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PET imaging of neurotransmission using direct parametric reconstruction

Yoann Petibon, Nathaniel M. Alpert, Jinsong Ouyang, Diego A. Pizzagalli, Cristina Cusin, Maurizio Fava, Georges El Fakhri, Marc D. Normandin
2020 NeuroImage  
Receptor ligand-based dynamic Positron Emission Tomography (PET) permits the measurement of neurotransmitter release in the human brain.  ...  A 11C-raclopride simulation study showed that the proposed approach substantially reduces the bias and variance of voxel-wise γ estimates as compared to standard methods.  ...  LSRRM parametric images were then estimated using IPR (voxel-wise fitting -Eq. 9-of native dynamic images), IPR smooth 417 (voxel-wise fitting of dynamic images smoothed with a standard 4-mm FWHM Gaussian  ... 
doi:10.1016/j.neuroimage.2020.117154 pmid:32679252 pmcid:PMC7800040 fatcat:urrpj4262bfjlhe7suzgqtl3zi

Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking

Evan D. Morris, Su Jin Kim, Jenna M. Sullivan, Shuo Wang, Marc D. Normandin, Cristian C. Constantinescu, Kelly P. Cosgrove
2013 Journal of Visualized Experiments  
We describe experimental and statistical steps for creating dopamine movies of the brain from dynamic PET data.  ...  Conventional methods for PET analysis estimate time-invariant kinetic model parameters which cannot capture short-term fluctuations in neurotransmitter release.  ...  Acknowledgements The authors thank the members of the Yale PET Center chemistry team for tracer synthesis, the imaging team for tracer injection and image acquisition and Ms.  ... 
doi:10.3791/50358 pmid:23963311 pmcid:PMC4046621 fatcat:bcismsqe6necbkv6z457kvpcua

Table of contents

2019 IEEE Transactions on Medical Imaging  
Righetti Direct Estimation of Voxel-Wise Neurotransmitter Response Maps From Dynamic PET Data ................... ........................................... G. I. Angelis, J. E. Gillam, W. J.  ...  Shmueli 1347 A Robust Method to Estimate the Time Constant of Elastographic Parameters .................................... .............................................................................  ... 
doi:10.1109/tmi.2019.2917568 fatcat:hqlo4l4y7ngvpn4utbzu2idmhm

Spatiotemporal Kernel Reconstruction for Linear Parametric Neurotransmitter PET Kinetic Modeling in Motion Correction Brain PET of Awake Rats

Alan Miranda, Daniele Bertoglio, Sigrid Stroobants, Steven Staelens, Jeroen Verhaeghe
2022 Frontiers in Neuroscience  
Striatum voxel-wise γ, td and tp values have lower variability using Kernel compared with IFR and IFR+HYPR.  ...  Here we use the spatiotemporal kernel reconstruction (Kernel) for noise reduction in dynamic PET, and lp-ntPET kinetic modeling.  ...  Particularly for the case of dynamic PET for kinetic modeling, direct reconstruction has been developed to reduce noise (Matthews et al., 2010) .  ... 
doi:10.3389/fnins.2022.901091 pmid:35645721 pmcid:PMC9133502 fatcat:apo3lqpfdnb6bnifprh7ycxrl4

Dopamine release during human emotional processing

Rajendra D. Badgaiyan, Alan J. Fischman, Nathaniel M. Alpert
2009 NeuroImage  
The technique exploited the competition between endogenously released dopamine and its ligand for receptor occupancy and involved dynamic voxel-wise measurement of the rate at which a dopamine receptor  ...  We used a novel dynamic molecular imaging technique to detect and map dopamine released during presentation of emotional stimuli.  ...  The model uses receptor kinetic parameters for voxel-wise estimation of changes in the rate of ligand displacement during task performance.  ... 
doi:10.1016/j.neuroimage.2009.06.008 pmid:19524047 pmcid:PMC2740985 fatcat:wnfekryulffc7bzqic4rwsnuoa

Neurotransmitter Imaging: Basic Concepts and Future Perspectives

Rajendra D. Badgaiyan
2011 Current Medical Imaging Reviews  
The PET data acquired dynamically isapplied to a receptor kinetic model, which estimates kinetic parameter values at multiple time point.  ...  In recent years investigators have used molecular imaging to develop methods for detection, mapping and measurement of neurotransmitters released acutely during cognitive processing in the live human brain  ...  During the experiment, PET data were acquired dynamically.  ... 
doi:10.2174/157340511795445720 fatcat:bpqi2o6robfnpo5daq4npqsace

Evidence of Dopaminergic Processing of Executive Inhibition

Rajendra D. Badgaiyan, David Wack, Angela Sirigu
2011 PLoS ONE  
The PET data were dynamically acquired during the experiment and analyzed using two variants of the simplified reference region model.  ...  Inhibition of unwanted response is an important function of the executive system.  ...  Molecular Imaging and PET Data Analysis: The dynamic molecular imaging technique exploits the competition between an injected radioligand and endogenously released neurotransmitter for occupancy of receptor  ... 
doi:10.1371/journal.pone.0028075 pmid:22162756 pmcid:PMC3230601 fatcat:cmdign6ypfbqtkstklglfuz7ou

Neurovascular coupling to D2/D3 dopamine receptor occupancy using simultaneous PET/functional MRI

C. Y. Sander, J. M. Hooker, C. Catana, M. D. Normandin, N. M. Alpert, G. M. Knudsen, W. Vanduffel, B. R. Rosen, J. B. Mandeville
2013 Proceedings of the National Academy of Sciences of the United States of America  
In this study, responses of the dopaminergic system in NHPs were assessed with PET/fMRI to characterize the dynamic relationship between hemodynamic responses and changes in neurochemistry.  ...  The latter were compared to receptor occupancy measures from PET in the domains of time, space, and dose.  ...  National Institutes of Health Grants R90DA023427, P41RR14075, P30DA28800, S10RR026666, S10RR017208, S10RR022976, and S10RR019933 supported this research.  ... 
doi:10.1073/pnas.1220512110 pmid:23723346 pmcid:PMC3703969 fatcat:q2v3qpzyf5e3rgnr5ohcribtgu

Striatal dopamine deficits predict reductions in striatal functional connectivity in major depression: a concurrent 11C-raclopride positron emission tomography and functional magnetic resonance imaging investigation

J. Paul Hamilton, Matthew D. Sacchet, Trine Hjørnevik, Frederick T. Chin, Bin Shen, Robin Kämpe, Jun Hyung Park, Brian D. Knutson, Leanne M. Williams, Nicholas Borg, Greg Zaharchuk, M. Catalina Camacho (+6 others)
2018 Translational Psychiatry  
We estimated raclopride binding potential (BP ND ), voxel-wise, and compared MDD and CTL samples with respect to BP ND in the striatum.  ...  group in which connectivity with striatal seed regions scaled linearly with BP ND from these regions.  ...  We then estimated BP ND voxel-wise from PET time activity curves constructed from data acquired from Minute 2 to Minute 17 (see Fig. 1 ).  ... 
doi:10.1038/s41398-018-0316-2 fatcat:w6pz37nxfffhrganlcdyede5nu

ABC in Nuclear Imaging [article]

Y. Fan, S. R. Meikle, G. Angelis, A. Sitek
2016 arXiv   pre-print
We demonstrate the utility of the proposed estimation methods on a neurotransmitter response model, and compare our approach to existing methods.  ...  We consider the parameter estimation of compartmental models in PET imaging analysis, and provide a simple ABC algorithm for its estimation.  ...  Application to a neurotransmitter response model Development of neurochemical assays that capture temporal signatures is critical because the neurotransmitter dynamics may encode both normal and abnormal  ... 
arXiv:1607.08678v1 fatcat:7yihzak3tvhkpdasa3njij57ou

Investigating the Spatial Associations Between Amyloid-β Deposition, Grey Matter Volume, and Neuroinflammation in Alzheimer's Disease

Lília Jorge, Ricardo Martins, Nádia Canário, Carolina Xavier, Antero Abrunhosa, Isabel Santana, Miguel Castelo-Branco, Josephine Barnes
2021 Journal of Alzheimer's Disease  
and 2) voxel-based multiple regression analysis between-modalities.  ...  To examine the effects of each one of the molecular pathologic mechanisms on neurodegeneration we computed: 1) ANCOVAs with the anatomic data, controlling for radiotracer uptake differences between groups  ...  the dynamic PET data.  ... 
doi:10.3233/jad-200840 pmid:33523050 fatcat:2flbmuzt7fgizhteimlykka7ja

Estimation from PET data of transient changes in dopamine concentration induced by alcohol: support for a non-parametric signal estimation method

C C Constantinescu, K K Yoder, D A Kareken, C A Bouman, S J O'Connor, M D Normandin, E D Morris
2008 Physics in Medicine and Biology  
We previously developed a model-independent technique (non-parametric ntPET) for extracting the transient changes in neurotransmitter concentration from paired (rest & activation) PET studies with a receptor  ...  Our findings lend credence to our model-independent estimates of F DA (t).  ...  Acknowledgments This work was funded in part by grants from the Whitaker Foundation (RG 02 0126 and TF 04 0034) and NIH R21 AA015077 to Evan D. Morris  ... 
doi:10.1088/0031-9155/53/5/012 pmid:18296766 fatcat:qv37vh7cnbbuxkxiqp5hilcrxy

Functional neuroanatomy of the human brain: positron emission tomography--a new neuroanatomical technique

R S Frackowiak, K J Friston
1994 Journal of Anatomy  
and hence to permit analysis of functional activation in the brain at the level of maps, networks and systems.  ...  Positron emission tomography (PET) is a noninvasive radiotracer-based technique which increasingly is being applied to describe the functional anatomy of the human brain in life.  ...  The review summarises ideas and uses illustrations from the work of members of the Clinical Neuroscience section of the MRC Cyclotron Unit and its collaborators.  ... 
pmid:8014115 pmcid:PMC1259983 fatcat:pxhv2t6o2fejpbwlw45uar74ba

Pharmacological differentiation of opioid receptor antagonists by molecular and functional imaging of target occupancy and food reward-related brain activation in humans

E A Rabiner, J Beaver, A Makwana, G Searle, C Long, P J Nathan, R D Newbould, J Howard, S R Miller, M A Bush, S Hill, R Reiley (+4 others)
2011 Molecular Psychiatry  
GSK1521498 was differentiated from NTX in terms of its pharmacokinetics, target affinity, plasma concentration-RO relationships and pharmacodynamic effects on food reward processing in the brain.  ...  GSK1521498 had high affinity for human brain ORs (GSK1521498 effective concentration 50 = 7.10 ng ml À1 ) and there was a direct relationship between receptor occupancy (RO) and plasma concentrations of  ...  Appropriate ethical committee and regulatory approvals were obtained from the NHS Brent Medical  ... 
doi:10.1038/mp.2011.29 pmid:21502953 pmcid:PMC3142667 fatcat:4qov4xiomjdcxjrpaagxgr6y3y

Excitatory–inhibitory balance within EEG microstates and resting-state fMRI networks: assessed via simultaneous trimodal PET–MR–EEG imaging

Ravichandran Rajkumar, Cláudia Régio Brambilla, Tanja Veselinović, Joshua Bierbrier, Christine Wyss, Shukti Ramkiran, Linda Orth, Markus Lang, Elena Rota Kops, Jörg Mauler, Jürgen Scheins, Bernd Neumaier (+7 others)
2021 Translational Psychiatry  
This research investigates these associations during the resting state (RS) condition using simultaneously recorded PET/MR/EEG (trimodal) data.  ...  The trimodal data were acquired from three studies using different radio-tracers such as, [11C]ABP688 (ABP) (N = 9), [11C]Flumazenil (FMZ) (N = 10) and 2-[18F]fluoro-2-deoxy-d-glucose (FDG) (N = 10) targeted  ...  Jorge Arrubla for his assistance in FDG trimodal human data acquisition. We are grateful to Dr. Andreas Matusch for his guidance with metabolite correction for PET imaging.  ... 
doi:10.1038/s41398-020-01160-2 pmid:33462192 fatcat:6aj3yh7nnberjnosrkwbilo3zi
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