications, and continued research in this area is warranted.  ...  the potential value of multi-tracer PET imaging in oncology.  ...  Parametric Images Parametric images display kinetic parameters on a voxel-by-voxel basis.  ... 
doi:10.7150/thno.5201 pmid:24312149 pmcid:PMC3840410 fatcat:3yu4qp43wvh63l2twcj2mzrlza

Comparison of PET template-based and MRI-based image processing in the quantitative analysis of C11-raclopride PET

Felix P Kuhn, Geoffrey I Warnock, Cyrill Burger, Katharina Ledermann, Chantal Martin-Soelch, Alfred Buck
2014 EJNMMI Research  
A PET template specific to raclopride may facilitate direct computation of parametric maps without the need for an additional MR scan, aiding automated image analysis.  ...  Conclusions: The PET template-based method for automated quantification of postsynaptic D 2 receptor density is simple to implement and facilitates rapid, robust and reliable image analysis.  ...  Acknowledgements The study team thanks Josephine Trinckauf, Verena Weichselbaumer, Marlena Hofbauer and their team from the PET-CT-MRI unit of the University Hospital Zurich for their excellent technical  ... 
doi:10.1186/2191-219x-4-7 pmid:24451009 pmcid:PMC3904930 fatcat:63n3nih5pzglnkddb3jipaf26y

Dynamic single photon emission computed tomography—basic principles and cardiac applications

Grant T Gullberg, Bryan W Reutter, Arkadiusz Sitek, Jonathan S Maltz, Thomas F Budinger
2010 Physics in Medicine and Biology  
The estimation of kinetic parameters directly from projection measurements improves bias and variance over the conventional method of first reconstructing 3D dynamic images, generating time-activity curves  ...  Although the potential applications of SPECT for imaging dynamic processes have not been fully realized in the clinic, it is hoped that this review illuminates the potential of SPECT for dynamic imaging  ...  We also want to thank Kathleen Gullberg for her helpful comments and edits.  ... 
doi:10.1088/0031-9155/55/20/r01 pmid:20858925 pmcid:PMC3306016 fatcat:6zgruhx37be7xcpdezgaswa7fu

ÉCole De Physique Des Houches [chapter]

2007 Les Houches  
activity in ideal surroundings for skiing, hiking or mountaineering.  ...  Established in 1951, the Physics School is located in a group of chalets surrounded by meadows and woods, at an altitude of 1150 m facing the Mont-Blanc range -a very favourable environment for intellectual  ...  C., Obry, F., Waltmann, E., Hadj-Rabia, S., Bodemer, C., Alembik, Y., Lesot, H., and Schmittbuhl, M. (2008) correlaTive analysis of recurrenT MulTicolor fluorescence iMaGes To characTerize in vivo  ... 
doi:10.1016/s0924-8099(13)60020-7 fatcat:jydcwidbbnf3nppqp4x3pyu6ga

École de Physique des Houches [chapter]

2008 Les Houches  
activity in ideal surroundings for skiing, hiking or mountaineering.  ...  Established in 1951, the Physics School is located in a group of chalets surrounded by meadows and woods, at an altitude of 1150 m facing the Mont-Blanc range -a very favourable environment for intellectual  ...  C., Obry, F., Waltmann, E., Hadj-Rabia, S., Bodemer, C., Alembik, Y., Lesot, H., and Schmittbuhl, M. (2008) correlaTive analysis of recurrenT MulTicolor fluorescence iMaGes To characTerize in vivo  ... 
doi:10.1016/s0924-8099(13)60004-9 fatcat:nxiezedqabbbtnfqonvw6c3doi

École de Physique des Houches [chapter]

2006 Les Houches  
activity in ideal surroundings for skiing, hiking or mountaineering.  ...  Established in 1951, the Physics School is located in a group of chalets surrounded by meadows and woods, at an altitude of 1150 m facing the Mont-Blanc range -a very favourable environment for intellectual  ...  C., Obry, F., Waltmann, E., Hadj-Rabia, S., Bodemer, C., Alembik, Y., Lesot, H., and Schmittbuhl, M. (2008) correlaTive analysis of recurrenT MulTicolor fluorescence iMaGes To characTerize in vivo  ... 
doi:10.1016/s0924-8099(06)80084-3 fatcat:6w7diik2k5af7cpowh4xz3nsky

Advances in clinical molecular imaging instrumentation

Brian F. Hutton, Kjell Erlandsson, Kris Thielemans
2018 Clinical and translational imaging  
In SPECT, CZT is well suited to multi-radionuclide and kinetic studies.  ...  For PET, SiPM technology provides MR compatibility and superior time-of-flight resolution, resulting in improved signal-to-noise ratio.  ...  The rapid development of solid-state read-out devices continues to reduce the barriers for PET TOF imaging, with theoretical limits for timing resolution now well below 100 ps.  ... 
doi:10.1007/s40336-018-0264-0 fatcat:jijyfdvxczholpvf3wdcq5ya54

What scans we will read: imaging instrumentation trends in clinical oncology

Thomas Beyer, Luc Bidaut, John Dickson, Marc Kachelriess, Fabian Kiessling, Rainer Leitgeb, Jingfei Ma, Lalith Kumar Shiyam Sundar, Benjamin Theek, Osama Mawlawi
2020 Cancer Imaging  
of reproducible quantitative parameters, an increase in volume sensitivity and a reduction in overall examination time.  ...  These include novel detector technologies for ionizing radiation used in CT and nuclear medicine imaging, and novel system developments in MRI and optical as well as opto-acoustic imaging.  ...  early time-point measurements shortly after tracer injection, and with parametric imaging.  ... 
doi:10.1186/s40644-020-00312-3 pmid:32517801 fatcat:jbfxzyffg5cqhkpkshnhpuoabu
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