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Meta-analysis identifies common variants associated with body mass index in east Asians

Wanqing Wen, Yoon-Shin Cho, Wei Zheng, Rajkumar Dorajoo, Norihiro Kato, Lu Qi, Chien-Hsiun Chen, Ryan J Delahanty, Yukinori Okada, Yasuharu Tabara, Dongfeng Gu, Dingliang Zhu (+51 others)
2012 Nature Genetics  
Multiple genetic loci associated with obesity or body mass index (BMI) have been identified through genome-wide association studies conducted predominantly in populations of European ancestry. We conducted a meta-analysis of associations between BMI and approximately 2.4 million SNPs in 27,715 East Asians, followed by in silico and de novo replication in 37,691 and 17,642 additional East Asians, respectively. We identified ten BMI-associated loci at the genomewide significance level (P<5.0×10
more » ... ), including seven previously identified loci (FTO, SEC16B, MC4R, GIPR/QPCTL, ADCY3/RBJ, BDNF, and MAP2K5) and three novel loci in or near the CDKAL1,PCSK1, and GP2 genes. Three additional loci nearly reached the genome-wide significance threshold, including two previously identified loci in the GNPDA2 and TFAP2B genes and a new locus near PAX6, which all had P<5.0×10 −7 . Findings from this study may shed light on new pathways involved in obesity and demonstrate the value of conducting genetic studies in non-European populations. Since 2007, genome-wide association studies (GWAS) have contributed to a major leap forward in understanding the genetic basis of obesity 1-11 . To date, 37 genetic loci associated with obesity or body mass index (BMI) have been identified through these GWAS. However, virtually all of these studies were conducted in populations of European ancestry and included limited data from Asian populations 9, 11 . Asians, which account for over 60% of the world's population, have a greater percentage of body fat and higher metabolic Users may view, print, copy, download and text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:
doi:10.1038/ng.1087 pmid:22344219 pmcid:PMC3288728 fatcat:l2ot6d2yu5dnpmtrjuoruepnnm

Biodiversity monitoring in China: from CForBio to Sino BON

Keping Ma
2015 Biodiversity Science  
Zhang Zhaochen, Hao Zhanqing, Ye Ji, Lin Fei, Yuan Zuoqiang, Xing Dingliang, Shi Shuai and Wang Xugao. 2013.  ...  Simon, Wang Xugao, Zhang Jian, Li Buhang, Yuan Zuoqiang, Xing Dingliang, Lin Fei, Ye Ji and Hao Zhanqing. 2012.  ... 
doi:10.17520/biods.2015025 fatcat:t3nqswopsrcnlpn65x2rpnxix4

Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index

Wanqing Wen, Wei Zheng, Yukinori Okada, Fumihiko Takeuchi, Yasuharu Tabara, Joo-Yeon Hwang, Rajkumar Dorajoo, Huaixing Li, Fuu-Jen Tsai, Xiaobo Yang, Jiang He, Ying Wu (+97 others)
2014 Human Molecular Genetics  
Recent genetic association studies have identified 55 genetic loci associated with obesity or body mass index (BMI). The vast majority, 51 loci, however, were identified in European-ancestry populations. We conducted a meta-analysis of associations between BMI and ∼2.5 million genotyped or imputed single nucleotide polymorphisms among 86 757 individuals of Asian ancestry, followed by in silico and de novo replication among 7488 -47 352 additional Asian-ancestry individuals. We identified four novel BMI-associated loci near the KCNQ1 (rs2237892,
doi:10.1093/hmg/ddu248 pmid:24861553 pmcid:PMC4168820 fatcat:pj3ngd7asnfchda7qxuewosowy

Epidemiological serosurvey of hepatitis B virus among children aged 1–14 years in Guangdong Province, China

Qi Zhu, Xiaoping Shao, Shaoli Chen, Dingliang Li, Xiaohong Chen, Wenjin Liu, Xianghua Wu, Zengyong Jian, Shannon Rutherford, Huizhen Zheng
2018 International Journal of Infectious Diseases  
Acknowledgements We thank the staff members of GDCDC (Huihong Deng, Chenggang Wu, Wenjia Liang, Jian Liang, Ke Hang, Yu Liu, Zhanjie Zhao, Qiu Tang, Jun Liu, Yongjie Lin, Xin Xie, Quan Qiu, Pei Hu, Churu  ... 
doi:10.1016/j.ijid.2018.01.027 pmid:29408358 fatcat:qxluwkjgbzdsxdnnratnlb5eve

Title Page / Table of Contents

2014 Cardiology  
Yining Yang, Yitong Ma, Fen Liu, Bangdang Chen……………………………………………………… (19) Different target organ venerability with several noninvasive arterial stiffness measurements Junli Zuo, Guili Chang, Pingjin Gao, Dingliang  ...  Yang ………………………………………………………………………………………………… (70) IVUS guided true lumen seek and tracking technique for complex chronic total occlusion lesions, experience from fuwai hospitalLei Song, Yuejin Yang, Liang  ... 
doi:10.1159/000365068 fatcat:hz3fjbczljgenp5zqqizq35ske

Configuring A Constitutional State: Officials and Assemblymen at the 1909 Sichuan Provincial Assembly Meeting

Xiaowei Zheng
2013 Twentieth-Century China  
its job would be to accumulate funds for the elite's future self-governance activities. 36 Concerning taxation, there was a proposal to change the way land tax was levied (剔除征收丁粮各弊 tichu zhengshou dingliang  ...  gentry supervise all taxation from the county, which meant that the gentry would not only supervise the behavior of the county magistrates and their clerks and runners in collecting the land tax (丁粮 dingliang  ... 
doi:10.1353/tcc.2013.0043 fatcat:mgi2774vkneezm44q5ehbcjo3m

Lack of Association between NADPH Quinone Oxidoreductase 1 (NQO1) Gene C609T Polymorphism and Lung Cancer: A Case-Control Study and a Meta-Analysis

Shujie Guo, Min Gao, Xiaobo Li, Yuqiong Li, Shaoli Chu, Dingliang Zhu, Wenquan Niu, Michihiko Kuwano
2012 PLoS ONE  
Lung cancer age, sex Asian Population NA NA Liang GY et al. Lung cancer age, sex Asian Hospital 60.90 60.50 Bock CH et al.  ...  Alexandrie AK et al. 0.221 0.344 ever/never/no information: 59.5/5.9/34.6 51.5/43.8/4.7 7 345/168/11 368/153/9 Lan Q et al. 0.660 0.650 smoing/non-smoing: 6/94 7/93 8 37/57/25 32/54/23 Liang  ... 
doi:10.1371/journal.pone.0047939 pmid:23110137 pmcid:PMC3480506 fatcat:jhndkyqiuzg6pb5cza6a7knn34

CONFIGURING A CONSTITUTIONAL STATE: OFFICIALS AND ASSEMBLYMEN AT THE 1909 SICHUAN PROVINCIAL ASSEMBLY MEETING

Xiaowei Zheng
2013 Twentieth-Century China  
its job would be to accumulate funds for the elite's future self-governance activities. 36 Concerning taxation, there was a proposal to change the way land tax was levied (剔除征收丁粮各弊 tichu zhengshou dingliang  ...  gentry supervise all taxation from the county, which meant that the gentry would not only supervise the behavior of the county magistrates and their clerks and runners in collecting the land tax (丁粮 dingliang  ... 
doi:10.1179/1521538513z.00000000029 fatcat:6p44ldj7mfcs5iwcqgzsynmdca

Research on the Measurement of Classroom Teaching Quality Evaluation System Based on Entropy Weight TOPSIS Method

Jin Liu
2021 Advances in Social Science, Education and Humanities Research   unpublished
Tan Dingliang and education quality.  ...  Tan Dingliang and Zhu Jianming figured the evaluation index of junior high school mathematics 3.  ... 
doi:10.2991/assehr.k.211217.012 fatcat:5d62txr7p5c3pf4v4ahl43ntsm

CVPRW 2020 TOC

2020 2020 IEEE/CVF Conference on Computer Vision and Pattern Recognition Workshops (CVPRW)  
Research Institute of Big Data) CVPM: Computer Vision for Physiological Measurement Photoplethysmography Based Stratification of Blood Pressure Using Multi-information Fusion Artificial Neural Network 1113 Dingliang  ...  ImagePairs: Realistic Super Resolution Dataset via Beam Splitter Camera Rig 2190 Hamid Reza Vaezi Joze (Microsoft), Ilya Zharkov (Microsoft), Karlton Powell (Microsoft), Carl Ringler (Microsoft), Luming Liang  ... 
doi:10.1109/cvprw50498.2020.00004 fatcat:6qao4eypyvg3xiiigih3kicniq

The Shanxi Banks

Randall K. Morck, Fan Yang
2010 Social Science Research Network  
Thereafter, the military budget [junxiang], poll tax [dingliang], sale tax [lijin], and provincial indemnity levies [gesheng ding'e tanpai waizhai] all moved about China throughinterest-free accounts at  ...  Rival Chinese banks gain similar flexibility under a 1901 German Civil Code (Kirby 1995; Goetzmann and Köll 2005) , and other took root in the foreign enclave despite legal discrimination (Liang 1930  ... 
doi:10.2139/ssrn.1594335 fatcat:sgksevhg7vbqneqbah4lojbyyq

Missile Science, Population Science: The Origins of China's One-Child Policy

Susan Greenhalgh
2005 The China Quarterly  
Song Jian and Li Guangyuan, "Renkou fazhan wenti de dingliang yanjiu" ("Quantitative research on the problem of population development"), Jingji yanjiu (Economy Research), No. 2, pp. 60-67. 55.  ...  She also rebuked Liang and dismissed his concerns about damaging social consequences, sending a chill throughout the social science community. 60 With the top population official on board, the stage  ... 
doi:10.1017/s0305741005000184 fatcat:pdnlb7wjc5bupn433n4clkcesm

Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians

Norihiro Kato, Fumihiko Takeuchi, Yasuharu Tabara, Tanika N Kelly, Min Jin Go, Xueling Sim, Wan Ting Tay, Chien-Hsiun Chen, Yi Zhang, Ken Yamamoto, Tomohiro Katsuya, Mitsuhiro Yokota (+37 others)
2011 Nature Genetics  
publicly available data [GTEx (Genotype-Tissue Expression) eQTL Browser (http://www.ncbi.nlm.nih.gov/gtex/test/GTEX2/gtex.cgi); http://eqtl.uchicago.edu/cgi-bin/gbrowse/eqtl/; http://www.sph.umich.edu/csg/liang  ... 
doi:10.1038/ng.834 pmid:21572416 pmcid:PMC3158568 fatcat:c27nnbm33rb7hbybixp7gbijie

White Ash and Black Coal: The Perception of Race in Modern China 1793-1949

Frank Dikotter
1990
It focuses mainly on the works of Liang Qichao, Tang Caichang and Kang Youwei, but also considers other writers who were preoccupied with the idea of race.  ...  Scholars like Fei Xiaotong, Wu Dingliang, or Lin Yaohua, for instance, would dissiminate the theories of their particular schools.94 While studying in the West, however, the Chinese were  ...  The aborigines, naive creatures sunk in 42 Liang Qichao, "Xin dalu youji" (Travel notes on America) in Liang Qichao, Yinbingshi zhuanji (Writings of Liang Qichao), Shanghai: Zhonghua shuju, 1941  ... 
doi:10.25501/soas.00034092 fatcat:vu6cztjmebfghpdzsn6ashpre4

A periodical for a science : Xinli and psychological knowledge in Republican China 1922-1927

Jia Yu
2017
Wu Dingliang (吴定良), "The Standard Educational Testing in America (美国标准的教育测验)," Xinli, 1922, 90 1(4).  ...  In 1922, for example, Wu Dingliang [吴定良] published an article titled "The Standard Educational Testings in America [美国标准的教育测验]" in Xinli.  ... 
doi:10.14288/1.0362238 fatcat:ikh5jhrnqfas3jajy6vsdiaejq
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