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Light flux from LED must be redistributed to meet the needs of lighting in most cases, a new method is proposed for its secondary optic design. Based on refractive equation and energy conservation, a set of firstorder partial differential equations which represent the characters of LED source and desired illumination were presented. The freeform lens was constructed by solving these equations numerically. The numerical results showed that we can get a freeform lens for the illumination ofdoi:10.1364/oe.16.012958 pmid:18711534 fatcat:ovfzht2hezatzh75tfaem2qc7i
more »... mity near to 90%, with considerable high computation speed. This method can shorten the designing time of the freeform lens with high accepted tolerance.
Closantel is an antiparasitic drug marketed in a racemic form with one chiral center. It is meaningful to develop a method for separating and analyzing the closantel enantiomers. In this work, two enantiomeric separation methods of closantel were explored by normal-phase high-performance liquid chromatography. The influences of the chiral stationary phase (CSP) structure, the mobile phase composition, the nature and proportion of different mobile phase modifiers (alcohols and acids), and thedoi:10.3390/molecules26237288 pmid:34885866 pmcid:PMC8659055 fatcat:a3m4g6trqvbwtnnpsllxkm22ze
more »... umn temperature on the enantiomeric separation of closantel were investigated in detail. The two enantiomers were successfully separated on the novel CSP of isopropyl derivatives of cyclofructan 6 and n-hexane-isopropanol-trifluoroacetic acid (97:3:0.1, v/v/v) as a mobile phase with a resolution (Rs) of about 2.48. The enantiomers were also well separated on the CSP of tris-carbamates of amylose with a higher Rs (about 3.79) when a mixture of n-hexane-isopropanol-trifluoroacetic acid (55:45:0.1, v/v/v) was used as mobile phase. Thus, the proposed separation methods can facilitate molecular pharmacological and biological research on closantel and its enantiomers.
We collect 214 Seyfert 1 galaxies (147 narrow line Seyfert 1 and 67 broad line Seyfert 1) and research black hole mass, bulge velocity dispersion, Eddington ratio, luminosity at 5100 Å and redshift. Our conclusions are follows: (1) when computing black hole mass, we should consider the effect of radiation pressure, especially for the narrow line Seyfert 1 galaxies; (2) when the effect of radiation pressure is considered, narrow line Seyfert 1 galaxies meet MBH-σ relation of normal galaxies anddoi:10.7498/aps.61.229801 fatcat:jesxk7nv7fbitkxeeatj3yinwa
more »... re in sub-Eddington accretion; (3) in a large samples, the evolution of Seyfert 1 galaxies is from narrow line Seyfert 1 galaxies to broad line Seyfert 1 galaxies, which is consistent with other results obtained in different ways.
Risk maps for the geographical distribution of human immunodeficiency virus (HIV) and the acquired immune deficiency syndrome (AIDS) are needed for the direction of HIV prevention interventions. Our study, based on county-level data on the numbers of HIV/AIDS patients in the Yunnan province, People's Republic of China, applied trend surface analysis and spatial autocorrelation analysis to demonstrate the geographical distribution of HIV-positive patients in the province. The case load of HIVdoi:10.4081/gh.2011.169 pmid:21590667 fatcat:zbxad7jspjcntcb5te5tc6ilgu
more »... found to be most severe in the central-west region of the province. While Kunming county was shown to be negatively correlated with its surrounding counties, many high-burden counties are surrounded by other counties with similar case numbers. We conclude that intervention efforts in Yunnan province should concentrate on the western and northeast regions, targeting the hotspots of infection.
Collaborative filtering recommendation algorithm is the most successful technology for recommendation systems. However, traditional collaborative filtering recommendation algorithm does not consider the change of time information. For this problem,this paper improve the algorithm with two new methods:Predict score incorporated with time information in order to reflect the user interest change; Recommend according to scores by adding the weight information determined by the item life cycle.doi:10.4028/www.scientific.net/amr.765-767.630 fatcat:zal5ypdt3rfmnay5jjpqh3z3ju
more »... imental results show that the proposed algorithm outperforms the traditional item in accuracy.
Core condition studies of radiation driven implosion for maximum compression time are the key contents of inertial confinement fusion research. Core conditions refer to the electron temperature and mass density in core region. The spatial distribution of core emission is calculated based on local thermal equilibrium by Multi one-dimensional simulation of core temperature and density. Assumption is made that the core temperature and density distributions each meet a Gauss distribution. Peakdoi:10.7498/aps.61.225204 fatcat:wpbhqzus6beofez5lro6t4wria
more »... s and full widths at half maximum of temperature and density spatial distribution can be inferred by parameter optimization. The data-processing for implosion experiment on Sheng-GuangIII prototype facility indicates that the peak values of temperature and density are 1.7 keV and 1.2 g/cm 3 respectively. The full widths at half maximum of temperature and density distribution are 20 µm and 18 µm respectively.
Previous studies reported thatNaja naja atravenom (NNAV) inhibited inflammation and adjuvant arthritis. Here we investigated the role of NNAV in regulation of immune responses in mice. Oral administration of NNAV to normal mice showed significant increase in natural killer cell activity, B lymphocyte proliferation stimulated by lipopolysaccharides, and antibody production in response to sheep red blood cells. Meanwhile, NNAV markedly decreased T lymphocyte proliferation stimulated bydoi:10.1155/2014/287631 pmid:25024726 pmcid:PMC4082923 fatcat:66aqj4d6yncq7jm6evqyfzdjwq
more »... n A, arrested the cell cycle at G0/G1phase, and suppressed CD4 and CD8 T cell divisions. Furthermore, NNAV inhibited the dinitrofluorobenzene-induced delayed-type hypersensitivity reaction. This modulation of immune responses may be partly attributed to the selective increase in Th1 and Th2 cytokines (IFN-γ, IL-4) secretion and inhibition of Th17 cytokine (IL-17) production. In dexamethasone-induced immunosuppressed mice, NNAV restored the concentration of serum IgG and IgM, while decreasing the percentage of CD4 and CD8 T-cell subsets. These results indicate that NNAV enhances the innate and humoral immune responses while inhibiting CD4 Th17 and CD8 T cell actions, suggesting that NNAV could be a potential therapeutic agent for autoimmune diseases.
The measurement of implosion velocity is the core problem of inertial confinement fusion and it is also a key quantity of estimation of fusion ignition. A clear implosion trajectory X-ray image of hohlraum-radiative-driven CH-capsule is obtained in Sheng-GuangII laser facility with 1600 J laser energy, triple frequency 1 ns pulse width. KB-microscope coupled with X-ray streak camera whose temporal resolution is about 10 ps is used for diagnosis. The maximal velocity of implosion is about 160doi:10.7498/aps.61.155208 fatcat:dscz3glewjcs3ixcjux22u46ju
more »... s which can be extracted from the experimental trajectory data. The experimental data are compared with Multi1D simulation results of velocity and both are in good agreement with each other.
Tuberculous spondylitis of the augmented vertebral column following percutaneous vertebroplasty or kyphoplasty has rarely been described. We report an unusual case of tuberculous spondylitis diagnosed after percutaneous kyphoplasty (PKP). A 61-year-old woman presented to our institution complaining of back pain following a fall 7 days before. Radiologic studies revealed an acute osteoporotic compression L1 fracture. The patient denied history of pulmonary tuberculosis (TB) and there were nodoi:10.1097/md.0000000000002940 pmid:26986102 pmcid:PMC4839883 fatcat:xxo2h4f2ivbuzg3tbqzasfgwhe
more »... s of infection. The patient was discharged from hospital 4 days after undergoing L1 PKP with a dramatic improvement in her back pain. Two years later, the patient was readmitted with a 1 year history of recurrent back pain. Imaging examinations demonstrated long segmental bony destruction involving L1 vertebra with massive paravertebral abscess formation. The tentative diagnosis of tuberculous spondylitis was made, after a serum T-SPOT. The TB test was found to be positive. Anterior debridement, L1 corpectomy, decompression, and autologous rib graft interposition, and posterior T8-L4 instrumentation were performed. The histologic examination of the resected tissue results confirmed the diagnosis of spinal TB. Anti-TB medications were administered for 12 months and the patient recovered without sequelae. Spinal TB and osteoporotic vertebral compression fractures are similar clinically and radiologically. Spinal surgeons should consider this disease entity to avoid misdiagnosis or complications. Early surgical intervention and anti-TB treatment should be instituted as soon as the diagnosis of spinal TB after vertebral augmentation is made. (Medicine 95(11):e2940) Abbreviations: CT = computed tomography, MRI = magnetic resonance imaging, PKP = percutaneous kyphoplasty, PVP = percutaneous vertebroplasty, TB = tuberculosis. Editor: Giuseppe Lapadula. FIGURE 2. Postoperative anteroposterior and lateral radiographs after L1 percutaneous kyphoplasty (PKP). PKP ¼ percutaneous kyphoplasty. FIGURE 3. Two years later, radiograph of the same patient showed bony destruction of L1, and bone cement dissemination.
This paper proposes a method to allow users to select target species for detection, generate an initial detection model by selecting a small piece of image sample and as the movie plays, continue training this detection model automatically. This method has noticeable detection results for several types of objects. The framework of this study is divided into two parts: the initial detection model and the online learning section. The detection model initialization phase use a sample size based ondoi:10.1016/j.procs.2018.10.500 fatcat:4tmmegu3mbduhcizk6thwrbwuq
more »... the proportion of users of the Haar-like features to generate a pool of features, which is used to train and select effective classifiers. Then, as the movie plays, the detecting model detects the new sample using the NN Classifier with positive and negative samples and the similarity model calculates new samples based on the fusion background model to calculate a new sample and detect the relative similarity to the target. From this relative similarity-based conservative classification of new samples, the conserved positive and negative samples classified by the video player are used for automatic online learning and training to continuously update the classifier. In this paper, the results of the test for different types of objects show the ability to detect the target by choosing a small number of samples and performing automatic online learning, effectively reducing the manpower needed to collect a large number of image samples and a large amount of time for training. The Experimental results also reveal good detection capability. Abstract This paper proposes a method to allow users to select target species for detection, generate an initial detection model by selecting a small piece of image sample and as the movie plays, continue training this detection model automatically. This method has noticeable detection results for several types of objects. The framework of this study is divided into two parts: the initial detection model and the online learning section. The detection model initialization phase use a sample size based on the proportion of users of the Haar-like features to generate a pool of features, which is used to train and select effective classifiers. Then, as the movie plays, the detecting model detects the new sample using the NN Classifier with positive and negative samples and the similarity model calculates new samples based on the fusion background model to calculate a new sample and detect the relative similarity to the target. From this relative similarity-based conservative classification of new samples, the conserved positive and negative samples classified by the video player are used for automatic online learning and training to continuously update the classifier. In this paper, the results of the test for different types of objects show the ability to detect the target by choosing a small number of samples and performing automatic online learning, effectively reducing the manpower needed to collect a large number of image samples and a large amount of time for training. The Experimental results also reveal good detection capability.
doi:10.4103/0366-6999.159365 pmid:26112730 pmcid:PMC4733714 fatcat:vsxrhzdofjfk3glxvwlstglrbi
Zheng et al. ... Numerical modeling work as shown in Zheng et al.  might be useful for further studies. ...doi:10.3390/rs13061113 fatcat:bi7wc5fjgjav5k6rvvaewwbs2a
Journal of Cancer
Cervical cancer is one of the most common cancer in female worldwide. The expression of high-risk human papillomavirus E7 oncogene is necessary for the maintenance of malignant phenotypes and transformation. Accumulating studies of this protein has been explored in cervical cancer, however, there are fewer studies on how E7 expression affects the expression of global circular RNA. CircRNA, a promising biomarker and even therapeutic target, has become a star molecular in research after miRNA anddoi:10.7150/jca.24253 pmid:30405847 pmcid:PMC6216014 fatcat:nalf26yrnrdkzisl35vhqumy3m
more »... long non-coding RNA. Our aim of this study was to investigate the global circRNA levels modulated by HPV E7 expression and identified the potential consequences for mechanism studies. Here we investigated the expression profiles of circRNAs by transfecting E7 siRNA in Caski cells with high-throughput microarray technology. In total, we identified 526 dysregulated circRNAs with fold change ≥2 or≤0.5, and p< 0.05. Among them, 352 were up-regulated and 174 were down-regulated. In addition, 8 selected circRNAs confirmed using qRT-PCR was in line with the results of microarray analysis. Furthermore, bioinformatic analyses indicated that differently expressed circRNAs might implicate in the mTOR signaling pathway, proline metabolism and glutathione metabolism. In conclusion, this study showed the expression profiles of circRNAs regulated by HPV16 E7 in cervical cancer cells and provides novel insights into the new potential candidates for future mechanism studies.
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